• Korean Journal of Pharmacognosy
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• v.42 no.3
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• pp.271-275
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• 2011

Sosihotang is a herbal medicine traditionally used to treat chronic liver disease. This study was performed to investigate the effect of steaming Sosihotang at a $121^{\circ}C$ on its major compounds and neuroprotective activity. We evaluated quantitative changes of 6 major compounds in Soshihotang, saikosaponin A, homogentisic acid, baicalin, ginsenoside $Rg_3$, glycyrrhizin and 6-gingerol using HPLC-DAD. After steaming produce, saikosaponin A, homogentisic acid, baicalin, glycyrrhizin and 6-gingerol in Sosihotang were decreased and ginsenoside $Rg_3$ was increased. The neuroprotective activity of steamed Sosihotang was determined by MTT assay, comparing to Sosihotang. The steamed sosihotang showed a higher neuroprotective activity than Sosihotang. In conclusion, steam produce could improve neuroprotective activity of Soshihotang.

• The Journal of Korean Medical History
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• v.27 no.2
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• pp.121-126
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• 2014

The purpose of this paper is to report a newly discovered book whose title is Ikkam (翼鑑) and prepare for a full-scale study. The book, Ikkam, has a variety of contexts in which it seems to be written by Park Ji-won. First, 'Sanin' in 'Yeonam-Sanin' is consistent with the behaviors of Yeonam Park Ji-won who lived in hiding in the Yeonam valley in 1777. In addition, many statements written in the introduction, such as "as we stick to the old things, we do not know a makeshift", "we are well versed in changes" and "many soldiers are not always good" remind us of other writings of Park Ji-won. Moreover, he writes the statements using antithesis. It is the force of writing style of a literary person who is not engaged in medical service. In addition, he puts six qi in the introduction, but it is not as sophisticated as Jejungsinpyeon (濟衆新編). It suggests that this book may be published earlier than Jejungsinpyeon. When comparing Ikkam with Euimunbogam (醫門寶鑑) and Jejungsinpyeon, it seems common to place six qi in the introduction at the time. In addition, through this book, we find that Park Ji-won known as a writer of Geumryosocho (金蓼小抄) has fairly much knowledge in the medicine. We can estimate his passion and depth about the medicine through a longing for a new medical book shown in the introduction of Geumryosocho. However, various approaches to similar disease symptoms shown in the introduction help us to recognize his true qualities in the medicine. In addition, like other experience prescriptions, this book excludes prescriptions using medicinal herbs with toxicity or rare medicinal herbs in the situation with a limited supply of them in remote areas but includes prescriptions which are widely used. It shows that experience prescriptions in the Joseon Dynasty are effective to specifically identify medicinal herbs and prescriptions which are widely used in Korea. These values cannot be compensated by Donguibogam (東醫寶鑑) which has an infinite value.

• Journal of Biomedical Engineering Research
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• v.28 no.5
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• pp.703-712
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• 2007

In this paper, we designed the RFID(Radio Frequency Identification) Emergency Medical Information System(REMIS). This REMIS offers the emergency patient's medical information using RFID and HL7(Health Level 7) to an emergency medical technician. In emergency situation as like coma, if the communication, from the patient's current location to the hospital, is possible, REMIS offer the medical information of the patient through REMIS server to an emergency medical technician. In the state of communication blocked, REMIS can offer the patient identification and the emergency information through RFID tag, which the patient wear, to an emergency medical technician. When this system was designed, the protection of the patient's medical information and their privacy was considered, and the HL7 was used to be compatible with another medical systems. Therefore, in this paper, REMIS was designed that it is always possible to offer the emergency patient's information to an emergency medical technician regardless of any communication status and to improve the emergency rescue process, effectively.

• Journal of Korean Medical classics
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• v.20 no.3
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• pp.57-65
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• 2007

This present study tried to observe an each feature that the difference of Neijing(內經) and Nanjing(難經) descriptions about the three-portion and nine-position pulse taking(三部九候脈). It was interpreted and contradistinguished that discrimination of position, diagnosis object, and the perceptions of Earth of the center among the Five Phase of each literature were described in Neijing and Nanjing for the three-portion and nine-position(三部九候). In Neijing, the three-portion and nine-position method divided three parts the whole body. Then the each three parts again divided with Heaven, Earth and Man(天地人). About the corresponding parts of pulse diagnosis, there mentioned for the head and the Zang-Fu organs(臟腑), but not mentioned for the hand and foot. In addition, Earth is assigned to the Earth(土), an each Earth accounted for the source of life. In Nanjing, three-portion divided Chon, Gwan, and Cheok(寸關尺) and each spots separated three stage of pulse taking. For the pulse taking spots and diagnosis, there mentioned the hand and foot instead of the unclear mention of Zang-Fu organs. Then Gwan spot and middle stage of pulse taking were assigned to the Earth, respectively. It was emphasized stomach Qi(胃氣) that the region of Earth, Gwan spot and middle stage among the pulse taking spots each literature were described in Neijing, Nanjing.

