• Journal of Pharmacopuncture
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• v.10 no.2 s.23
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• pp.87-91
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• 2007

Objectives : This experimental study was performed to investigate the continuous anti-bacterial potency of Jinpi-san on cultivation of Staphylococcus species(S. aureus, S. epidermidis) that induce eye disease. Methods : Minimal inhibitory concentration(MIC) was measured by dropping to 50${\mu}$l diluted Jinpi-san(100%, 10%, 1%, 0.1%) on S. aureus, S. epidermidis that were cultivated from 2 to 6 days. Anti-bacterial potency was measured by the size of inhibition zone with change of volume(20${\mu}$l, 30${\mu}$l, 40${\mu}$l, 50${\mu}$l). Results : 1. Anti-bacterial potency of Jinpi-san on S. aureus was appeared in 100% and increased on 6 days. Anti-bacterial potency with change of volume was increased in propotion to increase volume. Anti-bacterial potency of Jinpi-san on S. aureus was appeared continuous. 2. Anti-bacterial potency of Jinpi-san on S. epidermidis was appeared in 100%, 10%, 1% on 2 days and in 100%, 10% on 6 days. In 100% Jinpi-san, Anti-bacterial potency of 6 days was increased, in 10%, Anti-bacterial potency of 2 days was increased, in 1%, Anti-bacterial potency of 6 days was disappear. Anti-bacterial potency with change of volume was increased in propotion to increase volume except for 20${\mu}$l of 6days and increased on 6 days, but bacteria was increased. Anti-bacterial potency of Jinpi-san on S. epidermidis wasn't appeared continuous. Conclusions : Anti-bacterial potency of Jinpi-san on cultivation of S. aureus was showed continuous, but on cultivation of S. epidermidis was not showed continuous.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.1 s.32
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• pp.195-200
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• 2007

Objective : This experimental study was performed to investigate the effect of Jinpi-san on Staphylococcus aureus(S. aureus) and Staphylococcus epidermidis(S. epidermidis) that induce keratitis. Methods : Minimal inhibitory concentration(MIC) was measured by dropping to $50{\mu}l$ according to density Jinpi-san(100%, 10%, 1%, 0.1 %). Anti-bacterial potency was measured by the size of inhibition zone with change of volume. Results : 1. MIC on S. aureus in Jinpi-san was $40{\mu}l$ undiluted solution. 2. MIC on S. epidermidis in Jinpi-san was $20{\mu}l$ undiluted solution. Conclusions : These results indicate that Jinpi-san can be used to cure S. aureus, S. epidermidis that induce eye disease(keratitis). If further study is performed, the use of eye drops will be valuable and beneficial in the clinical medicines.

• Korean Journal of Environmental Agriculture
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• v.29 no.1
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• pp.66-71
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• 2010

Jinpi(Aurantii nobilis Pericarpium) is one of the most important material of oriental herbal medicine which is made from the peel of mandarin by washing with hot water and drying. Pesticides have necessarily used for mandarin cultivation according to their preharvest intervals (PHIs) but their maximum residue limits (MRLs) and PHIs for Jinpi are not established yet. This study is to know residue amount of organophosphorus insecticides in Jinpi and to establish the MRLs and PHIs for fenitrothion and phenthoate in Jinpi. Fenitrothion was sprayed once, twice and three times with 7 days interval before harvest. Its residue amount ranged from 0.14 to 1.17 mg/kg in mandarin, 0.59 to 4.02 mg/kg in its peel and 1.66 to 22.38 mg/kg in Jinpi. In case of phenthoate, it was sprayed with 10 days interval for 10 days before harvest. Its residue amounts in mandarin, its peel, and Jinpi ranged from 0.16 to 0.65, 0.69 to 2.41 and 1.69 to 11.3 mg/kg, repectively. Proposed MRLs of fenitrothion and phenthoate for Jinpi are suggested to 22.39 and 11.30 mg/kg, respectively. So we recommend PHIs of the pesticides that fenitrothion can be sprayed 3 times 7 days before harvest and in case of phenthoate, sprayed 3 times 10 days before harvest.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.1
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• pp.123-134
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• 2006

