• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2012.05a
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• pp.110-116
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• 2012

To analyze flow characteristics and performance of the side jet thruster with 4 shutters and rectangular nozzles, a 3-D simulation has been implemented. Numerical calculations for three rotation anlgles of the shutter, have been conducted. Internal recirculation in a chamber and asymmetric flow structure in a nozzle were observed. In addition, the more shutter rotated, the more asymmetries of flow increased, and this phenomena resulted in thrust bias. The degrees of thrust bias and thrust performance with the rotation angles of the shutter were predicted and comparisons with theoretical thrust were made.

• Journal of the Korean Society of Propulsion Engineers
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• v.17 no.2
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• pp.63-70
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• 2013

To analyze flow characteristics of the side jet thruster with 4 shutters and rectangular nozzles, a 3-D simulation has been implemented. Numerical calculations for two rotation angles of the shutter, have been conducted. Internal recirculation in a chamber and asymmetric flow structure in a nozzle were observed. In addition, the more shutter rotated, the more asymmetries of flow increased, and this phenomena resulted in thrust bias. The degrees of thrust bias and thrust performance with the rotation angles of the shutter were predicted and compared with theoretical thrust.

• Tuberculosis and Respiratory Diseases
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• v.85 no.1
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• pp.25-36
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• 2022

Background: Only a few studies directly compared the therapeutic efficacy and safety of two pressurized metered-dose inhalers (pMDIs) in asthma. We analyzed the asthma treatment outcomes, safety, and patient preferences using formoterol/beclomethasone (FORM/BDP), a pMDI with extra-fine particles, compared with formoterol/budesonide (FORM/BUD), another pMDI with non-extra-fine particles. Methods: In this randomized, double-blind, double-dummy parallel group study, 40 adult asthmatics were randomized to FORM/BDP group (n=18; active FORM/BDP and placebo FORM/BUD) or FORM/BUD group (n=22; active FORM/BUD and placebo FORM/BDP). During the two visits (baseline and end of 8-week treatment), subjects were asked to answer questionnaires including asthma control test (ACT), asthma control questionnaires (ACQ), and Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA). Lung function, compliance with inhaler, and inhaler-handling skills were also assessed. Results: Ten subjects in the FORM/BDP group and 14 in the FORM/BUD group completed follow-up visits. ACT, ACQ, QLQAKA (a primary outcome), and adverse events did not differ between two groups. We found that the increase in forced expiratory volume in 1 second/forced vital capacity and forced expiratory flow at 25% to 75% of the pulmonary volume in the FORM/BDP group was higher than in the FORM/BUD group. Regarding preference, subjects responded that the flume velocity of FORM/BDP was higher, but more adequate than that of FORM/BUD. They also answered that FORM/BDP reached the trachea and bronchus and irritated them significantly more than FORM/BUD. Conclusion: The use of pMDI with extra-fine particles may relieve small airway obstruction more than the one with non-extra-fine particles despite no significant differences in overall treatment outcomes. Some asthmatics have a misconception about the adequacy of high flume velocity of pMDIs.

• Journal of applied mathematics & informatics
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• v.15 no.1_2
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• pp.127-146
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• 2004

In this paper we consider a heat flow in an inhomogeneous. body without internal source. There exists special initial and boundary conditions in this system and we intend to find a convenient coefficient of heat conduction for this body so that body cool off as much as possible after definite time. We consider this problem in a general form as an optimal control problem which coefficient of heat conduction is optimal function. Then we replace this problem by another in which we seek to minimize a linear form over a subset of the product of two measures space defined by linear equalities. Then we construct an approximately optimal control.

• The Journal of Internal Korean Medicine
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• v.26 no.2
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• pp.310-319
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• 2005

Objectives: The aim is to identify any anti-tumor effects of Duchesnea indica(Andr.) Focke on colon cancer cells. Materials & Methods: Colo201 human adenocarcinoma cells were obtained from American Type Culture Collection. The boiled extract of Duchesnea indica(Andr.) Focke was added (10 and 20 microliters) to cultures and observed at 0, 6, and 12 hours, and at 12-hour intervals thereafter. Morphological changes in colon cancer cells were observed through an inverted microscope, Destruction of colon cancer cells was measured through Trypan blue exclusion testing. Suppression of the viability of colon cancer cells were measured via MTT assay. Anti-cancer mechanisms in the cell cycle of colon cancer cells were analysed via flow cytometry. Results: After introduction of Duchesnea indica(Andr.) Focke to cultures several changes were seen. Significant atrophy of the nucleus and cytoplasm of colon cancer cells was observed, indicating cell injury. Destruction of colon cancer cells was observed in direct proportion to dosage and duration. Suppression of viability of colon cancer cells for each test group was greater than that of the control group increasingly over time(36h, 48h, 60h, 72h), which was statistical significant (p<0.05). Cell numbers of the mitosis phase of the colon cancer cell cycle reduced. Conclusions: Statistcally significant anti-tumor effects of Duchesnea indica(Andr.) Focke were observed in this in vitro experiment. Results support a role for Duchesnea indica(Andr.) Focke in treatment of colon cancer. though it will required progressive research to develop a practical treatment.

