• The Journal of Internal Korean Medicine
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• v.34 no.2
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• pp.147-154
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• 2013

Objectives : The aims of this study was to find out whether Jichul-hwan (JCH) extract has an effect on gastric contractility in conscious rats by using a force transducer implanted in the body of the stomach. Methods : The force transducer (model: F-081S, Starmedical, JAPAN) was implanted to the exterior wall of the stomach body in rats. The gastric contractility was measured 30 minutes before and after administration of JCH (110.1 mg/kg). The control group was administrated with normal saline instead of JCH to compare the effect of JCH. The gastric contractility of the control group (normal saline: NS) was also measured 30 minutes before and after administration of NS. Results : The ratio of gastric contractility between before and after medication by JCH was $1.707{\pm}0.731$, and with NS was $0.701{\pm}0.541$. The gastric motility increased by JCH was significantly higher than NS. Conclusions : JCH extract increases gastric contractility in conscious rats. We could expect that this drug would be effective in the treatment of functional dyspepsia or post-surgical gastroparesis.

• The Journal of Internal Korean Medicine
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• v.29 no.1
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• pp.189-199
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• 2008

Background & Objective : Jichul-hwan(JCH) has been used for the treatment of functional dyspepsia, regarded as a gastric dysmotility disease. We investigated the effects of JCH on gastric motility and its mechanisms of action in rats. Methods : The gastric wall was injured by tracting a part of stomach body in rats. Gastric emptying was measured after administration of normal saline(NS) or JCH in normal rats and gastric wall injured rats. To evaluate the mechanism of JCH under delayed gastric emptying conditions, normal rats were treated with atropine sulfate(1mg/kg, s.c.), quinpirole HCl(0.3mg/kgg, i.p.), $NAME(N^{G}-nitro-L-arginine$ methyl ester, 75mg/kg s.c.) and cisplatin(10mg/kg, i.p.). The gastric slow waves were measured for 30 minutes before and after administration of each solution(NS, JCH). Results : JCH 110.1mg/kg improved gastric emptying for 2 hrs(p=0.014). JCH 110.1mg/kg improved gastric emptying in the gastric wall injured rats(p=0.001). Under the delayed gastric emptying, JCH 110.1mg/kg improved gastric emptying in the group treated with atropine $sulfate(1.83{\pm}0.96$ vs $8.43{\pm}8.46$, p=0.003), but aggravated it with quinpirole $HCl(4.7{\pm}2.9$ vs $1.61{\pm}2.09$, p=0.021). Administration JCH 110.1mg/kg increased EGG power in rats. Conclusions : JCH stimulates gastric motility through the cholinergic pathway, so we expect that it would be effective in the treatment of dysmotility-like functional dyspepsia with low activity of vagus nerve.

• Journal of Environmental Impact Assessment
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• v.24 no.5
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• pp.397-406
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• 2015

The different compliance concentration of effluent limit is applied to effluent discharged from public sewage treatment works(PSTWs) in each watershed on the basis of water quality thereof in accordance with the enforced Watershed Sewer System Maintenance Plan in 2013. It is necessary to set the compliance concentration of effluent limit for PSTWs in watershed sewer system, in order to achieve water quality criteria for regional watersheds or target water quality under TMDL program. Watershed Environmental Agencies establish the Watershed Sewer System Maintenance Plan and set the compliance concentration of effluent limit for PSTWs under the plan. The agencies have a plan to apply strengthened effluent BOD concentration limits for PSTWs in I to IV area grade, respectively. Effluent BOD concentration limits will be strengthened from 5~10 mg/L to 3 mg/L in II~III area grade, from 10 mg/L to 5 mg/L in IV area grade. Uniform application of effluent BOD concentration limits to PSTWs in the watershed sewer system need to be complemented considering type of sewage treatment technology employed and watershed characteristics. Therefore, this study presents assessment methodology which analyze for the compliance concentration of effluent limit to affect water quality of discharge watershed using simulation model for the Jinwee-stream watershed.