• 한국자원식물학회지
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• 제8권2호
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• pp.189-193
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• 1995

최근(最近) 질병(疾病)의 예방(豫防) 및 치료(治療) 한약재(韓藥材)와 국민건강증진(國民健康增進) 식료품(食料品)으로 수요(需要)가 증가(增加)하고 있는 작업(芍業)의 신품종(新品種) 육성(育成)을 위(爲)하여 경북(慶北) 농촌진흥원(農村進興院)에서는 1987년(年)부터 1993년(年)가지 7개년간(個年間) 국내(國內) 산야(山野)에서 지방재내종(地方在來種)을 수집(蒐集) 공시(供試)하여 순계(純系)를 분리(分離)하고 우량계(優良系) 통(統)에 대(對)한 생산력검정(生産力檢定)과 지방적응성(地方適應性) 및 농가실증시험(農家實證試驗)을 실시(實施)한 결과(結果) 기존(旣存)의 지방재래종(地方在來種)보다 양질다수성(良質多收性)인 의성작업(義城芍業)을 육성(育成)하였던바 그 主要特性(주요특성)과 수량성(收量性)을 요약(要約)하면 다음과 같다. 1. 의성작업(義城芍業)은 홀꽃의 적색(赤色)으로 풍기재래종(豊基在來種)에 비(比)해 맹아수(萌芽數)와 근수(根數)가 많고 줄기도 굵으며 뿌리도 직근(直根)이어서 초기생육(初期生育)이 왕성(旺盛)하여 양질(良質)의 생약재생산(生藥材生産)에 유리(有利)한 품종(品種)이었다. 2. 출현기(出現期)와 개화기(開化期)가 빠르고 경장(莖長)이 짧으며 주당(株當) 경수(莖數)와 근수(根數)가 많아 다수성(多收性) 품종(品種)으로 유망시(有望視)되었다. 3. 일반적(一般的) 품질(品質) 특성상(特性上)으로 의성작업(義략城릇芍)은 근육색(根肉色)이 백색(白色)이고 직근(直根)이며, Paeoniflorin 함량(含量)도 높았다. 4. 화학적(化學的) 품질특성상(品質特性上)으로는 풍기재내(豊基在來) 대비(對比) 총당(總糖)은 12.22%, 전분(澱粉)도 9.8%나 많았으며 조단백(粗蛋白)과 조회분(粗灰分)은 대등(對等)하였고 조섬유(粗纖維)는 1.17% 적었다. 5. 의성작업(義城芍業) 병충해(病蟲害) 및 도복성(倒伏性)도 대비(對比) 품종(品種)인 풍기재래종(豊基在來種)보다 강(强)하였다. 6. 10a당(當) 수량성(收量性)으로 볼때 의성작업(義城芍業) 대비(對比) 품종(品種)보다 생산력검정시험(生産力檢定試驗)에서 총수량(總收量)은 42%, 상품수량(商品收量)은 13% 많았고, 지성적응시험(地城適應試驗)에서 각각(各各) 32%, 17% 증수(增收)되었고 농가실증시험(農家實證試驗)에서도 총수량(總收量)은 27%, 상품수양(商品收量)은 19% 증수(增收)되는 양질(良質) 다수성(多收性) 품종(品種)이다.

• Journal of Acupuncture Research
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• 제33권1호
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• pp.1-7
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• 2016

Objectives : This study was conducted to analyze the single dose toxicity of Mecasin (Gami-Jakyak Gamcho buja Decoction) herbal acupuncture administered in the vein of Sprague-Dawley rats. Methods : All experiments were performed at the Medvill, an institution licensed to conduct nonclinical studies, under the Good Laboratory Practice (GLP) regulations. Sprague-Dawley rats were chosen in this pilot study. In the experiment, Sprague-Dawley rats were divided into four groups of five male and five female animals per group. Doses of Mecasin herbal acupuncture, at 0, 500, 1,000, and 2,000 mg/kg, were given to the experimental groups, and a dose of normal saline solution, at 2 ml/kg, was administered to the control group. Mecasin herb acupuncture and normal saline were injected into the vein at once, and we observed mortality, clinical signs, weights, and gross findings for 14 days after injection. This study was conducted under the approval of the Institutional Animal Ethics Committee. Results : There is no death or abnormality in any of the four groups. All groups put on weights favorably. There are no significant gross findings in necropsy examinations. Conclusions : The above results showed that intravenous injection of 500-2,000 mg/kg of Mecasin herb acupuncture did not cause any changes in weight or, in the results of necropsy examinations, in mortalities. Therefore, the toxicity of Mecasin herb acupuncture was not confirmed, and the presumptive lethal dose of Mecasin herb acupuncture was higher than 2,000 mg/kg. The outcomes suggest that treatment with Mecasin herbal acupuncture is relatively safe. Further evaluations on this subject are needed to yield more concrete evidence.

