• Journal of Pharmaceutical Investigation
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• 제32권4호
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• pp.241-258
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• 2002

Such osmotic drug delivery systems are based on osmosis, the diffusion of water transversely from a medium with a low osmotic pressure to a medium with a high osmotic pressure for the controlled delivery of active agents. In this review, U.S. Patents on osmotic drug delivery analyze 261 patents until December 2001. These devices form now a major market of drug delivery products. Because of their advantage and innovate idea, it appears that the future of oral drug delivery mark,εt in Korea is promising.

• Journal of Pharmaceutical Investigation
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• 제32권2호
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• pp.81-85
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• 2002

Three polymorphic modifications of CKD-602, water soluble derivative of camptothecin, were obtained by the recrystallization from different organic solvents and characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and X-ray powder diffraction (XRPD). The major endothermic peaks of the DSC curve of Form 1, Form 2 and Form 3 was shown at $268.71^{\circ}C$, $247.83^{\circ}C$, $244.76^{\circ}C$, respectively. Form 2 was elucidated to be an acetic acid solvate and Form 3 was elucidated to be a methanol solvate. The dissolution patterns of these three modifications were also checked in distilled water at $37{\pm}0.5^{\circ}C$, for 30 minutes. The polymorphic modifications showed differences in the dissolution rate. The dissolution rate of Form 1 was faster than that of other polymorphic modifications. When stored at different relative humidity over the period of 3 months, all of the polymorphic modifications did not undergo transformation.

• Journal of Pharmaceutical Investigation
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• 제32권2호
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• pp.95-101
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• 2002

Matrix tablets of nifedipine (NP) were prepared with Eudragit, diluent (lactose or Ca. phosphate) and Mg. stearate employing two different preparation methods (wet granulation and direct compression) to develop its sustained-release dosage forms. The effects of various formulation factors on the dissolution rate of the drug were investigated. Dissolution test was studied in pH 6.8 phosphate buffer containing 1% sodium lauryl sulfate using the paddle method. Formulation factors were the type and content of Eudragit, the type of diluent and the tablet preparation method. The optimum formula of NP matrix tablet, which resulted in a similar dissolution profile to that from Adalat Oros used as a reference, was 30 mg NP, 10% Eudragit RS, 2% Mg. stearate and an adequate quantity of lactose to yield 500 mg weight using the wet granulation method.

• Journal of Pharmaceutical Investigation
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• 제32권4호
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• pp.321-325
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• 2002

IVIVC (In vitro/in vivo correlation) is useful for predicting in vivo results from in vitro data. The aim of this study was to develop IVIVC of sustained release diltiazem. For this purpose, three types of diltiazem tablets with different in vitro dissolution rates were prepared. An in vitro dissolution testing method comprising of paddle apparatus, 50 rpm, water as dissolution medium was developed. Under these condition, we demonstrated that AUCinf could be predicted by evaluating $d_{70%}$ (time dissolved 70%) in vitro since the in vivo AUCinf was correlated with the in vitro $d_{70%}$ (r=-0.9981).

• 한국응용과학기술학회지
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• 제27권1호
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• pp.56-60
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• 2010

Titanium dioxide particles are used as photocatalysts, sensors, adsorbents and catalyst. Core-shell polymers of inorganic/organic pair, which have both core and shell component, were synthesized by sequential emulsion polymerization using Acrylate as a shell monomer and potassium persulfate (KPS) as an initiator. We found that when Acrylate core prepared by adding 0.5~2.0 wt% EU-S133D, Titanium dioxide / Acrylate core-shell polymerization was carried out on the surface of Titanium dioxide particle without forming the new Titanium dioxide particle during acrylate shell polymerized in the inorganic/organic core-shell polymer preparation. The structure of core-shell polymer were investigated by measuring to the thermal decomposition of polymer composite using thermogravimetric analyzer(TGA) and morphology of latex by scanning electron microscope(SEM).

• 한국응용과학기술학회지
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• 제27권1호
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• pp.93-97
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• 2010

Silicone dioxide absorbed polyoxyethylene alkylether sulfate (EU-S75D) surfactant was prepared. The core-shell composite of inorganic/organic were polymerized by using styrene(St) as a shell monomer and potassium persulfate(KPS) as an initiator. We studied the effect of surfactants on the core-shell structure of silicone dioxide/styrene in the presence of an anionic surfactant lauryl sulfate(SLS). The structure of core-shell polymer were investigated by measuring to the thermal decomposition of polymer composite using thermogravimetric analyzer(TGA) and morphology of latex by scanning electron microscope(SEM).

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2001년도 ICCAS
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• pp.126.4-126
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• 2001

Recently, researches on CIM in product lines of industrial plant are widely progressed, automation of working environment with modernization of product equipments is realized and also, installation of integrated control system based on computer is activated. Since the CIM system is basically developed by using computer, there are several complicated problems such as design problem of hardware interface between computer and many product machines with individual special functions, software development problem with realtime data process and multi communication functions for realtime data monitoring and control of product machines This paper shows the development results for a single board type of microcontroller and a monitoring software based on realtime processing database system ...

• 한국소음진동공학회논문집
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• 제25권11호
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• pp.731-738
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• 2015

This study proposed the method of the multi-crack detection using the sensitivity coefficient matrix which is calculated from the change of eigenvalues and eigenvectors before and after the crack. Each crack is modeled by a rotational springs. The method is applied to the cantilever beam with miulti-crack. The eigenvalues and eigenvectors are determined for different crack locations and depths. The prediction of multi-crack detection are in good agreement with the results of structural reanalysis.

• 한국소음진동공학회논문집
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• 제25권6호
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• pp.420-425
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• 2015

In this paper a transfer matrix method is developed to solve for bending vibration of beam with linearly reduced width, and subsequently used to determine the exact natural frequencies for such problems. The differential equation, shear force, and bending moment are derived from Hamilton's principle, and the roots of the differential equation are computed using the power series solution of the Frobenius method. The effect of various taper ratio for bending vibration of beam with linearly reduced width is investigated in detail, and to validate the accuracy of the proposed method the results computed are compared with those given from commercial software(ANSYS).

• 설비공학논문집
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• 제27권3호
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• pp.174-178
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• 2015

This paper describes a signal processing technique for identifying signals from defects by using an electromagnetic-ultrasonic guided waves method based on a magnetostrictive sensor that generates a torsional mode (T(0, 1)). Because this technique is based on the digital filtering, the filtered signals provide information on the relationship between the cutoff frequency of band-pass filter and the characteristic of defect signals in heat exchange tubes. To verify the performance of the technique, artificial defects with various thickness reduction ration and shape were machined in titanium tubes, and digital filtering results are reported. The results show that digital filtering provides information to the identify shape of defects and the contact condition between the tube and support ring. Therefore, the proposed technique has good potential as a tool for evaluating the integrity of heat exchange tubes.