• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제39권2호
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• pp.55-62
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• 2013

Bone tissue engineering is one of the important therapeutic approaches to the regeneration of bones in the entire field of regeneration medicine. Mesenchymal stem cells (MSCs) are actively discussed as material for bone tissue engineering due to their ability to differentiate into autologous bone. MSCs are able to differentiate into different lineages: osteo/odontogenic, adipogenic, and neurogenic. The tissue of origin for MSCs defines them as bone marrow-derived stem cells, adipose tissue-derived stem cells, and, among many others, dental stem cells. According to the tissue of origin, DSCs are further stratified into dental pulp stem cells, periodontal ligament stem cells, stem cells from apical papilla, stem cells from human exfoliated deciduous teeth, dental follicle precursor cells, and dental papilla cells. There are numerous in vitro/in vivo reports suggesting successful mineralization potential or osteo/odontogenic ability of MSCs. Still, there is further need for the optimization of MSCs-based tissue engineering methods, and the introduction of genes related to osteo/odontogenic differentiation into MSCs might aid in the process. In this review, articles that reported enhanced osteo/odontogenic differentiation with gene introduction into MSCs will be discussed to provide a background for successful bone tissue engineering using MSCs with artificially introduced genes.

• International Journal of Contents
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• 제12권4호
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• pp.76-82
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• 2016

This study aims to evaluate the effectiveness of the dual-punishment system by analysis of the financial performance of pharmaceutical companies before and after introduction of the dual-punishment system. This study analyzed the business performance of 136 pharmaceutical companies from 2009 to 2011. The results from paired t-tests found that sales, operating cost, and EBITDA showed significant differences in performance, and, according to the variance analysis, the five groups obtained through a hierarchical cluster analysis differed from each other in sales, operating cost, EBITDA, and research and development cost. Differences in financial performance among the groups seem to be related to the strategy for response to the regulation. The introduction of the dual-punishment system is generally acknowledged to have had positive effects on the pharmaceutical industry. However, some companies appear to be continuing kickback practices.

• The Korean Journal of Pain
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• 제33권4호
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• pp.386-394
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• 2020

Background: In the emergency department (ED), adequate pain control is essential for managing patients; however, children with pain are known to receive less analgesia than adults with pain. We introduce the Pain Passport to improve pain management in paediatric patients with suspected fractures in the ED. Methods: This was a before-and-after study. We reviewed the medical records of paediatric patients who were primarily diagnosed with fractures from May to August 2015. After the introduction of the Pain Passport, eligible children were enrolled from May to August 2016. Demographics, analgesic administration rates, time intervals between ED arrival and analgesic administration, and satisfaction scores were obtained. We compared the analgesic prescription rate between the two periods using multiple logistic regression. Results: A total of 58 patients were analysed. The baseline characteristics of subjects during the two periods were not significantly different. Before the introduction of the Pain Passport, 9 children (31.0%) were given analgesics, while after the introduction of the Pain Passport, a significantly higher percentage of patients (24/29, 82.8%) were treated with analgesics (P < 0.001). The median administration times were 112 (interquartile range [IQR], 64-150) minutes in the pre-intervention period and 24 (IQR, 20-74) minutes in the post-intervention period. The median satisfaction score for the post-intervention period was 4 (IQR, 3-5). The adjusted odds ratio for providing analgesics in the post-intervention period was 25.91 (95% confidence interval, 4.36-154.02). Conclusions: Patient-centred pain scoring with the Pain Passport improved pain management in patients with suspected fractures in the paediatric ED.

• Journal of Korean Neurosurgical Society
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• 제56권2호
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• pp.166-167
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• 2014

Subdural hemorrhage (SDH) can manifest various neurologic symptoms. However, SDH presenting with only hand weakness has rarely been reported. We report two SDH cases with only hand weakness mimicking peripheral neuropathy. Since SDH can present with hand weakness only, we suggest the clinicians to do a careful history taking and recommend a CT scan in the elderly patients.

• 대한수의학회지
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• 제58권2호
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• pp.73-79
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• 2018

Outbreaks of porcine reproductive and respiratory syndrome virus (PRRSV) in vaccinated sow herds from occurrence to stabilization were monitored and analyzed in terms of serology and reproductive performance. Three different conventional pig farms experienced severe reproductive failures with the introduction of a type 1 PRRSV. These farms had adopted mass vaccination of sows using a type 2 PRRSV modified live vaccine (MLV). Therefore, to control the type 1 PRRSV, an alternative vaccination program utilizing both type 1 and type 2 MLV was undertaken. Following whole herd vaccinations with both types of MLV, successful stabilization of PRRS outbreaks was identified based on serological data (no viremia and downward trends in ELISA antibody titers in both sows and suckling piglets) and recovery of reproductive performance. Additionally, through comparison of the reproductive parameters between outbreak and non-outbreak periods, it was identified that PRRSV significantly affected the farrowing rate and the number of suckling piglets per litter at all three pig farms. Comparison of reproductive parameters between periods when the different vaccination strategies were applied revealed that the number of piglets born in total and born dead per litter were significantly increased after the introduction of the type 1 PRRS MLV.