Objective : This experimental study was performed to investigate the effect of Herbe-medicine used for eye disease(Sean-tang, Jinpi-san, Tangpo-san, Copitdis Rhizoma) on Staphylococcus epidermidis keratitis. Methods : After administering various herbal eye drops on Staphylococcus epidermidis, I measured MIC and the size of inhibition zone. MIC was measured by dropping from 20 to $50{\mu}{\ell}$ according to density. Anti-bacterial potency was measured by the size of inhibition zone with change of volume under 2 days culture condition. Also continuous anti-bacterial potency of herbal eye drops was measured by the size of inhibition zone according to 2 days and 6 days culture each under the $50{\mu}{\ell}$ condition. Results : 1. MIC on Staphylococcus epidermidis in Sean-tang, Jinpi-san was 1%, $50{\mu}{\ell}$ 2. MIC on Staphylococcus epidermidis in Tangpo-san, Coptidis rhizoma was 10%, $50{\mu}{\ell}$ 3. MIC on Staphylococcus epidermidis in Cravit was 0.1%, $20{\mu}{\ell}$. 4. Under the 2 days culture condition, the size of inhibition zone on Staphylococcus epidermidis by volume for Sean-tang was 10.0mm in $50{\mu}{\ell}$, Jinpi-san was 16.0mm in $50{\mu}{\ell}$, Tangpo-san was 17.5mm in $50{\mu}{\ell}$, Coptidis rhizoma was 31.0mm in $50{\mu}{\ell}$ and Cravit was 34mm in $50{\mu}{\ell}$, showed the highest anti-bacterial potency. 5. Under the $50{\mu}{\ell}$ condition, the size of inhibition zone on Staphylococcus epidermidis by 2 and 6 culture days for Sean-tang was 47.5mm in 6days, Jinpi-san was 36.0mm in 6days, Tangpo-san was 45.0mm in 6 days and Cravit was 48.0mm in 6 days, which showed the highest anti-bacterial potency. 6. Under the $50{\mu}{\ell}$ culture condition, the size of inhibition zone on Staphylococcus epidermidis by 2 and 6 culture days for Coptidis rhizoma was 31.0mm in 2 days and 6 days, which showed the same anti-bacteria1 potency. Conclusions : The present author think that Herbe-medicine used for eye disease can be used to cure Staphylococcus epidermidis keratitis and if further study is performed, the use of the Herbe-medicine used for eye disease will be valuable and beneficial in the clinical medicines.

• Journal of Pharmacopuncture
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• v.11 no.1
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• pp.99-107
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• 2008

Objectives : This experimental study was performed to investigate the effect of herbal eye drops(Sean-tang, Jinpi-san, Tangpo-san, Copitdis Rhizoma) on Staphylococcus aureus keratitis. Methods : After administering various herbal eye drops on Staphylococcus aureus, I measured MIC and the size of inhibition zone. MIC was measured by dropping from 20 to $50{\mu}{\ell}$ according to density. Anti-bacterial potency was measured by the size of inhibition zone with change of volume under 2 days culture condition. Also continuous antibacterial potency of herbal eye drops was measured by the size of inhibition zone according to 2 days and 6 days culture each under the $50{\mu}{\ell}$condition. Results : 1. MIC on Staphylococcus aureus in Sean-tang, Jinpi-san and Tangpo-san was 100%, $20{\mu}{\ell}$. 2. MIC on Staphylococcus aureus in Coptidis rhizoma was 10%, $30{\mu}{\ell}$. 3. MIC on Staphylococcus aureus in Cravit was 0.1%, $50{\mu}{\ell}$. 4. Under the 2 days culture condition, the size of inhibition zone on Staphylococcus aureus by volume for Sean-tang was 12.0mm in $50{\mu}{\ell}$, Jinpi-san was 19.0mm in $50{\mu}{\ell}$, Tangpo-san was 15.0mm in $50{\mu}{\ell}$, Coptidis rhizoma was 32.7 mm in $50{\mu}{\ell}$ and Cravit was 31mm in $50{\mu}{\ell}$, Coptidis rhizoma showed the highest anti-bacterial potency. 5. Under the $50{\mu}{\ell}$ condition, the size of inhibition zone on Staphylococcus aureus by 2 and 6 culture days for Sean-tang was 12.0mm, Jinpi-san was 19.0mm, Tangpo-san was 15.0mm, Coptidis rhizoma was 32.7mm and Cravit was 31.0 mm, which showed sameness anti-bacterial potency in 2 days and 6 days. Conclusions : The present author think that the herbal eye drops can be used to cure Staphylococcus aureus keratitis and if further study is performed, the use of the herbal eye drops will be valuable and beneficial in the clinical medicines.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.5
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• pp.773-776
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• 2011

