• Journal of Microbiology and Biotechnology
• /
• 제19권2호
• /
• pp.204-207
• /
• 2009

We investigated novel antibacterial and synergistic activities of isocryptomerin isolated from Selaginella tamariscina. Isocryptomerin showed potent antibacterial activity against Gram-positive and Gram-negative bacterial strains including clinical isolates of antibiotic-resistant species such as methicillin-resistant Staphylococcus aureus(MRSA). Additionally, we further investigated the synergistic activity of isocryptomerin with a conventional antibiotic against MRSA. The result indicated that isocryptomerin had considerable synergistic activity in combination with cefotaxime. In summary, the present study suggests that isocryptomerin may have potential as a novel therapeutic agent for treatment of infectious diseases by not only human pathogenic bacteria but also multidrug-resistant bacteria.

• 생약학회지
• /
• 제22권4호
• /
• pp.207-210
• /
• 1991

From the chloroform and n-butanol extracts of Selaginella tamariscina, three biflavonoids were isolated by chromatographic separation. Structures of these compounds were determined as cryptomerin B, amentoflavone and isocryptomerin by spectroscopic analysis, and amentoflavone was further identified by comparison with the authentic sample. This is the first report of isolation of cryptomerin B from Selaginellaceae.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
• /
• pp.128-128
• /
• 1993

총 40종 생약의 hyaluronidase에 대한 저해 효과를 검색한 결과, 백지, 오수유, 향부자, 섬백리향, 배풍등, 황금, 황련, 진피, 소리쟁이, 반디나물 등 10종 생약에서 저해 활성을 관찰할 수 있었다. 또한 권백의 n-BuOH 분획에서 2개의 biflavonoid 성분인 amentoflavone, isocryptomerin을 분리하였으며, chloroform 분획에서 cryptomerin B를 분리하였다. 이들 화합물의 화학구조는 각종 기기분석 data를 이용하여 결정하였으며, 이들 화합물중 cryptomerin B는 Selaginellaceae에서 처음으로 분리 보고되는 화합물이다. 현재 이들 화합물의 생리 활성에 대하여 검사중이다.