• 동의생리병리학회지
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• 제24권6호
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• pp.1027-1033
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• 2010

This study aimed to evaluate the effects of Astragali radix on brain edema of intracerebral hemorrhage(ICH)-induced rats. Brain edema following ICH was induced via the stereotaxic intrastriatal injection of bacterial collagenase type VII in Sprague-Dawley rats. Ethanol extract of Astragli radix was treated once a day for 3 days. Then brain hematoma volume and edema were examined. Immunohistochemistry was processed for iNOS, c-Fos, Bax, and HSP72 expressions in the brain sections and each immuno-labeling were calculated with image analysis. Ethanol extract of Astragli radix reduced hematoma volume(not significantly) and brain edema(significantly) ICH induced rats. Ethanol extract of Astragli radix reduced iNOS expressions, c-Fos, Bax and HSP72 positive cells significantly and reduced apoptotic bodies and swollen neurons in ICH induced rat brain. These results suggest that Astragli radix plays an inhibitory role in the hemorrhagic, inflammatory and apoptotic events induced by ICH. And it is supposed that neuroprotective effect of Astragli radix reveals by anti-apoptosis mechanism.

• 한국병원경영학회지
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• 제15권2호
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• pp.15-26
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• 2010

Stroke is a high-risk disease. The future of the medical environment is that the proportion of elderly population is increasing, the average life expectancy is being increased, while the fatal rate of stroke will be low. These situation will due to the financial burden on medical insurance. The most important factor that affects on the medical costs of stroke patients is the length of stay. In this study the mean length of hospital for stroke stay was 21.81days(37.97days for intracerebral hemorrhage, 18.89 days for cerebral infarction). The payment per case of stroke was 6.86 million won(12.6 million won for intracerebral hemorrhage, 5.72 million won for cerebral infarction). The payment per case of intracerebral hemorrhage was 2.2 times more than that of cerebral infarction. The payment in the day of hospitalization was the highest and until the second day medical costs was high. After the third day medical costs tended to decline, after that seemed to show an almost constant level. The length of hospital stay was found to be the most important determinant of inpatient charges for stroke. Accordingly rational management of the length of stay will be beneficial to health care consumers, providers, states.

• 대한한방내과학회지
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• 제37권2호
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• pp.420-426
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• 2016

Objective: This case report examined a patient to determine if traditional Korean medicine treatment was effective for treating acute intracerebral hemorrhage (ICH) diagnosed with moyamoya disease.Method: The patient was treated with herbal medicine, acupuncture, and Western medicine and was followed up with for symptoms, vital signs, and brain computed tomography (CT) scans.Results: During the treatment, the patient’s mental state was mostly alert. The patient’s headaches were improved after the use of painkillers; the patient’s fever and blood pressure were well controlled. The cerebral hematoma was removed smoothly.Conclusion: Traditional Korean medical therapy (herbal medicine and acupuncture) along with Western methods appeared to be effective in managing the acute phase of ICH diagnosed with moyamoya disease.

• Journal of Korean Neurosurgical Society
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• 제38권6호
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• pp.425-430
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• 2005

Objective : Recently, the survival rate and prognosis of spontaneous intracerebral hemorrhage[S-ICH] has improved, and their enhanced survival has become associated with a consequent rise in the recurrence of S-ICH. The aim of this study is to improve the prevention of recurrent S-ICH. Methods : Between January 1999 and March 2004, we experienced 48 cases of recurrence. We classified the patients into the two groups; a double ICH group and a triple ICH group. We investigated their brain CTs, MRIs, cerebral angiographies, and medical records, retrospectively. Results : Majority of patients had the intervals at least 12 months, and most of patients underwent conservative treatment. The most common hemorrhage pattern of recurrence was ganglionic-ganglionic [basal ganglia - basal ganglia], and the second attack was contralateral side of the first attack in a large percentage of all patients. Prognosis of patients was worsened in recurrent attack. Nearly all patients had medical history of hypertension, and most patients have taken antihypertensive medication at the arrival of emergency room. Conclusion : In treating hypertension for S-ICH patients, we stress that blood pressure must be thoroughly controlled over a long period of time.

• Journal of Trauma and Injury
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• 제32권2호
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• pp.71-79
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• 2019

Purpose: Recent developments in minimally invasive techniques have the potential to reduce surgical morbidity, promote patient recovery, accelerate surgical procedures, and thus improve cost-effectiveness in case management. In this study, we compared the treatment efficacy and results of supraorbital keyhole approach (SOKA) with those of conventional unilateral frontal craniotomy (CUFC) for traumatic intracerebral hemorrhage (TICH) in the frontal lobe. Methods: We analyzed the data of 38 patients who underwent CUFC (n=30) and SOKA (n=8) and retrospectively reviewed their medical records and radiological findings. Furthermore, we tried to identify the best surgical method for such lesions by including patients who underwent burr hole aspiration and drainage (BHAD) (n=9) under local anesthesia due to various circumstances. Results: The difference in the initial Glasgow coma scale score, operative time, and length of hospitalization between the CUFC and SOKA were statistically significant. All radiological features between the two groups including associated skull fracture, amount of pre- and postoperative hematoma, percentage of complete hematoma removal, pre- and postoperative midline shifting of the hematoma, and development of postoperative delayed hematoma were not statistically significant. Our experience of 46 patients with TICH in the frontal lobe with any of the three different surgical methods including BHAD enabled us to obtain valuable findings. Conclusions: Although it is difficult to insist that one particular approach is more useful than the other, we are confident that SOKA will have more advantages over CUFC in carefully selected patients with frontal TICH depending on the surgical experience of a neurosurgeon.