This study was focused on a certain clinical symptom, which could applicated by Pyeongwi-san, and the radical treatment. Pyeongwi-san is applicable to dampness retention in the spleen and stomach, accompanied by abdominal fullness, anorexia, nausea and regurgitation. Main action of Pyeongwi-san is to dry dampness, invigorate the spleen, promote the flow of gi, and regulate the stomach. The herbal remedy drying dampness like Pyeongwi-san however, is just indicatio symptomatica therefore radical treatment must be used together. Jeunginmaegchi, a medical book written by Gyeong-Myeong Jin, who was lived in Myeong dynasty. This book contains many clinical applicable symptoms and constituents derived from Pyeongwi-san. The herbal prescriptions composing Pyeongwi-san is composed of Changchul, Hubak, Jinpi, Gamcho. The major action of these herbs is drying dampness. Therefore, it shoud be seriously consider that curative therapy must eliminate the cause of endogenous dampness.

• Journal of Haehwa Medicine
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• v.13 no.1
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• pp.269-277
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• 2004

1. The frequency of source of prescriptions is Dongweonshibse(東垣十書), Hagansanghansamyukse(河間傷寒三六書), Senmyoungronbang(宣明論方), Gogumuigam(古今醫鑑), Dangyesimbob(丹溪心法), Uihakgangmok(醫學綱目), Taepyonghyeininhwajekukbang(太平惠民和劑局方) in sequence. 2. The classification of prescriptions by efficacy is Haepyoy(解表藥), Igiyak(理氣藥), Boikyak(補益藥), Sahayak(瀉下藥), Chongyo1yak(淸熱藥等), etc., in sequence. 3. The frequency of used medicine is Gangwhal(羌活), Insam(人蔘), Hwangbaek(黃柏), Gamsu(甘遂), Jadakek(紫大戟), Daehwang(大黃), Seungma(升麻), Shiho(紫胡), Bangpung(防風), Jinpi(陳皮), Oyak(烏藥), Chongung(川芎), Changchul(蒼朮), Gobon(藁本), etc., in sequence. 4. The Song(性) of used medicine is mainly Onsong(溫性) and Hansong(寒性), the mi(味) is Sinmi(辛味), Gomi(苦味), Gammi(甘味), Hammi(鹹味) in sequence, the Gwigyong(歸經) is Bigyong (脾經), Wigyong(胃經), Gangyong(肝經), Paegyong(肺經), etc., in seguence.

• Korean Journal of Pharmacognosy
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• v.40 no.4
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• pp.370-375
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• 2009

Overproduction of peroxynitrite ($ONOO^-$) causes a variety of disease such as atherosclerosis, hypercholesterolemia, diabetes mellitus or obesity. Peroxynitrite scavenging activities and HPLC analysis on the five Oriental medicinal drugs belonging to the genus Citrus, Aurantium or Poncirus (Rutaceae family) and HPLC analysis were taken to evaluate flavanone glycosides with peroxynitrite scavenging activity. The $IC_{50}s$ of the five crude drugs were shown as follows: Aurantii nobilis Pericarpium (Jinpi, 18.3 ${\mu}g$/ml), Citrii unshiu Pericarpium (Chungpi, 7.50${\mu}g$/ml), Citrii unshiu Semen (Gyulhaek, >50.0${\mu}g$/ml), Aurantii Fructus (Jigak, 18.3${\mu}g$/ml), and Poncirii Fructus (Jisil, >50.0${\mu}g$/ml) where Korean crude drug's names are noted in the parenthesis. Peroxynitrite scavenging effect of flavanones or their glycosides usually contained in Citrus species were observed as follows: hesperetin (1.89 ${\mu}g$/ml), naringenin (7.77 ${\mu}g$/ml), hesperidin (8.44 ${\mu}g$/ml), poncirin (>50.0 ${\mu}g$/ml)and ponciretin(>50.0 ${\mu}g$/ml). The activities of naringin and poncirin with ${\alpha}$-L-rhamnopyranosyl($1{\rightarrow}2$)-${\beta}$-D-glucopyranosyl moiety were weak. HPLC analytical data revealed that Jinpi (the peels of mature fruits of Citrus unshiu) and Chungpi (the peels of immature fruits of C. unshiu) had high quantities of hesperidin as the value of 142.1${\pm}$0.21 and 104.51${\pm}$1.10 mg/g dried weight, respectively. Poncirin was clearly detected in only Jisil and naringenin and naringin were not observed on the HPLC chromatogram of the five crude drugs.

