• Archives of Pharmacal Research
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• v.28 no.8
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• pp.885-888
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• 2005

Jacaranone and related compounds (1-3) were isolated, along with three triterpenes (4-6), from the fresh fruits of Ternstroemia japonica. The compounds were identified as jacaranone (1), 3-hydroxy-2,3-dihydrojacaranone (2), 3-methoxy-2,3-dihydrojacaranone (3), 3-O-acetyl­oleanolic acid (4), 3-O-acetylursolic acid (5), and ursolic acid (6). Jacaranone and its derivatives were isolated for the first time from Theaceae. Of the isolated compounds, compound 3 is a new compound. Jacaranone (1) exhibited weak antioxidative effect on 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) radical.

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.199.3-200
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• 2002

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.194.1-194.1
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• 2003

Ternstroemia japonica (Theaceae) is widely distributed in Korea, Japan, Taiwan and China. The tree is a useful source of lumber, dye and horticulture. Its fruits have been used as folk medicine in Japan for the treatment of chest pain or numbness. Previously, we have isolated saponins and jacaranone derivatives from the fruits. In our continuous study on the same plant, the leaves of Ternstroemia japonica were extracted with MeOH and the MeOH extract was fractionated with solvents. The n-BuOH soluble fraction was separated by repeated column chromatographies on silica gel and Sephadex LH-20, and further purified by reversed phase HPLC. (omitted)