• Journal of Nutrition and Health
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• 제32권1호
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• pp.30-39
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• 1999

This study was designed to investigate the effect of Ca supplementation of 1,000mg per day for 53 weeks on lipid, Na, and K metabolism and on blood pressure in postmenopausal women. The subjects were 12 healthy women aged from 60 to 70 years. They were divided into two groups : the placebo(control group) and the Ca supplemented(1,000 mg/day) group(Ca group). Metabolic studies were conducted twice in the 1st and the 53rd weeks. The results were as follows : Serum triglyceride, total cholesterol and LDL-choesterol levels tended to be decreased after the experiment. Serum VLDL-cholesterol lowering effect was observed with Ca supplementation(p<0.05), and also the significantly elevated HDL/(LDL+VLDL) ratio in Ca supplemented subjects whose average Na intake was as high as 4.9g per day. This phenomena was accompanied with increased Na retention and increased Na excretion in feces, but with decreased urinary Na in Ca supplemented group. However, considering much higher Na reteniton in the control group at the end of experiment(control va Ca ; 1272.3mg vs 732.9mg), Ca supplementation may have some beneficial effects on Na blance. Serum aldosterone level increased significantly in the Ca group after the exsperiment(p<0.05). With these normotensive subjects, there were no level increased significantly in the Ca group after the experiment(p<0.05). With these normotensive subjects, there were no pronounced effect of Ca supplementation on blood pressure, however, decrease in diastolic blood pressure were observed at the 14th week and end of the experiment(p<0.05). In summary, the Ca supplementation on postmenopausal Koran women appears to exert a desirables effect on blood lipid patterns related to the coronary heart diseases and to be beneficial in controlling diastolic blood pressure. Further studies with hypertensive or/and hyperlipidemic subjects are required to clarify the effect of Ca supplementation in Koreans.

• 한국식품영양과학회지
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• 제32권5호
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• pp.710-714
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• 2003

본 연구는 식물성 지방급원이 당뇨모델의 지질대사에 미치는 영향을 검토하고자 수행하였다. 실험 모델은 STZ의 투여로 유발된 인슐린의존형 당뇨 마우스를 이용하였고, 4종류(라아드 10%에 각각 대두유, 쌀눈기름, 쌀겨 기름, 참기름 10% 첨가)의 실험식이를 7주간 급여하여 체내 지질 함량 및 대변으로의 배설량을 조사하였다. 그 결과 실험동물의 식이섭취량과 체중 및 장기 무게는 실험군 사이에 큰 차이가 없었으나, 혈청 중성지방은 쌀눈기름 및 쌀겨기름 첨가군에서 다른 실험군들보다 낮은 경향을 보였고, 간의 총콜레스테롤 함량은 쌀눈기름 첨가군에서 대조군보다 낮은 경향을 보였으며, 간의 총지질 함량도 쌀눈기름 첨가군에서 대조군보다 낮은 경향을 보였다. 그리고 대변으로의 총지질 및 총콜레스테롤 배설량은 쌀눈기름 첨가군과 쌀겨기름 첨가군에서 대조군인 대두유군보다 유의하게 많은 것으로 나타났다. 이상의 결과로부터 쌀눈기름과 쌀겨기름 급여군에서 체내 지질 함량이 낮았고 쌀눈기름군에서 쌀겨기름군보다 낮은 경향을 보였다. 그러므로 쌀눈기름은 인슐린의존형 당뇨마우스에서 체내 지질 함량 저하 효과가 있는 것으로 밝혀졌으며, 이는 쌀눈기름의 대변중 총지질 및 총콜레스테롤 배설량 증가와 관련된 것으로 평가되었다. 따라서 쌀눈기름은 대두유나 참기름보다 당뇨병 모델의 체내 지질대사에 개선 효과가 있는 것으로 보인다.