• 대한영상의학회지
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• 제83권1호
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• pp.199-205
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• 2022

뇌정맥발달기형은 일반적으로 증상을 유발하지 않는 흔한 두개 내 혈관 기형이다. 뇌정맥발달기형과 관련된 출혈은 동반된 해면상 기형이 원인인 경우가 대부분인 것으로 알려져 있으며, 뇌정맥발달기형 내 혈전증이 뇌출혈을 일으킨 경우는 극히 드물게 보고되어 있다. 저자들은 혈전증을 유발할 수 있을 것으로 보이는 특이한 구조의 뇌정맥발달기형을 가진 환자에서 혈전증과 큰 뇌출혈이 생긴 1예를 경험하였기에 컴퓨터단층촬영 소견과 자기공명영상 소견을 보고하고자 한다.

• Investigative Magnetic Resonance Imaging
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• 제6권1호
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• pp.21-27
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• 2002

목적: 뇌실질내 혈종의 시기별 확산강조영상 소견을 알아보고자 하였다. 대상 및 방법: 임상적으로 뇌출혈의 시기가 분명한 환자 17명을 대상으로 하였다. 확산강조영상은 1.5 tesla 자기공명영상 기기를 이용하였으며, b 값은 세 방향 모두 $1000{\;}sec/\textrm{mm}^2$으로 하였다. 출혈 시기는 12시간 이하인 초급성기 5예, 3일 이하인 급성기 4예, 3주이하의 아급성기 4예, 3주 이후의 만성기 4예였다. 확산강조영상에서 혈종의 중심부와 주변부의 신호강도를 뇌실질 신호와 비교하여 bright, high, iso, low, dark 신호로 분류하여 분석하였으며, 각 시기의 T2강조영상과 T1강조영상에서의 신호강도와 비교 관찰하였다. 결과: 확산강조영상에서 초급성기 혈종의 중심부와 주면부는 각각 high와 dark신호를 보였고, 급성기는 중심부와 주변부가 각각 dark와 high-bright 신호강도를 보였다. 아급성기와 만성기는 중심부와 주변부가 high-bright와 dark 신호강도를 보였다. 시간 경과에 따른 혈종의 신호 변화는 전체적으로 T2강조영상에서의 신호 변화와 비슷하나, T2강조영상에 비해 빠르고 현저한 신호 변화를 보였다. 결론: 뇌실질내 혈종은 확산강조 자기공명영상에서 중심부와 주변부의 신호강도가 시기별로 특징적으로 변하며 중심부는 초급성기, 아급성기와 만성기에 high-bright신호를, 급성기에는 dark 신호를 보였고, 주변부는 초급성기, 아급성기와 만성기에 dark 신호를, 급성기에는 high-bright 신호를 보였다.

• Molecules and Cells
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• 제40권2호
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• pp.133-142
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• 2017

Previous studies have shown that bone marrow mesenchymal stromal cell (MSC) transplantation significantly improves the recovery of neurological function in a rat model of intracerebral hemorrhage. Potential repair mechanisms involve anti-inflammation, anti-apoptosis and angiogenesis. However, few studies have focused on the effects of MSCs on inducible nitric oxide synthase (iNOS) expression and subsequent peroxynitrite formation after hypertensive intracerebral hemorrhage (HICH). In this study, MSCs were transplanted intracerebrally into rats 6 hours after HICH. The modified neurological severity score and the modified limb placing test were used to measure behavioral outcomes. Blood-brain barrier disruption and neuronal loss were measured by zonula occludens-1 (ZO-1) and neuronal nucleus (NeuN) expression, respectively. Concomitant edema formation was evaluated by H&E staining and brain water content. The effect of MSCs treatment on neuroinflammation was analyzed by immunohistochemical analysis or polymerase chain reaction of CD68, Iba1, iNOS expression and subsequent peroxynitrite formation, and by an enzyme-linked immunosorbent assay of pro-inflammatory factors (IL-$1{\beta}$ and TNF-${\alpha}$). The MSCs-treated HICH group showed better performance on behavioral scores and lower brain water content compared to controls. Moreover, the MSC injection increased NeuN and ZO-1 expression measured by immunochemistry/immunofluorescence. Furthermore, MSCs reduced not only levels of CD68, Iba1 and pro-inflammatory factors, but it also inhibited iNOS expression and peroxynitrite formation in perihematomal regions. The results suggest that intracerebral administration of MSCs accelerates neurological function recovery in HICH rats. This may result from the ability of MSCs to suppress inflammation, at least in part, by inhibiting iNOS expression and subsequent peroxynitrite formation.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1995년도 제34차 춘계학술대회 초록집
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• pp.186-186
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• 1995

• Journal of Korean Neurosurgical Society
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• 제30권1호
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• pp.110-113
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• 2001

The cerebral arteriovenous malformation(AVM) rarely coexists with primary intracranial tumor. The authors experienced a patient with intracerebral hematoma due to AVM rupture in whom intracranial meningioma and intracranial aneurysms coexisted. The meningioma was located at convexity of right frontal lobe, and arteriovenous malformation at temporo-occipital lobe of same hemisphere with feeding from right middle cerebral artery, and three intracranial aneurysms exist at the cavernous portion of right internal carotid artery, AVM feeding artery, and intranidal of the AVM. The authors report a rare case of coexisted intracranial AVM, meningioma and aneurysms with review of literatures.