• 보건의료산업학회지
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• 제9권3호
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• pp.187-199
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• 2015

Objectives : This study was conducted to examine social factors associated with problematic drinking among middle- and older-aged men in South Korea. Methods : The data were collected from the baseline survey of the Korean Longitudinal Study of Aging, and the sample consisted of 3,631 men between 45 and 64 years of age and 1,173 men aged 65 or older. This study employed variables identifying various socioeconomic features, social ties, and health-related factors. Logistic regressions were used for the data analysis. Results : Middle-aged men having frequent social relationship with close persons were significantly more likely to be problematic drinkers than those having less frequent social relationships with close persons. Lower education, unemployment, smoking, and depression were associated with problematic drinking only among middle-aged men. Conclusions : We suggest that health professionals develop specific intervention strategies that could lead to more moderate alcohol habits and better health in middle aged Korean men who are actively engaged in social networks. In addition, health professionals need to focus more on the unemployed, lower educated, depressed, and smoking groups for early detection of problematic drinking among middle-aged Korean men.

• 대한인간공학회지
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• 제24권3호
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• pp.1-10
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• 2005

The primary objective of this study is to design input methods for assisting button selection tasks on a PDA screen. Familiar methods in the existing computing environments were investigated to develop aiding methods. Factors manipulated in the experiment included aiding method, button size, and users' prior experience with PDAs. A total of sixteen participants examined the usability of button selection tasks. Two types of button selection tasks were used as experimental tasks; one was selecting a target button, and the other was selecting multiple target buttons consecutively. The results showed that the aiding method and the button size had significant effects on the subjective satisfaction as well as the performance. In addition, users' prior experience with PDAs affected the performance significantly. The interaction between the aiding method and the button size was found to have significant effects on the performance. However, the interaction effect between the button size and the PDA experience was significant on the task performance time only for the multiple button selection tasks. Design considerations were proposed based on the experimental results. These can be applied to the PDA interaction design to make the PDAs more usable.

• Journal of Microbiology and Biotechnology
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• 제27권12호
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• pp.2199-2210
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• 2017

Soil burial is the most widely used disposal method for infected pig carcasses, but composting has gained attention as an alternative disposal method because pig carcasses can be decomposed rapidly and safely by composting. To understand the pig carcass decomposition process in soil burial and by composting, pilot-scale test systems that simulated soil burial and composting were designed and constructed in the field. The envelope material samples were collected using special sampling devices without disturbance, and bacterial community dynamics were analyzed by high-throughput pyrosequencing for 340 days. Based on the odor gas intensity profiles, it was estimated that the active and advanced decay stages were reached earlier by composting than by soil burial. The dominant bacterial communities in the soil were aerobic and/or facultatively anaerobic gram-negative bacteria such as Pseudomonas, Gelidibacter, Mucilaginibacter, and Brevundimonas. However, the dominant bacteria in the composting system were anaerobic, thermophilic, endospore-forming, and/or halophilic gram-positive bacteria such as Pelotomaculum, Lentibacillus, Clostridium, and Caldicoprobacter. Different dominant bacteria played important roles in the decomposition of pig carcasses in the soil and compost. This study provides useful comparative date for the degradation of pig carcasses in the soil burial and composting systems.

• Molecules and Cells
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• 제25권1호
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• pp.99-104
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• 2008

Gangliosides, sialic acid-containing glycosphingolipids, are implicated in many neuronal diseases, but the precise molecular mechanisms underlying their pathological activities are poorly understood. Here we report that TLR2 participates in the initiation of ganglioside-triggered inflammatory signaling responses. Using FACS analysis and immunofluorescence microscopy, we found that gangliosides rapidly enhanced the cell surface expression of TLR2 in microglia, while reducing that of TLR4. The ganglioside-dependent increase of TLR2 expression was also observed at the messenger and protein levels. We also showed that gangliosides stimulate the interaction of TLR2 with Myd88, an adaptor for TLRs, and obtained evidence that lipid raft formation is closely associated with the ganglioside-induced activation of TLR2 and subsequent inflammatory signaling. These results collectively suggest that TLR2 contributes to the ability of gangliosides to cause inflammatory conditions in the brain.

