• Journal of Life Science
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• v.17 no.2 s.82
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• pp.248-253
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• 2007

This research investigated whether exposure of diesel exhaust particulate (DEP) and particulate matter (PM) effects on airway remodeling in asthma induced Balb/c and IL-10 knock out (KO) mouse. Mice were sensitized with intraperitoneal injection with ovalbumin, followed by challenges with intranasal ovalbumin. After that mice placed in inhalation chamber and exposed to DEP and $PM(10\;mg/m^3)$. The evidence of airway remodeling was assessed by masson's trichrome staining and PAS staining. The stainability of masson's trichrome and PAS reaction were increased in asthma-induced Baltic mice groups compared with control mice groups. More intensive stainability for masson's trichrome and PAS were appeared in the asthma-induced DEP and PM-exposed groups than asthama-induced groups. But, not significantly increased subepithelial fibrosis and the nember of goblet cell hyperplasia in asthma-induced IL-10 KO mice groups and asthma-induced+DEP and PM-exposed IL-10 KO mice than IL-10 KO mice groups. These results indirectly suggesting that exposure to DEP and PM in asthmatic patients might be aggravate clinical symptoms and IL-10 which seems to play a central role in allergic asthma. In conclusion, DEP and PM exposure might have additive effects on the ovalbumin- induced asthma in a murine model.

• Korean Journal of Agricultural and Forest Meteorology
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• v.16 no.3
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• pp.246-260
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• 2014

A 90-m horizontal-resolution numerical model was configured to study the micrometeorological features of local winds in the valley of Gwangneung KoFlux (Korea Flux network) Sites (GDK: Gwangneung Deciduous forest site in Korea, GCK: Gwangneung Coniferous forest site in Korea) during summer days. The U. S. Geological Survey (USGS) Shuttle Radar Topography Mission (SRTM) data were employed for high-resolution model terrain height. Model performance was evaluated by comparing observed and simulated near-surface temperature and winds. Detailed qualitative analysis of the model-simulated wind field was carried out for two selected cases which are a clear day (Case I) and a cloudy day (Case II). Observed winds exhibited that GDK and GCK, as well as Case I and Case II, had differences in timing, duration and strength of daytime and nighttime wind direction and speeds. The model simulation results strongly supported the existence of the drainage flow in the valley of the KoFlux tower sites. Overall, the simulated model fields realistically presented the diurnal cycle of local winds in and around the valley, including the morning drainage-upslope transition and the evening reversal of upslope wind. Also, they indicated the complexity of local winds interactions by presenting that daytime westerly winds in the valley were not always pure mountain winds and were often coupled with larger-scale wind systems, such as synoptic-scale winds or mesoscale sea breezes blowing from the west coast of the peninsula.

• Geotechnical Engineering
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• v.13 no.1
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• pp.35-46
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• 1997

The isotropic single-hardening constitutive model has been applied to predict the behavior of soils during reorientation of principal stresses in the field. The predicted response by the model agrees well with the measured behavior for a series of torsion shear tests performed on hollow cylinder specimens of Ko consoildated clay along various stress -paths. This indicates that the soil behavior during reorientation of principal stresses can be predicted by using the model with application of simple informations given by isotropic compression tests and conventional consolidated-undxained triaxial compression tests. Isotropic elasto-plastic soil behavior has been served during primary loading from both the torsion shear tests and the predictions by the model. However, the directions of maj or principal strain increment given by the model have not coincided with the directions for tests during stress reversal, such as unloading and reloading, within isotropic yield surface for Ko consolidated stress. This indicates that kinematic hardening model instead of isotropic hardening model should be developed to predict the soil behavior during stress reversal. The experimental strain increment vectors in the work-space have been compared with the directions expected for associated and nonassociated flow rules.

