• Title/Summary/Keyword: Irradiation Dose

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Late Biological Effect of High-dose Radiation in the Mice (마우스에서의 고선량(高線量) 방사선(放射線)에 의한 만성장해(慢性障害))

  • Kim, Sung-ho;Kim, Young-ju;Oh, Yeong-ran;Yun, Taik-koo
    • Korean Journal of Veterinary Research
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    • v.27 no.2
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    • pp.269-275
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    • 1987
  • Radiation-induced life shortening, carcinogenesis and other pathological changes were investigated in NIH(GP) mice after $^{60}Co-{\gamma}$ ray irradiation(100~700rads). The results were summarized as follows: 1. There were little difference in body weights, hematological examination and other clinical findings between normal and irradiated groups. 2. Mean survival time of the mice after irradiation were decreased dose-dependently. 3. Main gross findings of the mice irradiated were appeared as enlargement of spleen, thymus and lymph nodes, tumorous nodules of lung and cyst of ovary. Especially, enlargement of thymus was promineort in high dose group. 4. Microscopically, there were various findings including myeloid leukemia, thymic lymphoma, lung adenoma, adenosquamous cell carcinoma of pancreas, pneumonia and other pathological changes. Especially thymic lymphoma was highly frequent in the 700 rads group.

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Flavonoids of Rosa roxburghii Tratt Act as Radioprotectors

  • Xu, Ping;Zhang, Wen-Bo;Cai, Xin-Hua;Lu, Dan-Dan;He, Xiao-Yang;Qiu, Pei-Yong;Wu, Jiao
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.19
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    • pp.8171-8175
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    • 2014
  • Background: To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT). Materials and Methods: The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation. Results: The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. The survival rate was the highest at 87% with a concentration of $30{\mu}g/mL$. Pretreatment with FRT was needed to realize its radioprotective activity in mice at the dose of 60 mg/kg. With the increasing doses of 30 mg/kg, 60 mg/kg and 120 mg/kg, the numbers of CFU-S increased, and were significantly different compared with the control group. Conclusions: Pretreatment with FRT prior to irradiation resulted in significantly higher cell survival at 24 h after 5 Gy radiation, increased 30-day survival in mice after exposure to a potentially lethal dose of 8 Gy, and resulted in a higher number of CFU-S in mice after exposure to a dose of 6 Gy. These results collectively indicate that FRT is an effective radioprotective agent.

Electrical Characteristics of IGBT for Gate Bias under $\gamma$ Irradiation (게이트바이어스에서 감마방사선의 IGBT 전기적 특성)

  • Lho, Young-Hwan
    • Journal of the Institute of Electronics Engineers of Korea SC
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    • v.46 no.2
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    • pp.1-6
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    • 2009
  • The experimental results of exposing IGBT (Insulated Gate Bipolar Transistor) samples to gamma radiation source show shifting of threshold voltages in the MOSFET and degradation of carrier mobility and current gains. At low total dose rate, the shift of threshold voltage is the major contribution of current increases, but for more than some total dose, the current is increased because of the current gain degradation occurred in the vertical PNP at the output of the IGBTs. In the paper, the collector current characteristics as a function of gate emitter voltage (VGE) curves are tested and analyzed with the model considering the radiation damage on the devices for gate bias and different dose. In addition, the model parameters between simulations and experiments are found and studied.

BETTER UNDERSTANDING OF THE BIOLOGICAL EFFECTS OF RADIATION BY MICROSCOPIC APPROACHES

  • Kim, Eun-Hee
    • Nuclear Engineering and Technology
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    • v.40 no.7
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    • pp.551-560
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    • 2008
  • Radiation has stochastic aspects in its generation, its choice of interaction mode during traveling in media, and its impact on living bodies. In certain circumstances, like in high dose environments resulting from low-LET radiation, the variance in its impact on a target volume is negligible. On the contrary, in low dose environments, especially when they are attributed to high-LET radiation, the impact on the target carries with it a large variance. This variation is more significant for smaller target volumes. Microdosimetric techniques, which have been developed to estimate the distribution of radiation energy deposited to cellular and subcellular-sized targets, contrast with macrodosimetric techniques which count only the average value. Since cells and DNA compounds are the critical targets in human bodies, microdosimetry, or dose estimation by microscopic approach, helps one better analyze the biological effects of radiation on the human body. By utilizing microbeam systems designed for individual cell irradiation, scientists have discovered that human cells exhibit radiosensitive reactions without being hit themselves (bystander effect). During the past 10 or more years, a new therapeutic protocol using discontinuous multiple micro-slit beams has been investigated for its clinical application. It has been suggested that the beneficial bystander effect is the essence of this protocol.

