• Herbal Formula Science
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• v.20 no.2
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• pp.47-54
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• 2012

Objectives : This study aimed to build up information system for the 25 cases of Korean Medicine (KM) prescriptions which are used mostly often in clinic and aimed to offer information about its effect and safety to public and researcher. Methods : We used KM prescription data-bank which came from 'The Bio-informatics for herbal formula' and 'The evidence based medicine for herbal formula' projects of Korean Institute of Oriental Medicine (KIOM) Results : First, we analyzed prescription data and categorized 7 classes, then we built up prescription database based on it. Second, we designed and developed user functions of prescription information system, then we link it to OASIS. Third, we developed adminstration system to manage the prescription data. Conclusions : From this study we hope that KM prescription information system will be used for fusion research based on KM. Because the implemented system is linked to OASIS, we expect it will be widely used.

• The Korean Journal of Physiology
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• v.4 no.1
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• pp.1-11
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• 1970

Studies on the analysis of walking were performed on 33 male subjects. A prescription of physical exercise (walking at a speed of greater than 6 km/hr for more than one hour daily) for the promotion of individual health is presented on the basis of walking analysis. Presumptions were made that adequate physical exercise does promote health and is beneficial for the healthy life and increases the life span. These presumptions were derived from the numerous experimental literatures. The literatures support indirectly the presumptions. The following results were obtained and prescription of physical exercise is presented. 1. Oxygen uptake in a walking on a treadmill at a speed of 4 km/hr was only 3 times of the resting oxygen uptake. This kind of moderate exercise did not stimulate the cardiopulmonary system adequately. Heart rate at a 4 km/hr walking was 101 beats/min in boys of less than 20 years old and 83 beats/min in adults. Oxygen uptake at a 6 km/hr walking exceeded 4 times of the resting oxygen uptake. It was interpreted that walking at 6 km/hr stimulated the cardiopulmonary system for the promotion of health. Heart rate at this speed was greater than 110 beats/min in boys and greater than 100 beats/min in adults. 2. Heart rates in a walking of 10 km/hr were 172 beats/min in boys, and 143 beats/min in adults, respectively. Maximal heart rates were 185 beats/min in boys, 180 in office clerks, and 168 beats/min in construction site laboreres. 3. The correlation between heart rate and oxygen uptake was high, namely, r>0.95. Subsequently heart rate could be used as a measure of degree of intensity of physical exercise instead of the cumbersome oxygen uptake measurement. 4. The prescription of physical exercise for the promotion of health is: Daily walking for more than one hour at a speed of greater than 6 km/hr. Bodily functions in this daily walking are in boys (body weight, 50 kg): heart rates of 110 beats/min; breathing frequency, 28/min; oxygen uptake, greater than 4 times of the resting uptake; pulmonary ventilation, 351/min; stride, 124 strides/min; cumulative number of strides for one hour, 7,440 strides, and energy expenditure of more than 300 kcal. In adults (body weight, 60 kg) the bodily functions are: heart rates of 100 beats/min, breathing frequency, 28/min; oxygen uptake, greater than 4 times of the resting uptake; Pulmonary ventilation, 301/min; stride, 127 strides/min; cumulative number of strides for one hour, 7,670 strides, and energy expenditure of more than 300 kcal.

• The Journal of Korean Medicine
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• v.39 no.4
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• pp.62-73
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• 2018

Objectives: This study conducted a retrospective review to compare the effectiveness of herbal medicine, while confirming the effectiveness of Korean medicine (KM) in traffic accidents (TA). Methods: We investigated the medical records of TA patients who were hospitalized at Muuido Korean medicine hospital from January 2016 to June 2018 retrospectively. Medical records included general characteristics (Gender, age), TA & treatment-related information (Collision type, chief complaint, hospitalization period, and herbal medicine prescription), and clinical scales (Five-scale improvement, numerical rating scale (NRS)). Statistical analysis was performed for data distribution and effectiveness comparison. Results: 755 TA patients showed 0.78:1 gender ratio. 20-50s years old, rear collision, pain in the cervical and lumbar spine, and hospitalization period within 14 days were the majority. KM improved 83.18% of 755 TA patients' symptoms and ROM over 'improvement' level, which indicated 30-70% improvement. With common KM treatments including acupuncture, cupping, heat therapy, and manipulation therapy, TA patients received various herbal medicines and herbal medicine for breaking severe blood stasis (Tongdo-san) showed improvement in both five-scale improvement and NRS change at the same time. Conclusions: We could confirm the effectiveness of KM, particularly herbal medicine in TA. It would be necessary to develop new herbal medicines such as Tongdo-san to treat TA-related symptoms.

