• 대한한방내과학회지
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• 제34권2호
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• pp.147-154
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• 2013

Objectives : The aims of this study was to find out whether Jichul-hwan (JCH) extract has an effect on gastric contractility in conscious rats by using a force transducer implanted in the body of the stomach. Methods : The force transducer (model: F-081S, Starmedical, JAPAN) was implanted to the exterior wall of the stomach body in rats. The gastric contractility was measured 30 minutes before and after administration of JCH (110.1 mg/kg). The control group was administrated with normal saline instead of JCH to compare the effect of JCH. The gastric contractility of the control group (normal saline: NS) was also measured 30 minutes before and after administration of NS. Results : The ratio of gastric contractility between before and after medication by JCH was $1.707{\pm}0.731$, and with NS was $0.701{\pm}0.541$. The gastric motility increased by JCH was significantly higher than NS. Conclusions : JCH extract increases gastric contractility in conscious rats. We could expect that this drug would be effective in the treatment of functional dyspepsia or post-surgical gastroparesis.

• 대한한방내과학회지
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• 제29권1호
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• pp.189-199
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• 2008

Background & Objective : Jichul-hwan(JCH) has been used for the treatment of functional dyspepsia, regarded as a gastric dysmotility disease. We investigated the effects of JCH on gastric motility and its mechanisms of action in rats. Methods : The gastric wall was injured by tracting a part of stomach body in rats. Gastric emptying was measured after administration of normal saline(NS) or JCH in normal rats and gastric wall injured rats. To evaluate the mechanism of JCH under delayed gastric emptying conditions, normal rats were treated with atropine sulfate(1mg/kg, s.c.), quinpirole HCl(0.3mg/kgg, i.p.), $NAME(N^{G}-nitro-L-arginine$ methyl ester, 75mg/kg s.c.) and cisplatin(10mg/kg, i.p.). The gastric slow waves were measured for 30 minutes before and after administration of each solution(NS, JCH). Results : JCH 110.1mg/kg improved gastric emptying for 2 hrs(p=0.014). JCH 110.1mg/kg improved gastric emptying in the gastric wall injured rats(p=0.001). Under the delayed gastric emptying, JCH 110.1mg/kg improved gastric emptying in the group treated with atropine $sulfate(1.83{\pm}0.96$ vs $8.43{\pm}8.46$, p=0.003), but aggravated it with quinpirole $HCl(4.7{\pm}2.9$ vs $1.61{\pm}2.09$, p=0.021). Administration JCH 110.1mg/kg increased EGG power in rats. Conclusions : JCH stimulates gastric motility through the cholinergic pathway, so we expect that it would be effective in the treatment of dysmotility-like functional dyspepsia with low activity of vagus nerve.

• 환경영향평가
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• 제24권5호
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• pp.397-406
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• 2015

2013년 시행된 유역하수도정비계획에서는 유역별 수질상황을 고려하여 하수처리시설별 방류수 수질 준수농도(기준)를 별도로 적용하는 것이 가능하다. 유역의 중권역 목표기준 또는 수질오염총량관리 목표수질을 달성하기 위하여 유역하수도 제도 도입에 따라 유역 내 지역별 시설규모별 하수처리시설에 대한 방류수 수질 준수농도(안)을 설정하는 것이 필요하다. 유역환경청에서 수립하고 있는 유역하수도정비계획 수립 시 공공하수처리시설 방류수 수질 준수농도(기준)을 설정하는데 있어 II지역인 미호천유역의 경우 BOD 5 mg/L에서 3 mg/L, II III지역이 혼재되어 있는 영산강 상류유역의 경우 BOD 5~10 mg/L에서 3 mg/L로, IV지역인 안성천유역의 경우 BOD 10 mg/L에서 5 mg/L로 일률적으로 강화하도록 계획하고 있다. 이렇게 일률적으로 정하고 있는 준수농도에 대해 하수 처리기술, 유역특성을 고려한 유역하수도 공공하수처리시설의 방류수 수질 준수농도를 설정하는 방법을 제시하는 것이 필요하다. 본 연구에서는 공공하수처리시설 방류수 수질 준수농도 강화(안)을 설정할 때 이 강화된 준수농도가 공공수역 수질에 미치는 영향을 평가하여 어떤 강화(안)이 유역관리에 좀 더 효과적인지 고찰하였다.