• Tuberculosis and Respiratory Diseases
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• 제57권5호
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• pp.470-475
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• 2004

저자들은 특별한 원인질환 없이 말초혈액내의 호산구 증가와 골수의 호산구 증식 소견을 보이면서 양측성 흉막삼출과 양측성 재발성 기흉으로 발현된 과호산구증후군을 진단하고 부신피질호르몬 경구치료로 호전을 보인 환자 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제76권1호
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• pp.38-41
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• 2014

Immunoglobulin G4 (IgG4)-related disease is a newly recognized condition characterized by fibroinflammatory lesions with dense lymphoplasmacytic infiltration, storiform-type fibrosis and obliterative phlebitis. The pathogenesis is not fully understood but multiple immune-mediated mechanisms are believed to contribute. This rare disease can involve various organs and pleural involvement is even rarer. We report a case of IgG4-related disease involving pleura. A 66-year-old man presented with cough and sputum production for a week. Chest radiography revealed consolidation and a pleural mass at right hemithorax. Treatment with antibiotics resolved the consolidation and respiratory symptoms disappeared, but the pleural mass was unchanged. Video-assisted thoracoscopic surgery was performed. Histopathology revealed dense lymphoplasmacytic infiltration and storiform fibrosis with numerous IgG4-bearing plasma cells. The serum IgG4 level was also elevated. Further examination ruled out the involvement of any other organ. The patient was discharged without further treatment and there is no evidence of recurrence to date.

• Tuberculosis and Respiratory Diseases
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• 제79권3호
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• pp.184-187
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• 2016

Since IgG4-related pancreatitis was first reported in 2001, IgG4-related disease has been identified in other organs such as salivary gland, gallbladder, thyroid, retroperitoneum and kidney; but lung invasion is rare. A 63-year-old man presented with hemoptysis at the pulmonary clinic and chest computed tomography revealed about 4.1 cm irregular shaped mass with spiculated margin at the left upper lobe. Despite no elevation of serum IgG4 level, he was finally diagnosed as IgG4-related lung disease by transthoracic needle biopsy. After treatment with oral glucocorticoids, hemoptysis disappeared and the size of lung mass was decreased.

• Tuberculosis and Respiratory Diseases
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• 제56권1호
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• pp.91-96
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• 2004

저자들은 기침을 주소로 내원한 62세 여자환자에서 폐소세포암의 진단과 함께, 경피적 세침 생검 흡입술로 확진된 반대측 유방전이 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 동의생리병리학회지
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• 제23권1호
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• pp.34-40
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• 2009

After a research on appearance diagnosis and fish, bird, horse, and turtle types, this study concluded as following. Appearance diagnosis is a technique that exams five jang organs by color and shape of eye, nose, mouth, and ear. Four HyungSang types-including fish, bird, horse and turtle types-are evaluated upon the external shape that are created while type of seed changes. Appearance diagnosis focuses on five jang organs. Four HyungSang types focus on external shape, but are eventually related to five jang organs. Thus, two different techniques possess a point in common; five jang organs. The assignment of nose, eye, ear and mouth to the Five elements varies between two techniques. On the viewpoint of formation, appearance diagnosis assigns them to metal-water-wood-fire-earth and movement, and four HyungSang types do to wood-fire-earth-metal-water and constitution. On the viewpoint of body/use and static/dynamic, appearance diagnosis assigns them to metal-water-wood-fire-earth and constitution, and four HyungSang types do to wood-fire-earth-metal-water and movement. If nose, eye, ear, and mouth are assigned by on four HyungSang types, which are based on external shape, the assignment can be utilized in diagnosis. If, however, they are assigned by appearance diagnosis, it can be focus on treatment. Five jang organs and six fu organs are affected by internal conditions because they are located inside of human body, while four HyungSang types are affected by external conditions because it deals with external shape. If a disease occurs in the developed part of the body, it would be difficult to be cured because four HyungSang types depend on external shapes.

