• Archives of Pharmacal Research
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• 제26권10호
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• pp.816-820
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• 2003

The chloroform extract of the aerial part of Limnophila geoffrayi showed antimycobacterial and antioxidant activities. Bioassay-guided fractionation has led to the isolation of the flavones nevadensin (5,7-dihydroxy-6,8,4'-trimethoxyflavone, 1) and isothymusin (6,7-dimethoxy-5,8,4'-trihydroxyflavone, 2). Both compounds 1 and 2 exhibited inhibition activity against Mycobacterium tuberculosis, with equal MIC value of $200{\;}\mu\textrm{g}/mL$. Only compound 2 exhibited antioxidant activity against the radical scavenging ability of DPPH, with the $IC_{50}$ value of $7.7{\;}\mu\textrm{g}/mL$. The crude hexane, chloroform and methanol extracts as well as the pure compounds 1 and 2 did not exhibit mutagenic activity in the Bacillus subtilis recassay.

• Natural Product Sciences
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• 제4권1호
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• pp.38-41
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• 1998

From the dried leaves of Isodon eriocalyx (Labiatae) six flavonoids were isolated and two of them were elucidated to be novel ones named 5,7,8,4'-tetrahydroxy-6-methoxyflavone (1), and $isothymusin-8-O-{\beta}-D-glucoside$ (2).