• Title/Summary/Keyword: K-ABC

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Psychoeducational Profile-Revised, Korean Wechsler Preschool and Primary Scale of Intelligence, Fourth Edition, and the Vineland Adaptive Behavior Scale, Second Edition: Comparison of Utility for Developmental Disabilities in Preschool Children

  • Sumi Ryu;Taeyeop Lee;Yunshin Lim;Haejin Kim;Go-eun Yu;Seonok Kim;Hyo-Won Kim
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.34 no.4
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    • pp.258-267
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    • 2023
  • Objectives: This study aimed to compare the utility of the Psychoeducational Profile-Revised (PEP-R), Korean Wechsler Preschool and Primary Scale of Intelligence, Fourth Edition (K-WPPSI-IV), and Vineland Adaptive Behavior Scale, Second Edition (VABS-II) for evaluating developmental disabilities (DD) in preschool children. Additionally, we examined the correlations between the PEP-R, K-WPPSI-IV, and VABS-II. Methods: A total of 164 children aged 37-84 months were assessed. Children's development was evaluated using the PEP-R, K-WPPSI-IV, VABS-II, Preschool Receptive-Expressive Language Scale, and Korean Childhood Autism Rating Scale, Second Edition. Results: Of the 164 children, 103 had typical development (TD) and 61 had DD. The mean of the PEP-R Developmental Quotient (DQ), K-WPPSI-IV Full-Scale Intelligence Quotient (FSIQ), and VABS-II Adaptive Behavior Composite (ABC) scores were significantly higher in the TD group than in the DD group (p<0.001). The estimated area under the curve of the PEP-R DQ, K-WPPSI-IV FSIQ, and VABS-II ABC scores was 0.953 (95% confidence interval [CI]=0.915-0.992), 0.955 (95% CI=0.914-0.996), and 0.961 (95% CI=0.932-0.991), respectively, which did not indicate a statistically significant difference. The PEP-R DQ scores were positively correlated with the K-WPPSI-IV FSIQ (r=0.90, p<0.001) and VABS-II ABC scores (r=0.84, p<0.001). A strong correlation was observed between the K-WPPSI-IV FSIQ and VABS-II ABC scores (r=0.89, p<0.001). Conclusion: This study found that the PEP-R, K-WPPSI-IV, and VABS-II effectively distinguished DD from TD in preschool children, and no significant differences in utility were observed between them.

Characteristics of Chemical Species in Gaseous and Aerosol Phase Measured at Gosan, Korea During ABC-EAREX2005 (ABC-EAREX2005 기간 동안 제주도 고산지역 대기 중 가스상 및 입자상 물질의 분포특성)

  • Moon K.J.;Han J.S.;Kong B.J.;Lee M.D.;Jung I.R.
    • Journal of Korean Society for Atmospheric Environment
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    • v.21 no.6
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    • pp.675-687
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    • 2005
  • In this study, the cyclone/denuder/filter pack sampling system was used to measure the daily concentrations of water soluble inorganic compounds of fine ($D_{p}< 2.5\;{\mu}m$) and coarse ($D_{p}<10{\mu}m$m) size fractions of aerosol and related gases at Gosan super site during ABC-EAREX 2005. The mean concentrations for $HNO_{3},\;HNO_{2},\;NH_{3}$, were 0.39, 0.08, and $0.29\;{\mu}g/m^3$. respectively. Average concentrations of sulfate, nitrate, and ammonium in $PM_{2.5}$ were 3.39, 1.06, and $1.04\;{\mu}g/m^3$, which occupied about $26\%$ of total $PM_{2.5}$ mass. In particular, more than half of these ionic species were found in size of less than $2.5\;{\mu}m$. Gas phase nitric acid concentrations have shown high correlation coefficient with $HNO_{2}$(R=0.80) and $O_{3}$(R=0.78), implying the active photochemical reactions from its precursors. Equivalent molar ratios between major ion components, $NH_{4}\;^{+}/nss\;SO_4\;^{2-},(0.83\;for\;PM_{2.5},\;0.86\;for\;PM_{10})$, revealed that the existing forms of the secondary aerosols were probably $(NH_{4})_{2}SO_{4}\;and\;(NH_{4})_{3}H\;(SO_{4})_{2}$. Especially, $(NH_{4}\;^{+}+K^{+}+Ca^{2+}+Mg^{2+})/(NO_{3}\;^{-}+nss\;SO_{4}\;^{2-}) (0.99\;for\;PM_{2.5},\;1.05\;for\;PM_{10})$ indicated that some of them existed not only as $NH_{4}NO_{3}$ but also as $CaSO_{4}\;or\;KNO_{3}$, which pointed out the probability of influences from the abundant soil components during Asian dust (AD) periods. These neutralized types of secondary aerosols showed that pollutants could be aged and transported from a distance.

