• Proceedings of the Optical Society of Korea Conference
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• 1996.09a
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• pp.68-68
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• 1996

• Archives of Pharmacal Research
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• v.28 no.5
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• pp.582-586
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• 2005

The present study was designed to characterize the possible roles of spinally located cholera toxin (CTX)- and pertussis toxin (PTX)-sensitive G-proteins in pro- inflammatory cy tokine induced pain behaviors. Intrathecal injection of tumor necrosis factor-a (TNF-${\alpha}$; 100 pg), interleukin-1${\beta}$ (IL-1${\beta}$ 100 pg) and interferon-${\gamma}$ (INF-${\gamma}$; 100 pg) showed pain behavior. Intrathecal pretreatment with CTX (0.05, 0.1 and 0.5 mg) attenuated pain behavior induced by TNF-${\alpha}$ and INF-${\gamma}$ administered intrathecally. But intrathecal pretreatment with CTX (0.05, 0.1 and 0.5${\mu}g$) did not attenuate pain behavior induced by IL-1${\beta}$. On the other hand, intrathecal pretreatment with PTX further increased the pain behavior induced by TNF-${\alpha}$ and IL-1${\beta}$ administered intrathecally, especially at the dose of 0.5 ${\mu}g$. But intrathecal pretreatment with PTX did not affect pain behavior induced by INF-${\gamma}$. Our results suggest that, at the spinal cord level, CTX- and PTX-sensitive G-proteins appear to play important roles in modulating pain behavior induced by pro-inflammatory cytokines administered spinally. Furthermore, TNF-${\alpha}$, IL-1${\beta}$ arid INF-${\gamma}$ administered spinally appear to produce pain behavior by different mechanisms.

• Proceedings of the IEEK Conference
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• 2002.07a
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• pp.94-97
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• 2002

A VLSI architecture of an Ogg Vorbis decoder is proposed : which is dedicated to portable audio appliances. Referring to the computational cost analysis of the decoding processes, the LSP (Line Spectrum Pair) process, which takes more than 50% of the total processing time, can be regarded as a bottleneck to achieve realtime processing by embedded Processors. Thus in our decoder a specific hardware architecture is devised for the LSP process so as to be integrated into a single chip together with an ARM7TDMI processor. In addition, in order to reduce the total hardware cost, instead of the floating point arithmetic, the fixed point arithmetic is adopted. The LSP module has been implemented with 9,740 gates by using a Virtual Silicon 0.l5$\mu\textrm{m}$ CMOS technology, which operates at 58.8MHz with the total CPU load reduced by 57%. It is also verified that the use of the fixed point arithmetic does not incur any significant sound distortion.

• Korean Journal of Veterinary Research
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• v.42 no.1
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• pp.123-130
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• 2002

To investigate the cardiopulmonary and anesthetic effects of propofol in dogs, experimental dogs were randomly divided into 4 groups (propofol infusion anesthesia, P/INF, propofol intermittent anesthesia, P/INTER, propofol induction anesthesia, P/ISO, thiopental Na induction anesthesia, T/ISO) and monitored analgesic and anesthetic effects, recovery time, body temperature, heart rate, mean arterial pressure, respiratory rate, systolic and diastolic pressure. In all groups, apnea was not observed. In the P/INF group, the respiratory rate(RR) was slightly decreased, but in the P/INTER group, RR was increased and shallowing. In the groups of P/ISO and T/ISO, the respiratory rate was decreased. Heart rate(HR) was increased after induction anesthesia in all groups, but gradually decreased. Mean arterial pressure(MAP) was decreased after injection anesthesia in the groups of P/INF and P/INTER. In the groups of P/ISO and T/ISO, however, MAP was slightly increased. Systolic and diastolic arterial pressure were gradually decreased after induction anesthesia, but not significantly. In the groups of P/INF and P/ISO, recovery time was shorter than the groups of P/INTER and T/ISO. In all groups, body temperature of animals was decreased gradually according to time but no significant changes were observed. Propofol injection doesn't make the complete loss of responses of animals, especially, in the P/INTER group. In the P/INF group, deep pain was present until the end of anesthetic period. During recovery period, any other side effects except incoordination were not monitored. The present study suggested that infusion anesthesia was superior to intermittent anesthesia as injection anesthetic agent, and propofol was better than thiopental Na as induction anesthetic agent.

• Journal of the Korean Geotechnical Society
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• v.27 no.11
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• pp.17-25
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• 2011

In this study, we considered the bearing capacity of strip footing over clay layers partially replaced by sand. The FEM analysis is performed to calculate the ultimate bearing capacity. Partial replacement is defined by multiples of footing width(B) and inclination of sides. The cases(B'=inf.) of sand layers equal to clay layers are preferentially conducted. The baring capacity of B'=inf. is comparative value for bearing capacity of partial replacement layers. ${\beta}$ is the ratio of ultimate bearing capacity of B'=inf and partial ultimate bearing capacity replacement. ${\beta}$ is used to analyze the characteristic of bearing capacity of clay layers partially replaced by sand. Each of the three undrained shear strengths of clay and friction angles of sand is considered. The result of this analysis shows that ${\beta}$ depends on sand depth.