• 동의생리병리학회지
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• 제22권1호
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• pp.13-24
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• 2008

This Chapter mentioned Terror and Palpitation due to Fright(驚悸) and Hemorrhagic disease(血證). Terror and Palpitation due to FrightAcctually Terror(驚) is different from Palpitation(悸). Terror(驚) is one of the seven emotions. But in this case, It refer to the Palpitation and the uneasiness of mind due to one's hearing a strange sound of seeing a strange. Tremulous Pulse can be appear. So Terror(驚) is caused by Exopathic Factors(外因) and belongs to Excess syndrome(實證). Palpitaion(悸) is the sensation of plamus, palpitation and unrest not because of being frightened. It is usurally caused by the deficiency of Ki(氣) and blood(血). So Deep, Thready and weak pulse can be appear. So Palpitaion(悸) is caused by Endopathic Factors and belongs to Deficiency Syndrome. In this Chapter, Terror and Palpitation due to Fright(驚悸) treat with the Kyeji-ke-jakyak-ka-chokchil-moryu-yongkol-kuyuk-tang(桂枝去芍藥加蜀漆牡蠣龍骨救逆湯) and Banha-mahwang-hwan(半夏麻黃丸). There are two type in Hemorrhagic disease(血證). One is bleeding(出血) and another is blood stasis(瘀血). The contents which relate with the Hemorrhagic disease(血證) are Hematemisis(吐血), Rhinorrhagia, Hemafecia(下血). In hemorrhage pathological mechanisms, there are two mechanisms. One is that Fire and Heat(火熱) pressure blood. Another is that cold and deficiency(虛寒) disable Ki(氣) from keeping blood flowing within vessels. Blood stasis(瘀血) can be called Extravasated Blood(惡血), Coagulated Blood, Blood retention(蓄血,積血), Dead Blood(死血) and Emaciation due to Blood disorder(乾血). It refer to a morbid state of unsmooth circulation and blood stagnancy often resulting from Ki(氣) stagnation, Ki(氣) deficiency and accumulation of pathogenic coldness. The symptom of Blood stasis are 'Fullness sensation in the chest, Lip Flaccidity, Cyonotic Tongue and Dryness of Mouth'. And the man who have Blood stasis, want to rinse his mouth with the water, but he can't drink the water because there isn't interior Heat of Excess Type. The symptom of Cyonotic Tongue(舌靑) had influence on diagnosing Blood stasis(瘀血) in offspring.

• 동의생리병리학회지
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• 제20권1호
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• pp.174-180
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• 2006

We examine the effect of Geiji-Bokryung-Hwan(GBH) on erectile function in a rat model of hypercholesterolemic erectile dysfunction. GBH, a drug preparation consisting of five herbs of Cinnamomi Ramulus (Geiji), Poria Cocos (Bokryun), Mountan Cortex Radicis (Mokdanpi), Paeoniae Radix (Jakyak), and Persicae Semen (Doin) is a traditional Korean herbal medicine that is widely used in the treatment of atherosclerosis-related disorders. In this study, 3-month-old Sprague-Dawley rats were used. The 6 rats control animals were fed a normal diet and the other 18 rats were fed 1% cholesterol diet for 3 months. After 1 months, GBH was added to the drinking water of the treatment group of 12 rats but not the cholesterol only group of 6 rats. Of the 12 rats 6 received 30 mg/kg per day (group 1) and 6 received 60 mg/kg per day (group 2) of GBH. At 3 months erectile function was evaluated with cavernous nerve electrostimulation in all animals. Penile tissues were collected for electron microscopy, and to perform Western blot for endothelial nitric oxide synthase (eNOS), neuronal nitric oxide synthase (nNOS), basic fibroblast growth factor (bFGF) and caveolin-1. Systemic arterial pressure was not significantly different between the animals that were fed the 1% cholesterol diet and the controls. Conversely erectile function was not impaired in the herbal medicine treated rats. Electron microscopy showed many caveolae with fingerlike processes in the cavernous smooth muscle and endothelial cell membranes in control and treated rats but not in the cholesterol only group of rats. Western blot showed differences among groups in protein expression for eNOS, nNOS, caveolin-1 and bFGF protein expression in penile tissue. Increased eNOS and nNOS protein expressions dy high cholesterol diet were significantly decreased in group 1 and group 2. Interestingly, caveolin-1 and bFGF protein expression was significantly higher in groups 1 and 2 than in the cholesterol only and control groups.