• The Journal of Internal Korean Medicine
• /
• v.35 no.3
• /
• pp.317-331
• /
• 2014

Objectives: The root of Platycodon grandiflorum (PG) has been known to possess a range of pharmacological activities including anti-cancer, anti-inflammatory, and anti-oxidant effects. The present study was designed to investigate whether or not PG-induced cell death was connected with autophagy and apoptosis in NCI-H460 human lung cancer cells. Methods: Effects on the cell viability and apoptotic activity were quantified using MTT assays and flow cytometry analysis, respectively. Protein activation was measured by immunoblotting. Autophagy was measured by LC3 immunofluorescence and immunoblotting. ROS production and loss of mitochondria membrane potential (MMP) were checked with flow cytometry analysis. Results: Following exposure to PG, NCI-H460 cell proliferation decreased simultaneously inducing autophagic vacuoles and up-regulation of microtubule-associated protein 1 light chain 3 and beclin-1 protein expressions. Interestingly, pre-treated with autophagy inhibitors, 3-methyladenin or bafilomycin A1 further triggered reduction of cell viability. PG treatment also induced apoptosis that was related modulation of Bcl-2 family proteins, death receptors and activation of caspases. In addition, PG stimulation clearly enhanced loss of MMP and reactive oxygen species (ROS) generation. Conclusions: Our results suggest that PG elicited both autophagy and apoptosis by increasing loss of MMP and ROS production. PG induced-autophagy may play a cell protective role.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.18 no.5 s.120
• /
• pp.503-510
• /
• 2007

This paper proposes the design scheme of internal triple band antenna intended for using in GSM900, DCS1800, and PCS1900 bands. The suggested folding metal plates of the two branches are mounted on a dielectric coated ground plane for size miniaturization and durability. Return losses are overlapped when length of metal branches are controlled. This is important technique for wide band operation. For the suggested antenna geometry its return loss was calculated by HFSS 9 simulator, and was shown to be -10 [dB] less within the required band. Also, gain and radiation pattern of antenna were measured using far field measurement system in an anechoic chamber. The measured peak gain is more than 3.0 [dBi], and the average gain is over -1.0 [dBi] for the triple band, which is regarded as satisfactory for the internal antenna application. Also, the radiation pattern for two frequencies shows a similar shape each other within the required band.

• 유체기계공업학회:학술대회논문집
• /
• 2004.12a
• /
• pp.419-426
• /
• 2004

A three-dimensional computation was conducted to understand effects of the inlet boundary layer thickness on the loss mechanism in a low-speed axial compressor operating at the design condition(${\phi}=85\%$) and near stall condition(${\phi}=65\%$). At the design condition, the flow phenomena such as the tip leakage flow and hub comer stall are similar independent of the inlet boundary layer thickness. However, when the axial compressor is operating at the near stall condition, the large separation on the suction surface near the casing is induced by the tip leakage flow and the boundary layer on the blade for thin inlet boundary layer but the hub corner stall is enlarged for thick inlet boundary layer. These differences of internal flows induced by change of the boundary layer thickness on the casing and hub enable loss distributions of total pressure to be altered. When the axial compressor has thin inlet boundary layer, the total pressure loss is increased at regions near both casing and tip but decreased in the core flow region. In order to analyze effects of inlet boundary layer thickness on total loss in detail, using Denton's loss models, total loss is scrutinized through three major loss categories in a subsonic axial compressor such as profile loss, tip leakage loss and endwall loss.