• Journal of Korean Medicine for Obesity Research
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• v.10 no.2
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• pp.41-49
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• 2010

Objectives This study is to suggest the herbal bathing and the manual therapy with herbs for obesity patients according to the Sasang constitutional medicine. Methods In this study, first, we found the books, web sites and papers about bathing. And also we classified the herbs those are used each therapy according to the Sasang constitutional medicine theory. Results and Conclusions: We make good used of salts, sulfur or herbal agents inserted into a bath, when we are bathing. And we knew that "The Pinda manual therapy" is a therapy with medical herbs in the West. The Pinda manual therapy is a fomentation therapy with wrapped in cloth and steamed medical herbs. According to Sasang constitutional right to bath in each prescription were as follows. Taeeumin: Taeeumin Galgeunhaegi-tang. / Soyangin: Soyangin Hyeongbangpaedok-san. / Soeumin: Gunggwihyangso-san, Soeumin Kwakhyangjeonggi-san. / Taeyangin: Ogapijangchuk-tang. And also, by Sasang constitution, applicable herbs to the Pinda therapy were as follows. Taeeumin: Seokchangpo, Wonji, Gobon, Gamguk, Sokdan, Wiryeongseon.. / Soyangin: Hyeonggae, Bangpung, Bakha, Ganghwal, Dokhwal. / Soeumin: Kwakhyang, Soyeop, Danggwi, Cheongung, Sesin, Jinpi. / Taeyangin: Ogapi, Mokgwa, Nogeun, Gyomaek. It will be need to more study for effective clinical applications.

• Journal of Sasang Constitutional Medicine
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• v.14 no.1
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• pp.10-25
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• 2002

1. Purpose This Study is intended to catch the expasion of theory of Sasang Constitutional Medicine through comparision DongyiSooseBowon Chopanbon with DongyiSooseBowon Chobonguen and DongyiSooseBowon Gabobon. 2. Method I compared the Soeumin's prescriptions and medications of DongyiSooseBowon Chopanbon with those of DongyiSooseBowon Chobonguen and DongyiSooseBowon Gabobon. 3. Result and conclusion 1. The Soeumin's meducations used in the prescriptions of chobonguen are 44 and those of Gabobon are 47, those of chopanbon are 46 2. Soeumin;s Medications of the same kind in Chobonguen's precriptions and Gabobon's and Chopanbon's are twenty-five;like Daejo(大棗), Jinpi(陳皮), Gamcho(甘草), etc. and these medications are the princople in soeumin's disease. 3. Soeumin's Prescriptions of the same name in Chobonguen's prescriptions and Gabobon's and Chopanbon's are two;Gwakhanggeunggisan(藿香精氣散) and Bogungikgitang(補中益氣湯). These two prescriptions are correspond to the prescriptions those were recorded in Song-won-myuong Soeumin's princple prescription of experience(宋元明 少陰人經驗行用要藥). 4. Soeumin's Prescriptions of the same name in Chobonguen's precriptions and Gabobon's are two;Gwakhanggeunggisan(藿香精氣散) and Bogungikgitang(補中益氣湯). Chobonguen's precriptions were composed of Old prescriptions(古方) except the medications those were considered of wrong Sang Constitutional medications. 5. Soeumin's Prescriptions of the same name in Gabobon's prescriptions and Chopanbon's are nine and except Padudan(巴豆丹) have differences in the kind of medications and quantites. This fact shows that Dongmu(東武) roform the Sasnag Constitutional prescriptions continuously. 6. As this, Dongmu(東武) selected Sasang Constitutional prescription and medication in detail as he has the more experince of treatment.