• The Journal of Internal Korean Medicine
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• v.38 no.6
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• pp.971-979
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• 2017

Objectives: The aim of this study was to analyze the effects of Cheongsimyeonja-tang on the human body. Methods: This was a retrospective study, conducted using electronic medical records (EMR). Appropriate clinical cases were identified and databased through EMR. Changes of vital signs, blood tests, and functional tests before and after taking Cheongsimyeonja-tang were determined. Results: There were several significant changes after taking Cheongsimyeonja-tang. Hemoglobin, total blood proteins, and total bilirubin were increased. Eosinophil, aspartate aminotransferase, total cholesterol, and low-density lipoprotein cholesterol were decreased. Conclusions: Cheonseomyeonja-tang had significant effects, including improvement of blood cell count (increase of red blood cells and hemoglobin), improvement of blood lipid level (decrease of total cholesterol and LDL-cholesterol), and blood pressure control (reduction of systolic blood pressure).

• Korean Journal of Clinical Pharmacy
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• v.15 no.2
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• pp.118-126
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• 2005

In our study, osteoporosis was induced by ovariectomized in female Sprague-Daweley (SD) rats, and the prevention and treatment efficacy of the climacteric disease the ostmenopausal type I pattern was examined by using the experimental substance soybeans and arowroot. No clinical signs and mortality after continuous oral administration of experimental substances for 14 weeks were not observed, however, the weight of experimental animals underwent ovariectomized was increased significantly in comparison with control group (p<0.01). The atrophy of the uterus due to T3 group was 23.64% after 7 weeks, 24.44% after 14 weeks (in comparison with N.C. group), and it was statistically significantly increased. In regard to the change of blood cells, it was observed that platelets were statistically significantly reduced in the ovariectomized group, and administered orally experimental substances continuously for 7 weeks, in all groups administered experimental substances, it was found that platelets had the tendency to be increased more than N. C. group. In regard to He change of blood biochemistry, removed the ovary, the concentration of ALP showed the tendency to be increased than control group, and particularly in T3 group, it was increased significantly. In regard to the concentration of cholesterol, in comparison with negative control group, it was reduced 68% at 7 weeks and 35% at 14 weeks. After ovariectomized, the amount of estrogen was found to be reduced by 21.37% in comparison with control group, it showed the tendency to be increased by 4.49% in T1 group and 7.62% in T2 group, the concentration of estrogen in each group showed the tendency to be increased than negative control group, and in T3 group, it was increased to 100.46% and 117.65% in T4 group, and it was increased more than control group. Based on the above experimental results, in the experimental animals female rats, because of the hormonal imbalance induced by ovariectomized, a large mount of fat is accumulated in the body and due to it osteoporosis, obesity, hypertension, hyperlipidemia, fat of the liver, arteriosclerosis, diabetes, and other metabolic diseases were developed. Hence, when the experimental substance Extraction of ferment arrowroot was orally administered continuously for 14 weeks, it was thought that a certain proportion of the hormonal balance was maintained that functioned as a substance interfering the accumulation of fat, and it was considered to be of help in the treatment of not only osteoporosis Type I, but also for the prevention and treatment of various endocrinal diseases.