• The Journal of Korean Medicine
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• v.44 no.3
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• pp.189-200
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• 2023

Objectives: The purpose of this study is to analyze the current state of quantitative literature evidence for the prescription of 56 herbal medicines covered by health insurance that have been studied in Korea for the past 30 years, to evaluate the reliability of the evidence, and to find out the research direction of herbal medicine prescription in the future. Methods: 56 kinds of herbal medicine prescriptions were searched in domestic literature search databases OASIS, DBpia, and overseas PubMed, classified into chemistry, toxicity, cells, animals, clinical cases, and clinical trial studies, and built into an EBM pyramid structure. Results: When classified according to research contents, there were 61 cases (7.5%) of physicochemical analysis to identify constituent substances, 80 cases (9.8%) of toxicity evaluation, and 672 cases (82.7%) of efficacy evaluation. The efficacy evidence was classified according to the evidence-based medical pyramid structure: 196 cell trials (29.1%), 372 animal trials (55.4%), 89 case and case reporting series (13.3%), 7 comparative case studies (1.1%), and 8 randomized control clinical trials (1.2%). In the pyramid composition, the basis for the validity of 56 kinds of herbal medicines prescribed was 568 cases (84.5%) in cell and animal units, which could not be said to be highly reliable. There was no relationship between the ranking of quantitative literature evidence for herbal medicine prescriptions and the ranking of salary administration. Conclusions: In an era that continues to require scientific evidence for herbal medicine, traditional herbal medicine should secure the basis for safety validity even for the 10th most frequent prescription among 56 herbal medicine prescriptions for consumers. In particular, traditional herbal medicine should increase the quantitative and qualitative level of case reports on related herbal medicine prescriptions, focusing on each clinical society, and move toward comparative case studies and randomized clinical trial so that traditional herbal medicine is positioned as Evidence-based medicine.

• Journal of Society of Preventive Korean Medicine
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• v.24 no.2
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• pp.31-41
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• 2020

Background : The introduction of policies expanding the coverage of uninsured Korean Medicine (KM) services have requires an understanding of the following components of the service : current financial expenses, degree of financial burden on the patient, and financial effect of the coverage expansion. Objectives : This study aims to determine the annual trend of outpatients' characteristics and the category of out-of-pocket spending in KM. Methods : This study uses data from the Korea Health Panel to analyze use of KM in the Korean population. Using the user characteristics and behavior drawn from the Korea Health Panel data, out-of-pocket spending trends of KM were analyzed by year. The diagnosis and prescription of out-of-pocket spending were also analyzed. Results : The proportion of patients receiving uninsured medical treatment and the number of uninsured medical treatment in outpatient clinics have increased. However, the average out-of-pocket spending per person and out-of-pocket spending per visit are consistent or have decreased. Meaningful trends are the increase of R00-R99 (unclassified symptoms) and the decrease of K00-K93 (digestive system disease) and J00-J99 (respiratory system disease). Conclusions : Expansion of KM medical service and insurance is influenced by uninsured medical treatment of KM. Hence, research to increase medical treatment categories for out-of-pocket spending or explore diseases where KM diagnosis has been proven effective should be further developed.

• Natural Product Sciences
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• v.20 no.2
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• pp.102-106
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• 2014

Gumiganghwal-tang (GMT) is a traditional herbal prescription used for treatment of the common cold, pain, and inflammatory diseases. Variations in the amounts of bioactive components of GMT and GMT fermented with 10 Lactobacillus strains were investigated by high-performance liquid chromatography coupled with diode array detection (HPLC-DAD). Simultaneous qualitative and quantitative analyses of eleven bioactive compounds (prim-O-glucosylcimifugin, liquiritin, cimifugin, baicalin, liquiritigenin, wogonoside, baicalein, wogonin, butylphthalide, imperatorin, and isoimperatorin) were performed, with comparison of their retention times (tR) and UV spectra with those of standard compounds. The amounts of baicalin (8.71 mg/g), liquiritigenin (5.28 mg/g) and butylphthalide (5.10 mg/g) were the major compounds in GMT. We found that L. fermentum KFRI 145 fermented wogonoside and baicalin to their aglycones, wogonin and baicalein, respectively. These results indicated that L. fermentum KFRI 145 has potential as a functional starter culture for manufacturing fermented GMT.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.3
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• pp.489-498
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• 2018

This study was conducted to investigate the effect of walking exercise with blood flow restriction (BFR) on insulin resistance, adipokines and gut hormones in middle aged obese women. Eleven obese women (BMI > 25kg/m2; body fat > 30%) wore pneumatic pressure belts at both femurs and performed walking exercise consisting of walking for 2 min and resting for 1min twice per day, 3 days/wk for 4 weeks. Insulin significantly increased after exercise (p<0.05), while glucose increased slightly, but not significantly. Additionally, HOMA-IR decreased significantly after exercise (p<0.05), while adiponectin and visfatin increased, but not significantly. Finally, ghrelin (p<0.05) and GLP-1 (p<0.05) increased significantly after exercise. These results suggest that walking exercise with blood flow restriction for 4 weeks improves insulin resistance, adipokines, and gut hormones in obese middle-aged women. Therefore, high intensity walking exercise with blood flow restriction for short periods of time has more positive effects on prevention and treatment of obesity-related metabolic diseases.

