• Journal of the Architectural Institute of Korea Planning & Design
• /
• v.34 no.4
• /
• pp.123-131
• /
• 2018

This study discusses that the US zoning system came from "progressive movement" in the early 20th century. The US progressive movement was closely related with the scientific management movement in terms of efficiency. In that context, the ontological significance of zoning is found in realizing public interests by blocking external effects based on the value-neutral expertise. Another aspect of the US zoning system is the political one. It is closely related to progressive movement in common with efficiency. The zoning system was introduced as a measure to prevent the racial and class mixture resulting from the influx of immigrants. Today, the racial aspect of zoning is succeeded to exclusionary zoning. This study examines the fact that exclusive interests of US mainstream society have served as more important background than the fundamental aspect preventing external effects in the introduction and evolution of the zoning system.

• Electronics and Telecommunications Trends
• /
• v.37 no.3
• /
• pp.33-40
• /
• 2022

Communication technologies are evolving to meet the ever-increasing demand for fast transmission speeds and large capacity. However, the introduction of new mobile networks, such as 5G, should be accompanied by changes in corresponding frequency and modulation techniques to enable the commercialization of its services. Hence, investigating the human health effects of electromagnetic exposures used in these new communication systems is crucial. Since in vitro electromagnetic experiments can provide essential information on important mechanisms of exposure effects, this article presents in vitro exposure systems necessary for reliable experiments. Moreover, the fundamental requirements for system implementation and the features of various systems are discussed.

• Journal of Preventive Medicine and Public Health
• /
• v.56 no.4
• /
• pp.303-311
• /
• 2023

Traditional mediation analysis, which relies on linear regression models, has faced criticism due to its limited suitability for cases involving different types of variables and complex covariates, such as interactions. This can result in unclear definitions of direct and indirect effects. As an alternative, causal mediation analysis using the counterfactual framework has been introduced to provide clearer definitions of direct and indirect effects while allowing for more flexible modeling methods. However, the conceptual understanding of this approach based on the counterfactual framework remains challenging for applied researchers. To address this issue, the present article was written to highlight and illustrate the definitions of causal estimands, including controlled direct effect, natural direct effect, and natural indirect effect, based on the key concept of nested counterfactuals. Furthermore, we recommend using 2 R packages, 'medflex' and 'mediation', to perform causal mediation analysis and provide public health examples. The article also offers caveats and guidelines for accurate interpretation of the results.

• Biomolecules & Therapeutics
• /
• v.32 no.1
• /
• pp.25-37
• /
• 2024

Atopic dermatitis (AD) is an allergic disorder characterized by skin inflammation. It is well known that the activation of various inflammatory cells and the generation of inflammatory molecules are closely linked to the development of AD. There is accumulating evidence demonstrating the beneficial effects of herbal extracts (HEs) on the regulation of inflammatory response in both in vitro and in vivo studies of AD. This review summarizes the anti-atopic effects of HEs and its associated underlying mechanisms, with a brief introduction of in vitro and in vivo experiment models of AD based on previous and recent studies. Thus, this review confirms the utility of HEs for AD therapy.

• Korean Journal of Veterinary Research
• /
• v.47 no.1
• /
• pp.103-115
• /
• 2007

The aim of this study was to compare the reaction of the cardiovascular system, and the anesthetic effect among 3 experimental groups, epidural administration of medetomidine as a single agent, the combination of buprenorphine and medetomidine, and the combination of fentanyl and medetomidine. Twenty one dogs were anesthetized with isoflurane and allowed to breathe spontaneously. Epidural, arterial, and venous catheters were inserted. The tip of epidural catheter was positioned at the level of the space between the sixth and seventh lumbar vertebra. After a stable plane of anesthesia was achieved, these dogs were each administered one of the following treatments epidurally : medetomidine $10{\mu}g/kg$ (Group M), a combination of medetomidine $5{\mu}g/kg$ and buprenorphine $10{\mu}g/kg$ (Group M/B), and a combination of medetomidine $5{\mu}g/kg$ and fentanyl $10{\mu}g/kg$ (Group M/F). Heart rate (HR), Respiratory rate (RR), End-tidal carbon dioxide (EtCO2), and arterial blood pressure were measured before drug administration (base line) and 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, and 60 min postinjection. Blood gas analysis was performed before injection and 5, 15, 25, 35, 45, 60 min postinjection. Isoflurane was discontinued 80 min postinjection and pain/motor function were evaluated up to 260 min postinjection every 15 min. At the early stage of drug introduction (until 5 min), the HR was decreased significantly in all 3 groups compared with base line. In Group M, HR was significantly decreased compared with the other 2 groups. With time (starting 20 min after drug introduction), the HR was decreased significantly in Group M/B in respect to base line. However, no significant difference was seen number-wise in all 3 groups. During 60 min after drug introduction, the systolic, diastolic and mean arterial pressures were highest in Group M and lowest in Group M/F. Among 3 groups, drug action and motor loss duration were longest in Group M/F. Analgesic effect observed in the M/F group was the most prominent and long-lasting, compared to those seen in the other 2 groups. Given the fact that the recovery of motor function takes place in a short period of time after analgesic effects disappeared, additional use of M/F depending on the patient's condition would be a good way to achieve effective pain management. However, proper care should be taken to ensure the function of cardiovascular system in the patient because the administration of M/F under isoflurane anesthesia results in a significant decline in arterial blood pressure ($65{\pm}10mmHg$).

