• 대한한방내과학회지
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• 제36권2호
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• pp.105-121
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• 2015

Objectives: This study investigated the effects of Gagam-daewhang mangcho-tang (GDM) and its components on cerulein-induced acute pancreatitis (AP) in mice Methods: The AP mouse model was induced by intra-peritoneal injection of cerulein (50 μg/kg) at hourly intervals for 6 times. The experimental drug was administrated intraperitoneally 1 hour prior to the first injection of cerulein. Mice were sacrificed at 6 hours after the last injection of cerulein. Blood samples were taken to determine serum amylase level. The pancreas and lungs were rapidly removed for histochemical examination and myeloperoxidase (MPO) assays. Results: Administration of modified GDM significantly reduced the ratio of pancreas/body weight, level of serum amylase, neutrophil infiltration, and histological damage of the pancreas and lung. In a test of the components of GDM, the Salvia miltiorrhiza (SM) group showed a significant suppression of the severity of AP. In an experiment testing the concentration of SM, the 150 mg/kg SM group showed significant attenuation of the severity of AP. Conclusions: Modified GDM and a SM water extract could attenuate AP and AP-associated lung injury via suppression of digestive enzyme secretion and MPO activity.

• 한국산학기술학회논문지
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• 제17권7호
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• pp.687-693
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• 2016

항공기의 가속도 운동이나 급격한 선회는 연료탱크 내부에서 슬로싱(연료 쏠림) 현상을 발생시킨다. 급격한 기동으로 발생하는 슬로싱 현상은 연료탱크 내부에 장착되는 구성품들에 상당한 하중으로 작용될 수 있다. 심각한 상황에서는 연료탱크 내부 구성품 및 배관의 파손이 발생하여 연료탱크 자체의 찢어짐으로도 이어질 수 있다. 따라서, 슬로싱 현상에 대해 연료탱크 내부 구성품이 구조 건전성을 보유하도록 설계되어야만 승무원의 생존성을 향상시킬 수 있다. 이러한 점을 고려하여 연료탱크 내부 구성품의 설계를 위해서는 구성품에 작용하는 슬로싱 하중의 확보가 선행되어야 한다. 본 논문에서는 회전익 항공기용 연료탱크 내부에서 발생할 수 있는 슬로싱 수치해석을 수행하여 내부 구성품에 작용하는 슬로싱 하중을 고찰하였다. 슬로싱 수치해석을 위해 입자법을 기반으로 하는 유체-구조 연성해석을 수행하였고, 미군사 규격(MIL-DTL-27422D)에서 규정하는 시험조건을 수치해석 조건으로 적용하였다. 수치해석 결과로써 슬로싱 현상에 의해 회전익항공기용 연료탱크 내부 구성품에 작용하는 하중과 최대 등가응력을 분석함으로써 유체-구조 연성해석을 통해 슬로싱 하중을 고려할 수 있는 설계 데이터 확보 가능성을 검토하였다.

• 대한한방내과학회지
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• 제34권2호
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• pp.165-177
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• 2013

Objectives : The object of this study was to observe the protective effects of 8 types of individual herbal components of Yijintang-gamibang, on the reflux esophagitis (RE) in rats as compared with omeprazole. Methods : Each 100 mg/kg individual herbal component was orally pretreated, at 1 hr before and 6 hrs after pylorus and forestomach ligation, the changes on the esophageal lesion areas, gastric volumes, acid and pepsin outputs, antioxidant effects, esophageal total hexose and sialic acid contents were observed with changes on the esophageal histopathology. The results were compared with an omeprazole 10 mg/kg treated group. Results : Pylorus and forestomach ligation-induced RE were inhibited by treatment of all 8 herbal components and omeprazole except for Pinella Rhizoma and Massa Meicata Fermentata, in order of Atractylodis Rhizoma, Citri Pericarpium, omeprazole, Glycyrrhizae Radix, Hordei Fructus Germiniatus, Holelen and Citri Pericarpium, as compared with RE control. Pinella Rhizoma and Massa Meicata Fermentata did not show any favorable protective effects against RE nor antioxidant effects in the present study. Conclusions : The main active herbal components showing favorable protective effects on RE of Yijintang-gamibang mediated by antioxidant effects, were Atractylodis Rhizoma, Citri Pericarpium, Glycyrrhizae Radix, Hordei Fructus Germiniatus, Holelen and Citri Pericarpium. Furthermore Atractylodis Rhizoma and Citri Pericarpium showed more favorable protective effects as compared with omeprazole, therefore, it is expected that Atractylodis Rhizoma and Citri Pericarpium have potential as new alternatives or safe therapeutics against RE.

