• Journal of Haehwa Medicine
• /
• v.17 no.1
• /
• pp.173-180
• /
• 2008

Purpose : The purpose of this paper is to report the effect of oriental medicine to primary infertility caused by polycystic ovarian syndrome. Methods : The patient in this case, 29 years-old female was treated with oriental treatment for 3 month. Before oriental treatment, she had been diagnosed as primary infertility caused by polycystic ovarian syndrome and treated medication and injection for IUI(intrauterine insemination) in 4 times. But she had failed in gestation. Results : After lasting oriental treatments, she became pregnant. Conclusion : According to this result, we concluded the oriental medicine could improve fertility rate. After this paper, further study and clinical approach based on oriental medicine will be needed about infertility caused by polycystic ovarian syndrome.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.18 no.3
• /
• pp.242-249
• /
• 2005

Purpose : The purpose of this paper is to report the effect of oriental medicine to primary infertility caused by uterus unicornis. Methods : The patient in this case, 30 years-old female was treated with herb medication(Sosihotang, Gyejibokryeonghwan) for one month. Before oriental treatment, she had been diagnosed as primary infertility caused by uterus unicornis in Samsung Cheil Hospital and treated medication and injection for IUI(intrauterine insemination) in 2 times. But she had failed in gestation. Results : After taking herb medication she became pregnant. Conclusion : According to this result, we concluded that herb medication could improve fertility rate. After this paper, further study and clinical approach based on oriental medicine will be needed about infertility caused by uterus unicornis.

• Clinical and Experimental Reproductive Medicine
• /
• v.36 no.2
• /
• pp.111-119
• /
• 2009

Objective: The aim of this study was to compare the clinical efficacy of clomiphene citrate (CC) and letrozole combined with gonadotropins for controlled ovarian stimulation (COS) in patients with CC-induced thin endometrium Methods: Fifty-one intrauterine insemination cycles performed in patients who previously had a thin endometrium (<8 mm) to ovulation induction using CC were included in this study. A CC 100 mg/day (CC+gonadotropin group, n=26) or letrozole 2.5 or 5 mg/day (letrozole+gonadotropin group, n=25) was administered on day 3~7 of the menstrual cycle, combined with gonadotropins at dose 75~150 IU every other day starting on day 5~7. We compared total dose of gonadotropin used, endometrial thickness, endometrial pattern, number of follicles ${\geq}14\;mm$ on hCG day, pregnancy rate and multiple pregnancy rate between the two groups, which were statistically analyzed using Mann-Whitney U test or Fisher's exact test, where appropriate. Results: There were no significant differences in clinical characteristics such as age, duration of infertility, number of previous IUI cycles, basal serum hormone levels and cause of infertility between the two groups. In both groups, the endometrium was significantly thicker than that of previous ovulation induction cycles using CC. No significant differences were found in the total dose of gonadotropin used, day of hCG administration, the rate of triple endometrium and pregnancy rate. The number of follicles ${\geq}14\;mm$ was significantly lower ($3.7{\pm}1.7$ vs. $2.8{\pm}1.7$, p=0.03) and the endometrium on hCG day was significantly thicker ($7.7{\pm}1.5$ vs. $9.1{\pm}1.7$, p=0.001) in letrozole+gonadotropin group compared to CC+gonadotropin group. Conclusion: The clomiphene citrate and letrozole combined with gonadotropins appear to avoid the undesirable effects on the endometrium frequently seen with CC for ovulation induction. However, in terms of adequate endometrial development or optimal follicular growth, letrozole may be more beneficial than CC for gonadotropin-combined COS in patients with CC-induced thin endometrium. Further prospective randomized controlled studies in a larger scale will be necessary to confirm our findings.