• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.7
• /
• pp.3615-3617
• /
• 2016

Background: Breast cancer molecular analysis by linkage analysis has the advantage of facilitating early diagnosis in asymptomatic genetic carriers, with a view to the preventive follow-up of these subjects and genetic counseling. The aim of this study was to evaluate BRCA1 gene D17S855 and D17S1322 markers in breast cancer patients. Materials and Methods: A series of 85 BC patients and 85 unrelated healthy women were recruited for haplotype analysis performed using two short tandem repeat markers located within the BRCA1 gene locus. Each marker was amplified with PCR genomic DNA from each individual and fluorescently end-labeled primers. Results: Both D17S855 and D17S1322 markers included 12 kinds of alleles. Results indicate that most of the BC patients shared two common 121-150 (11.2%, RR=1.56 and p=0.02) and 121-146 (5.6%, RR=1.9 and p=0.02) haplotypes. Conclusions: Our results should be helpful to understand the haplotype phase in the BRCA1 gene and establish a genetic screening strategy in the Iranian population.

• Korean Journal of Environmental Biology
• /
• v.26 no.2
• /
• pp.87-93
• /
• 2008

To assess effects of contaminants on fish in Nakdong river, feral yellowfin goby Acanthogobius flavimanus were caugt in two different sites and its hepatic monooxygenase enzyme, including cytochrome P450 (CYP), NADPH-cytochrome P450 reductase (P450R), NADH-cytochrome b5 reductase (b5R), ethoxyresorufin deethylase (EROD), glutathione S-transferase (GST) were quantitatively determined. Gonadosomatic index (GSI), hepatosomatic index (HSI) and three sex steroid hormone (17$\beta$-estradiol, E2; testosterone, T; 11-ketotestosterone, 11-KT) levels of the fish were also investigated. HSI of fish from polluted site (site 1) were significantly higher than that of unpolluted site (site 2), but GSI levels were significantly lower in polluted site. No significant differences in plasma 11-KT and T levels were observed in two sites surveyed. E2 level was, however, significantly (p<0.05) higher in female fish from site 1 than site 2. In addition, hepatic EROD activity and CYP level of site 1 fish were lower than those of site 2 fish, whereas relatively high levels of P450R, b5R and GST activities were found in site 1. The results imply that yellowfin goby, especially female fish in Nakdong river estuary are affected from contaminants disrupting sex steroid hormone system.

• Journal of Korean Society of Coastal and Ocean Engineers
• /
• v.22 no.4
• /
• pp.224-229
• /
• 2010

Collision fragility analysis of offshore bridge by ship was performed. Collision velocity and angle were chosen as random variables then collision of 18,000DWT and 30,000DWT ships with bridge was analyzed. Displacement response surface of bridge by ship collision was estimated by varying ship velocity from 2 m/s to 7 m/s. Using the result of reliability analysis, fragility curves of collision was established and risk of offshore bridge to collision velocity as median and log-standard deviation was presented.

• Ocean and Polar Research
• /
• v.25 no.spc3
• /
• pp.353-360
• /
• 2003

Estimation of undrained shear strength $(S_u)$ of clayey soils from piezocone penetration test (CPTu), which has widely been known as one of very promising in situ test methods, requires piezocone factors. Empirical correlations are generally utilized to derive piezocone factors, but previous studies on the empirical piezocone factors are site-specific and in some cases need engineering characteristics, which should be obtained from additional laboratory tests. In this study, empirical cone factors were evaluated by comparing 6 CPTu results at Shihwa region in Korea with reference $S_u$ values obtained from field vane test (FVT). From previous CPTu results of other regions in Korea as well as the results herein, the correlations between piezocone factor, $N_{kT}$ and CPTu results were investigated and three simplified evaluation methods of $S_u$ using only CPTu results were presented. The $S_u$ values estimated by $(q_T-{\sigma}_v)/{\sigma}'_v$ method shows better matches with those obtained from laboratory tests for marine clays at Shihwa region.

• Development and Reproduction
• /
• v.14 no.2
• /
• pp.51-58
• /
• 2010

This research investigated that the effect of water temperature on egg developmental stages of largescale blackfish Girella punctata and smallscale blackfish Girella melanichthys. The required times from fertilized embryos to hatching for the G. punctata were 67.8~37.5 hrs from 15 to $21^{\circ}C$, shorter as the water temperature increased. But fertilized embryos were dead after Kuffer's vesicle appearance stage at $24^{\circ}C$ and morula stage at $27^{\circ}C$. Biological minimum temperature (starting point for embryonic development) of the egg development was estimated to be $7.6^{\circ}C$ in average. In G. melanichthys, fertilized embryos were hatched within 61.2~38.3 hr from 15 to $21^{\circ}C$, the times were shorter as the water temperature increased to hatching, but its were dead on above $24^{\circ}C$. Biological minimum temperature of the egg development was estimated to be $6.5^{\circ}C$ in average. Based upon these results, it is recommended that the range of optimum water temperature for embryonic development of G. punctata and G. melanichthys is $15{\sim}21^{\circ}C$.