• 대한한의학회지
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• 제33권3호
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• pp.160-183
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• 2012

Objectives: Coptidis Rhizoma is one of the most popular and multi-purpose herbs in traditional medicine. The purpose of this study was to contribute to research and applications of Coptidis Rhizoma in clinic, by analyzing and reviewing international studies on its chemical compositions and pharmacological effects. Methods: This study analyzed 344 articles published from 2000 to 2010 in PubMed, Refworks, Riss, and KTKP. The search keywords were "Coptis chinensis", "Coptis japonica", "Coptidis Rhizoma", "huanglian" and "huanglian in Chinese". From them, we selected 114 articles which met our inclusion criteria. Results: This study reviewed 114 articles on Coptidis Rhizoma and its active components in terms of 'Active components', 'Experimental studies', 'Clinical studies', 'Industrial use' and 'Side Effects/Toxicity'. Conclusions: The active components of Coptidis Rhizoma are berberine, coptisine, epiberberine, palmatine, jateorrhizine, magnoflorine, worenine, etc. It is reported that Coptidis Rhizoma and its active components have anti-inflammatory, antibacterial, antitumor, and antioxidant activity, and cardiovascular, hepatoprotective, antidiabetic, neuroprotective, gastrointestinal, pain relieving, discharge phlegm and metrocyte proliferation effects. Moreover, we found that Coptidis Rhizoma can be used for bath preparation, cosmetic products and as a natural antimicrobial substance.

• ETRI Journal
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• 제29권6호
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• pp.811-813
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• 2007

We report on a ridge waveguide laser diode with laterally tapered waveguides fabricated in a single growing step using a double patterning method. In this structure, nearly constant output power is obtained with the change of the lower tapered waveguide width, and the facet power ratio of 1.4 to 1.5 is observed over the current range. The asymmetric facet power property is also investigated.

• 한국자동차공학회논문집
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• 제17권4호
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• pp.63-71
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• 2009

The elastic effects of the valve train components are analyzed by using the finite element models of the rocker arm and valve. The whole equations of motion of the valvetrain of an internal combustion engine formulated by finite element techniques are solved by imposing the contact conditions with the augmented Lagrange multiplier method. The velocity and acceleration constraints as well as the displacement constraints are imposed on the contact points. The numerical simulations show that, even if the magnitude of the elastic deformation of the components is very small, it may have large effects on the valvetrain dynamics of a high-speed engine.

• 한국자동차공학회논문집
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• 제11권2호
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• pp.31-39
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• 2003

Numerical analysis for valve train dynamics of an internal combustion engine is presented. The components of the valve train are modeled by finite element techniques, and the dynamic contacts between the components are analyzed by the solution strategies of differential algebraic equations. Also an iterative scheme similar to the augmented Lagrange multiplier method is employed to enforce the contact constraints. It is shown that the contact and separation between the components of the valve train can be computed by the finite element techniques, and the numerical examples are presented to demonstrate the efficiency of the solution.

• 한국컴퓨터정보학회논문지
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• 제21권2호
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• pp.131-136
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• 2016

This study aims to present suggestions on the causes and effects between internal marketing and customer-oriented trends of social welfare halls based on the issue that internal marketing should be activated based on previous studies on the relationship between internal marketing and customer-oriented trends. For this purpose, as a result of analysing the research hypothesis through a questionnaire, this study has meaning in that it supported the results of previous studies on internal marketing and customer-oriented trends as theoretical suggestions and analysed the relationship between internal marketing and customer-oriented trends. It was politically suggested and emphasized that internal marketing is needed in social welfare halls and to encourage social welfare workers to be customer-oriented, components of internal marketing should be established in an organic and systematic manner.

• Kidney Research and Clinical Practice
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• 제37권4호
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• pp.393-403
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• 2018

Background: This study compared nutritional parameters in hemodialysis (HD) subjects and controls using bioimpedance analysis (BIA) and investigated how BIA components changed before and after HD. Methods: This cross-sectional study included 147 subjects on maintenance HD from two hospitals and 298 propensity score-matched controls from one healthcare center. BIA was performed pre- and post-HD at mid-week dialysis sessions. Results: Extracellular water/total body water (ECW/TBW) and waist-hip ratio were higher in the HD patients; the other variables were higher in the control group. The cardiothoracic ratio correlated best with overhydration (r = 0.425, P < 0.01) in HD subjects. Blood pressure, hemoglobin, creatinine, and uric acid positively correlated with the lean tissue index in controls; however, most of these nutritional markers did not show significant correlations in HD subjects. Normal hydrated weight was predicted to be higher in the pre-HD than post-HD measurements. Predicted ultrafiltration (UF) volume difference based on pre- and post-HD ECW/TBW and measured UF volume difference showed a close correlation ($r^2=0.924$, P < 0.01). Remarkably, the leg phase angle increased in the post-HD period. Conclusion: The estimated normal hydrated weight using ECW/TBW can be a good marker for determining dry weight. HD subjects had higher ECW/TBW but most nutritional indices were inferior to those of controls. It was possible to predict UF volume differences using BIA, but the post-HD increase in leg phase angle, a nutritional marker, must be interpreted with caution.

• ETRI Journal
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• 제33권2호
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• pp.275-278
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• 2011

This letter presents a polymer $1{\times}2$ thermo-optic totalinternal-reflection digital optical switch (TIR-DOS) with an index contrast of 1.5%-${\delta}$ operating at low power consumption. The structure of our $1{\times}2$ TIR-DOS was created by adding a reflection port to that of a conventional multimode filtering variable optical attenuator. To improve the total-internalr-eflection efficiency, a heater offset was applied to the crossing region of multimode waveguides of the TIR-DOS. The fabricated $1{\times}2$ TIR-DOS shows a low electrical power consumption of 18 mW for an on-off ratio of 35 dB.