• The Journal of Korean Medical History
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• v.33 no.2
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• pp.105-127
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• 2020

The three major medical compilations of the Joseon Dynasty, Hyangyak-jipseongbang, Uibang-yuchwi, and Dongui-bogam, directly cited a total of 376 kinds of medical books. Among them, 11 medical books were commonly referred: Gyeongheom-yangbang, Deukyobang, Saminbang, Seonmyeongnon, Seongje-chongnok, Seonghyebang, Eoui-chwaryo, Yeongnyu-geombang, Wisaeng-bogam, Cheongeumbang, and Tangaek-boncho. Most of them were medical classics and formularies representing the period from the Song to the early Ming Dynasties, which most likely influenced the establishment of Joseon's medical tradition throughout the Joseon Dynasty. The reason why the majority of the medical reference books was formularies seems to be that prescription practices and the use of medicinals value knowledge with accumulated experience over a long period, whereas medical ideas and doctrines change with time. Besides, except for Eoui-chwaryo compiled in the Goryeo Dynasty, the three significant compilations referred to Chinese medical books, which indicates that the compilers made efforts to accommodate the newly introduced foreign knowledge. At the same time, the former compilations, Hyangyak-jipseongbang and Uibang-yuchwi, later appeared as primary references in Dongui-bogam's Medical Formularies of Successive Generations. However, in order to avoid overlapping the same contents, the compilers tried to form a differentiated version by extracting only the unique contents.

• The Journal of Korean Medicine
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• v.17 no.1 s.31
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• pp.132-145
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• 1996

Ethyl ether fractions of Ferula Resina(EFR) and Lithospermi Radix(ELR) and hexane fraction of Salviae miltiorrhizae Radix(HSR) exerted an inhibitory effect on cell adhesion of A549 to extracelluar matrix most effectively in vitro cell adhesion assay. Thus, with above fractions for the evaluation of antitumor activity, T／C% was monitored in ICR bearing S-180 and for antimetastatic effect, pulmonary colonization assay, weight of organs, changes of WBC and platelet were studied. In pulmonary colonization assay incidence rate to control was 73 % 42 %, 14 % in ELR, HSR and EFR-treated groups repsectively. Gain of lung weight was significantly inhibited in all groups while spleen weight was significantly reduced only in SMR group, but no changes in kidney and liver as compared with control. Number of platelet was significantly increased in all groups to normal range as compared with thrombocytopenic contol. WBC was significantly reduced only in LR group. These results suggest that ethyl ether fraction of Ferula Resina has more effective antimetastatic activity.

• Journal of Korean Medical classics
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• v.36 no.2
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• pp.77-96
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• 2023

Objectives : The purpose and application method of the five kinds of Gagamjeong-gisan in the Onbyeongjobyeon were analyzed and their significance was examined. Methods : First, contents within medical texts on the Gwakhyangjeong-gisan, the original formula for the Gagamjeong-gisan were analyzed. Next, application, symptoms and pathogenic mechanism, treatment principle, composition of the Gagamjeong-gisan as written in the Onbyeongjobyeon were analyzed. Characteristics of each formula as deduced from this process were compared and examined. Results : The Gwakhyangjeong-gisan covers both external contraction and internal damage, applied regardless of external or internal symptoms. It restores the Yang qi of the Spleen and Stomach, balancing the Zheng qi to respond to the external qi. The Gagamjeong-gisan takes after the Gwakhyangjeong-gisan, reflecting such properties. However, the latter differs in that it excludes ingredients unfit for treating dampness-warmth, and uses different application methods according to the level of discharge of dampness pathogen. Conclusions : The Gagamjeong-gisan is modified from the Gwakhyangjeong-gisan, which is applied to cold damage and internal damage to better treat warm disease. It can be said to have acted as a bridge for warm disease scholars in composing formulas that deal with dampness-heat disease.

• Journal of Plant Biotechnology
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• v.45 no.3
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• pp.250-256
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• 2018

To determine whether metabolite fingerprinting for whole cell extracts based on Fourier transform infrared spectroscopy (FT-IR) can be used to discriminate and compare metabolic equivalence, standard medicinal parts of Cynanchum wilfordii (Maxim.) Hemsl. and their adventitious roots were subjected to FT-IR. The principal component analysis (PCA) and partial least square discriminant analysis (PLS-DA) from FT-IR spectral data showed that whole metabolic pattern from the adventitious root of Cynanchum wilfordii was highly similar to its standard medicinal parts. These results clearly showed that mass proliferation of adventitious roots could be applied for the novel supply of standard medicinal parts of medicinal plants. Furthermore, FT-IR spectroscopy combined with multivariate analysis established in this study could be applied as an alternative tool for discriminating of whole metabolic equivalence from standard medicinal parts. Thus, it is proposed that these metabolic discrimination systems from the adventitious root of Cynanchum wilfordii could be applied for metabolic standardization of in vitro grown Cynanchum wilfordii.