Disinfection Effect of Film Cassettes by Ultraviolet Irradiation (자외선을 이용한 Film Cassette의 소독 효과)

  • Kweon, Dae-Cheol;Park, Peom
    • Journal of Radiation Protection and Research
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    • v.26 no.4
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    • pp.425-432
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    • 2001
  • A bacteria infection on film cassette contact surface was examined at the diagnostic radiology department. Studies have demonstrated a bactericidal effect of ultraviolet irradiation, and to assess the contamination level on film cassette contact surface as a predictor of patient prevent from nosocomial infection. The study showed that the laboratory result was identified non-pathologic and pathologic bacterial in the five different cassette size of the contact surface. Film cassettes were exposed to ultraviolet light for 1, 2 and 3 minutes. Ultraviolet light disinfection practices suitable for bacteria. The study concludes that presence of a bacterial infection will prevent a using antiseptic technique on film cassette contact surface. In conclusion, ultraviolet irradiate on film cassette over the surface more than 2 minutes. Ultraviolet dose of $1565 {\mu}W{\codt}s/cm^2$ Win in 30 second relative to ultraviolet dose in time.

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Radiation Damage of SiC Detector Irradiated by High Dose Gamma Rays

  • Kim, Yong-Kyun;Kang, Sang-Mook;Park, Se-Hwan;Ha, Jang-Ho;Hwang, Jong-Sun
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2006.12a
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    • pp.87-90
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    • 2006
  • Two SiC radiation detector samples were irradiated by Co-60 gamma rays. The irradiation was performed with dose rates of 5 kGy/hour and 15 kGy/hour for 8 hours, respectively. Metal/semiconductor contacts on the surface were fabricated by using a thermal evaporator in a high vacuum condition. The SiC detectors have metal contacts of Au(2000 ${\AA}$)/Ni(300 ${\AA}$) at Si-face and of Au(2000 ${\AA}$)/Ti(300 ${\AA}$) at C-face. I-V characteristics of the SiC semiconductor were measured by using the Keithley 4200-SCS parameter analyzer with voltage sources included. From the I-V curve, we analyzed the Schottky barrier heights(SBHs) on the basis of the thermionic emission theory. As a result, the 6H-SiC semiconductor showed- similar Schottky barrier heights independent to the dose rates of the irradiation with Co-60 gamma rays.

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Effect of $Ga^+$ Ion Beam Irradiation On the Wet Etching Characteristic of Self-Assembled Monolayer ($Ga^+$ 이온 빔 조사량에 따른 자기 조립 단분자막의 습식에칭 특성)

  • Noh Dong-Sun;Kim Dea-Eun
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2005.10a
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    • pp.326-329
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    • 2005
  • As a flexible method to fabricate sub-micrometer patterns, Focused Ion Beam (FIB) instrument and Self-Assembled Monolayer (SAM) resist are introduced in this work. FIB instrument is known to be a very precise processing machine that is able to fabricate micro-scale structures or patterns, and SAM is known as a good etch resistance resist material. If SAM is applied as a resist in FIB processing fur fabricating nano-scale patterns, there will be much benefit. For instance, low energy ion beam is only needed for machining SAM material selectively, since ultra thin SAM is very sensitive to $Ga^+$ ion beam irradiation. Also, minimized beam spot radius (sub-tens nanometer) can be applied to FIB processing. With the ultimate goal of optimizing nano-scale pattern fabrication process, interaction between SAM coated specimen and $Ga^+$ ion dose during FIB processing was observed. From the experimental results, adequate ion dose for machining SAM material was identified.

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Electron Dose Measurement with Polycarbonate Film Dosimeter

  • Yoo, Young-Soo
    • Nuclear Engineering and Technology
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    • v.8 no.1
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    • pp.9-17
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    • 1976
  • Dosimetrical properties of polycarbonate film for high-level dosimetry of electrons have been examined. Polycartonate film of 0.1mm in thickness was chosen for this purpose. It can cover the dose range of 1.0-130 Mrad and the measurable range can be extended up to 200 Mrad by using calibration curve. The measurement error was within 3.5%. The radiation induced optical density at 330nm shows rapid initial fading of 7-l3n for one day after irradiation at room temperature and subsequent fading rate is very small, about 0.6% per day. The fading depends on the absorbed dose, storage temperature, and wavelengths. The effects of storage time and temperature during and after irradiation of this film are presented. For practical dosimetry, it is necessary to stabilize the induced optical density by storing the irradiated film for a day or by heat treatment at 10$0^{\circ}C$ for an hour.

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