• Asian-Australasian Journal of Animal Sciences
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• 제16권11호
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• pp.1666-1672
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• 2003

The objective of this study was to evaluate the potential of an alumninosilicate clay, marketed under the trade name Biotite V, to improve growing-finishing pig performance and to determine its effects on nutrient digestibility and excretion. Sixty crossbred pigs (22.3${\pm}2.7kg$, Camborough 15 Line female${\times}$Canabred sire) were assigned on the basis of sex, weight and litter to one of four dietary treatments in a $2{\times}4$ (two sexes and four treatments) factorial design experiment. The experimental diets were based on barley and soybean meal and contained 0, 0.25, 0.5 or 0.75% biotite during the growing period (22.3-60.5 kg) and 0, 0.5, 1.0 or 1.5% biotite during the finishing period (60.5-110.3 kg). Each pig was allowed access to its own individual feeder for 30 min twice daily (07:00 and 15:00 h). Individual pig body weight, feed consumption and feed conversion were recorded weekly. The pigs were slaughtered at a commercial abattoir when they reached an average weight of 110.3 kg. Carcass weight was recorded and dressing percentage calculated. Carcass fat and lean measurements were obtained with a Destron PG 100 probe between the 3rd and 4th last ribs, 70 mm of the midline. Total tract digestibility coefficients for dry matter, energy, nitrogen and phosphorus were determined using three males and three females per treatment starting at an average weight of $52.2{\pm}3.8kg$. These pigs were housed under identical conditions as those used in the growing stage and were fed the same diets modified only by the addition of 0.5% chromic oxide as a digestibility marker. Over the entire experimental period (22.3-110.3 kg), daily gain was unaffected (p>0.05) by the inclusion of biotite in the diet. There was a cubic response for feed intake (p=0.06) and a quadratic response (p=0.07) for feed conversion due to biotite. Feeding biotite produced no significant (p>0.05) linear or quadratic effects on any of the carcass traits measured. Dry matter digestibility decreased linearly (p=0.02) with increasing levels of biotite in the diet. However, digestibility coefficients for energy, nitrogen and phosphorus were unaffected (p<0.05) by biotite inclusion. Lactobacilli and enterobacteria numbers were unaffected by inclusion of biotite while Salmonella was not detected in any of the fecal samples. The overall results of this experiment indicate that biotite inclusion did not reduce fecal excretion of nitrogen or phosphorus and failed to improve nutrient digestibility. Neither growth rate nor carcass quality was improved while a modest improvement in feed conversion was observed at lower levels of inclusion. Based on the results of this experiment, it would be difficult to justify the routine inclusion of biotite in diets fed to grower-finisher pigs. Whether or not a greater response would have been obtained with pigs of a lower health status is unknown.

• Journal of Nutrition and Health
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• 제38권5호
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• pp.380-385
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• 2005

This study was designed to investigate the effects of mulberry leaf powder supplementation on lead (Pb) status and mineral (Ca, Fe, Cu and Zn) content in Pb-administered rats for 4 weeks. Thirty two male rats were divided into 4 groups: a control, Pb, Pb5M (500 ppm $Pb + 5\%$ mulberry leaf powder), and Pb10M (500 ppm $Pb + 10\%$ mulberry leaf powder). There were no significant differences in food intake and initial body weight among groups. Mulberry leaf powder treatments showed significant decreases in food efficiency ratio and body weight gain. But FER of $Pb5M\%$ and Pb10M were significantly increases than that of Pb group. The levels of serum aspartate transaminase (AST) and creatinine were decreased by mulberry leaf powder treatment. Minerals content of liver and kidney were significantly decreased in the Pb groups than that of control group. Whereas, fecal minerals content were significantly increased in the Pb5M and Pb10M than those of control group. Pb content of serum, liver and kidney was significantly increased in the Pb group than those of control group. However, by mulberry leaf powder administration (Pb5M and Pb10M), Pb level of serum, liver and kidney were lowered than that of Pb group. And fecal Pb excretion was significantly increased in the Pb5M and Pb10M than that of Pb group. These results showed mulberry leaves were effective for lowing Pb accumulation in serum, organs, which may have potential to prevent Pb toxicity.

• Nutritional Sciences
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• 제7권3호
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• pp.151-157
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• 2004

The aim of this study was to investigate the effects of chicory fructan fiber supplementation on bone mineral density, apparent absorption of minerals and serum parameters related to bone turnover in postmenopausal women. Twenty-six healthy Korean postmenopausal women participated in the study. 1be participants were randomly divided into two groups in a double-blind parallel design and took one of the supplements for 3 months; either a placebo of 8g maltodextrins/sucrose mixture (control group) or 8g chicory fructan fiber (fructan group). During the 3-month experimental period no differences were found in bone mineral density (BMD) between the two groups. Apparent calcium absorption significantly increased by 42% in the fructan group, while that of the control group decreased by 29% as compared to the values at baseline. Urinary calcium excretion was not significantly different between the group;;. After 3 months, the level of serum alkaline phosphatase (ALP) was significantly lower in the fructan group than in the control group and deoxypyridinolin showed a trend toward a slight reduction. In conclusion, intake of chicory fructan fiber with a regular increases apparent calcium absorption in postmenopausal women.

