• Title/Summary/Keyword: KFDA

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THE EFFECT OF FLUTAMIDE ON PUBERTY IN MALE RATS: AN EVALUATION OF THE PROTOCOL FOR THE ASSESSMENT OF PUBERTAL DEVELOPMENT AND THYROID FUNCTION

  • Shin, J.H.;Kim, H.S.;Moon, H.J.;Kang, I.H.;Kim, T.S.;Seok, J.H.;Kim, I.Y.;Nam, S.Y.;Park, K.L.;Han, S.Y.
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.05a
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    • pp.147-147
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    • 2001

  • To establish a test protocol for the rodent 20-day thyroid/pubertal assay, we dosed flutamide(fl), a non-steroidal androgen antagonist to intact male SD rats from postnatal day 33 for 20 days, and examined several reproductive endpoints for assessing the sensitivity of a list of parameters for detecting endocrine-related effects of endocrine-disrupting chemicals.(omitted)

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