Determination of Sodium Chondroitin Sulfate by Enzymatic Digestion and HPLC (효소분해와 HPLC를 이용한 황산콘드로이틴나트륨의 정량)

  • Kang, Seong-Ho;Shin, Hoon;Chang, Sun-Ki;Yoon, Hyung-Jung
    • Analytical Science and Technology
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    • v.7 no.2
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    • pp.245-251
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    • 1994
  • In order to determine sodium chondroitin sulfate in the mixture, chondroitinase ABC was used for enzymatic reaction. The procedure was rapid, simple, quantitative and the HPLC analysis of ${\Delta}Di-6S$(2-actamido-2-deoxy-3-0-(${\beta}$-D-gluco-4-enepyranosyluronic acid)-6-0-sulfo-D-galactose) in the sodium chondroitin sulfate was obtained. The absorbance was measured at 230nm and detection limit was $1{\mu}g/ml$. When we applied this method to the drugs(capsule, opthalmic solution), it gave the mean contents of $100.01{\pm}1.58%$ and $99.89{\pm}1.80%$ respectively.

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Effects of Nitrogen Supplementation Status on CO2 Biofixation and Biofuel Production of the Promising Microalga Chlorella sp. ABC-001

  • Cho, Jun Muk;Oh, You-Kwan;Park, Won-Kun;Chang, Yong Keun
    • Journal of Microbiology and Biotechnology
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    • v.30 no.8
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    • pp.1235-1243
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    • 2020
  • The use of microalgal biomass as feedstock for biofuels has been discussed for decades as it provides a sustainable approach to producing fuels for the future. Nonetheless, its feasibility has not been established yet and various aspects of biomass applications such as CO2 biofixation should also be explored. Therefore, in this study, the CO2 biofixation and lipid/carbohydrate production potential of Chlorella sp. ABC-001 were examined under various nitrogen concentrations. The highest biomass productivity and CO2 biofixation rate of 0.422 g/l/d and 0.683 g/l/d, respectively, were achieved under a nitrogen-rich condition (15 mM nitrate). Carbohydrate content was generally proportional to initial nitrate concentration and showed the highest value of 41.5% with 15 mM. However, lipid content showed an inverse relationship with nitrogen supplementation and showed the highest value of 47.4% with 2.5 mM. In consideration as feedstock for biofuels (bioethanol, biodiesel, and biogas), the sum of carbohydrate and lipid contents were examined and the highest value of 79.6% was achieved under low nitrogen condition (2.5 mM). For lipid-based biofuel production, low nitrogen supplementation should be pursued. However, considering the lower feasibility of biodiesel, pursuing CO2 biofixation and the production of carbohydrate-based fuels under nitrogen-rich condition might be more rational. Thus, nitrogen status as a cultivation strategy must be optimized according to the objective, and this was confirmed with the promising alga Chlorella sp. ABC-001.

Design of Robust Face Recognition System with Illumination Variation Realized with the Aid of CT Preprocessing Method (CT 전처리 기법을 이용하여 조명변화에 강인한 얼굴인식 시스템 설계)

  • Jin, Yong-Tak;Oh, Sung-Kwun;Kim, Hyun-Ki
    • Journal of the Korean Institute of Intelligent Systems
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    • v.25 no.1
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    • pp.91-96
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    • 2015
  • In this study, we introduce robust face recognition system with illumination variation realized with the aid of CT preprocessing method. As preprocessing algorithm, Census Transform(CT) algorithm is used to extract locally facial features under unilluminated condition. The dimension reduction of the preprocessed data is carried out by using $(2D)^2$PCA which is the extended type of PCA. Feature data extracted through dimension algorithm is used as the inputs of proposed radial basis function neural networks. The hidden layer of the radial basis function neural networks(RBFNN) is built up by fuzzy c-means(FCM) clustering algorithm and the connection weights of the networks are described as the coefficients of linear polynomial function. The essential design parameters (including the number of inputs and fuzzification coefficient) of the proposed networks are optimized by means of artificial bee colony(ABC) algorithm. This study is experimented with both Yale Face database B and CMU PIE database to evaluate the performance of the proposed system.

