• Tuberculosis and Respiratory Diseases
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• 제85권1호
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• pp.18-24
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• 2022

Background: Neutrophilic asthma (NeuA) is usually resistant to corticosteroids. Tiotropium bromide (TIO) is a bronchodilator that is used as an add-on therapy to inhaled corticosteroid and long-acting β2 agonist in asthma treatment. However, the role of TIO in NeuA is not fully known. Thus, the aim of this study was to evaluate the effect of TIO on NeuA compared to that of corticosteroids. Methods: C57BL/6 female mice were sensitized with ovalbumin and lipopolysaccharide to induce neutrophilic inflammation. Dexamethasone (DEX) was administered on days 14, 17, 20, and 23. TIO was inhaled on days 21, 21, and 23. On day 24, mice were sacrificed. Airway hyper-responsiveness, levels of cytokines in bronchoalveolar lavage (BAL) and lung homogenates, and lung tissue histopathology were compared between the two groups. Results: Neutrophil counts, T helper 2 cells (T_H2)/T_H17 cytokines, and pro-inflammatory cytokine in BAL fluids were elevated in the NeuA group. TIO group showed lower total cells, neutrophil counts, and eosinophil counts in BAL fluids than the DEX group (p<0.001, p<0.05, and p<0.001, respectively). Airway resistance was attenuated in the TIO group but elevated in the NeuA group (p<0.001). Total protein, interleukin (IL)-5, and IL-17A levels in BAL fluids were lower in the TIO group than in the NeuA group (all p<0.05). Conclusion: TIO showed more potent effects than DEX in improving airway inflammation and attenuating airway resistance in NeuA.

• 한국음향학회지
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• 제31권3호
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• pp.142-150
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• 2012

도파관유한요소법 (waveguide finite element method, WFEM)은 단면의 형상이 길이방향으로 일정한 도파관 구조물의 진동을 해석하기 위한 수치해석 기법이다. 도파관유한요소법은 2차원 단면만을 FE 모델링하여 길이방향 파동 전파를 해석하므로 기존의 유한요소법에 비해 해석 모델의 크기가 작고 연산 시간이 짧다는 장점을 가진다. 본 연구에서는 기존의 도파관유한요소법을 확장하여 내부 및 외부에 유체가 채워진 도파관 구조물에 대한 진동 해석을 수행하였다. 이를 위해 내부 유체와 도파관 구조물은 WFE로, 외부 유체는 파수경계요소 (waveguide boudnary element, WBE)로 모델링하고 이들을 연성시킨 운동방정식을 제시하였다. 이 방법의 적용 예로써 내부에 물이 채워진 몰수된 파이프의 진동 및 방사 음향 파워를 해석하였다. 내부 및 외부 유체의 유/무에 따른 분산 선도와 가진점 모빌리티 (point mobility)를 구하고 유체 연성의 효과를 살펴보았다.

• 한국전산유체공학회지
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• 제7권2호
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• pp.17-24
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• 2002

The transient flow fields in a direct injection engine was analyzed by using the STAR-CD CFD code doting the intake/compression processes. The analyses were focused on the computation grid generation by using the IC3M code which is a pre-developed and especially well adapted for the analyses of internal combustion engine. The results showed that the used grid generation technique was well suited for the flow analyses on any internal combustion engine.

• 한국전산유체공학회지
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• 제12권2호
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• pp.46-52
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• 2007

An experimental and numerical investigation of the ejector-jets focusing on its geometric parameters that effect on thrust performance was carried out. The area ratio of the primary nozzle that was tested in the present study was 2.17 and 3.18, while the ratio of the length to the diameter of the duct downstream the primary nozzle inlet had values of 3.41, 6.82, and 10.23. Internal flow properties of ejector-jet were estimated by comparison experiment data and CFD analysis for basic study of ejector-jet thrust performance. For examination of thrust performance, the thrust ratios increased with increase in L/D. Especially at AR=2.17, the maximum thrust augmentation was 33 percent for the shortest L/D. It is expected that the increase of mixing duct length of ejector-jet will be helpful in a thrust performance by improving mixing efficiency.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년도 12th Asian Congress of Fluid Mechanics
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• pp.80.5-81
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• 2008

• 한국전산유체공학회지
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• 제14권1호
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• pp.9-17
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• 2009

In this study we investigated the characteristics of fluid flow and heat transfer within a coolant passage in the cylinder head assembly of an internal combustion engine by using a commercial CFD code, CFX The complex coolant passage of the cylinder head assembly was modelled by suitable choice of a grid system and careful attention was paid in the construction of meshes near the walls where significant cooling occurs. To treat the simultaneous heating and cooling of the combustion walls we invented a methodology allowing a heat source within the solid wall and the convective cooling at the interface between the solid and the fluid. We managed to reproduce the experimental results by adjusting parameters appropriately. We have found that high temperature was concentrated at the surface of the cylinder jacket. It turned out that the effect of oil cooling from the piston head was unexpectedly significant. On the other hand the effect of cooling from the ambient air is almost negligible. The CFD method proposed in this study is believed to be useful in the early stage of the design of the engine-cooling system.

