• 제목/요약/키워드: J domain

검색결과 843건 처리시간 0.024초

Crystal structures of human DJ-1 and Escherichia coli Hsp31 that share an evolutionarily conserved domain

  • Cha, Sun-Shin
    • 한국생물물리학회:학술대회논문집
    • /
    • 한국생물물리학회 2003년도 정기총회 및 학술발표회
    • /
    • pp.33-33
    • /
    • 2003
  • Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family whose members contain a conserved domain. DJ-1 is associated with autosomal recessive early-onset parkinsonism and Hsp31 is a molecular chaperone. Structural comparisons between DJ-1, Hsp31, and an archeal protease, a member of ThiJ/PfpI family, lead to the identification of the chaperons activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the comparisons provide insights into how the functional diversity is realized in proteins that share an evolutionarily conserved domain. On the basis of the chaperons activity, the possible role of DJ-1 in the pathogenesis of Parkinson's disease is discussed.

  • PDF

Numerical calculation of the wind action on buildings using Eurocode 1 atmospheric boundary layer velocity profiles

  • Lopes, M.F.P.;Paixao Conde, J.M.;Gomes, M. Gloria;Ferreira, J.G.
    • Wind and Structures
    • /
    • 제13권6호
    • /
    • pp.487-498
    • /
    • 2010
  • When designing structures to the wind action, the variation of the mean wind velocity and turbulence parameters with the height above the ground must be taken into account. This paper presents the numerical simulation results of atmospheric boundary layer (ABL) airflows, in a numerical domain with no obstacles and with a cubic building. The results of the flow characterization, obtained with the FLUENT CFD code were performed using the ${\kappa}-{\varepsilon}$ turbulence model with the MMK modification. The mean velocity and turbulence intensity profiles in the inflow boundary were defined in accordance with the Eurocode 1.4, for different conditions of aerodynamic roughness. The maintenance of the velocity and turbulence characteristics along the domain were evaluated in an empty domain for uniform incident flow and the ABL Eurocode velocity profiles. The pressure coefficients on a cubic building were calculated using these inflow conditions.

Three-dimensional Detonation Cell Structures in a Circular Tube

  • Cho, D.R.;Won, S.H.;Shin, Edward J.R.;Choi, J.Y.
    • 한국추진공학회:학술대회논문집
    • /
    • 한국추진공학회 2008년 영문 학술대회
    • /
    • pp.597-601
    • /
    • 2008
  • Three-dimensional structures of detonation wave propagating in circular tube were investigated. Inviscid fluid dynamics equations coupled with a conservation equation of reaction progress variable were analyzed by a MUSCL-type TVD scheme and four stage Runge-Kutta time integration. Variable-$\gamma$ formulation was used to account for the variable properties between unburned and burned states and the chemical reaction was modeled by using a simplified one-step irreversible kinetics model. The computational code was parallelized based on domain decomposition technique using MPI-II message passing library. The computations were carried out using a home made Windows based PC cluster having 160 AMD AthloxXP and Athlon64 processor. The computational domain consisted of through a roundshaped tube with wall conditions. As an initial condition, analytical ZND solution was distributed over the computational domain with disturbances. The disturbances has circumferential large gradient. The unsteady computational results in three-dimension show the detailed mechanisms of multi-cell mode of detonation wave instabilities resulting diamond shape in smoked-foil record.

  • PDF

Aerodynamic Analysis of Helicopter Rotor by Using a Time-Domain Panel Method

  • Kim, J.K.;Lee, S.W.;Cho, J.S.
    • 한국추진공학회:학술대회논문집
    • /
    • 한국추진공학회 2008년 영문 학술대회
    • /
    • pp.638-642
    • /
    • 2008
  • Computational methods based on the solution of the flow model are widely used for the analysis of lowspeed, inviscid, attached-flow problems. Most of such methods are based on the implementation of the internal Dirichlet boundary condition. In this paper, the time-domain panel method uses the piecewise constant source and doublet singularities. The present method utilizes the time-stepping loop to simulate the unsteady motion of the rotary wing blade. The wake geometry is calculated as part of the solution with no special treatment. To validate the results of aerodynamic characteristics, the typical blade was chosen such as, Caradonna-Tung blade and present results were compared with the experimental data and the other numerical results in the single blade condition and two blade condition. This isolated rotor blade model consisted of a two bladed rotor with untwisted, rectangular planform blade. Computed flow-field solutions were presented for various section of the blade in the hovering mode.

