• 제목/요약/키워드: KR

검색결과 1,641건 처리시간 0.024초

Genetic parameters and correlations of related feed efficiency, growth, and carcass traits in Hanwoo beef cattle

  • Mehrban, Hossein;Naserkheil, Masoumeh;Lee, Deuk Hwan;Ibanez-Escriche, Noelia
    • Animal Bioscience
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    • 제34권5호
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    • pp.824-832
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    • 2021
  • Objective: This study aimed to estimate the genetic parameters and genetic correlations for related feed efficiency, growth, and carcass traits in Hanwoo cattle. Methods: Phenotypic data from 15,279 animals born between 1989 and 2015 were considered. The related feed efficiency traits considered were Kleiber ratio (KR) and relative growth rate (RGR). Carcass traits analyzed were backfat thickness (BT), carcass weight, eye muscle area, and marbling score. Growth traits were assessed by the average daily gain (ADG), metabolic body weight (MBW) at mid-test age from 6 to 24 months, and yearling weight (YW). Variance and covariance components were estimated using restricted maximum likelihood using nine multi-trait animal models. Results: The heritability estimates for related feed efficiency (0.28±0.04 for KR and RGR) and growth traits (0.26±0.02 to 0.33±0.04) were moderate, but the carcass traits tended to be higher (0.38±0.04 to 0.61±0.06). The related feed efficiency traits were positively genetically correlated with all the carcass traits (0.37±0.09 to 0.47±0.07 for KR, and 0.14±0.09 to 0.37±0.09 for RGR), except for BT, which showed null to weak correlation. Conversely, the genetic correlations of RGR with MBW (-0.36±0.08) and YW (-0.30±0.08) were negative, and those of KR with MBW and YW were close to zero, whereas the genetic correlations of ADG with RGR (0.40±0.08) and KR (0.70±0.05) were positive and relatively moderate to high. The genetic (0.92±0.02) correlations between KR and RGR were very high. Conclusion: Sufficient genetic variability and heritability were observed for traits of interest. Moreover, the inclusion of KR and/or RGR in Hanwoo cattle breeding programs could improve the feed efficiency without producing any unfavorable effects on the carcass traits.

Antiplatelet Activity of [5-(2-Methoxy-5-chlorophenyl)furan-2-ylcarbonyl]guanidine (KR-32570), a Novel Sodium/hydrogen Exchanger-1 and Its Mechanism of Action

  • Lee Kyung-Sup;Park Jung-Woo;Jin Yong-Ri;Jung In-Sang;Cho Mi-Ra;Yi Kyu-Yang;Yoo Sung-Eun;Chung Hun-Jong;Yun Yeo-Pyo;Park Tae-Kyu;Shin Hwa-Sup
    • Archives of Pharmacal Research
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    • 제29권5호
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    • pp.375-383
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    • 2006
  • The anti platelet effects of a novel guanidine derivative, KR-32570 ([5-(2-methoxy-5-chlorophenyl) furan-2-ylcarbonyl]guanidine), were investigated with an emphasis on the mechanisms underlying its inhibition of collagen-induced platelet aggregation. KR-32570 significantly inhibited the aggregation of washed rabbit platelets induced by collagen $(10{\mu}g/mL)$, thrombin (0.05 U/mL), arachidonic acid $(100{\mu}M)$, a thromboxane (TX) $A_2$ mimetic agent U46619 (9,11-dideoxy-9,11-methanoepoxy-prostaglandin $F_2,\;1{\mu}M$) and a $Ca^{2+}$ ATPase inhibitor thapsigargin $(0.5{\mu}M)$ ($IC_{50}$ values: $13.8{\pm}1.8,\;26.3{\pm}1.2,\;8.5{\pm}0.9,\;4.3{\pm}1.7\;and\;49.8{\pm}1.4{\mu}M$, respectively). KR-32570 inhibited the collagen-induced liberation of $[^3H]$arachidonic acid from the platelets in a concentration dependent manner with complete inhibition being observed at $50{\mu}M$. The $TXA_2$ synthase assay showed that KR-32570 also inhibited the conversion of the substrate $PGH_2$ to $TXB_2$ at all concentrations. Furthermore, KR-32570 significantly inhibited the $[Ca^{2+}]_i$ mobilization induced by collagen at $50{\mu}M$, which is the concentration that completely inhibits platelet aggregation. KR-32570 also decreased the level of collagen $(10{\mu}g/mL)$induced secretion of serotonin from the dense-granule contents of platelets, and inhibited the NHE-1-mediated rabbit platelet swelling induced by intracellular acidification. These results suggest that the antiplatelet activity of KR-32570 against collagen-induced platelet aggregation is mediated mainly by inhibiting the release of arachidonic acid, $TXA_2$ synthase, the mobilization of cytosolic $Ca^{2+}$ and NHE-1.