• The Korean Journal of Medicine
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• 제99권4호
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• pp.199-205
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• 2024

Benign small bowel strictures can occur in association with various conditions, including small bowel Crohn's disease, nonsteroidal anti-inflammatory drug-induced enteritis, ischemic enteritis, intestinal tuberculosis, radiation enteritis, postoperative adhesions, and anastomotic strictures. Benign small bowel strictures are classified into two categories, low-grade and high-grade. Low-grade small bowel strictures involve a partial reduction of the internal diameter of the small intestine, causing slight obstruction of the passage of food and digestive fluids without significant bowel obstruction symptoms. By contrast, high-grade small bowel strictures involve a severe narrowing of the intestinal lumen, leading to marked obstruction of the passage of food and digestive fluids and pronounced bowel obstruction symptoms. Small bowel strictures can be diagnosed using various methods, including abdominal plain radiography, abdominal computed tomography, computed tomography enterography, magnetic resonance enterography, balloon-assisted enteroscopy, and abdominal ultrasound. Each diagnostic method has unique advantages and disadvantages as well as differences in diagnostic specificity and sensitivity. Therefore, even if small bowel strictures are not observed using a single imaging technique, their presence cannot be completely excluded. A comprehensive diagnosis that combines clinical information from multiple diagnostic modalities is necessary. Therapeutic approaches for managing small bowel strictures include medical therapy, endoscopic balloon dilation using balloon-assisted enteroscopy, and surgical methods such as strictureplasty and segmental resection. Endoscopic balloon dilation, in particular, can help reduce complications associated with repeated surgeries for strictures.

• 한국유체기계학회 논문집
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• 제7권4호
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• pp.32-39
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• 2004

This study deals with the Benard Flow of Magnetic Fluids in a rectangular cavity which the ratio between height and width is 1 : 4 and the base side or left side is a heating face while other sides are to be cooling faces. When Magnetic field was equally impressed, considering the internal rotation of the elementary ferromagnetic particle, we found the following result from the numerical analysis of the GSMAC algorithm applied to the equation of the magnetic fluid. Benard flow is controlled by intensity and direction of magnetic fields, and critical point appears when especially magnetic field with a heating base and side area near H=-7000 and H=-10000 is applied.

• 한국자기학회지
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• 제12권2호
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• pp.73-79
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• 2002

자성유체는 고액혼상유체로 뉴턴유체와 달리 자기력에 반응하는 유체이다. 본 연구에서는 금속과 유체의 특성을 겸비한 자성유체의 열전달 특성을 밀도 있게 연구함을 목적으로, 그 대상을 이중원관으로 하여 열대류현상을 고찰하기 위해 내부원관을 가열하고, 외부원관을 냉각하면서, 또한 외부에서 인가자장의 세기와 방향에 따라 자연대류 현상의 변화 및 열전달 특성을 수치해석적으로 연구하여, 실험결과와 비교 검토하였다. 자성유체의 자연대류현상은 인가자장에 따라 제어할 수 있었고, 평균 뉴셀트수를 구한 결과로서 자장을 가하지 않았을 경우와 비교해 보면 열전달은 자장을 중력방향으로 가하거나 중력과 반대방향으로 그세기를 -14 mT이상 가했을 때 증가하였고, 중력과 반대방향으로 감했을 때 감소하였다. 특히 자장의 세기가 -14 mT가 되면 열전달은 최소가 되었다.

• Journal of Advanced Marine Engineering and Technology
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• 제22권2호
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• pp.190-199
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• 1998

a new measuring method is suggested to determine the time constant of a thermocouple wire to be applied for the measurement of the true fluid temperatures in varying flow states. Based on the techniques of internal heating which are commonly used to measure mean time constants we extend the existing method to measure instantaneous time constants continuously. A method of measurement and analysis is presented and verified experimentally.