• Biomolecules & Therapeutics
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• 제14권4호
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• pp.189-193
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• 2006

This study was designed to assess the distribution of cytochrome P450 2E1 (CYP2E1) polymorphism among Korean patients on warfarin therapy. CYP2E1 polymorphism was analyzed at 5' flanking region of CYP2E1 gene using restriction fragment length polymorphism method. Patient characteristics including the measured internal normalized ratio (INR) were also evaluated. Based on the warfarin dose and the bleeding cases, the patients were grouped as the regular dose control, the regular dose bleeding, the low dose control, and the low dose bleeding. Total 96 patients were evaluated for both Pst I and Rsa I loci of the CYP2E1 gene and the results showed that both loci were tightly linked. Thirty-three patients(34.4%) were heterozygotes and 4 patients(4.2%) were homozygote. There was no significant difference in patient characteristics in the dose and bleeding case groups. CYP2E1 polymorphism showed a little difference among the groups but was not statistically significant, however, lower INR value was observed in homozygote genotype groups. It was also revealed that genotype allele frequencies of CYP2E1 in Korean was close to other Asian groups but was significantly different from other Caucasian and African-American populations.

• 한방재활의학과학회지
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• 제23권2호
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• pp.95-104
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• 2013

Objectives : The purpose of this study is to analyze internal research trends of work-related musculoskeletal disorders(WMSDs) and provide problems of researches forward. Methods : 6 Korean databases were searched for articles of WMSDs published from 2000 to 2012, and 264 research were systematic reviewed. An analytical method was used descriptive statistics, an actual number and percentage. Results : The results of distribution by year were reported more than 20 articles after 2004, and 45 articles in 2009. Industrial classification distribution of research subjects the manufacturing industry was many most at the 84. Research contents in most description were 147 whether it was risk factor and relation. Research design type of articles was most description survey research 226. In the research field 89 articles were reported to the journal related to technologies. Conclusions : It is considered to be necessary that ergonomic approach would cooperate with other approaches such as integrated health management system as well as industrial medicine considering psychosocial factors.

• 한국대기환경학회지
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• 제24권5호
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• pp.512-522
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• 2008

Ammonia is a major compound of odor in livestock house. To enhance the performance of ammonia oxidation (decomposition). the gas-liquid, two phase photocatalytic oxidation system was designed and prepared in this study. Commercial P-25 as $TiO_2$ catalyst was used for ammonia decomposition. V/P-25 catalyst prepared by sol gel method was also used for the removal of by-producted $NO_x$ in $NH_3$ oxidation reaction. When $TiO_2$ was used as a photocatalyst, the conversion to $N_2$ in ammonia decomposition reached above 90% until 200hr (The air flow rate of 4L/min with the ammonia concentration up to 25ppm.). However, considerable amounts of NO and $NO_2$ were formed as a result of $NH_3$ oxidation (as a by-product). Therefore, we added Vanadia impregnated $TiO_2$(P-25) catalyst for the removal of $NO_x$ at the end of reaction trail. The results of a pilot-scale operation were successful to achieve the simultaneous removal of $NH_3\;and\;NO_x$ about 81 and 87%, respectively.

• 생약학회지
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• 제39권3호
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• pp.233-236
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• 2008

In order to find the antioxidative components, fractionation of Cyperus amuricus (Cyperaceae) methanol extract was performed by measuring the DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging effect. Three compounds, 3,4-dimethoxy benzoic acid (1), 4-hydroxybenzoic acid (2), and piceatannol (3) were isolated from the active ethylacetate soluble fraction of C. amuricus through repeated silica gel and Sephadex LH-20 column chromatography. Among them, compound 3 showed the significant antioxidative effect on DPPH free radical scavenging test. These compounds are reported for the first time from this plant.

• Bulletin of the Korean Chemical Society
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• 제27권6호
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• pp.909-917
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• 2006

2,2-Dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyran analogues (eg., 7 and 8) were identified as prolyl 4-hydroxylase inhibitors via a screening process using HSC-T6 and LI 90 cells that express an immortalized rat hepatic stellate cell line and as part of a test of the type I collagen contents employing the ELISA method. A subsequent lead optimization effort based on solid-phase parallel synthesis led to the identification of 2,2-dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyrans as potent inhibitors of prolyl 4-hydroxylase.

• 한방재활의학과학회지
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• 제26권4호
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• pp.57-65
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• 2016

Objectives Our goal was to review literatures on tool-based manipulation for musculoskeletal diseases with emphasis on guasha and IASTM (Instrument Assisted Soft Tissue Manipulation) by searching foreign and domestic controlled trials. Methods We found literatures published up to August 2016 in electronic databases (OASIS, KoreaMed, KMbase, NDSL, RISS, KISS, MEDLINE/PubMed, EMBASE, Cochrane Central Register of Controlled Trials) without any limitations on language. Results 17 studies were included in the review. 13 out of 17 articles were published within this decade. VAS was the main evaluation tool for most of the articles (14 out of 17). 10 studies showed statistically significant difference between the experimental group and the control group. In terms of materials used for treatment, 6 out of 17 studies used stainless steel. Considering anatomical locations for treatment, trunk area was treated the most, accounting for 7 out of 17 studies. Conclusions Our results show that recently, research on tool-based manipulation treatments for musculoskeletal diseases are actively being performed. Diseases of the vertebral column were the main target for tool-based manipulation treatments, and stainless steel was the most popular and safe material used. Further research should be performed for more accurate data.