• Tuberculosis and Respiratory Diseases
• /
• v.50 no.6
• /
• pp.668-675
• /
• 2001

Background : Non-smalll lung cancer(NSCLC) develops as a result of the accumulation of multiple genetic abnormalities. Loss of heterozygosity(LOH) is one of the most frequent genetic alterations that is found in NSCLC, and the chromosomal regions that display a high rate of LOH are thought to harbor tumor suppressor genes(TSGs). This study was done to determine the frequency of LOH in 21q with the aim of identifying potential TSG loci. Method : Thirty-nine surgically resected NSCLCs were analysed. Patients peripheral lymphocytes were used as the source of the normal DNA. Five microsatellite Inarkers of 21q were used to study LOH : 21q21.1(D21S1432, and D21S1994); 21q21.2-21.3(D21S1442) ; 21q22.1(21S1445) ; and 21q22.2-22.3(D21S266). The fractional allelic loss(FAL) in a tumor was calculated as the ratio of the number of markers showing LOH to the number of informative markers. Result : LOH for at least one locus was detected in 21 of 39 tumors(53.8%). Among the 21 tumors with LOH, 5(21.8%) showed LOH at almost all informative loci. Although statistically not significant, LOH was found more frequently in squamous cell carcinomas(15 of 23, 65.2%) than in adenocarcinomas(6 of 16, 37.5%). In the squamous cell carcinomas the frequency of LOH was higher in stage II-III (80.0%) than in stage I (53.8%). The FAL value in squamous cell carcinomas($0.431{\pm}0.375$) was significantly higher than that found in adenocarcinomas($0.l92{\pm}0.276$). Conclusion : These results suggest that LOH on 21q may be involved in the development of NSCLC, and that TSG(s) that contribute to the pathogenesis of NSCLC may exist on 21q.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2008.04a
• /
• pp.795-800
• /
• 2008

The sound transmission loss is a key index to evaluate the acoustic performance of a car-body structure at the high frequency range. From this paper, a new validation method for in-situ sound transmission loss is proposed. First, in-situ sound transmission loss is measured by using PU intensity probe on the condition of complete vehicle. Second, validation test, which is consisted of internal, external and total frequency response function test, is performed by using volume acceleration source and microphones. Then, these test results are compared to validate the accuracy of in-situ sound transmission loss. Finally, the test result of in-site method is compared with results of two reverberant room test method and SEA analytical method. The reliability of in-situ method is confirmed by these procedures.

• The Journal of Economics, Marketing and Management
• /
• v.3 no.1
• /
• pp.33-39
• /
• 2015

Managers are always trying to be the best internal controls in their organizations copper approximate because they know that be effective internal control over previous systems, to fulfill the mission of the organization and minimize unexpected events will be extremely difficult. On the other hand, the existence of internal controls to increase efficiency, reduce head loss, assets and achieving a reasonable assurance of the reliability of financial statements and compliance with laws and regulations will be. Internal control, not an event, but a series of operations and activities on the basis of output. Internal controls help to achieve the goal of minimizing the problems of implementing appropriate internal controls. Internal control is an integral component of corporate governance that will provide reasonable assurance of achieving the organization's objectives. preventing, detecting errors and fraud goes to work. Responsibility for the prevention and detection of fraud and error in the public sector is the responsibility of managers. Managers of internal control and consistently applying appropriate accounting systems, this responsibility will play (Lin et al., 2011). Since the public sector organizations differ from each other, thus establishing internal controls cant be the same for all organizations and agencies of the public sector. Establish specific controls on each system to factors such as size, type of operation and organizational goals that the system is designed, it depends. On the other hand, rapid advances in information technology, the need to update internal control guidelines in relation to Create a new computer system so as to ensure that the activities of managers and effective control Should be updated if necessary.

• Kosin Medical Journal
• /
• v.33 no.3
• /
• pp.402-408
• /
• 2018

Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) are proposed as a novel approach for the management of type 2 diabetes mellitus. SGLT2 cotransporters are responsible for reabsorption of 90 % of the glucose filtered by the kidney. The glucuretic effect resulting from SGLT2 inhibition contributes to reduce hyperglycaemia and also assists weight loss and blood pressure reduction. In this study, we presented the case of a 59-year-old male who developed hyperosmolar hyperglycemic state (HHS), possibly caused by a sodium-glucose cotransporter 2 (SGLT2) inhibitor, a novel class of antihyperglycemic agents. This case highlights that HHS can develop in patients with diabetes treated with SGLT2 inhibitors.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.28 no.2
• /
• pp.171-183
• /
• 1992

