• Korean Journal of Health Education and Promotion
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• v.26 no.4
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• pp.105-116
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• 2009

Objectives: In recent years, pregnancy rate among female adolescents has increased and caused a variety of physical and social problems. Therefore, this study aimed to investigate sexual behavior, delinquent behavior, and pregnancy rate among Korean female adolescents. Methods: In light of the growing interest in adolescent pregnancy, this study conducted a web-based survey, titled "The 2006 Youth Health Risk Behavior Survey." The Korean Center for Disease Control (KCDC) collected questionnaire responses from 34,200 young women. The collected data were analyzed through chi-square test and logistic regression using SPSS Win 14.0 version. Results: This study analyzed main factors, which can predict pregnant experience. The statistic results showed two types of the predicting factors: (1) personal factors: sexual relations after drinking (odds 25.1), Narcotic drug taking (odds 13.0), sexual violence act (odds 7.0), part-time job(odds 2.5), drinking, smoking ; and (2) environmental factors: stepfather(odds 4.2) and natural mother. Conclusion: The influential factor identification for predicting pregnancy rate is important to develop an effective education program for preventing the adolescent pregnancy. The education programs with referring to the identified factors can contribute to reducing the unwilling pregnancy rate of young woman.

• Korean Journal of Health Education and Promotion
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• v.26 no.4
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• pp.117-127
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• 2009

Objectives: The primary objective of the study is to analyze the utilization patterns of provincial patients discharged from hospitals located in Seoul area. Methods: For the analysis, the study employed the nationwide data on 'Survey of Injured Patients Discharged from Hospitals' conducted by KCDC (Korea Centers for Disease Control and Prevention). The statistical methodology used in the measurement model is a logistic regression model. Results: The study has three major findings. First, compared to other disease groups, the discharged on both 'neoplasm(cancer)' and 'congenital malformation, deformity and chromosomal abnormalities' disease groups are more likely to utilize hospitals in Seoul area. Second, as for 'neoplasm(cancer)' disease group, patients with 'bones and articular cartilage' areas are more likely to utilize hospitals in Seoul area. Finally, Hospitals with more than 1,000 beds was primary factor in selecting Seoul-based hospitals by the discharged in provincial areas. Conclusion: In sum, the study showed that patients in provincial areas are more likely to utilize hospitals located in Seoul area regardless of the severity of their cases. Local authority, therefore, is required to monitor local hospitals on regular basis, as well as support them to establish specialized medical centers by providing human and physical resources.

• Korean Journal of Community Nutrition
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• v.11 no.6
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• pp.761-770
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• 2006

The purpose of this study was to plan a 5-day menu using antioxidant-rich foods (vitamin A. vitamin C, vitamin E, phytochemicals) for a congregate meal program for the elderly and to evaluate the satisfaction of menus. The elderly participated in the congregate meal program at Guro Elderly Welfare Facility during October, 2003 (120 persons / day). The elderly liked yungyangbab, cooked rice with sweet potato and pumpkin, soybean paste soup with chinese cabbage, pan-fried cuttlefish patty with chopped soybean sprout, pan-fried beef patty with tofu and ginseng, fresh vegetable salad and most of desserts. The leftovers of menus were negatively correlated with satisfaction of menus. The 5-day menu contained over 1/3 of KDRIs (Dietary Reference Intakes for Koreans) except fiber calcium, vitamin K and vitamin E. In conclusion, menus using antioxidant-rich foods for a congregate meal program for the elderly will improve nutrient intakes and satisfaction of the meal program. It may help to prevent chronic diseases and improve healthy lives of the Korean elderly.

• Quantitative Bio-Science
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• v.36 no.1
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• pp.23-31
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• 2017

Datasets from DNA microarray experiments, which are in the form of large matrices of expression levels of genes, often have missing values. However, the existing statistical methods including the principle components analysis (PCA) and Hotelling's t-test are not directly applicable for the datasets having missing values due to the fact that they assume the observed dataset is complete in general. Many methods have been proposed in previous literature to impute the missing in the observed data. Troyanskaya et al. [1] study the k-nearest neighbor (kNN) imputation, Kim et al. [2] propose the local least squares (LLS) method and Rubin [3] propose the multiple imputation (MI) for missing values. To identify differentially expressed genes, we propose a new testing procedure when the missing exists in the observed data. The proposed procedure uses the Stouffer's z-scores and combines the test results of individual imputed samples, which are dependent to each other. We numerically show that the proposed test procedure based on MI performs better than the existing test procedures based on single imputation (SI) by comparing their ROC curves. We apply the proposed method to analyzing a public microarray data.

• BMB Reports
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• v.54 no.6
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• pp.305-310
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• 2021

Cereblon (CRBN) is a multi-functional protein that acts as a substrate receptor of the E3 ligase complex and a molecular chaperone. While CRBN is proposed to function in mitochondria, its specific roles are yet to be established. Here, we showed that knockdown of CRBN triggers oxidative stress and calcium overload in mitochondria, leading to disruption of mitochondrial membrane potential. Notably, long-term CRBN depletion using PROteolysis TArgeting Chimera (PROTAC) induced irreversible mitochondrial dysfunction, resulting in cell death. Our collective findings indicate that CRBN is required for mitochondrial homeostasis in cells.