• Journal of Gynecologic Oncology
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• 제29권6호
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• pp.93.1-93.11
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• 2018

The introduction of checkpoint inhibitors revolutionized immuno-oncology. The efficacy of traditional immunotherapeutics, like vaccines and immunostimulants was very limited due to persistent immune-escape strategies of cancer cells. Checkpoint inhibitors target these escape mechanisms and re-direct the immune system to anti-tumor toxicity. Phenomenal results have been reported in entities like melanoma, where no other therapy was able to demonstrate survival benefit, before the introduction of immunotherapeutics. The first experience in ovarian cancer (OC) was reported for nivolumab, a fully human anti-programmed cell death protein 1 (PD1) antibody, in 2015. While the data are extraordinary for a mono-immunotherapeutic agent and very promising, they do not match up to the revolutionary results in entities like melanoma. The key to exceptional treatment response in OC, could be the identification of the most immunogenic patients. We hypothyse that BRCA mutation could be a predictor of improved response in OC. The underlying DNA-repair-deficiancy should result in increased immunogenicity because of higher mutational load and more neoantigen presentation. This hypothesis was not tested to date and should be subject to future trials. The present article gives an overview of the immunologic background of checkpoint inhibition (CI). It presents current data on nivolumab and other checkpoint-inhibitors in solid tumors and OC specifically and depicts important topics in the management of this novel substance group, such as side effect control, diagnostic PD-1/programmed cell death-ligand 1 (PD-L1) expression assessment and management of pseudoprogression.

• Journal of Acupuncture Research
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• 제37권4호
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• pp.290-293
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• 2020

Several modalities that have been used in Korean medicine have not undergone evaluation. The Korea Institute of Oriental Medicine (KIOM), a South Korean national research agency, launched the Korean medicine case Report (KORE) program in May 2019 to promote case reports, especially among clinicians. The aim was to (1) introduce the KIOM-initiated KORE program, (2) report the results from the KORE program, and (3) present the challenges and limitation from the KORE program. We conducted a narrative review of the cases to which KORE was applied. A total of 16 proposals were reviewed since May 2019. Five proposals were rejected, and 7 case reports were included. Case reports for 3 therapies have been created under guidance. The KORE program makes it easier for Korean medicine doctors to initiate and complete case reports.

• 동의생리병리학회지
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• 제24권6호
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• pp.1068-1076
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• 2010

This study was to establish and evaluate international educational program for foreign traditional medicine students with traditional Korean medicine in School of Korean Medicine, Pusan National University, and discussed prerequisite requirements for international educational program. The Introduction to Traditional Korean Medicine (TKM) was constructed with Korea and TKM, Understanding TKM, Future of TKM, Clinical Skills (lecture and practice), Clinical practice (observation), Field trip, and others. The overall assessment was concluded as excellent (91.7%). The prerequisite requirements for planning and operating educational program, and key points for the success of international program were discussed. And the necessity of Center for International Educational of Traditional Medicine was described. This study can be used as a reference manual for globalization of TKM education and proposal for making policy on TKM.

• 혜화의학회지
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• 제8권2호
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• pp.329-339
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• 2000

I got the following result from the bibliographic study of disease in relation to sexual psychology. The results are follows. 1. Sexual disorder is divided sexual disfunction, paraphilias, gender identity disorder, homosexuality and that is subdivided fetishism, transvestic fetishism, pedophilia, exhibitionism, voyerism, sexual masochism, sexual sadism, frotteurism, gender identity disorder of childhood, gender identity disorder of youth and adult, intersexual disorders. 2. In korean oriental medicine mainly refer to sexual disfunction, and sexual psychological disorder include Hwajeon(花癲), Buinmongio(婦人夢交), Guabusani disease(寡婦師尼病). 3. Social psychologic cause and, oedipus complex, sexual hormone induce sexual psychological disorder but in korean oriental medicine, recognized sexual psychological disorder place under the category of sexual disfunction. 4. The latest medicine has various medical treatment in sexual disorder as avoidence conditioning, medication, role playing, behavior modification, psychoanalysis theraphy but in korean oriental medicine has only medication theraphy, so need more introduction of medical treatment.

• 대한한방내과학회지
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• 제39권2호
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• pp.154-158
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• 2018

Introduction: This case report assessed the effects of Korean medicine treatments on a chronic migraine patient who did not respond to triptan. Case Presentation: The patient received Korean medicine treatments, such as acupuncture, moxibustion, cupping, and herbal medication, during a hospitalization period. The effects of treatments were assessed with the Numerical Rating Scale (NRS) and migraine attack frequency. The intensity and attack frequency of migraines were significantly reduced after the complete treatment. Conclusions: For migraines, Korean medicine such as acupuncture and herbal medication could be an alternative to conventional therapy.