• Tuberculosis and Respiratory Diseases
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• v.56 no.6
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• pp.611-618
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• 2004

Background : Idiopathic pulmonary fibrosis(IPF), a subtype of IIP(idiopathic interstitial pneumonia), is a fatal disease with a 3-5 year median survival. Many attempts at treating this condition have failed to demonstrate a survival benefit in IPF. Recently Ziesche et $al^{12}$ reported the efficacy of IFN-${\gamma}$ for treating IPF but there is still some controversy. The aim of this study was to determine the efficacy of IFN-${\gamma}$ in patients with advanced IPF who had not been responsive to steroid and cytotoxic agents. Method : Nine patients with advanced IPF(age: $55.4{\pm}15.3$ years, Male: Female=8:1) were enrolled. One year treatment regime with 2 million IU of IFN-${\gamma}$ administered subcutaneously three times a week, and low dose prednisolone(10-30 mg/d) was also used. In the case of a definite aggravation and serious side effects, the IFN-${\gamma}$ was discontinued. During the IFN-${\gamma}$ trial, a pulmonary function test and chest radiography were checked every three month throughout the study. Result : 1) Among 9 patients, only 4 patients were able to complete the 12 month treatment with IFN-${\gamma}$, and 5 patients died during the treatment period. 2) No improvement either in the respiratory symptoms or pulmonary functions were observed any of the patients, even in those who completed the 12 months trial of IFN-${\gamma}$, 3) At the time of IFN-${\gamma}$ trial, the survivors who finished the IFN-${\gamma}$ treatment for 12 months had a higher oxygen level($81.3{\pm}2.8$ vs. $67.4{\pm}8.4$, P=0.024) and a better pulmonary function(FVC: $61.3{\pm}5.1$ % predicted vs. $45.7{\pm}12.3%$, P=0.048, and $D_Lco$: $45.0{\pm}5.0%$ predicted vs. $30.8{\pm}11.2%$, P=0.048) than the non-survivors. Conclusion : Our data suggested that IFN-${\gamma}$ therapy was not effective in the patients with advanced IPF refractory compared with other therapeutic agents. Furthermore, these results suggest that severe impairment of the pulmonary function and hypoxemia during the IFN-${\gamma}$ therapy requires special attention.

• Journal of Acupuncture Research
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• v.27 no.4
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• pp.223-231
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• 2010

Objectives : The objective of this study is to study the effects of Euonymi Lignum Suberatatum pharmacopuncture solution on NO and IL-6 production in macrophage. Methods : At first, the RAW 264.7 macrophage was subclutured. In order to evaluate cytotoxicity, MTT assay performed. Then, the cell was induced by LPS, INF-$\gamma$ and Experimental groups were divided into five(Normal, Control, Euonymi Lignum Suberatatum 100, 200, $300{\mu}g/m{\ell}$). Then Euonymi Lignum Suberatatum pharmacopuncture solution was put into cell. We measured IL-6, iNOS, NO. Results : The cytotoxic effect of Euonymi Lignum Suberatatum pharmacopuncture solution in RAW 264.7 macrophage was not appeared. $300{\mu}g/m\ell$ Euonymi Lignum Suberatatum pharmacopuncture solution inhibited IL-6 production in LPS, INF-$\gamma$-stimulated RAW 264.7 macrophages significantly. Euonymi Lignum Suberatatum pharmacopuncture solution inhibited iNOS revelation in LPS, INF-$\gamma$-stimulated RAW 264.7 macrophages. All group of Euonymi Lignum Suberatatum pharmacopuncture solution inhibited NO production in LPS, INF-$\gamma$-stimulated RAW 264.7 macrophages significantly. Conclusions : Our study demonstrated that Euonymi Lignum Suberatatum pharmacopuncture solution had an inhibition effect on NO production, iNOS revelation, IL-6 production. So Euonymi Lignum Suberatatum pharmaco puncture solution may have an Anti-inflammation effect.

• Proceedings of the Korean Society of Computer Information Conference
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• 2017.07a
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• pp.336-337
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• 2017

본 논문에서는 이처럼 중요한 역할을 하는 무릎의 굽힘(flexion)과 폄(extension)에 대하여 측정을 한다. 무릎과 엉덩이를 펴고 골반을 중립상태로 두고 엎드려 무릎을 구부리고 편다. 일반인의 도수 측정 각도는 구부렸을 때 $110^{\circ}$에서 $135^{\circ}$ 사이의 값이 나온다. 여기서 구부렸을 때 고통을 호소하면 무릎 관절 및 근육에 이상이 있는 것이다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2017.07a
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• pp.338-339
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• 2017

안쪽번짐과 가쪽번짐이란 발목을 $90^{\circ}$중립자세가 되게하고 발 안쪽면과 바깥쪽면으로 구부리는 것을 말한다. 안쪽번짐의 각은 $20{\sim}35^{\circ}$가 정상이고 가쪽번짐의 각은 $10{\sim}20^{\circ}$가 정상이다. 발의 안쪽번짐과 가쪽번짐의 각이 정상치에 미달하거나 고통을 호소하면 이상이 있는 것이다. 따라서 그에 알맞은 치료법도 제시한다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2017.07a
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• pp.340-341
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• 2017

본 논문에서는 근골격계 질환 중에서 종종 발생하는 어깨 부위의 질환에 대하여 알아보도록 한다. 본 논문에서는 팔을 반듯이 위로 올렸을 때 통증이 발생하는 어깨 질환에 대한 도수치료법을 제시한다. 실험에서는 도수진단을 위하여 팔을 반듯이 위로 올릴 때 팔의 각도를 입력하고, 이상이 발생할 시 진단 및 치료법까지 시스템에서 제시한다.