In this paper, the behaviour of cavitation erosion, influence of corrosion and corrosion control on slide bearing metals for internal combustion engine were investigated, and this experiment was done by the vibratory cavitation erosion tester. The main results obtained are as follows: 1. With decreasing the space between horn and specimen, the weight loss and its rate increased step by step. But the weight loss and its rate of 0.2mm space decreased conversely more than that of 0.4mm space at early stage. 2. The weight loss and its rate with change of pH were appeared to the order of pH2>pH12>pH7>pH4. And the weight loss and its rate at pH 4 decreased at best. 3. The weight loss and its rate by cavitation erosion for bearing metals were shown to the order of W.M7>W.M1>K.M4. 4. There appeared mainly small pit hole at pH2, and appeared the pit of netting thread type at pH12 by the results of the damaged surfaces at pH2 and pH12 environments that were sensitive to cavitation erosion. 5. With increasing the viscosity of lubricating oil, the weight loss rate by cavitation erosion became dull at the space below 0.5mm. 6. The protective efficiency of cavitation erosion-corrosion is superior inhibitor of chormate(25 ppm) to cathodic protection.

• Journal of Hydrogen and New Energy
• /
• v.19 no.5
• /
• pp.367-376
• /
• 2008

To obtain the data of the pressure loss and differential pressure at the inside of the stack that was composed of 126 cells with 7,500 cm2 electrode area, 75kW molten carbonate fuel cell system has been operated. Computational fluid dynamics was applied to estimate reactions and thermal fluid behavior inside of the stack that was adopted with internal manifold type separator. The pressure loss coefficient K showed 72.29 to 84.01 in anode and 6.34 to 8.75 in cathode at low part of cells at the inside of 75 kW MCFC stack respectively. Meanwhile, the pressure loss coefficient of the higher part of cells at the interior of the stack showed 15.36 and 56.44 in anode and cathode respectively. These results mean that there is no big total pressure difference between anode and cathode at the inner part of 75 kW MCFC stack. This result will be reflected in 250kW MCFC system design.

• The Journal of Internal Korean Medicine
• /
• v.16 no.1
• /
• pp.1-16
• /
• 1995

This study was done in order to investigate the etiology and pathology of dementia in the variety literature. Dementia in elderly persons(above the age of 60) mainly classfied Alzheimer disease and Cerebral vascular dementia. The results were as follows: 1. Dementia patients have abnormal mental function, who have no mental weakness but defects of memory, verbal disturbance, behavior disturbance and loss of intellectual function. 2. Dementia regard as 'me-beng(?病)', 'jeon-gwang(癲狂)', and 'heo-ro(虛勞)' in oriental medicine and the symptom is a silence with no response, mixing, a crying or a laugh, a stranger behavior and a amnesia; disturbances of speech, emotion, behavior. 3. Dementia caused by Alzheimer disease, Multi infarct dementia, Parkinson's disease, sequelae of acute CO poisoning, head injury and alcoholism(occidental medically) and the 'Dam(痰) and Damhwa(痰火), weakness of heart and spleen(心脾虛) caused by pent up anger of seven emotions(七情鬱結), the weakness of liver and kidney(肝腎不足)(oriental medically). 4. The causes of Alzheimer disease are various; a heredity factor, a morphological factor of brain tissues, a psychological factor and a biochemical factor (occidental medically) ; the 'Dam(痰) and Damhwa(痰火) caused by weakness of the internal organs and disturbance of the emotions(oriental medically). 5. Cerebral vascular dementia caused by loss of the certain cerebral neurons and oriental medically caused by obstruction of 'dam(痰)' or 'eo heul(瘀血)'. It is recommended that further study of many sided investigations, specially against a weakness of spiritual functions and a certain neurotoxin in the future.