• Journal of Nutrition and Health
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• 제5권1호
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• pp.33-42
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• 1972

This study was designed to investigate the nutritional value of fermented soybean bran as animal feed. Natural soybean bran has low protein quality and high cellulase contents. The soybean bran was supplemented by urea and ammoniumsulfate as N-source for incubation of Aspergillus niger. After incubation of soybean bran with Aspergillus niger, the nutritional quality of protein and riboflavin contents were increased in general and more in aging process than in fermentation. In order to elucidate the biological efficiency of prepared soybean bran, 120 male weanling rats were divided into 22 groups, five rats each, and were fed by standard casein diet mixed with soybean bran in the proportion of 1/10, 1/15, 1/20 respectively. The animals were kept under the experimental diet for nine weeks. In the result of this study, food efficiency ratio showed higher in the groups of urea and ammonium-sulfate-add group than row soybean bran group but the former group is lower than the later in the body weight gains. Protein efficiency ratio was also same trend. It was noteworthy that the nitrogen retention rate in total body on the basis of urinary nitrogen excretion and dietary intake nitrogen and in big organ such as liver and spleen were higher in fermented group than raw soybean bran fed group. It was worth while to treat the soybean bran in first place fermentation and further aging process to elevate the biological efficiency and effect of nutritional values specifically of protein and of riboflavin.

• 한국환경과학회지
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• 제14권5호
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• pp.499-511
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• 2005

This study was performed to determine the effects of genetic polymorphisms, such as glutathione S-transferase ${\mu}1(GSTM1)$, glutathione S-transferase ${\Theta}1\;(GSTM1)$, glutathione S-transferase ${\pi}l (GSTP1)$, aryl hydrocarbon N-acetyltransferase 2 (NAT2), cytochrome P450 2E1 (CYP2E1), cytochrome P450 1A1 (CYP1A1) on the concentrations of urinary 1-hydroxypyrene (1-OHP) and 2-naphthol in general population with no occupational exposure to polycyclic aromatic hydrocarbons (PAHs). Study subjects were 257 men who visited a health promotion center in Susan. A questionnaire was used to obtain detailed data about age, smoking, drinking, body fat mass, intake of fat etc. Urinary l-OHP and 2-naphthol concentration were analyzed by HPLC system with a fluorescence detector. A multiplex PCR method was used to identify the genotypes for GSTM1 and GSTT1. The polymorphisms of GSTP1, NAT2, CYP1A1 and CYP2E1 were determined by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Urinary 1-OHP concentration was higher in deleted genotype of GSTM1, increased as smoking and alcohol drinking increased. Urinary 2-naphthol concentration was also rely on the age and smoking. Neither genetic polymorphism nor drinking-related factors were significantly related to urinary 2-naphthol concentration. No significant relation was found between physical characteristics and concentrations of urinary PAHs metabolites in the subjects, but the geometric mean of urinary 1-OHP and 2-naphthol was higher in the group with higher value compared to median value. These data suggest that in general population occupationally not exposed to PAHs, urinary concentration of PAHs metabolites is influenced by smoking, alcohol drinking and deleted genotype of GSTM1 in 1-OHP and smoking in 2-naphthol.

• Asian-Australasian Journal of Animal Sciences
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• 제11권6호
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• pp.697-701
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• 1998

In order to improve silage quality and utilization of napier grass (Pennisetum purpureum Schum.) by goats, the grass was ensiled with molasses (MOL) and/or defatted rice bran (DRB). Napier grass was harvested at the growing stage in July and cut into 3 cm length. The grass was mixed with 4% MOL and/or 15% DRB, ensiled 15 kg each into plastic bags and stored for 9 months. Dry matter content of the silage ensiled with MOL (MOL-silage) was 13.4%, but increased to 20% with DRB addition. The addition of MOL decreased pH value and ammonia nitrogen content, but increased lactic acid content. MOL-silage contained about 6% spoilage, but addition of DRB decreased spoilage to less than 1%. Goats were fed the silage at a level of 2.25% (DM basis) of their body weight. Goats fed DRB- or MOL/DRB-silages maintained nitrogen retention, but goats fed MOL-silage did not. The rumen fluid of goats fed DRB-silage tended to be higher in acetic acid and lower in propionic acid than those fed the other silages. Ammonia in the rumen fluids, urea nitrogen in the blood and the urinary nitrogen excretion were the lowest in goats fed MOL/DRB-silage. As the result, the ratio of retained nitrogen to nitrogen intake was the highest in goats fed MOL/DRB-silage. In conclusion, addition of DRB to napier grass increased DM of silage and decreased the volume of spoilage. The combination of MOL and DRB can improve the fermentation quality and thus enhance the utilization of the silage by goats, more than the MOL or DRB being as a single treatment.