• 대한본초학회지
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• 제23권2호
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• pp.225-233
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• 2008

Objectives : The purpose of the present study was to development of neuroprotective antioxidant agents. For the purpose, we investigated the neuroprotective effect of anti oxidant herb, the root of Polygonum cuspidatum on transient focal cerebral ischemia in rats. Methods : The roots of Polygonum cuspidatum were extracted by 85% MeOH (PCE). Radical scavenging effects were investigated using DPPH assay and TBARs (Thiobarbituric acid reaction substance) assay in brian homogenates. Neuroprotective effect was investigated using transient focal cerebral ischemia rat model (2 h of ischemia, 22 h of reperfusion) by behavioral test and measurement of brain damage using 2, 3, 5-triphenyltetrazolium chloride staining. Results : PCE showed potent and dose dependent radical scavenging effects in DPPH and TBARs assay. Oral administration of PCE reduced brain infarct volume by 29.7% and improved the sensory motor functional deficit by 29% compared with vehicle treated group. Conclusions : PCE showed radical scavenging effects and neuroprotective effect on stroke rat model. Therefore, Polygonum cuspidatum could be a candidate for the development of neuroprotective-antioxidant agents.

• 한국생활과학회지
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• 제7권1호
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• pp.1-9
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• 1998

The major purpose of this study was to investigate chief's perception of institution management according to the types of the institution for the child care and education. The subjects for the analysis were 220 chiefs who actually run the institutions for the child care and education, including kindergarten, private nursery, group day care home, and private educational institute. The data were analyzed by the five different methods, which were frequency, percentage, chi-square test, one-way ANOVA and Scheffe test, using the 7.5 version of SPSSWIN program. The major research results were that (1) the chiefs of the institutions for the child care and education have suffered many difficulties in the administrative and financial respects ; (2) the main area in need of the government's assistance is either that of personnel expenses for teachers or that of expenditures necessary for improving their status ; and (3) on the whole chief's perception of institution management differed by the types of the institution for the child care and education.

• The Korean Journal of Physiology
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• 제30권2호
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• pp.269-278
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• 1996

The mechanism of impaired endothelium-dependent relaxation in the aorta of one-kidney, one clip Goldblatt hypertensive (1K,1C-GBH) rats was investigated. 8 week-old Wistar-Kyoto (WKY) rats were made hypertensive by left renal artery stenosis with contralateral nephrectomy. Endothelium-dependent relaxation was significantly reduced in 1K,1C-GBH rats as compared with WKY rats. However, the relaxation by sodium nitroprusside in 1K,1C-GBH rats was not reduced as compared with WKY rats. The impairment of endothelium-dependent relaxation in 1K,1C-GBH rats was partially restored by the pretreatment of indomethacin or SQ29548. When the nitric oxide production was inhibited by L-nitroarginine methyl ester, acetylcholine (ACh) induced a endothelium-dependent contraction that was greater in 1K,1C-GBH rats than in WKY rats. Endothelium-dependent contraction by ACh was completely abolished by indomethacin or SQ29548. However, imidazole, tranylcypromine and superoxide dismutase did not affect the endothelium-dependent contraction in 1K,1C-GBH rats. These results suggest that impaired endothelium-dependent relaxation in the 1K,1C-GBH rats might be due to the simultaneous release of EDCF, and that prostaglandin B2 may be involved as a mediator of endothelium-dependent contraction.

• Journal of Microbiology and Biotechnology
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• 제26권1호
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• pp.28-37
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• 2016

Numerous plants have been documented to contain phenolic compounds. Thymol is one among these phenolic compounds that possess a repertoire of pharmacological activities, including anti-inflammatory, anticancer, antioxidant, antibacterial, and antimicrobial effects. Despite of the plethora of affects elicited by thymol, its activity profile on gastric cancer cells is not explored. In this study, we discovered that thymol exerts anticancer effects by suppressing cell growth, inducing apoptosis, producing intracellular reactive oxygen species, depolarizing mitochondrial membrane potential, and activating the proapoptotic mitochondrial proteins Bax, cysteine aspartases (caspases), and poly ADP ribose polymerase in human gastric AGS cells. The outcomes of this study displayed that thymol, via an intrinsic mitochondrial pathway, was responsible for inducing apoptosis in gastric AGS cells. Hence, thymol might serve as a tentative agent in the future to treat cancer.