• 한국소음진동공학회논문집
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• 제22권1호
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• pp.81-87
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• 2012

This paper establishes a modeling and simulation procedure for structural response and reliability of a cylindrical array sensor on submarines under the shock generated by underwater explosion. The structural reliability of SONAR is important because the submarine could get out of combat ability by the structural damage of the SONAR upon explosion. A cylindrical array sensor was first modeled using the finite element method. Modal analysis was then performed for the check of the reliability of the modeling. The shock resistance simulations were performed for the responses to the structural shock waves and for the responses to the directly applied underwater shock waves, according to BV-043 and MIL-STD-901D, respectively. The stresses of the structure were evaluated with von-Mises scheme. Vulnerable regions were exposed through mapping the maximum stress to the structural model. Maximum stress of the SONAR was compared with the yield stress of the material to examine the structural reliability.

• 한국정밀공학회지
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• 제23권1호
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• pp.64-71
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• 2006

Ultraprecision machining and MEMS technology have been taken more and more important position in machining of microparts. Micro endmilling is one of the prominent technology that has wide spectrum of application field ranging from macro parts to micro products. Also, the method of micro-grooving using micro endmill is used widely owing to many merit, but has problems of precision and quality of products due to tool wear and tool fracture. This investigation deals with state monitoring using acoustic emission(AE) signal in the micro-grooving. Characteristic evaluation of AE raw signal, AE hit and frequency analysis for condition monitoring is presented. Also, the feature extraction of AE signal directly related to machining process is executed. Then, the distinctive micro endmill state according to the each tool condition is classified by the fuzzy C-means algorithm.

• 한국멀티미디어학회논문지
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• 제23권6호
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• pp.747-755
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• 2020

In this paper, we deal with outlier data problems that occur when constructing a PM_2.5 fine dust forecasting system using a neural network. In general, when learning a neural network, some of the data are not helpful for learning, but rather disturbing. Those are called outlier data. When they are included in the training data, various problems such as overfitting occur. In building a PM_2.5 fine dust concentration forecasting system using neural network, we have found several outlier data in the training data. We, therefore, remove them, and then make learning 3 ways. Over_outlier model removes outlier data that target concentration is low, but the model forecast is high. Under_outlier model removes outliers data that target concentration is high, but the model forecast is low. All_outlier model removes both Over_outlier and Under_outlier data. We compare 3 models with a conventional outlier removal model and non-removal model. Our outlier removal model shows better performance than the others.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권1호
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• pp.70-74
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• 2008

저자들은 건강했던 12세 남아가 발열, 연하통, 삼킴 곤란 증세를 호소하여 시행한 내시경 상 식도의 궤양과 수포성 병변이 보이고 헤르페스 I형 항체 양성반응으로 진단된 헤르페스 식도염을 항바이러스제와 proton pump inhibitor 등 보존적 치료로 치유시킨 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 한국치위생학회지
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• 제14권5호
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• pp.765-773
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• 2014

Objectives : The objective of study is to investigate the relationship between the satisfaction of dental service, value quality, and reuse intention among dental implant patients. Methods : A self-reported questionnaire was filled out by 316 dental implant patients in 4 dental clinics in Daejeon from December, 2013 to March, 2014. Results : The average of dental service satisfaction was 4.14(SD=.562). The average of value satisfaction was 3.88(SD=.648), and that of reuse intention was 3.98(SD=.662). The tangibility was defined as the influence of the quality of medical service on the value satisfaction(t=4.042, p<0.001) and the confidence(t=2.997, p<0.01). The influence of the service value on the intention to reuse was 0.486(t=10.796, p<.001) of path coefficient. Conclusions : The quality of medical service is decided by the value satisfaction and the intention to reuse including the value satisfaction.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2003년도 춘계학술대회
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• pp.180-180
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• 2003

Transcript profiling is a particularly valuable tool in the field of steroid receptor biology, as these receptors are ligand-activated transcription factors and therefore exert their initial effects through altering gene expression in responsive cells. Also, an increased awareness of endocrine disrupting chemicals (EBCs) and their potential to affect wildlife and humans has produced a demand for practical screening methods to identify endocrine activity. Here we developed an in-house cDNA microarray, named KISTCHIP-400, with 401 clones, hormone related genes, factors, and ESTs, based on public database and research papers. Theses clones contained estrogen, androgen, thyroid hormone St receptors, sex hormone signal transduction ＆ regulation, c-fos, c-myc, ps2 gene, metabolism related genes etc. And to validate the KISTCHIP-400, we investigated gene expression profiles with reference hormones, 10$\^$-8/ M 17be1a-estradiol, 10$\^$-7/ M testosterone, 10$\^$-7/ M progesterone, and thyroxin in MCF-7 cell line. Although it is in first step of validation, low doses and combinations of EDCs need to be tested. Our preliminary results that indicate the developed microarray may be a useful laboratory tool for screening EDCs and elucidating endocrine disrupting mechanism.