• Journal of Yeungnam Medical Science
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• 제4권1호
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• pp.123-128
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• 1987

도시 노인들의 고혈압증의 빈도 및 분포를 파악하기 위하여 1986년 1월부터 동년 12월 사이에 대구시에 거주하는 노인 남자 565명, 여자 762명 총 1,327명에 대해 조사한 성적을 요약하면 다음과 같다. 수축기혈압의 평균치는 $134.2{\pm}24.78mmHg$로 남자 $136.0{\pm}25.01mmHg$, 여자 $133.0{\pm}24.56mmHg$였다. 이완기혈압의 평균치는 $83.0{\pm}14.43mmHg$로 남자 $83.7{\pm}14.41mmHg$, 여자 $82.4{\pm}14.43mmHg$였다. 세계보건기구의 기준에 따른 고혈압증 유병률에 있어 pure systolic hypertension (${\geq}160$/<95mmHg)인 자는 7.2%로 남자 7.8%, 여자 6.8%였다. Pure diastolic hypertension (<160/${\geq}95mmHg$)인 자는 4.8%로 남자 6.0%, 여자 3.9%였다. Both systolic and diastolic hypertension (${\geq}60/{\geq}95mmHg$)인 자는 12.9%로 남자 13.5%, 여자 12.9%였다. 합동위원회의 기준에 의하면 normal (/<90mmHg)인 자는 49.1%로 남자 46.7%, 여자 50.8%였다. Mild hypertension (/90-104mmHg)인 자는 34.6%로 남자 34.5%, 여자 34.6%였다. Moderate hypertension (/105-114mmHg)인 자는 3.6%로 남자 5.1%, 여자 2.5%였다. Severe hypertension ($/{\geq}115mmHg$)인 자는 2.7%로 남자 2.3%, 여자 3.0%였다. Boderline isolated systolic hypertension (140-159/<90mmHg)인 자는 7.6%로 남자 9.0%, 여자 6.6%였다. Isolated systolic hypertension (${\geq}160$/<90mmHg)인 자는 2.4%로 남자 2.3%, 여자 2.5%였다.

• Journal of Medicine and Life Science
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• 제19권3호
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• pp.79-89
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• 2022

Whereas systolic blood pressure (SBP) continuously rises with age, diastolic blood pressure (DBP) gradually decreases after the age of 55 years. Therefore, hypertension in the elderly shows the pattern of isolated systolic hypertension. There is evidence on the benefits of controlling blood pressure (BP) in elderly patients with hypertension. The BP lowering effect has also been demonstrated in patients over 80 years of age with hypertension. The BP threshold for the initiation of antihypertensive drug treatment for older adults with hypertension is gradually decreasing. The antihypertensive treatment is recommended if, despite therapeutic lifestyle modifications, SBP ≥140 mmHg or DBP ≥90 mmHg in those aged 65-79 years old, and SBP ≥140-160 mmHg or DBP ≥90 mmHg in those aged ≥80 years old. Although there is no consensus on the target BP for older adults with hypertension, a target SBP of <130-140 mmHg and DBP of <80-90 mmHg are recommended. In older adults over 80 years of age with hypertension, the target SBP is <140-150 mmHg. When the dose of antihypertensive drugs is increased to reach the target SBP, DBP may decrease to less than 70 mmHg, but it should not be <60 mmHg. Thiazide diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers can be selected as the first-line drug for older adults with hypertension. Beta-blockers may be selected in case of compelling indications.

• The Korean Journal of Physiology and Pharmacology
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• 제20권6호
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• pp.621-628
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• 2016

Hypertension can be caused by various factors while the predominant causes include increase in body fluid volume and resistance in the circulatory system that elevate the blood pressure. Consumption of probiotics has been proven to attenuate hypertension; however, the effect is much strain-dependent. In this study, a newly isolated Lactobacillus casei (Lb. casei ) strain C1 was investigated for its antihypertensive properties in spontaneously hypertensive rats (SHR). Lactic acid bacteria (LAB) suspension of 11 log colony-forming unit (CFU) was given to SHR (SHR+LAB, n=8), and phosphate buffer saline (PBS) was given as a control in SHR (SHR, n=8) and in Wistar rats as sham (WIS, n=8). The treatment was given via oral gavage for 8 weeks. The results showed that the weekly systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP) and aortic reactivity function were remarkably improved after 8 weeks of bacterial administration in SHR+LAB. These effects were mostly attributed by restoration of wall tension and tensile stress following the bacterial treatment. Although not statistically significant, the level of malondialdehye (MDA) in SHR+LAB serum was found declining. Increased levels of glutathione (GSH) and nitric oxide (NO) in SHR+LAB serum suggested that the bacterium exerted vascular protection through antioxidative functions and relatively high NO level that induced vasodilation. Collectively, Lb. casei strain C1 is a promising alternative for hypertension improvement.