  • PDF

CONTROLLABILITY OF NONLINEAR DELAY PARABOLIC EQUATIONS UNDER BOUNDARY CONTROL

  • Park, Jong-Yeoul;Kwun, Young-Chel;Jeong, Jin-Mun
    • 대한수학회지
    • /
    • 제33권2호
    • /
    • pp.333-346
    • /
    • 1996
  • Let $A(\zeta, \partial)$ be a second order uniformly elliptic operator $$ A(\zeta, \partial )u = -\sum_{j, k = 1}^{n} \frac{\partial\zeta_i}{\partial}(a_{jk}(\zeta)\frac{\partial\zeta_k}{\partial u}) + \sum_{j = 1}^{n}b_j(\zeta)\frac{\partial\zeta_j}{\partial u} + c(\zeta)u $$ with real, smooth coefficients $a_{j, k}, b_j$, c defined on $\zeta \in \Omega, \Omega$ a bounded domain in $R^n$ with a sufficiently smooth boundary $\Gamma$.

  • PDF

신뢰성 있는 분산 도메인 객체 서비스를 위한 적응형 퍼지 드럽 관리기 (Adaptive Fuzzy Drop Manager for Service of Reliable Distribution Application Domain Objects)

  • 정택원;이종득
    • 한국지능시스템학회논문지
    • /
    • 제19권4호
    • /
    • pp.511-518
    • /
    • 2009
  • 최근에 사용자 위주의 서비스 요구가 증가됨에 따라 분산 도메인의 객체 정보를 서비스하기 위한 여러 기법들이 제안되고 있다. 본 논문에서는 이와 같은 요구에 따라 신뢰성 있는 분산 도메인 객체를 서비스하기 위한 퍼지 드롭 관리기를 제안하였다. 제안된 시스템은 사본 변수 $c_{i,j}$와 접근행렬 Z를 이용하여 도메인에 접근할 수 있도록 하였으며, 도메인 내에서는 인트라 도메인 퍼지 적합도를 사상시켜 퍼지집합 사이의 관계성을 적용하여 객체들의 참조 관련성을 평가하였다. 그리고 질의를 확장하기 위해 도메인의 객체들에 대해서는 알파 레벨을 적용하여 참조 관련성에 따라 알파 레벨 집합을 생성하였다. 그 결과 우리의 기법이 다른 기법들에 비해서 성능평가가 향상됨을 알 수 있었다.

FINDING THE OPTIMUM DOMAIN OF A NONLINEAR WAVE OPTIMAL CONTROL SYSTEM BY MEASURES

  • J., A.Fakharzadeh
    • Journal of applied mathematics & informatics
    • /
    • 제13권1_2호
    • /
    • pp.183-194
    • /
    • 2003
  • We will explain a new method for obtaining the nearly optimal domain for optimal shape design problems associated with the solution of a nonlinear wave equation. Taking into account the boundary and terminal conditions of the system, a new approach is applied to determine the optimal domain and its related optimal control function with respect to the integral performance criteria, by use of positive Radon measures. The approach, say shape-measure, consists of two steps; first for a fixed domain, the optimal control will be identified by the use of measures. This function and the optimal value of the objective function depend on the geometrical variables of the domain. In the second step, based on the results of the previous one and by applying some convenient optimization techniques, the optimal domain and its related optimal control function will be identified at the same time. The existence of the optimal solution is considered and a numerical example is also given.

Reduced Complexity Signal Detection for OFDM Systems with Transmit Diversity

  • Kim, Jae-Kwon;Heath Jr. Robert W.;Powers Edward J.
    • Journal of Communications and Networks
    • /
    • 제9권1호
    • /
    • pp.75-83
    • /
    • 2007
  • Orthogonal frequency division multiplexing (OFDM) systems with multiple transmit antennas can exploit space-time block coding on each subchannel for reliable data transmission. Spacetime coded OFDM systems, however, are very sensitive to time variant channels because the channels need to be static over multiple OFDM symbol periods. In this paper, we propose to mitigate the channel variations in the frequency domain using a linear filter in the frequency domain that exploits the sparse structure of the system matrix in the frequency domain. Our approach has reduced complexity compared with alternative approaches based on time domain block-linear filters. Simulation results demonstrate that our proposed frequency domain block-linear filter reduces computational complexity by more than a factor of ten at the cost of small performance degradation, compared with a time domain block-linear filter.