• Title/Summary/Keyword: Jin

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Susceptibility of various Helicobacter pyloris to New Antiulcer Agents

  • Tae W. Woo;Han Y. Yoo;Man S. Chang;Young K. Chung;Kim, Kyu B.;Sang K. Son;Kim, Sung K.;Dae P. Kang;Park, Whan S.
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1996.04a
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    • pp.197-197
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    • 1996

  • Helicobacter pylori (H. pylori) is a microaerophilic spiral bacterium and infection by it in the human stomach causes gastritis, furthermore, it is considered to be involved in the pathogenesis of peptic ulcers and the development of gastric carcinoma. We assessed the inhibitory activity of new antiulcer drugs against Helicobacter pylori. The activities of new antiulcer agents against Helicobacter pylori strains were determined by the standard agar dilution method with blood agar base #2, supplemented with 5% sheep blood and 4 antibiotics to support growth of these organisms. They were inoculated by multipoint inoculator and incubated at 37$^{\circ}C$ for 3 days under microaerophilic atmosphere. The MIC of antiulcer agents was the lowest concentration that inhibited visible growth of these organisms. According to results of various biochemical tests, these bacteria were identified as Helicobacter pylori strains. And the MIC results showed that the strains were very susceptible to omeprazole and YJA20379s. Some of YJA20379s were more potent than omeprazole. These results suggest that our new antiulcer drugs have potent inhibitory activity against Helicobacter pylori, so that our new antiulcer drugs might be useful for the clinical eradication of gastrointestinal Helicobacter pylori.

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Pharmacognostical Study on the Korean Folk Medicine 'Jin Hae Cho Ip' (한국 민간약 "진해초잎"의 생약학적 연구)

  • Lee, Joon-Do;Lee, Yu-Jin;O, Jong-Yung;Park, Jong-Hee
    • Korean Journal of Pharmacognosy
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    • v.35 no.3 s.138
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    • pp.215-228
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    • 2004

  • The Korean folk medicine 'Jin Hae Cho Ip' has been used as a remedy for neuralgia and as an invigorating drug after a childbirth, etc in Korea. With regard to the botanical origin of 'Jin Hae Cho Ip', several species of Potentilla (Rosaceae) has been refired, but no pharmacognostical study has yet been performed in this regard. To clarify the botanical origin of the 'Jin Hae Cho Ip', the morphological and anatomical characteristics of the leaflets and petioles of Potentilla and Sibbaldia species growing in Korea, such as P. chinensis, P. cryptotaeniae, P. dickinsii, P. discolor, P. fragarioides var. major, P. freyniana, P. kleiniana, P. matsumurae, P. paradoxa, and S. procumbens, were compared. As a result, it was found that 'Jin Hae Cho Ip' was composed of the leaves of P. Chinensis and P. discolor.

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Inhibitory mechanism of a newly synthesised proton pump inhibitor, YJA20379-8

  • Sang K. Sohn;Man S. Chang;Young K. Chung;Kim, Kyu B.;Tae W. Woo;Kim, Sung K.;Park, Wahn S.
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1997.04a
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    • pp.100-100
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    • 1997

  • To treat peptic ulcer diseases, many potent proton pump inhibitors have been developed for suppressing the gastric acid secretion in clinical patients. However, most of these agents have common irreversible mechanisms against H$\^$+/, K$\^$+/-ATPase which might be the cause of hypergastrinemia and ECL cell hyperplasia. Therefore, the development of new reversible inhibitors is prompted. In this study, we investigated the inhibitory mechanism of a newly synthesized proton pump inhibitor, YJA20379-8 using lyophilized hog gastric microsomes. YJA20379-8 inhibited K$\^$+/-stimulated H$\^$+/K$\^$+/-ATPase activity uncompetitively with respect to K$\^$+/, and in the other hand, showed competitive inhibitory pattern with ATP, respectively. From these data, we suggest that YJA20379-8 may be a proton pump inhibitor with a new inhibitory mechanism.

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Wayu during the late Chosun Period and Gyeongsan Lee Han Jin's (조선 후기의 산수(山水) 와유(臥遊)와 경산(京山) 이한진(李漢鎭)의 <속어부사(續漁父詞)>)

  • Jo, Eun-byeol
    • (The)Study of the Eastern Classic
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    • no.70
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    • pp.185-210
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    • 2018

  • This thesis investigates wrote by Lee Han Jin who edited "Chung Ku Young Un(靑丘永言)" with supposition that was affected by Lee Han Jin's literary activity and poetic direction, and Wayu(臥遊) was enjoyed by Sajok(士族) in the late Chosun Period. Lee Han Jin kept company with The Yeonam Faction and their friendship was based on Lee Han Jin's blood-relationship. Lee Han Jin's musical sense and poetic direction are verified by records about their poetic activity. In his old age, Lee Han Jin retired in the Yeongpyeong of Gyeonggido and edited "Chung Ku Young Un", Lee Han Jin's poetic direction is also verified by Sijo's theme which was included in "Chung Ku Young Un" and Lee Han Jin's Sijo. Meanwhile, Kyunghwasajok(京華士族) in the late Chosun Period wanted to overcome their situation that they could not leave city by imagination about landscape. That activity was Wayu. They didn't consider whether they see landscape, and they made good use of many genre of literature for effective Wayu. Lee Han Jin and his group's literary activity was formed by that cultural air. Lee Han Jin wrote though his retirement in mountain. It was also for effective imagination about landscape that he didn't see. So unworldly landscape was appeared in compared to other fishermen motif poems. The tension between Situation that he couldn't see real landscape and desire for effective Wayu get solved by form named that have distinct characteristic as a Jipgusi(集句詩).

  • https://doi.org/10.16880/SEC.2017.70.07.185 인용