• Korean Journal of Bronchoesophagology
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• v.5 no.2
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• pp.153-158
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• 1999

Background and Objectives : The treatment of supraglottic stenosis remains a challenging problem in the field of otolaryngology due to its association with dyspnea, dysphagia, and frequent recurrence. Any satisfactory treatment is not yet known. The author experienced six cases of supraglottic stenosis and report the successful treatment of five cases by repeated endoscopic laryngeal excision with KTP-532 laser under suspension layngoscopy. Materials and Methods : Six adults who were treated for supraglottic stenosis between March 1994 and December 1998 at the Department of Otoloaryngology-Head and Neck Surgery, Korea University Medical Center were studied retrospectively. The patients were placed under general anesthesia followed by endoscopic laryngeal excision with KTP-532 laser under supension laryngoscopy. The scar tissue and granulation tissue were visualized with an operating microscope, and then removed using KTP-532 laser (15watts, continuous mode). Intraoperative local steroid(Triamcinolone ) was injected in all cases after the stenotic portions were removed. Results : Endoscopic excision was performed in five cases ; among the five cases, cricoid cartilage was concomitantly removed in two cases, and epiglottis was removed in one case. Satisfactory swallowing and airway respiration were possible in all five patients who underwent endoscopic widening. Conclusion : The treatment of supraglottic stenosis is different from that of tracheal or glottic stenosis in that supraglottic stenosis is mainly developed in membraneous form. Repeated laser excision and local steroid injection under suspension laryngoscopy is an effective and recommend able method for the treatment of supraglottic stenosis.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.07b
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• pp.631-634
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• 2004

The method that exists in Photodynamic Therapy uses Photosensibility drug strongly Influencing tumour accumulation together with photochemical laser effect and makes the structure of tumour be localized and become extinct. The intracavity transformation of the Nd :YAP main radiation 1079 nm was Raman converted in barium nitrate crystal and the Stokes frequency (1216 nm) was doubled using KTP or RTA crystals. The LiF or Cr:YAG crystals are used for the Q-switch. The radiation Parameters were obtained at 100 Hz pump repetition frequency. The average power at 608 nm radiation with LiF and KTP was 700 mW at multi-mode generation. The 3-6 single 10-15 ns pulses were generated during one cycle of pumping. The doubling efficiency with RTA was two times more than with KTP. The cells of Ehrlich adenocarcinoma (0.1 ml) were i.m. implanted in hind thighs of ICR white non-imbred mice. The cells were preliminarily diluted in medium 199 in the ratio of 1 to 5. HpD was intravenous administered in a dose of 10 mg/kg. The left clean-shaven hind leg was irradiated with laser light 21-27 hours after the administration of the preparation. The right non-Irradiated leg of each animal served as a control. The animals with the transplanted tumor that were not injected with HpD sewed as a control to estimate the complex effect (HpD+ irradiation). Before the administration of HpD and on 3 and 4 days after irradiation the tumor size was measured and the percent of the tumor growth inhibition was calculated. The results of animal treatments has shown high efficiency of PDT method for cancer treatment by means 0.608 m high power pulse solid state laser.

• Korean Journal of Optics and Photonics
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• v.14 no.3
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• pp.292-297
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• 2003

A diode-pumped single-mode Nd:YV $O_4$ green laser was developed. Frequency doubling of the laser was achieved by using an intracavity KTP generated green beam (532 nm). By comparing the diode laser spectrum with absorption spectrum of the Nd:YV $O_4$ crystal, we found optimal operating temperature of the diode laser. From output power measured for various mirror curvatures and cavity lengths, we found the optimal matching of TE $M_{00}$ mode with the pump beam gives the best efficiency. When the pump power was 1.9 W, 80 ㎽ of TE $M_{00}$ mode green beam was obtained. We tried to get a single longitudinal mode lasing as the fluctuation of the laser power was caused by the shift of longitudinal modes and the beating between the modes. We tested the intracavity etalon method and birefringent filter method for single mode operation. The etalon method resulted in the best single mode output power of 60 ㎽. The power fluctuation of the single-mode laser was reduced to 1/10 of that of the multi-mode laser.