• Korean Journal of Ecology and Environment
• /
• v.43 no.2
• /
• pp.212-220
• /
• 2010

Effects of sediment and toxic cyanobacterium Microcystis aeruginosa on feeding behaviors of an omnivorous fish, gold fish (Carassius auratus) were examined in laboratory and in situ mesocosm. Laboratory feeding experiments were performed in small aquaria (7 L) with cyanobacterial blooms (mainly M. aeruginosa) under the condition of sediments and no-sediments, and toxic (NIES-298) and non-toxic M. aeruginosa (NIES-101). In situ feeding experiments were conducted at the shore of eutrophic lake (Lake Ilgam, Seoul) in the mid-July, 2005. Results showed that fish introduction decreased the concentration of Chlorophyll-a (Chl-a) at higher rate in no sediment-containing aquaria. In contrast, there was a drastic increase of Chl-a in the sedimentcontaining aquaria. Fish effectively removed the M. aeruginosa cells without algal toxin (microcystin). Fish also selectively removed the large size Chl-a (>$50{\mu}m$), although all kinds of nutrients were increased after fish introduction, especially ammonia. Our results indicate that the strategic introduction of domestic omnivores Carassius auratus, to control cyanobacterial bloom in eutrophic lake will negatively play in the water quality improvement via a sediment disturbance and a density-dependent digestion.

• Journal of Industrial Convergence
• /
• v.20 no.10
• /
• pp.137-146
• /
• 2022

The use of RPA (Robotic Process Automation) has been recently reviewed in various industries, but it seems that it is not being applied to companies faster than ever expected. In this study, three perceived risk factors affecting the acceptance conflict and acceptance intention of RPA technology were proposed and the effects of RPA on acceptance conflict and acceptance intention were investigated using RPA experienced people, gender and ICT industries as control variables. For the research, online survey was conducted targeting office workers and analyzed the results by using SPSS 22.0 and AMOS 22.0. As a result, it was found that among the three perceived risk factors, concern about introduction failure, employment insecurity, and execution errors, employment insecurity and execution errors did not affect the acceptance conflict and acceptance intention of RPA. This research shows that concerns over the introduction failure affected the acceptance conflict and acceptance intention. In addition, the acceptance conflict was judged as a factor of the mediation effect of the acceptance intention. From the perspective of companies that want to apply RPA, the theoretical and practical implications of business management are meaningful in that they can identify and respond to particularly important factors among perceived risks.

• Information Systems Review
• /
• v.22 no.3
• /
• pp.99-118
• /
• 2020

At present, our society is developing into the intelligent information society in the wave of the 4th industrial revolution, and this change will have the positive effect of innovating all industry fields. However, due to the duality of technology, there will be positive and negative effects. With intelligence, threats to cyber dysfunction such as hacking, terrorism, privacy infringement, and illegal content distribution will become more serious. Until now, the security system of the Internet has been a proactive security system, but in recent years, a proposal for a trust network, a preventive security system, has been introduced. Therefore, this study aims to analyze the possibility of resolving cyber dysfunction of intelligent information society about Bright Internet, one of trust network technologies. This study defines the cyber dysfunction of the intelligent information society and analyzes the perceptions of changes in the cyber dysfunction of the intelligent information society on the introduction of the five principles of the Bright Internet. The change of cyber dysfunction severity of the intelligent information society due to the introduction of the trust network is analyzed to reflect the technical and social demands. This work will guide the structure of the trust network and the direction of practical technological introduction and its influence.

• The Journal of Internal Korean Medicine
• /
• v.26 no.2
• /
• pp.398-408
• /
• 2005

Objective: Graves' disease encompasses hyperthyroidism and diffused goiter associated with auto-antibodies to the thyroid stimulating hormone(TSH) receptors. In clinical environment, treatments of Graves' disease have many side effects such as recurrence and hypothyroidism. We've studied the effects of Sipyukmiyukieum on DNA synthesis, cAMP synthesis, and MHC-class II expression of FRTL-5 thyroid cells were studied. Methods: DNA synthesis was investigated by using BrdU staining and cAMP synthesis by ELISA kit, and expression of $interferon-{\gamma}$ activated MHC class II by Flow cytometer. Results: After introduction of Sipyukmiyukieum, significant inhibition of DNA synthesis. cAMP synthesis, and expression of $interferon-{\gamma}$ activated MHC class II of FRTL-5 thyroid cells was observed. Conclusions: Judging from these results, Sipyukmiyukieum has potential as a potent herbal treatment for inhibiting the enlargement of goiter, synthesis of abnormal thyroidal hormones, and autoimmuine responses of Graves' disease.

• Journal of Biosystems Engineering
• /
• v.31 no.4 s.117
• /
• pp.323-333
• /
• 2006

Introduction of a direct engine-PTO driveline to agricultural tractors has reduced production cost and increased transmission efficiency of the PTO driveline. However, this type of PTO driveline has caused a severe rattle noise in the PTO gearbox under idle conditions. This study was conducted to investigate the causes of the rattle noise and the effects of driveline parameters on it. A mathematical model was developed for a direct engine-PTO driveline. The model was proved experimentally to be accurate enough to simulate the dynamic characteristics of the PTO driveline motions. The simulation study showed that the rattle noise was caused by collisions between the driving and driven gears in the PTO gearbox due to velocity variation of the gears, which was induced by torque fluctuations from the engine. It was also found that the rattle noise decreased with the drag torque and mass moment of inertia of the engine flywheel. Smaller mass moment of inertia of the driven gears and backlash also reduced the rattle noise. However, increasing the drag torque and mass moment of the engine flywheel or decreasing the backlash and mass moment of inertia of the driven gears were limited practically by their detrimental effects on transmission efficiency, gear strength and smooth meshing of the gears.