• Journal of Animal Science and Technology
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• 제59권5호
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• pp.10.1-10.11
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• 2017

Background: Transfer of pesticides from environment to animal products is inevitable, so the purpose of the present work was to evaluate phosalone consumption via feeding with or without sodium bentonite (SB) on performance, blood metabolites and its transition to milk of Iranian Baluchi sheep. Methods: Twenty Baluchi ewes were divided into four treatments (P1 as control, P2, P3, and P4) of five animals in which phosalone, an organophosphate pesticide, was given via diet (only for P2 and P3) at a dose of 280 mg/sheep/day for 63 consecutive days. The SB (32 g/sheep/day; for P3 and P4) was also evaluated for its ability to reduce deleterious effects of phosalone in the sheep diets. The control group (P1) did not receive any phosalone and SB during the experiment. Sampling was conducted in two periods of time including weeks 5 and 9. Results: Phosalone residues were observed in the milk samples of P2 and P3 groups during two sampling periods. During period 1, the transfer rate of phosalone from feed to milk was 0.23 and 0.02%, respectively for the contaminated diets (P2 and P3), which is relatively similar to period 2 (0.22 and 0.02%). Only 0.34 (period 1) and 0. 36% (period 2) of phosalone residue are excreted in the feces of P2 group following its daily consumption. Transfer of phosalone from feed to milk was affected (P < 0.05) by the dietary inclusion of a commercial SB, as it (SB) decreased excretion of phosalone via milk (P3). The phosalone and SB alone or together had no significant effect (P > 0.05) on the dry matter intake (DMI) and body weight (BW) gain, but feed efficiency, milk production, milk fat, dry matter (DM) and organic matter (OM) digestibility, acetylcholinesterase (AChE) inhibitory activity, hemoglobin (Hb), red blood cell (RBC), serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), albumin and mean corpuscular hemoglobin concentration (MCHC) affected by the treatments in period 1 or 2 (P < 0.05). The Hb, RBC, and MCHC were significantly decreased (P < 0.05) by about 9.72, 20.77, and 9.71%, respectively in the group P2 as compared to those of the control group during period 1. The AChE inhibitory activity (period 1 and 2) significantly increased when phosalone administered via the diet (P < 0.05). Conclusions: Although there were no adverse effects on the performance of sheep following the intake of phosalone alone (P2 vs. P1), but other research on the long and short times to the phosalone in high and low doses with more animals is suggested. Overall, compared to the control group, addition of SB in the diet of sheep improved nutrient digestibility, animal performance, and milk health.

• 한국식품과학회지
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• 제38권4호
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• pp.562-566
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• 2006

본 연구는 거대배아미 급여가 당뇨모델의 지질대사에 미치는 영향을 검토하고자 수행되었다. 실험모델은 스트렙토조토신으로 유발된 인슐린 의존형 당뇨 흰쥐를 이용하여, 실험식이를 6주간 급여한 후의 체내 지질함량 및 대변으로의 배설량을 각각 조사 하였다 거대배아미를 급여한 경우에는 당뇨가 유발되었음에도 불구하고 체중 증가의 현상이 나타났고, 장기 비대 현상은 억제 되고 있었다. 혈청 중성지방 몇 간의 총 콜레스테롤 함량도 현미 및 거대배아미 급여군에서 억제효과가 있었다. 그리고 대변으로 배설되는 총지질 및 콜레스테롤의 양도 거대배아미 급여군에서 대조군보다 유의하게 많은 것으로 나타났다. 이상의 결과들로부터 거대배아미 식이는 인슐린 의존형 당뇨쥐에서 대변중의 총 지질 및 총 콜레스테롤 배설량의 증가와 연관지어 당뇨병 모델의 체내 지질대사에 개선효과가 있음을 알 수 있다.