• Journal of Cadastre & Land InformatiX
• /
• v.44 no.1
• /
• pp.165-177
• /
• 2014

The KML verification tool supports people who want to produce the highest quality KML file. In other words, it validate that a given KML document is well-formed with respect to XML standard meaning, and conform not only to the KML schema and the specification. Then it's only to notify error code line. People who want to use the KML file written by others would like to know both whether the validity of that file and general summary of feature's location, shape, and number. In this study, we recommended the user-friendly KML validator using OpenLayers and reporting geometries and images of the KML file.

• Journal of Korean Society for Geospatial Information Science
• /
• v.19 no.4
• /
• pp.35-45
• /
• 2011

The purpose of this study is visualizing climate change contents from Weather Research and Forecasting model and providing useful tool to anyone who want to use them for communication and actual movement. As a results, we have built a process and user interface for publishing Arrow KML, BWS KML, and DI KML. Arrow KML provide wind rose service and wind attribute information for each arrow. BWS KML provide a wind power index and DI KML provide a thermal comfort. All KML contents are more reliable because those are visualized from the scientifically verified climate change prediction model. Further study will focus on searching for climate change contents mining and useful contents design for wide range of climate change mitigation/adaptation activity.

• BMB Reports
• /
• v.40 no.6
• /
• pp.959-965
• /
• 2007

Two isolectins (KML-IIU and the KML-IIL) were individually isolated from the previously reported Korean mistletoe lectin, KML-C, by using an immunoaffinity column. Molecular weights of the KML-IIU and the KML-IIL were 64 kDa and 60 kDa respectively. Both of the lectins were composed of heterogeneous A and B subunits linked with a disulfide bond, and showed the same carbohydrate-binding specificities for Gal and GalNAc. However, they are different not only in biophysical properties (glycosylation and amino acid compositions) but also bioactivities (cell killing and cytokine induction). The KML-IIL showed 17-145 times stronger in cytotoxicities to various human and mouse cancer cell lines than the KML-IIU. The KML-IIL also induced TNF-$\alpha$ secretion from mouse peritoneal macrophages 4.5 times better than the KML-IIU. The results demonstrated isolectins in Korean mistletoe were varied in bioactivities and the KML-IIL may be developed as an anti-cancer agent.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.32 no.4_1
• /
• pp.353-361
• /
• 2014

The study has planned to analyze the most typical specification validation in Korea and the other countries, which shows the well-formed and schema validation, in purpose to enhance users' conveniences. Also, we suggested the validation system to provide the information compatibility regarding to application programs for non-expert. The featured KML specification supported by the VWorld 3D Desktop and the Google Earth. Based on this above estimation, the system has been designed to inform potential problems and the applicability in 3D Desktop and Google Earth for the user. The KML information passed through the proposed validation is simply expressed on the map, so as instructed the information on the program selection and additional details instruct users as a text file. When not being suitable for the proposed program, another program can be considered, and the problems which may be occurred are also announced to increase the compatibility of KML.

• YAKHAK HOEJI
• /
• v.45 no.3
• /
• pp.251-257
• /
• 2001

The study was carried out to evaluate the preliminary toxicity and general pharmacology of KML-IIU, a purified pectin from Korean Mistletoe (Viscum album coloratum). KML-IIU was administered intravenously to ICR mice and Spargue-Dawley rats to investigate the acute toxicity. LD50 values in mice and rats were above 30 $\mu$g/kg. KML-IIU had no effects on the general behaviors, acetic acid induced writhing syndrome, pentobarbial induced sleeping time, pentylenetetrazole induced convulsion and the change of body temperature. In addition, KML-IIU did not show any effects on digestive system and blood coagulation system.

• Journal of Navigation and Port Research
• /
• v.35 no.1
• /
• pp.9-15
• /
• 2011

IMO adopt the revision of SOLAS convention on requirement systems for ECDIS and considered an ECDIS as the major system for E-Navigation strategy on marine transportation safety and environment protection. ENC(Electronic Navigational Chart) as the base map of ECDIS is considered as a principal information infrastructure that is essential for navigation tasks. Because ENCs are not easy to utilize for being encoded according to ISO/IEC 8211 file format, used for navigational purpose mainly, it's required to utilize in parts of Marine GIS and various marine application. In this paper, we developed KML conversion technology for ENC application. In details, we analyzed data model and encoding method of ENC, schema structure and data file of KML. Based on this results, we developed the program of KML conversion of ENCs.