• Journal of the Korea Society of Computer and Information
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• v.26 no.12
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• pp.53-59
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• 2021

In this paper, we propose a BERGPT-chatbot, a domestic AI chatbot that can alleviate negative emotions based on text input such as 'Replika'. We made BERGPT-chatbot into a chatbot capable of mitigating negative emotions by pipelined two models, KR-BERT and KoGPT2-chatbot. We applied a creative method of giving emotions to unrefined everyday datasets through KR-BERT, and learning additional datasets through KoGPT2-chatbot. The development background of BERGPT-chatbot is as follows. Currently, the number of people with depression is increasing all over the world. This phenomenon is emerging as a more serious problem due to COVID-19, which causes people to increase long-term indoor living or limit interpersonal relationships. Overseas artificial intelligence chatbots aimed at relieving negative emotions or taking care of mental health care, have increased in use due to the pandemic. In Korea, Psychological diagnosis chatbots similar to those of overseas cases are being operated. However, as the domestic chatbot is a system that outputs a button-based answer rather than a text input-based answer, when compared to overseas chatbots, domestic chatbots remain at a low level of diagnosing human psychology. Therefore, we proposed a chatbot that helps mitigating negative emotions through BERGPT-chatbot. Finally, we compared BERGPT-chatbot and KoGPT2-chatbot through 'Perplexity', an internal evaluation metric for evaluating language models, and showed the superity of BERGPT-chatbot.

• Animal Systematics, Evolution and Diversity
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• v.17 no.1
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• pp.145-153
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• 2001

Two new species of the genus Burmoniscus, B. siamenis and B. phanganensis, are described from Ko Samui and Ko Pha Ngan, Thailand. B. siamenis is similar to B. mauritiensis (Taiti and Ferrara, 1983) in color pattern and the shape of telson, but distinguished by the shape of pereonite 7 with obtuse postero-lateral angle and the peculiar shape of male pleopod 2 endopod with truncated apex. B. phanganensis is close to B. ocellatus Verhoeff, 1928) in the shape of pereonite 7 and telson, but easily distinguished by the peculiar shape of male pleopod 1 endopod with two rows of denticles on caudal surface.

• Development and Reproduction
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• v.17 no.3
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• pp.179-186
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• 2013

Neural stem cells are found in adult mammalian brain regions including the subgranular zone (SGZ) of the dentate gyrus (DG) and the subventricular zone (SVZ). In addition to these two regions, other neurogenic regions are often reported in many species. Recently, the subcallosal zone (SCZ) has been identified as a novel neurogenic region where new neuroblasts are spontaneously generated and then, by Bax-dependent apoptosis, eliminated. However, the development of SCZ in the postnatal brain is not yet fully explored. The present study investigated the precise location and amount of neuroblasts in the developing brain. To estimate the importance of programmed cell death (PCD) for SCZ histogenesis, SCZ development in the Bax-knockout (KO) mouse was examined. Interestingly, an accumulation of extra neurons with synaptic fibers in the SCZ of Bax-KO mice was observed. Indeed, Bax-KO mice exhibited enhanced startle response to loud acoustic stimuli and reduced anxiety level. Considering the prevention of PCD in the SCZ leads to sensory-motor gating dysfunction in the Bax-KO mice, active elimination of SCZ neuroblasts may promote optimal brain function.

• Biomedical Science Letters
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• v.12 no.1
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• pp.53-56
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• 2006

The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is the circadian pacemaker entrained to the 24-hr day by environmental time cues. Major circadian genes such as mPeriod ($mPer1{\sim}3$) and mCryptochrome ($mCry1{\sim}2$) are actively transcribed by the action of CLOCK/BMAL heterodimers, and in turn, these are being suppressed by the mPER/mCRY complex. In the study, the locomotor activity rhythms of mPer1 Knockout (KO) mice are measured, and the expression profiles of Heat Shock Protein 105kDa (HSP 105) genes in the SCN were measured by in situ hybridization. In agreement with previous reports, the locomotor activity rhythm of mPer1 KO mice was much shorter than that of wildtype. In addition, the total bout of activity of mPer1 KO was less in comparison to control mice. The expression of HSP 105 in the SCN of mPer1 KO mice was ranged from CT6 to CT22, with a peak level at CT14, implying that the gene are under the control of circadian clock. However, the expression of HSP 105 in the SCN of wildtype could not be detected in our study. Further analysis will reveal the direct or indirect regulation by mPer1 on the expression in the SCN and the role of the gene in the circadian clock.