• The Journal of Natural Sciences
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• v.14 no.2
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• pp.25-31
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• 2004

레이저 거리 측정기나 화생탐지 라이다용으로 사용할 수 있는 눈에 안전한 적외선 레이저 광원을 개발하였다. 펌프레이저로는 소형 플래쉬 램프로 구동되는 Nd:YAG 레이저를 사용하였으며, OPO(Optical Parametric Oscillator) 결정으로는 Flux 성장된 KTP를 사용하였다. OPO 송진기는 레이저 공진기 내부에 설치하여 비선형 광학 현산에 의한 파라메트릭 발진이 쉽게 일어나도록 하였다. 효율적인 파라메트릭 발진을 위해서 Type II 비임계 위상정합$(\theta=90^{\circ},\;\phi = 0^{\circ})$을 사용하여 공진기를 구성하였다. Nd:YAG 레이저는 Cr:YAG 결정을 사용하여 수동형 큐-스위칭 되었으며 OPO 출력은 1mJ 정도이었다. OPO 펄스폭은 4ns로서 수동형 큐스위칭 레이저 펄스폭보다 20% 정도로 작았다. OPO 출력의 펄스폭이 펌프레이저의 펄스폭 보다 작은 것은 이론적 계산을 통하여 확인할 수 있었다.

• Korean Journal of Optics and Photonics
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• v.9 no.4
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• pp.236-239
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• 1998

We constructed a frequency doubler with a frequency-stabilized Nd:YAG Laser, a nonlinear crystal KTP, and an external resonant cavity. Using type II phase-making method and a resonant cavity, one usually have a serious problem that the second harmonic conversion efficiency is decreased greatly, for under usual circumstances ordinary ray and extraorninary ray cannot be resonated in a cavity simultaneously. With the change of temperature and incident angle of KTP, we found an optimized condition for the phase-matching and double-resonance. As a result we produced 26 mW of green light with 318 mW of fundamental laser power from a cw Nd:YAG laser.

• Journal of Chest Surgery
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• v.30 no.12
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• pp.1237-1241
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• 1997

Tracheal stenosis is a difficult disease entity to manage. Laser ablation is one effective treatment for treacheal stenosis and can be utilized if tracheal reconstructive surgery is impossible. Potassium titanyl phosphate laser, transmitted via flexible quartz fiber, can be precisely manipulated through flexible bronchoscope under local anesthesia. We treated 7 patients with trach al and broncheal lesion under local anesthesia with KTP laser from January 1995 to July 1996. The patients included three males and four females. The age of patients ranged from 22 to 66 years with a mean of 43.7 years The etiology of tracheal stenosis in patients was stenosis after tracheostomy(3 cases), prolong inturbation in cases of sepsis(1 cases), and the recurrence of lung cancer within endobronchial lesion(2 cases). In the cases of tracheal stenosis treated with laser ablation, there were 2 cases of recurrence of stenosis at the anastomosis site after the operation, 3 cases of stenosis at tracheostomy site, and 2 cases of local recurrence of lung cancer. The site of the tracheal stenosis was the balloon site of the tracheostomy tube(3-4cm inferior to the tracheostomy site, 2-3cm superior to the carina) and the anastomosis site that were narrowed to less than 5mm(4 cases). For the stenosis lesion in the endobronchial area, there were 2 patients with a lesion at the anterior wa l, 1 patient with a lesion at the posterior wall, 2 patients with circumferential stenosis. Laser ablation time was 25.4 $\pm$5.9min and used energy was 1768 $\pm$365J. We have used KTP laser via (lexible bronchoscope without major complications. Adjuvant radiation therapy may prevent fibroblast proliferation which leads to restenosis. In three patients of restenosis after laser ablation, adjuvant irradiation started within 4 hours after laser ablation, and the radiation doses were 1500cGy given in five fraction. In patients with adjuvant radiation therapy, stenosis has not recurred