• 대한한의학회지
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• 제30권3호
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• pp.79-85
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• 2009

Aim : To evaluate the pharmaceutical safety of the herbal formula Myelophil, composed of Astragali Radix and Salviae Radix, via systemic subacute toxicological study using SD rats. Methods : Forty male and 40 female SD rats were fed with Myelophil (5000, 2500 or 1250 mg/10 mL/kg) or distilled water for four weeks. Adverse effects were examined intensively by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, hematology, urinalysis, and blood biochemical analysis. Results : No altered clinical symptoms including body weight, diarrhea, anorexia, death, and abnormal necropsy of major organs were observed in male or female rats. No drug-induced abnormalities in histopathological finding, hematological values, urinalysis, and blood biochemical values were found at any doses of Myelophil. Conclusion : Myelophil should be very safe when used in a clinical application with a wide therapeutic index.

• Environmental Analysis Health and Toxicology
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• 제16권2호
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• pp.43-50
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• 2001

A daily newspaper in Korea addressed an controversial issue recently that the concentration of radon measured from the groundwater in Taejon was found out a relatively high level. The cancer risk arising from ingestion of such radon should be derived from calculation of the dose absorbed by the tissues at risk. The study performed by the National Research Council in United States confirmed that the use of a PBPK model for the ingested radon could provide the useful information regarding the distribution of radon among the organs of the body. This study presents an approach for the internal dose assessment of ingested radon for this case. At first, the study develops a PBPK model for ingested radon. However, the important issue is how to simulate a more realistic situation using the model associated with repeated oral doses rather than a single oral dose. The simulations are performed for repeated oral exposures per 8-hour interval using the PBPK model for a male adult. The concentration and cumulative value of radon concentration are calculated and analyzed for lung tissue and adipose group, respectively. The results could be used for the realistic prediction of the internal dose of radon in the human body for repeated oral exposures.

• Journal of Yeungnam Medical Science
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• 제34권1호
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• pp.19-28
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• 2017

The incidence of type 2 diabetes mellitus and insulin resistance is growing rapidly. Multiple organs including the liver, skeletal muscle and adipose tissue control insulin sensitivity coordinately, but the mechanism of skeletal muscle insulin resistance has not yet been fully elucidated. However, there is a growing body of evidence that lipotoxicity induced by mitochondrial dysfunction in skeletal muscle is an important mediator of insulin resistance. However, some recent findings suggest that skeletal mitochondrial dysfunction generated by genetic manipulation is not always correlated with insulin resistance in animal models. A high fat diet can provoke insulin resistance despite a coordinate increase in skeletal muscle mitochondria, which implies that mitochondrial dysfunction is not mandatory in insulin resistance. Furthermore, incomplete fatty acid oxidation by excessive nutrition supply compared to mitochondrial demand can induce insulin resistance without preceding impairment of mitochondrial function. Taken together we suggested that skeletal muscle mitochondrial overloading, not mitochondrial dysfunction, plays a pivotal role in insulin resistance.

• 대한한의학회지
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• 제29권4호
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• pp.161-170
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• 2008

Objectives: This study aimed at comparing Sasang constitutional medicine(SCM) with other constitutional theories of the world. Methods: From PubMed database, we first searched all papers using the term 'constitution', then filtered those having really constitution-focused papers. Then, they were analyzed to compare each constitutional theory and medicinal practice. Results: There were five constitution-related medicines which have been practiced in medical field: Sasang, iridology, somatotype, dermatoglyphics and Ayurveda. There was the largest number of scientific researches for dermatoglyphics while the smallest number of papers was for SCM. The other three constitutional theories were based on anatomic/histologic difference between types in contrast to SCM and Ayurveda, which relied on inherited functional differences of four or three internal organs. Conclusions: This study simultaneously compared five major constitutional theories currently practiced as medicines in the world. We found that even as SCM seems to have the most potential as therapeutic medicine it should be studied more using scientific methodologies to be a world-wide medicine.

• IMMUNE NETWORK
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• 제13권3호
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• pp.107-110
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• 2013

Graft-versus-host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). However, a similar syndrome has been reported in autologous stem cell transplantation (ASCT) as well. The target organs of GVHD in ASCT are the skin, liver and gastrointestinal (GI) tract, which are consistent with those in allo-SCT. Histologic findings from the skin and the mucosa of the GI tract also show similar features. Here we describe a case of autologous GVHD involving the skin of a patient who underwent ASCT for multiple myeloma. In this patient, the response to a total prednisone dose of 0.5 mg/kg/day was unsatisfactory, and the patient required more intensive and prolonged immunosuppressive therapy with slow tapering.