• Molecules and Cells
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• v.41 no.9
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• pp.830-841
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• 2018

Recent studies have indicated that microRNAs (miRNAs) play an important role in hepatocellular carcinoma (HCC) progression. In this study, we showed that miR-766-3p was decreased in approximately 72% of HCC tissues and cell lines, and its low expression level was significantly correlated with tumour size, TNM stage, metastasis, and poor prognosis in HCC. Ectopic miR-766-3p expression inhibited HCC cell proliferation, colony formation, migration and invasion. In addition, we showed that miR-766-3p repressed Wnt3a expression. A luciferase reporter assay revealed that Wnt3a was a direct target of miR-766-3p, and an inverse correlation between miR-766-3p and Wnt3a expression was observed. Moreover, Wnt3a up-regulation reversed the effects of miR766-3p on HCC progression. In addition, our study showed that miR-766-3p up-regulation decreased the nuclear ${\beta}-catenin$ level and expression of Wnt targets (TCF1 and Survivin) and reduced the level of MAP protein regulator of cytokinesis 1 (PRC1). However, these effects of miR-766-3p were reversed by Wnt3a up-regulation. In addition, PRC1 upregulation increased the nuclear ${\beta}-catenin$ level and protein expression of TCF1 and Survivin. iCRT3, which disrupts the ${\beta}-catenin-TCF4$ interaction, repressed the TCF1, Survivin and PRC1 protein levels. Taken together, our results suggest that miR-766-3p down-regulation promotes HCC cell progression, probably by targeting the Wnt3a/PRC1 pathway, and miR-766-3p may serve as a potential therapeutic target in HCC.

• The Journal of the Korea Contents Association
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• v.3 no.2
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• pp.65-72
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• 2003

In this paper, the new scheme using a Combined Cache(CC) that combing the Paging and Routing Cache(PRC) and an alternative handoff method according to the type of data transmission for achieving the efficient realtime communication. The PRC and quasi-soft handoff method reduce the path duplication. But they increase the network traffic load because of the handoff state packet of Mobile Host(MH). Moreover the use the same handoff method without differentiating the type of transmission data. Those problems are solved by operating U with a semi-soft handoff method for realtime data transmission and with a hard handoff method for non-realtime data transmission. As a result or simulation a better performance is obtained because of the reduction of the number of control packet in case that the number of cells are below 20. And the packet arrival time and loss of packet decreased significantly for realtime data transmission.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.2
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• pp.179-186
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• 2011

Purpose: This study aimed to compare and assess changes of visual functions in viewing an anaglyph 3D image. Methods: Visual functions were examined before and after viewing a 2D image and an anaglyph 3D image with red-green glasses on seventy college students (mean age = 22.29${\pm}$2.19 years). Visual function tests were carried out for von Graefe phoria test, accommodative amplitude test by (-) lens addition, negative relative accommodation (NRA) and positive relative accommodation (PRA) test, negative relative convergence (NRC) and positive relative convergence (PRC) test, accommodative facility, and vergence facility test. Results: Assessment of the visual functions indicated that near exophoria and accommodative amplitude were reduced after viewing a 3D image, and although there were small changes in relation to these findings, NRC and PRC showed tendencies to increase and decrease at near, respectively. There were no significant changes with NRA and PRA, and accommodative and vergence facility were shown to have improved. Conclusions: Changes of visual functions were more in the 3D image than the 2D image, especially at near than distance. Particularly, the improvement of accommodative and vergence facility could be related to an effect of subsequent accommodation and vergence shift to have stereopsis in the 3D image. These results indicate that an anaglyph 3D image may, to some extent, be the effect of vision training such as anaglyphs.

• Journal of Advanced Navigation Technology
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• v.6 no.2
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• pp.130-137
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• 2002

We present Space-Time Trellis Coded Code Division Multiple Access systems, which maintain the full diversity and coding gain of Space-Time Trellis Codes(STTC) and have the immunity to performance degradation caused by multipath fading. These STTC CDMA systems are constructed by adding the spreading and despreading processes of PN codes to STTC systems. In multipath fading channels, delay spreaded signals are detected and combined, then decoded. According to the combining and decoding methods, there are four decoding methods. There are optimum ML decoding without combining, adding multipath signals in each receive antenna before decoding, combining multi path signals in each antenna before decoding, and combining all received signals before decoding. Performance of these methods is proportional to complexity. Besides, all methods are shown to compensate the irreducible error rate which appears in multipath fading channels.

• Geomechanics and Engineering
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• v.31 no.5
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• pp.477-488
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• 2022

Pile composite foundation (PCF) has been commonly applied in practice. Existing research has focused primarily on semi-infinite media having equal pile lengths with little attention given to the effects of inclined bedrock and dissimilar pile lengths. This investigation considers the effects of inclined bedrock on vertical loaded PCF with dissimilar pile lengths. The pile-soil system is decomposed into fictitious piles and extended soil. The Fredholm integral equation about the axial force along fictitious piles is then established based on the compatibility of axial strain between fictitious piles and extended soil. Then, an iterative procedure is induced to calculate the PCF characteristics with a rigid cap. The results agree well with two field load tests of a single pile and numerical simulation case. The settlement and load transfer behaviors of dissimilar 3-pile PCFs and the effects of inclined bedrock are analyzed, which shows that the embedded depth of the inclined bedrock significantly affects the pile-soil load sharing ratios, non-dimensional vertical stiffness N₀/wdE_s, and differential settlement for different length-diameter ratios of the pile l/d and pile-soil stiffness ratio k conditions. The differential settlement and pile-soil load sharing ratios are also influenced by the inclined angle of the bedrock for different k and l/d. The developed model helps better understand the PCF characteristics over inclined bedrock under vertical loading.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.3
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• pp.287-291
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• 2010