• YAKHAK HOEJI
• /
• v.45 no.2
• /
• pp.180-189
• /
• 2001

We have reported that water-extracted Korean mistletoe (KM-110) had various biological activities such as antitumor and immunomodulatory activity, and the pectin fraction (KML-C) of the extract was one of major factors related to its biological functions. In this paper, we produced murine monoclonal antibody (mAb) against KML-C. The cAbs obtained were largely classified into two groups according to specificity to KML-C and ML-I, a pectin from European mistletoe. One group mAbs (9H7-D10 and 3C2-lH4) strongly reacted with KML-C, but not ML-I. In contrast, another group cAbs (8Bll-2C5, BE12-3E9 and 5E10-Fl) reacted with both KML-C and ML-1. The subisotypes of these mobs were shown to be IgGl (9H7-lD10, 3C2-lH4 and 8Bll-2C5) or IgM (8E12-3E9 and 5E10-Fl). To develop an assay system for determination of the amount of KML-C, we established the sandwich ELISA (enzyme-linked immunosorbent assay) method using these mAbs and horse radish peroxidase (HRP)-labelled cAbs. In various combinations of the cAbs for coated antibody and detection antibody, the sandwich ELISA quantitatively detected KML-C, showing the detection limit ranging from 7-5,000 ng/ml. Especially reproducibility (C.V) of the sandwich ELISA, in which 8E12-3E9 was used for coating antibody and 8Bll-2C5-HRP for detection antibody, was 4.59-5.83 in intra assay, and 3.9-9.4 in inter assay.

• Archives of Pharmacal Research
• /
• v.26 no.10
• /
• pp.861-867
• /
• 2003

Inhibitory effect of the lectins (KML-C) isolated from Korean mistletoe (KM; Viscum album coloratum) on tumor metastases produced by murine tumor cells (B16-BL6 melanoma, colon 26M3.1 carcinoma and L5178Y-ML25 lymphoma cells) was investigated in syngeneic mice. An intravenous (i.v.) administration of KML-C (20-50 ng/mouse) 2 days before tumor inoculation significantly inhibited lung metastases of both B16-BL6 and colon 26-M3.1 cells. The prophylactic effect of 50 ng/mouse of KML-C on lung metastasis was almost the same with that of 100 $\mu$ g/mouse of KM. Treatment with KML-C 1 day after tumor inoculation induced a significant inhibition of not only the experimental lung metastasis induced by B16-BL6 and colon 26M3.1 cells but also the liver and spleen metastasis of L5178Y-ML25 cells. Furthermore, multiple administration of KML-C given at 3 day-intervals after tumor inoculation led to a significant reduction of lung metastasis and suppression of the growth of B16-BL6 melanoma cells in a spontaneous metastasis model. In an assay for natural killer (NK) cell activity. i.v. administration of KML-C (50 ng/mouse) significantly augmented NK cytotoxicity against Yac-1 tumor cells 2 days after KML-C treatment. In addition, treatment with KML-C (50 ng/mouse) induced tumoricidal activity of peritoneal macrophages against B16-BL6 and 3LL cells. These results suggest that KML-C has an immunomodulating activity to enhance the host defense system against tumors, and that its prophylactic and therapeutic effect on tumor metastasis is associated with the activation of NK cells and macrophages.

• Korean Journal of Food Science and Technology
• /
• v.43 no.1
• /
• pp.72-76
• /
• 2011

The adjuvant effects of Korean mistletoe lectin-C (KML-C) were investigated following the oral administration of KML-C with ovalbumin (OVA) as an antigen. Mice were orally immunized with OVA alone or admixed with various doses of KML-C or cholera toxin (CT), and the titer of OVA-specific antibody in the serum and mucosal secretions were determined. OVA+KML-C-treated mice showed high titers of IgA specific to CT in mucosal secretions. The antibody titers in the serum of OVA+KML-C-treated mice were comparable to those in the serum of OVA+CT-treated mice. When mice were immunized with OVA+KML-C or with CT alone and subsequently injected with OVA on the footpads after the primary immunization, they showed a more significant increase in delayed-type hypersensitivity reactions than when they were administered CT alone. These results suggest that KML-C is a potent immunoadjuvant that enhances both humoral and cellular immunity by the mucosal immune system.

• Journal of Cadastre & Land InformatiX
• /
• v.45 no.1
• /
• pp.169-179
• /
• 2015

Recently, as the amount of data increases rapidly, the development of IT technology entered the 'Big Data' era, dealing with large-volume of data at once. In the spatial field, a spatial data service technology is required to use that various and big amount of data. In this study, firstly, we explained the technology of typical spatial information data services abroad, and then we have developed large KML data processing techniques those can be applied as KML format to VWorld desktop. The test was conducted using a large KML data in order to verify the development KML partitioned methods and tools. As a result, the index file and the divided files are produced and it was visible in VWorld desktop.