• Journal of Preventive Medicine and Public Health
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• v.43 no.2
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• pp.99-104
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• 2010

The World Health Organization (WHO) announced the emergence of a novel influenza on April 24, 2009, and they declared pandemic on June 11. In Korea, the proportion of influenza-like illness and the consumption of antiviral agents peaked in early November. The government established the Central Headquarters for Influenza Control and operated the emergency response system. In the quarantine stations, we checked the body temperature and collected quarantine questionnaires from all the arrivals from infected countries. We also isolated the confirmed cases in the national isolation hospitals. However, as the community outbreaks were reported, we changed strategy from containment to mitigation. We changed the antiviral agent prescription guideline so that doctors could prescribe antiviral agents to all patients with acute febrile respiratory illness, without a laboratory diagnosis. Also the 470 designated hospitals were activated to enhance the efficacy of treatment. We vaccinated about 12 million people and manage the adverse event following the immunization management system. In 2010, we will establish additional national isolation wards and support hospitals to establish fever clinics and isolation intensive care unit (ICU) beds. We will also make a computer program for managing the national isolation hospitals and designated hospitals. We will establish isolation rooms and expand the laboratory in quarantine stations and we will construct a bio-safety level 3 laboratory in each province. In addition, we plan to construct a bio-safety level 4 laboratory at a new Korea Centers for Disease Control and Prevention (KCDC) facilities in Ossong.

• Journal of Society of Preventive Korean Medicine
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• v.24 no.2
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• pp.43-55
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• 2020

Objectives : The general and specific characteristics inherited in Korean traditional medicine research is to be identified and on the basis of this, the role of researchers, research institutes and government organizations is to be presented. Method : Analysis data targeted 399 cases of traditional medicine researches out of 696 cases, excluding overlapped 297 cases, that are relevanttokey-words, 'Oriental Medicine' and 'Herbal Prescription' registered in the National Institutes of Health Clinical Research Information Service(CRIS) as of 31 December, 2019. Including the regulation of the Ministry of Food and Drug Safety, research fund supporting, type of mediation, targeting disease and so forth, frequency analysis was carried out in order to confirm the general and specific characteristics of traditional medicine. Results : As a result of analyzing the data, researches of medicines(herbal medicines) and mediation(acupuncture, moxibustion) and were identified as the most and in the case of the targeting disease, it appeared in the order of targeting the research on musculoskeletal system and the healthy person.

• Parasites, Hosts and Diseases
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• v.56 no.5
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• pp.401-408
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• 2018

Korea is successfully controlled intestinal parasitic infections owing to economic development and high health consciousness. The Division of Vectors and Parasitic Diseases (formerly the Division of Malaria and Parasitology) is in the Center for Laboratory Control of Infectious Diseases of the Korea Centers for Disease Control and Prevention. It has been the governmental agency responsible for controlling and leading scientific research on parasitic diseases. The Division of Vectors and Parasitic Diseases has conducted and funded basic research and disseminated the research results to various medical fields, ultimately promoting public health in Korea. Among the noteworthy achievements of this division are the national surveillance of healthcare-associated parasitic infections, prevention and control for parasitic infections, and the elimination of lymphatic filariasis from Korea. On a broader scale, the division's research programs and academic supports were influential in preventing and treating infectious parasitic diseases through public policies and laws. In this review, we summarize the past and present role of the Division of Vectors and Parasitic Diseases in preventing and treating infectious parasitic diseases in Korea.

• The Journal of the Korea Contents Association
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• v.18 no.4
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• pp.1-9
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• 2018

The worldwide population is aging rapidly. In this circumstance, Korean society is in need of the urgent comprehensive countermeasures that will help the elderly with their health problems and infection control in their daily life. Universal design has supportive, adaptable, accessible and safety-oriental design standards for the elderly. Is this study, we propose the guidelines of the mobile application development based on the application of the universal design for infection control in the elderly. From the perspective of the universal design, there are several important guidelines including 'generalized access', 'simple and intuitive usage', 'low physical effort', and 'visualized language' based on the KCDC(Korea centers for disease control and prevention) principles for the elderly. These findings show that the guidelines for improving the health literacy of the mobile application via universal design are necessary to enhance the health behavior of infection control for the elderly.

• The Journal of the Korea Contents Association
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• v.16 no.9
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• pp.628-637
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• 2016

The purpose of this study was to explore factors influencing quality of life among cancer survivors in order to identify strategies for cancer survivors to go back to normal life and carry on stable and high quality life. This study used Korea National Health and Nutrition Examination Survey(2010-2014), conducted by Korea Centers for Disease Control and Prevention(KCDC). The sample of this study was 610 cancer survivors and their average time since diagnosis was about 11 years. The most powerful influencing factors for quality of life among cancer survivors were activity limitation(${\beta}$=.30, p<.001), followed by age(${\beta}$=-.20, p<.001), subjective health status(${\beta}$ =-.19, p<.001), and economic status(${\beta}$=.12, p=.004). According to the result, limitation on daily activities or social activities due to physical or mental debilitation was a strong factor that lowers quality of life among cancer survivors. Hence, there is a need for manpower and infrastructure that facilitates, supports, and manage daily activities of cancer survivors.