Purpose: The aim of this study was to compare binocular functions such as near point of convergence (NPC), AC/A ratios, heterophoria, accommodation, accommodation lag, positive relative accommodation (PRA), negative relative accommodation (NRA), positive relative convergence (PRC), negative relative convergence (NRC) in normal subjects and convergence insufficiency. Methods: 86 subject (male n=45, female n=41, mean $age{\pm}SD=23.27{\pm}2.85$ years) without amblyopia, strabismus, and ocular pathology were studied. Forty three patients each group were classified as normal subjects and convergence insufficiency group based on AC/A ratio and far and near phoria. Binocular function of the two groups was measured using phoropter. r. Results: The values between normal subjects and convergence insufficiency were 5.71 cm and 7.07 cm for NPC, 5.28 and 2.81 for Heterophria AC/A, 0.92 exo/3.36 exo and 2.17 exo/10.84 exo for far and near phoria, 15.49/23.30/13.30 and 13.50/20.02/9.09 for PRC, respectively. However, there were no significant differences between normal subjects and convergence insufficiency for accommodative amplitude, accommodative lag, PRA, NRA, BI vergence test, BO vergence test, NRC. Conclusions: Both groups were a significant difference for cover test, NPC, Heterophria AC/A, far and near phoria, break point of PRC, and recovery point of PRC.

• Journal of Positioning, Navigation, and Timing
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• v.4 no.2
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• pp.79-85
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• 2015

Existing Differential GPS (DGPS) pseudorange correction (PRC) generation techniques based on a virtual reference station cannot effectively assign a weighting factor if the baseline distance between a user and a reference station is not long enough. In this study, a virtual reference station DGPS PRC generation technique was developed based on an enhanced inverse distance weighting method using an exponential function that can maximize a small baseline distance difference due to the dense arrangement of DGPS reference stations in South Korea, and its positioning performance was validated. For the performance verification, the performance of the model developed in this study (EIDW) was compared with those of typical inverse distance weighting (IDW), first- and second-order multiple linear regression analyses (Planar 1 and 2), the model of Abousalem (1996) (Ab_EXP), and the model of Kim (2013) (Kim_EXP). The model developed in the present study had a horizontal accuracy of 53 cm, and the positioning based on the second-order multiple linear regression analysis that showed the highest positioning accuracy among the existing models had a horizontal accuracy of 51 cm, indicating that they have similar levels of performance. Also, when positioning was performed using five reference stations, the horizontal accuracy of the developed model improved by 8 ~ 42% compared to those of the existing models. In particular, the bias was improved by up to 27 cm.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.389-392
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• 2005

In the maskless photolithography based on the Digital Micromirror Device (DMD) by Texas Instruments Inc. (TI), the micromirror array works as a virtual photomask to write patterns directly onto Flat Panel Display (FPD) at high speed with low cost. However, it is neither simple to generate region-based patterns for the micromirror array nor easy to deliver sequences of patterns for the micromirror controller. Moreover, the quality of lithography yields the precise synchronization between generating sequence of patterns and irradiation rate off micromirrors. In this study, the region-based pattern generating system for maskless photolithography is devised. To verify salient features of devised functionalities, the prototype system is implemented and the system is evaluated with actual DMD based photolithography. The results show that proposed pattern generating method is proper and reliable. Moreover, the devised region-based pattern generating system is robust and precise enough to handle any possible user specified mandate and to achieve the quality of photolithography required by FPD manufacturer.

• The Korean Journal of Air & Space Law and Policy
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• v.22 no.1
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• pp.55-74
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• 2007

When the People's Republic of China destroyed one of its own defunct meteorological satellites, the Fengyun-1C, at an altitude of some 865 km above the earth's surface, the PRC was accused of initiating, or at the very least risking an(other) arms race in outer space also. The test also gave rise to a few legal questions as to the permissibility of this test, and the broader permissibility of using space for military and other weapon-touting activities, Whilst the test cannot be considered to constitute a direct threat to international peace and security so as to invoke relevant legal principles and consequences in terms of the UN Charter for example, it highlights the importance of such clauses in international space law as requiring international cooperation and consultation, due regard for the interests of all other countries both on earth and in outer space, and the further development of general regimes of registration and space debris-prevention. From that perspective, the PRC violated international outer space law not so much by the test itself but by the accompanying lack of information, consultation and due regard for other states', and indeed mankind's, interests.

• Journal of Arbitration Studies
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• v.25 no.3
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• pp.113-133
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• 2015

This article reviews some recent decisions of the Supreme People's Court (SPC) of the People's Republic of China (PRC) on the recognition and enforcement of several South Korean arbitral awards. It explains the implementation of the New York Convention in the PRC and in particular the so-called Report System under the current Mainland Chinese law and judicial practice. It identifies some deficiencies in the People's Courts' approaches to the application and interpretation of the New York Convention and argues that the Mainland Chinese courts should adopt the pro-enforcement principle in the determination of the relevant issues under the New York Convention. It proposes further enhancement of the Report System and that the current categorization of 'domestic, foreign-related and foreign' in the context of arbitration agreements and arbitral awards needs to be further reviewed and clarified by the SPC. Last but not the least, it recommends some steps that South Korean parties should take to enhance the enforceability of South Korean Arbitral Awards in Mainland China.