• Proceedings of KOSOMES biannual meeting
• /
• 2004.11a
• /
• pp.43-47
• /
• 2004

Two different sensors (here, KOMPSAT and RADARSAT) are considered for ship detection, and are used to delineate the detection performance for their data The experiments are set for coastal regions of Mokpo Port and Ulsan Port and field experiments on board pilot boat are conducted to collect in situ ship validation information such as ship type and length This paper introduce mainly the experiment result of ship detection by both RADARSAT SAR imagery and land-based RADAR data, operated by the local Authority of South Korean, so called vessel traffic system (VTS) radar. Fine imagery of Ulsan Port was acquired on June 19, 2004 and in-situ data such as wind speed and direction, taking pictures of ships and natural features were obtained aboard a pilot ship. North winds, with a maximum speed of 3.1 m/s were recorded Ship's position, size and shape and natural features of breakwaters, oil pipeline and alongside ship were compared using SAR and VTS. It is shown that KOMPSAT/EOC has a good performance in the detection of a moving ship at a speed of kts or more an hour that ship and its wake can be imaged. The detection capability of RADARSAT doesn't matter how fast ship is running and depends on a ship itself, e.g. its material, length and type. Our results indicate that SAR can be applicable to automated ship detection for a VTS and SAR combination service.

• Journal of Korean Society of Coastal and Ocean Engineers
• /
• v.7 no.2
• /
• pp.176-197
• /
• 1995

Two-dimensional and three-dimensional structures of tidal currents on southeastern waters of Korea off Kyungnam coast were investigated via a series of numerical models based on dynamic principles. With a two-dimensional tidal model, tidal regimes of major eight tidal constituents (M$_2$, S$_2$, K$_1$, O$_1$, N$_2$, K$_2$, P$_1$, Q$_1$) were computed. Model results showed that the computed results were in good agreement with coastal observations. On the basis of these results the model was further improved to compute three-dimensional structure of tidal current in inner Jinhai and Masan Bay regions of the model area where severe pollutions occur due to red tide by combination of the previous two-dimensional model and inner three-dimensional model. For this work, three-dimensional Galerkin-Spectral model and two-dimensional depth-integrated model are dynamically combined by the method presented by Davies (1980). In addition to the previous work by Davies, the advective term and quadratic bottom friction term are included in present Three-dimensional numerical model. The computed results of M$_2$ tidal current ellipses with respect to depth showed general agreements with those of current observations by KORDI (1990).

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
• /
• v.12 no.3
• /
• pp.211-218
• /
• 2007

In this study, we investigated the spatial distribution of macrozoobenthos in the estuarine sandy flat, the Bongam tidal flat located in Masan Bay during March, 2004. A total 13 species were identified at 12 stations within the tidal flat. The mean density was $20,267\;ind./m^2$, and mean biomass was $228.1g/m^2$. Dominant species in the Bongam tidal flat were all polychaetes: Prionospio japonicus ($11,716\;ind./m^2$, 57.8%) and Polydora ligni ($3,929\;ind./m^2$, 19.4%) of spionoid polychaete, and Neanthes succinea ($3,425\;ind./m^2$, 16.9%) of nereid polychaete. The most dominant species, P. japonicus distributed evenly all stations in the tidal flat. But N. succinea showed high density at the upper area of the tidal flat. Species diversity index (H') was in the range of 0.6 to 1.2 which is relatively low due to the prominent of P. japonicus and few species richness at each station. The study area was divided into two station groups (group A and B) based on the cluster analysis and MDS ordination, and the spatial distribution of macrozoobenthos on the Bongam tidal flat seemed to be in the influence of exposure duration from tidal levels and specific geological topography.

• Korean Journal of Environmental Biology
• /
• v.27 no.1
• /
• pp.6-19
• /
• 2009

We investigated the macrozoobenthos at major two harbors of Korea in July and August 2007 in order to check the changes in the species composition due to the invasive species and to make a species inventory at each harbor system. At the Incheon Harbor, a total of 88 species was sampled with abundance of 3,212 ind. m$^{-2}$ and biomass of 239 g m$^{-2}$. The most dominant species was Tharyx sp. belong to polychaete taxa, followed by Chaetozone setosa in the harbor area. The dominant species of outer area were Musculus senhousia and Sternaspis scutata. The diversity index ranged between 0.9$\sim$2.4, and evenness index between 0.3$\sim$0.9, and richness index between 1.8$\sim$3.9. Benthic pollution index ranged between 16$\sim$74. The highest benthic pollution index was at station 4. On the other hand the lowest value was at station 6, where a large amount of M. senhousia belong to mollusca occurred. At the Busan Harbor, a total of 89 species was sampled with density of 1,845 ind. m$^{-2}$ and biomass of 133.6 g m$^{-2}$ in August 2007. The most dominant species was Tharyx sp., followed by M. japonica and Cirratulus cirrata within harbor area. M. japonica was dominant species in the outer area. The diversity index ranged between 0.7$\sim$2.2, evenness index between 0.3$\sim$1.0, and richness index between 1.1$\sim$4.1. Benthic pollution index ranged between 31$\sim$90. The lowest benthic pollution index was found at site 2 within harbor area.

• Proceedings of the KIEE Conference
• /
• 2007.04a
• /
• pp.319-321
• /
• 2007

This paper introduces a general overview of the 6000m class deep-sea ROV. Hemire and Henuvy. and then describes its motion control system. It is developed by Korea Ocean Research & Development Institute(KORDI) for 6 years since 2001. sponsored by the Ministry of Maritime Affairs and, Fisheries (MOMAF). Hemire is remotely operated by a fiber optic telemetry. where 6 thrusters are controlled by operator in manual mode and by auto depth control and auto heading control in auto mode. In this paper. operational mechanism of manual and automatic mode with some convenient functions for operator is desc.ribed. Finally, results of sea trial conducted at the Philippine sea where a depth is 5.770m are shown.