홍백 비단잉어와 홍백 비단잉어×홍잉어 교배종의 적색소 분석 (Analysis of Red Coverage in Red- and White-koi Carp (Cyprinus carpio) and Red- and White-koi Carp (C. carpio)×Red Common Carp (C. carpio) Cross Progenies)

  • 황주애;김정은;이정호;김대희;김형수
    • 한국어류학회지
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    • 제30권4호
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    • pp.238-241
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    • 2018
  • 본 연구는 고품질 비단잉어 생산을 위해 비단잉어와 홍잉어 교배종의 성장과 적색색소의 빈도분석을 통해 비단잉어 색도를 분석하였다. 색소 및 성장도 분석을 위해 부화 후 170일령 비단잉어를 각 교배 집단별로[비단잉어${\times}$비단잉어(KK), 비단잉어${\times}$홍잉어(KR)와 홍잉어${\times}$비단잉어(RK)] 100개체씩 분석하였다. 성장도 분석 결과 비단잉어${\times}$홍잉어(KR) 교배집단에서 전장과 전중의 성장이 가장 높았다. 교배 그룹 모두 흰색, 적색-흰색, 적색의 3가지 색소 패턴을 보였다. 적색색소 분포는 KK 집단이 64%, KR 집단이 56%, RK 집단이 36%였다. 적색 색소 범위의 빈도분석 결과 적색색소 30~50%를 차지하는 비율이 KK 집단이 10%, RK 집단이 12% 그리고 KR 집단이 14%로 가장 높았다. 비단잉어 적색색소 빈도 분석에 관한 연구는 비단잉어 선별을 위한 분석 도구로서 활용이 가능할 것으로 판단된다.

Si(100)에 주입된 불활성 기체 이온들의 방출 특성 (Thermal Effusion of Implanted Inert Gas Ions from Si(100))

  • 조삼근
    • 한국진공학회지
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    • 제15권1호
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    • pp.73-80
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    • 2006
  • Si(100)에 주입된 불활성 기체 이온들의 열적 방출 특성을 열탈착(temperature-programmed desorption; TPD) 질량분석법으로 고찰하였다. 약 400K의 표면 온도 조건에서 1keV 비온빔에 시료를 노출시켜 주었을 때, He은 $500\~1100 K$의 넓은 온도 범위에서 Si(100)결정 밖으로 분출되어 나온 반면, Ne, Ar, 및 Kr은 각각 810, 860, 875 K 근처에서 매우 좁은 온도 범위에서 TPD 피크를 나타내며 급격하게 방출되었다. He+ 이온으로 처리된 Si(100)은 표면 원자 구조의 손상이 상대적으로 최소한으로 일어났지만, $Ne^+,\;Ar^+,\;Kr^+$ 등의 이온들로 처리된 경우는 질량이 클수록 표면이 원자 스케일로 더 심하게 손상되었음이 수소 흡탈착 분석 결과로 밝혀졌다. 이온빔에 의한 결정 내부의 결함 생성과 관련하여 이러한 실험적 결과가 시사하는 점들을 논의하였다

멀티모달 가이던스가 독보 기능 습득에 미치는 영향: 드럼 타격 시퀀스에서의 사례 연구 (Effects of Multi-modal Guidance for the Acquisition of Sight Reading Skills: A Case Study with Simple Drum Sequences)

  • 이인;최승문
    • 로봇학회논문지
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    • 제8권3호
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    • pp.217-227
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    • 2013
  • We introduce a learning system for the sight reading of simple drum sequences. Sight reading is a cognitive-motor skill that requires reading of music symbols and actions of multiple limbs for playing the music. The system provides knowledge of results (KR) pertaining to the learner's performance by color-coding music symbols, and guides the learner by indicating the corresponding action for a given music symbol using additional auditory or vibrotactile cues. To evaluate the effects of KR and guidance cues, three learning methods were experimentally compared: KR only, KR with auditory cues, and KR with vibrotactile cues. The task was to play a random 16-note-long drum sequence displayed on a screen. Thirty university students learned the task using one of the learning methods in a between-subjects design. The experimental results did not show statistically significant differences between the methods in terms of task accuracy and completion time.

흑연 표면에 흡착된 Kr 기체의 열역학적 성질 (Thermodynamic Properties of Kr Gas Adsorbed on Graphite Surface)

  • 안운선;함경희;유은아;이광순
    • 대한화학회지
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    • 제26권4호
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    • pp.211-217
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    • 1982
  • 흑연 표면에 흡착된 Kr분자를 2D기체로 보고 2D비리알상태방정식의 넷째 비리알 계수를 cluster intergral을 이용해서 계산하였으며, 또한 Henry 상수와 둘째 및 셋째 비리알계수도 계산하였다. 그리고 이 상태방정식으로부터 흡착등온곡선을 구하여 실험결과와 비교하여 본 결과 상당히 만족스런 결과를 얻었다. Kr-고체표면 사이의 상호작용 에너지는 Lennard-Jones(12,6)퍼텐셜의 pairwise additivity를 가정하여 구하였으며, 여기에 사용한 파라미터는 ${\varepsilon}_{gs}$/k = 71.1 K, ${\varepsilon}_{gg}$/k = 170 K, ${\sigma}_{gs}$ = 354 pm 및 ${\sigma}_{gg}$ = 368 pm이다.