• Korean Journal of Adult Nursing
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• v.14 no.4
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• pp.501-509
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• 2002

Purpose: This study was performed to identify the illness intrusiveness, quality of life, and their relationships in patients with chronic liver disease. Method: Data was collected using scales of illness intrusiveness developed by Devins et al and Korean health related quality of life (KoQoLS) developed by Shim et al to measure the illness intrusiveness and quality of life from 141 chronic liver disease patients. Result: The total mean score of illness intrusiveness was $38.85{\pm}18.45$. The domain of illness intrusiveness which showed the highest mean score was health ($4.60{\pm}2.02$), and the lowest mean score domain was relationship with spouse ($20.4{\pm}1.69$). The subcategory of KoQoLS which showed the highest mean score was bodily pain ($6.96{\pm}2.98$), and the lowest mean score subcategory was vitality ($2.75{\pm}1.20$). There were negative relationships between illness intrusiveness and KoQoLS in all subcategories. Abovel all, Illness intrusiveness had the strongest negative relationship with role limitation (r=-0.641) among the KoQoLS subcategories. Conclusion: Because the illness intrusiveness had negative influence on the quality of life in patients with chronic liver disease, further research will need to specify detailed illness intrusiveness and to explore influencing factors on quality of life in them.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2015.10a
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• pp.286-287
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• 2015

DGPS의 안정적인 운영 및 제공을 위해서는 중파대역 송출 전파의 안정성을 확보하여야 한다. 특히 대지 전도율의 변화에 따른 반사파의 변동은 안정적인 측위정보 제공 및 DGPS 기준국 운영에 영향을 미칠 수 있다. 본 논문은 반사파의 변동에 영향을 미치는 환경 변화 요인을 분석하고자 기준국 반사파의 변동과 기상인자의 상관성을 분석하였다. 도서 지역 DGPS 기준국의 반사파 변동과 기상인자와의 상관성을 분석하고자 시계열분석, 산포도 분석, 상관계수 산정 등의 방법을 이용하였다. 분석 결과 반사파 변동과 풍속, 습도는 양의 상관관계를 나타내었으며 기압과는 음의 상관관계가 나타났다. 이는 풍속과 습도가 높을수록 반사파가 크게 발생하며, 기압이 낮을수록 반사파가 낮게 나타나는 것을 의미한다. 송신 전파 특성상 기상의 변화가 반사파 변동에 직접적인 영향을 주지는 않으나 반사파가 생성되는 환경 요인에 영향을 끼치는 것으로 사료된다.

• Natural Product Sciences
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• v.25 no.1
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• pp.76-80
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• 2019

Bioactivity-guided fractionation of MeOH extract of the dried fruits of Amomum tsao-ko led to isolation of nine compounds (1 - 9). Their structures were elucidated by spectroscopic methods including extensive 1D and 2D-NMR, as alpinetin (1), naringenin-5-O-methyl ether (2), naringenin (3), hesperetin (4), 2',4',6'-trihydroxy-4-methoxy chalcone (5), tsaokoin (6), boesenbergin B (7), 4-hydroxyboesenbergin B (8), and tsaokoarylone (9). Of these, compound 8 was isolated from a natural source for the first time, which was previously reported as a synthetic product. The isolated compounds (1 - 9) were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Among them, three chalcone derivatives (compounds 5, 7, and 8) and a diarylheptanoid (compound 9) exhibited significant inhibitory activity on the NO production with $IC_{50}$ values ranging from 10.9 to $22.5{\mu}M$.