• YAKHAK HOEJI
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• v.57 no.4
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• pp.293-298
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• 2013

Hwangryunhaedok-tang (HRT) is a traditional herbal medicine, which has been known as a useful prescription for anti-biotic, anti-inflammatory, anti-oxidative and immunosuppressive activity. In this study, the variation in the amount of eight bioactive components of Hwangryunhaedok-tang (HRT) and its fermentation HRT with Lactobacillus casei KFRI 127, Lactobacillus curvatus KFRI 166 and Lactobacillus confuses KFRI 227 was investigated via high-performance liquid chromatography coupled with diode array detection (HPLC-DAD). Simultaneous qualitative and quantitative analysis of eight bioactive components; geniposide, genipin, baicalin, wogonoside, palmatine, berberine, baicalein and wogonin was achieved by comparing their retention times ($t_R$) and UV spectra with those of the standard components. All calibration curve of standard components showed good linearity ($r^2$ >0.979). As a result, the geniposide amount was $15.52{\pm}0.19{\mu}/mg$ that as a main components in HRT. The wogonoside was decreased by 29.28~58.35% with Lactobacillus casei KFRI 127 and L. confuses KFRI 227 ($3.17{\pm}0.31{\mu}g/mg$ and $3.55{\pm}0.13{\mu}g/mg$) compared with the original HRT ($5.02{\pm}0.14{\mu}g/mg$). Otherwise wogonin was increased by 16.28~41.86% with Lactobacillus casei KFRI 127 and L. confuses KFRI 227 ($0.61{\pm}0.01{\mu}g/mg$ and $0.50{\pm}0.02{\mu}g/mg$) compared with the original HRT($0.43{\pm}0.00{\mu}g/mg$). HRT fermented with L. casei KFRI 127 and L. confuses KFRI 227 were evaluated as creating the changes in wogonoside to that aglycon wogonine. In the fermented HRT using Lactobacillus acidophilus KFRI 166, the genipin was only detected, among 3 species of fermentation strains. Thus, these results considered that the strains 166 were exhibited the remarkable changes in genipin.

• Journal of Sasang Constitutional Medicine
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• v.25 no.4
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• pp.373-383
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• 2013

Objectives The purpose of this clinical trial was evaluate the safety and efficacy of Mahwangjeongcheon-tang (MJT). Methods Twenty six volunteers were recruited as subjects. They were divided into two groups, which were MJT test group and placebo group. The investigated items related to the safety were the weight, the results of renal function and liver function. The investigated items related to the efficacy are the results of the spirometer, the clinical asthma measurement scale in oriental medicine-V (CAMSOM-V) and the quality of life questionnaire for adult Korean asthmatics (QLQAKA). Results There are no difference in the weight, the results of the renal functions and the liver functions between MJT test group and placebo group. There are the some differences in the result of the questionnaires related to the efficacy between MJT test group and placebo group. The significant difference were observed in the CAMSOM-V at the 4th visit. Conclusion MJT is the safe and effective herbal prescription that is useful to the asthma patients.

• Korean Journal of Applied Biomechanics
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• v.25 no.1
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• pp.123-130
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• 2015

Purpose : The purpose of this study was to investigate the reliability of 3D-inertia measurement unit (IMU) based shoes in gait analysis. This was done with respect to the results of the optical motion capturing system and to collect reference gait data of healthy subjects with this device. Methods : The Smart Balance$^{(R)}$ system of 3D-IMU based shoes and Osprey$^{(R)}$ motion capturing cameras were used to collect motion data simultaneously. Forty four healthy subjects consisting of individuals in 20s (N=20), 40s (N=13), and 60s (N=11) participated in this study voluntarily. They performed natural walking on a treadmill for one minute at 4 different target speeds (3, 4, 5, 6 km/h), respectively. Results : Cadence (ICC=.998), step length (ICC=.970), stance phase (ICC=.845), and double-support phase (ICC=.684) from 3D-IMU based shoes were in agreement with results of optical motion system. Gait data of healthy subjects according to different treadmill speeds and ages were matched to previous literature showing increased cadence and reduced step length for elderly subjects. Conclusion : Conclusively, 3D-IMU based shoes in gait analysis were a satisfactory alternative option in measuring linear gait parameters.