The Efficacy of Early Start Denver Model Intervention in Young Children with Autism Spectrum Disorder Within Japan: A Preliminary Study

  • Tateno, Yukie;Kumagai, Kahoru;Monden, Ryunosuke;Nanba, Kotaro;Yano, Ayumi;Shiraishi, Eri;Teo, Alan R.;Tateno, Masaru
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.32 no.1
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    • pp.35-40
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    • 2021
  • Objectives: Among the many intervention programs for children with autism spectrum disorder (ASD), the Early Start Denver Model (ESDM) is one of the few approaches that has succeeded in demonstrating clinical efficacy in randomized control trials. Here, we investigate the clinical efficacy of ESDM intervention in young children with ASD in a community setting within Japan. Methods: All subjects were children with ASD who received ESDM intervention during the study period. Each ESDM session lasted 75 min and occurred once per week for at least 12 weeks. The outcome measures consisted of the Kyoto Scale of Psychological Development (K-test), Aberrant Behavior Checklist-Japanese version (ABC-J), and the Clinical Global Impression-Severity scale (CGI-S). Results: Twenty-seven subjects (29.4±6.4 months old) received ESDM intervention that lasted for 8.0±2.6 months on average. The score on Language and Social developmental quotient on the K-test increased significantly after the intervention. The total scores on the ABC-J and CGI-S significantly decreased after completion of the ESDM intervention. Conclusion: Our results suggest that ESDM intervention could reduce the severity of distinct clinical features of ASD, such as impairments in social interaction and communication assessed by the K-test, and maladaptive behavior rated by the ABC-J and CGI-S. We believe that the ESDM adapted to each institution might become one of the standard options for children with ASD in Japan.

Human Cord Serum as a Fetal Bovine Serum Substitute for the Culture of Human Amnion-Derived Stem Cells (인간의 양막유래 줄기세포의 체외 배양 시 소태아혈청 대체제로서의 인간제대혈청)

  • Kim, Jin-Young;Park, Se-A;Kang, Hyun-Mi;Kim, Eun-Su;Kim, Hae-Kwon
    • Development and Reproduction
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    • v.11 no.2
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    • pp.85-96
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    • 2007
  • Mesenchymal stem cells (MSC) are promising candidates for cell-based therapies. One major obstacle for their clinical use is the unsafety of fetal bovine serum (FBS), which is a crucial part of all media currently used for the culture of MSC. We investigated the effect of human cord serum (HCS) on the growth response, mRNA and protein expressions of human amnion-derived stem cells (HAM). HAM were isolated from the amnion after a Caesarean section and cultured in DMEM supplemented with 10% FBS, 5% HCS or 10% HCS. During culture, their biological characteristics at earlier and later passages were analyzed using RT-PCR and immunocytochemistry. Regardless of serum sources, HAM showed the prominent expression of Oct-4, Rex-1, SCF, FGF-5, BMP-4, nestin, GATA-4, NCAM and HLA ABC genes. The expression profile was observed even at later passages. Similarly, HAM cultured in either FBS or HCS exhibited the distinct protein expression of collagen I, II, III and XII, fibronectin, $\alpha$-smooth muscle actin, vimentin, CK18, CD54, FSP, TRA-1-60, SSEA-3, -4 and HLA ABC. However, desmin expression was only observed in HAM cultured in medium supplemented with FBS and vWF expression was only found in HAM cultured in medium supplemented with HCS. Overall pattern of gene and protein expression of HAM was typical of known adult stem cells such as bone marrow-derived MSC. In conclusion, HCS could be as effective as FBS for the culture of HAM.

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Characterization of Human Thigh Adipose-derived Stem Cells (사람의 허벅지지방유래 줄기세포의 특성 분석)

  • Heo, Jin-Yeong;Yoon, Jin-Ah;Kang, Hyun-Mi;Park, Se-Ah;Kim, Hae-Kwon
    • Development and Reproduction
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    • v.14 no.4
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    • pp.233-241
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    • 2010
  • Human adipose stem cells are an abundant, readily available population of multipotent progenitor cells that reside in adipose tissue and these cells have characteristics very similar to bone marrow mesenchymal stromal cells (BMMSCs). However, liposuction procedure, donor age, body mass index, and harvesting sites might generate differences in the initial cell population and the preparations are a heterogeneous mixture of precursors with different subsets. Therefore, in this study, we investigated the characteristics of human thigh adipose stem cells and the differentiation potential into mesodermal and endodermal lineage. Thigh adipose stem cells maintained fibroblast-like morphology similar to BM-MSCs and they underwent average 56.5 doublings and produced $5{\times}10^{22}$ cells. These cells expressed SCF, Oct4, nanog, vimentin, CK18, FGF5, NCAM, Pax6, BMP4, HNF4a, nestin, GATA4, HLA-ABC, and HLA-DR genes at p3 and they also expressed Oct4, Thy-1, FSP, vWF, vimentin, desmin, CK18, CD54, CD4, CD106, CD31, a-SMA, HLA-ABC proteins. Moreover, they could differentiate into mesodermal lineage cells such as adipocyte, osteoblast and chondrocyte. In addition, they also differentiated into insulin secreting cells in our culture condition. In conclusion, human thigh adipose stem cells retain proliferative potential and expression patterns similar to BM-MSCs and they also differentiate into various cell types. Thus, human thigh adipose stem cells might be useful alternative cell source for clinical application.