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Effects of Knowledge of Result Versus Knowledge of Performance on Treadmill Training on gait ability in Stroke Patients: A Randomized Clinical Trial

  • Park, Jin
    • The Journal of Korean Physical Therapy
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    • 제32권2호
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    • pp.107-113
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    • 2020
  • Purpose: This study compared the walking ability of chronic stroke patients following either treadmill training with knowledge of the result (KR group) or treadmill training with knowledge of the performance (KP group). Methods: Nineteen patients with chronic stroke were recruited from a rehabilitation hospital. The patients were divided into two groups: a KR group (10 patients) and a KP group (9 patients). They received 30 minutes of neuro-developmental therapy and treadmill training 30 minutes, five times a week for three weeks. The gait parameters were measured before and after training using the Optogait system. Results: After the training periods, the KR group showed significant improvement in gait speed, cadence, step length of the unaffected limb, stance time of the affected limb, and functional gait assessment compared to the KP group (p<0.05). Conclusion: The results showed that treadmill training with KR was more effective in improving the gait speed and cadence, step length of the unaffected limb, stance time of the affected limb, and functional gait ability than the treadmill training with KP. Therefore, to improve the walking ability of stroke patients, it is necessary to consider treadmill training with KR. If it can be combined with conventional neurological physiotherapy, it would be an effective rehabilitation for stroke patients.

High-performance liquid chromatographic assay and oral pharmacokinetics of new anti-HIV uracil derivatives, KR-V analogues, in rats

  • Lee, Youngmi;Heeok Shim;Seoungryong Yu;Hochul Shin;Moonkoo Chung;Jungkoo Roh
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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    • pp.123-123
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    • 1998
  • A number of uracil derivatives have been developed as anti-AIDS drugs having a mechanism of inhibiting cellular reverse transcriptase. A simple and rapid assay technique for recently synthesized KR-V analogues was developed using a high-performance liquid chromatography, and oral pharmacokinetics was examined for assessing their oral bioavailabilites. Plasma samples were analyzed by reversed-phase HPLC using an ODS column with an ultraviolet detection system. All the analogues were eluted within 12 min and the LOQ was 15-30 ng/$m\ell$. The extraction recoveries were higher than 85%, except KR-V1039, 1068 and 1720 having ester group. This chromatic method was well applied to the kinetic studies for KR-V analogues. Among 16 analogues tested in the present work, the 6 compounds including KR-V1123, 1122, 1784, 1783, 1736 and 1700 were found to be bioavailable for oral administration to rats.

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Metabolism of a New Neuroprotective Agent for Ischemia-Reperfusion Damage, KR-31543 in the Rats using Liquid Chromatography/Electrospray Mass Spectrometry

  • Kim, John;Ji, Hye-Young;Lee, Seung-Seok;Yoo, Sung-Eun;Kim, Sun-Ok;Lee, Dong-Ha;Lim, Hong;Lee, Hye-Suk
    • Archives of Pharmacal Research
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    • 제25권5호
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    • pp.664-668
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    • 2002
  • KR-31543,(2S,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amino]-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-1-benzopyran is a new neuroprotetive agent for ischemia-reperfusion damage. The in vitro and in vivo metabolism of KR-31543 in rats has been studied by LC-electrospray mass spectrometry. Rat liver microsomal incubation of KR-31543 in the presence of NADPH resulted in the formation of a metabolite M1. M1 was identified as N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine on the basis of LC-MS/MS analysis with the synthesized authentic standard. Rat CYP3A1 and 3A2 are the major CYP isozymes involved in the formation of M1.

다중바이트 문자집합 텍스트에서의 문자열 검색 알고리즘 (String Matching Algorithm on Multi-byte Character Set Texts)

  • 김은상;김진욱;박근수
    • 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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    • 제16권10호
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    • pp.1015-1019
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    • 2010
  • 문자열 완전일치 검색 알고리즘용 지금까지 많은 연구가 되어왔지만, EUC-KR 용 다중바이트 문자집합에 대해서는 연구원 것이 부족한 상황이다. 이 논문에서는 기존의 KMP 알고리즘을 사용할 때 EUC-KR과 같은 다중바이트 문자집합 텍스트에서 오검색이 발생할 수 있음을 보이며, 문자 단위의 접두사 함수를 적용하여 오검색이 발생하지 않도록 개선한 KMP 알고리즘을 제안한다. 또한, 널리 사용되고 있는 편집기인 Vim과 Emacs의 검색 알고리즘 및 기존의 오토마타 방식의 연구 결과에 비해 논문에서 제안한 알고리즘이 더 빠른 속도를 보이는 실험 결과를 제시한다.