• Tunnel and Underground Space
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• v.25 no.1
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• pp.46-55
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• 2015

A water tube with detonating cord was devised to control the blast dust. Water diffusion experiments with different detonating cord positions were conducted during the series of experiments to optimize the design parameters of the tube. Images from high speed camera were analyzed to evaluate the results. AUTODYN program was adopted to simulate the diffusion process of water and compared with the images. Diffusion of water shows cross flow in case of external charge while the internal case shows radial flow. A bubble ring was formed during the numerical analysis of internal charge case as occurred in underwater blast. An additional bubble ring was formed by the reflection pressure from the ground. And the Weber number was determined as sufficient for spray atomization performance of the water tube.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.2
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• pp.438-443
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• 2007

The purpose of this research is to examine the effects of Kamijihwang-tang(KJHT) on CD+4 T cells and CD8+ T cell ovalbumin (OVA)-induced asthmatic mice. C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (four a week) for asthma induction. Two experimental groups were treated with different concentrations of KJHT (400 mg/kg and 200 mg/kg) extract and cyclosporine A (10 mg/kg) for the later 8 weeks. At the end of the experiment, the mice lung, peripheral lymph node (PLN), and spleen were removed and CD4+ T cells and CD8 + T cells for analyzed by flow cytometer. Number of CD4+ T cells in lung, PLN, spleen of the KJHT group (400 mg/kg) were significantly decreased compared with that of control group. Number of CD8+ T cells in lung, PLN, spleen of the KJHT group (200 mg/kg) were significantly decreased compared with that of control group. The results of this study suggest that KJHT alleviated asthmatic hyperactivity through CD4+ and CD8+ T cells. Further study of relative cytokines is expected.

• Advances in aircraft and spacecraft science
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• v.10 no.4
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• pp.317-334
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• 2023

This paper presents a basic methodology and a set of numerical tools for the preliminary design of solid-fueled ramjet missiles. An elementary code determines the baseline system configuration comprised of warhead, guidance-control, and propulsion masses and geometries from specific correlations found in the literature. Then, the system is refined with the help of external and internal ballistics codes. Equations of motion are solved for the flight's ascending, cruising, and descending stages and the internal ballistic set of equations designs the ramjet engine based on liquefying fuels. The combined tools sized the booster and the ramjet sustainer engines for a long-range missile, intended to transport 200 kg of payload for more than 300 km range flying near 14,000 m altitude at Mach 3.0. The refined system configuration had 600 mm in diameter and 8,500 mm in length with overall mass of 2,128 kg and 890 kg/m3 density. Ramjet engine propellant mass fraction was estimated as 74%. Increased missile range can be attained with paraffin-polyethylene blend burning at near constant regression rate through primary air mass flow rate control and lateral 2-D air intakes.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.26 no.7
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• pp.329-334
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• 2014

This study indicated the possibility of energy regeneration from waste coolant heat, by using thermoelectric generation integrated with heat pipe. The internal combustion engine rejects more than 60% wasteful energy to the atmosphere by heat. The thermoelectric generator has recently been studied, to convert the energy from engine waste heat into electricity. For coolant waste heat recovery, a thermoelectric generator was investigated, to find out the possibility of vehicular application. Performance characteristics were conducted with various test conditions of coolant temperature, coolant mass flow rate, air temperature, and air velocity, with the thermoelectric generator installed either horizontally or vertically. Experimental results show that the electric power and conversion efficiency increases according to the temperature difference between the hot and cold side of the thermoelectric generator, and the coolant flow rate of the hot side heat exchanger. Performance improvement can be expected by optimizing the heat pipe design.

• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.148-151
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• 2008

In a double-passage cascade apparatus, only two blades are installed in order to increase the accuracy of experimental result by applying bigger blade than the size of multi-blades on the same apparatus. However, this causes difficulties to make correct periodic condition. In this study, sidewalls are designed to meet periodic condition without removing the operating fluid or adjusting tail boards. Surface Mach number on the blade surface is applied to a responsible variable, and 12 design variables which are related with sidewall profile control are selected. A gradient based optimization is adopted for wall design and CFX-11 is used for the internal flow computation. The computed result shows that it could obtain the same flow structure by modifying only the sidewalls of the double-passage cascade apparatus.