Differentially Up-expressed Genes Involved in Toluene Tolerance in Pseudomonas sp. BCNU106 (유기용매 내성 세균 Pseudomonas sp. BCNU106 균주에서 차별적으로 상향 발현되는 유전자군의 톨루엔 내성과의 연관성)

  • Joo, Woo Hong;Bae, Yun-Ui;Kim, Da Som;Kim, Dong Wan
    • Journal of Life Science
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    • v.30 no.1
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    • pp.88-95
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    • 2020
  • Using a random arbitrarily primed polymerase chain reaction, messenger RNA expression levels were assessed after exposure to 10% (v/v) toluene for 8 hr in solvent-tolerant Pseudomonas sp. BCNU 106. Among the 100 up-expressed products, 50 complementary DNA fragments were confirmed to express repeatedly; these were cloned and then sequenced. Blast analysis revealed that toluene stimulated an adaptive increase in the gene expression level in association with transcriptions such as LysR family of transcriptional regulators and RNA polymerase factor sigma-32. The expression of catalase and Mn2+/Fe2+ transporter genes functionally associated with inorganic ion transport and metabolism increased, and the increased expression of type IV pilus assembly PilZ and multi-sensor signal transduction histidine kinase genes, functionally categorized into signal transduction and mechanisms, was also demonstrated under toluene stress. The gene expression level of beta-hexosaminidase in association with carbohydrate transport and metabolism increased, and those of DNA polymerase III subunit epsilon, DNA-3-methyladenine glycosylase II, DEAD/DEAH box helicase domain-containing protein, and ABC transporter also increased after exposure to toluene in DNA replication, recombination, and repair, and even in defense mechanism. In particular, the RNAs corresponding to the ABC transporter, Mn2+/Fe2+ transporter, and the β-hexosaminidase gene were confirmed to be markedly induced in the presence of 10% toluene. Thus, defense mechanism, cellular ion homeostasis, and biofilm formation were shown as essential for toluene tolerance in Pseudomonas sp. BCNU 106.

Activity-Based Costing and Management Applied to Occupational and Environmental Health (산업보건 및 환경분야에 대한 활동기준원가계산 및 관리의 응용)

  • Park, Doo Yong;Brandt, Michael T.;Levine, Steven P.;Paik, Nam Won
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.6 no.1
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    • pp.144-155
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    • 1996
  • During the 1990s the workplace has grown more complex and business competition has increased world-wide. All organizations, whether for-profit or non-profit have been forced to respond to market changes. More advanced information and technology, greater product diversity, shorter product life cycles, increased quality requirements, more regulation oversight, decreasing productivity, more competitors, and increasing overhead costs have motivated organizations to focus on ways to deliver products cheaper, better, and faster. Many organizations are searching for ways to reduce costs through downsizing, reengineering business processes, implementing quality management, outsourcing, and improving cost management. Support departments that provide services internal to an organization such as human resources, legal, and environmental, safety, and health (ES&H) are often the first organization targeted for cost reduction and cost control initiatives because these functions are part of a rapidly increasing overhead cost. Recently, ES&H functions are incresingly being integrated into the business of business to contribute value to organization beyond mere compliance with ES&H regulations. The discussions and development of the ISO compatible Environmental Management Standards or Occupational Safety and Health Management Standards is another impetus to integrate ES&H function into the business of business. Thus, ES&H professional need new skills to analyze the cost of their function and communicate the value of the products and services they provide. In recent years, the need for and the importance developing cost management and business skills by ES&H professionals have been emphasized in the literature. Communicating with decision makers in terms of cost and value to the organization, and by using business language and business arguments is the first step toward effectively integrating ES&H activities into the business of business. Activity-based costing (ABC) is a cost management method that measures the cost of a product or service based on the actual use of resources by activities, and based on the actual amount of activities used to produce a product or service. ABC is recommended as a tool for managers of ES&H organizations to determine the cost of developing and providing ES&H products within a for-profit firm or non-profit agency. This paper discusses the trend of integration of ES&H functions into the mainstream of business activities within an organization. The general principles of treditional cost accounting are presented as a bases for understandging why and how ABC will provide more accurate estimates of cost. The principles and concepts of ABS are presented as a tool for determining more accurately the true cost of ES&H products and services.

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