• Medical Lasers
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• v.10 no.3
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• pp.170-175
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• 2021

Background and Objectives Cisplatin is an important chemotherapy drug for the treatment of head and neck cancer. Interstitial laser treatment (ILT) has cosmetic utility and is very important for maintaining the function of the head and neck after cancer treatment. This study examined the synergistic effects of locally injected cisplatin-epigel and high fever induced by an interstitial potassium titanyl phosphate (KTP) laser treatment on a xenografted human Heinz squamous cell carcinoma. Materials and Methods SNU-1041 (107 cells/0.1 ml) cells were xenografted into the back of nude mice by subcutaneous injection. The ILT group (n = 10) was treated with a KTP laser (1 J/mm³) through a cylindrical diffuser tip inserted into the tumor, monitoring the temperature at 43-45℃. In the combined treatment group (n = 10), local hyperthermia was induced by intratumoral injection of 100-200 ㎍ of cisplatin into a collagen-based gel carrier (cisplatin-epigel), which was released slowly four hours before ILT. After four weeks of follow-up, the treated tumors were evaluated for tumor remission and volume change. Results Eight (80%) of the combined group showed complete tumor remission at the four-week follow-up, whereas only three (30%) of the ILT group showed remission (30%) (p < 0.01). Conclusion The current study has shown the synergistic effects of a local cisplatin injection and high fever from ILT on a xenografted human Heinz squamous cell carcinoma.

• Journal of the Korean Magnetics Society
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• v.21 no.1
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• pp.32-36
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• 2011

We fabricated a sensor for measuring the water level and water temperature using GMR-SV (giant magnetoresistance-spin valve) device, simultaneously. It could be applied to the medical cooling system of the potassium titanylphosphate KTP) laser system for the therapy of a benign prostatic hyperplasia. The middle point of GMR-SV device was set to the near position of a high magnetic sensitivity with 2.8%/Oe. The sensitivity for the water level and water temperature of the fabricated sensor were $400\;m{\Omega}/mm$ and $100\;m{\Omega}/^{\circ}C$, respectively.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.05a
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• pp.419-423
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• 2003

In this paper, we have constructed singly resonant KTP OPO system pumped by 532 nm to obtain broadly frequency tunable pulses. Also we have mathematically simulated frequency tuning range, phase matching angle for 900 nm output and threshold energy, and we calculated output intensity using wave propagation equations for optical parametric oscillator which include walk-off, pump depletion.

• Korean Journal of Materials Research
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• v.6 no.6
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• pp.636-643
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• 1996

공진기형 제 2고조파소자(SHG)는 레이저 빔의 에너지 밀도가 높아 고내구성 박막이 필요하다. 본 연구에서는 광학박막 재료로 고융점 산화물인 ZrO2, TiO2, SiO2를 사용하였다. 반응성 스퍼터링 방법으로 제작한 ZrO2, TiO2, SiO2 박막을 XRD, SAM을 사용하여 분석하였고, 박막의 광학적 특성을 평가하였다. SHG 소자의 KTP 및 Nd:YAG 결정의 반사방지막(A/R 코팅)구성은 ZrO2와 SiO2를 사용하여 컴퓨터로 계산하였는데 기본파인 1064nm와 제 2고조파인 532nm에서 각각 0.1%, 0.5%이하의 반사율을 갖도록 하였다. 또한 고반사막(H/R 코팅)의 경우 1064nm에서 99.9%의 반사율을 갖도록 TiO2와 SiO2로 디자인하였다. 제작한 광학박막의 광학적 특성, 레이저 내구성(laser damage threshold), 온습도 안정성 실험 등을 통해 광학박막을 평가하였다.