• Title/Summary/Keyword: Isoindoloquinoxaline

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Synthesis and Cytotoxic Activities of 8-Alkyl or 8-Aryl-8,9-dihydro-7H-isoindolo[5,6-g]quinoxaline-7,9-diones

  • Jung Jae-Kyung;Jung Eun-Kyung;Kwon Nam-Goong;Cho Jung-Sook;Kim Hwan-Mook;Park Sung-Gyu;Yoo Yeong-Ah;Kwon Joo-Hee;Lee Hee-Soon
    • Archives of Pharmacal Research
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    • v.29 no.4
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    • pp.276-281
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    • 2006
  • A series of 8-alkyl-and 8-aryl-8,9-dihydro-7H-isoindolo[5,6-g]quinoxaline-7,9-diones were synthesized using sultine chemistry as a key step in good yield. These compounds were evaluated for their in vitro cytotoxicity against six human cancer cell lines (HCT15, SK-OV-3, A549, SNB19, MCF7 and MCF7/ADR).