• Journal of Soil and Groundwater Environment
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• v.9 no.4
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• pp.32-41
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• 2004

Analysis of water-level fluctuation due to goundwater-surface water interaction in coastal aquifers is carried out by numerical modeling. The conceptual model used in this study has a stream boundary and a tidal boundary that forms a right angle and the stream partially penetrates the aquifer. We analyzed the effect of each boundary and the simultaneous effect of the two boundary conditions. The area of influence caused by the stream boundary increased during the simulation, while the influence zone of the coastal boundary was relatively constant. The groundwater level near the zone where two boundaries meet may rise by the action of combined effect of the two boundaries or may not change by cancelling the effect of each boundary. Thereafter, care must be taken when hydraulic parameters are estimated using sinusoidal oscillations of hydraulic head in coastal aquifers. Sensitivity analysis is employed to develop insight into the controls on groundwater level fluctuations. In this study our analyses focused on the effect of conductance and the stream width to the aquifer nearby.

• Journal of Life Science
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• v.26 no.7
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• pp.868-874
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• 2016

Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 are members of the serine or threonine protein kinase superfamily that phosphorylates the hydroxyl group of serine or threonine through the highly conserved kinase region. The RIPK family plays a crucial role not only in inflammation and innate immunity, but also in mediating programmed cell death, such as apoptosis and necroptosis. The interaction between RIPK1 and other TNFR1-related proteins has been shown to assemble a signaling complex I that controls activation of the pro-survival transcription factor NF-κB upon binding of cytokines to TNF receptor 1 (TNFR1). Moreover, RIPK1 and RIPK3 interact through their RIP homotypic interaction motifs (RHIMs) to mediate programmed necrosis, which has long been considered an accidental and uncontrolled cell death form with morphological characteristics differing from those of apoptosis. Highly conserved sequences of RHIM in RIPK1 and RIPK3 were shown to regulate their binary interaction, leading to assembly of a cytosolic amyloid complex termed the “necrosome”. The necrosome also contains mixed lineage kinase domain-like protein (MLKL), which has been found recently to be a substrate of RIPK3 to mediate downstream signaling. This review provides an overview of the functional and physiological characteristics of RIPKs and MLKL in TNF signaling.

• Archives of design research
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• v.20 no.3 s.71
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• pp.235-246
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• 2007

The study aims to design an integrated remote controller, which is an increasingly essential device in the home, for more convenient use. For this purpose, an alternative user interface (UI) design was developed by applying the user interface system of a popular existing product to an integrated remote control highly usable and easy to learn for domestic use, and the usability was evaluated. For the existing popular product, a cellular phone was selected, the operation method of which is similar to the stick-type integrated remote control for which the user interface design was to be developed in this research. Common characteristics of the UI of the selected cellular phone were derived and the characteristics were applied as much as possible to the design of a stick-type integrated remote control. The prototype of the alternative design, which was simulated with Flash, went through two pilot tests for further improvement before making the final experimental prototype. Based on the results, prototype buttons that improved the feeling of use in terms of physical operation and feedback were made, and the usability of the new UI design of a stick-type integrated remote control for domestic use were evaluated with 41 university students in their 20s. According to the results of the experiment, the newly designed stick-type integrated remote control based on the UI of an existing product may improve the usability of remote controls and the outcome of this study is expected to provide a good model for R&D of new UI designs of stick-type integrated remote controls for domestic use.

• Genomics & Informatics
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• v.8 no.4
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• pp.206-211
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• 2010

The Fas (TNF receptor superfamily, member 6) (FAS)/FAS ligand (FASLG) interaction plays a central role in the regulation of programmed cell death. FAS and FASLG polymorphisms in promoter regions affect transcriptional activities. To investigate whether FAS and FASLG polymorphisms are associated with the development and clinical phenotypes of stroke, 2 promoter single nucleotide polymorphisms (SNPs) in FAS (rs1800682, -670C/T) and FASLG (rs763110, -844C/T) were selected and genotyped by direct sequencing in 220 stroke patients [107 ischemic stroke (IS), 77 intracerebral hemorrhage (ICH), and 36 subarachnoid hemorrhage (SAH)] and 369 control subjects. For the analysis of clinical symptoms, all stroke patients were divided into 3 clinical phenotypes according to the respective results of the National Institutes of Health Stroke Survey (NIHSS) and the Modified Barthel Index (MBI) and the presence or absence of complex regional pain syndrome (CRPS). The SNPStats, SNPAnalyzer, and Helixtree programs were used to analyze the genetic data. Multiple logistic regression models (codominant, dominant, and recessive) were used to estimate odds ratios (ORs), 95% confidence intervals (CIs), and p-values. The promoter SNP rs1800682 was associated with stroke in the codominant (OR=0.48, 95% CI=0.25-0.94, p=0.04) and dominant models (OR=0.51, 95% CI=0.30-0.87, p=0.011). However, a FASLG SNP (rs763110) was not in Hardy-Weinberg equilibrium (p<0.05). In the analysis of stroke types, rs1800682 was associated with IS in the codominant (OR=0.30, 95% CI=0.12-0.74, p=0.025), dominant (OR=0.44, 95% CI=0.23-0.88, p=0.018), and recessive models (OR=0.45, 95% CI=0.21-0.99, p=0.042). The genotype frequencies of rs1800682 were different between ICH and controls in the dominant model (OR=0.49, 95% CI=0.26-0.94, p=0.031) but not between SAH and controls. In the analysis of clinical symptoms, however, rs1800682 was not related to the 3 clinical phenotypes (NIHSS, MBI, and CRPS). These results suggest that a promoter SNP (rs1800682, -670C/T) in FAS may be associated with the development of stroke in the Korean population.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.4
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• pp.1192-1198
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• 2004

Sasang Constitutional Medicine is a major branch of Korean Traditional Medicine. The differences of disease susceptibility to be shown in Sasang constitution may be due to genetic factors. Therefore, I examined interrelationship among cerebral infarction (CI), apolipoprotein E (apo E) gene polymorphism, and Sasang constitutional classification. Apo E is a key protein modulating the highly atherogenic apoB containing lipoproteins and is a candidate gene for the development of coronary artery disease (CAD). The ε2 and/or ε4 alleles were the first to be implicated in premature CAD, which resulted in this polymorphism being extensively studied. I investigated the association between apo E genotype and CI by case-control study in a Korean population. I also classified CI patients and control group into groups according to Sasang Constitutional Medicine. 218 CI patients and 379 controls without CI were examined. Apo E genotype was determined by 8% polyacrylamide gel separation after DNA amplification. A frequency of apo E ε3/ε3 in the apo E genotype distribution was higher in the CI patients compared with that in controls. Also, it was widely known that Taeumin was easily attacked with CI, but there was no association between apo E polymorphim and Taeumin. However, the Taeumin constitution did not enhance the relative risk for CI in the subjects with apo E ε2 and/or ε4 alleles. No differences in the apo E genotypes frequencies were observed in the Taeumin compared with that in the other constitutions. In addition, I investigated whether the DD(deletion/deletion) or ID(insertion/deletion) genotype of angiotensin converting enzyme (ACE) gene, a candidate gene for CI, was associated with CI, Taeumin constitution, and apo E polymorphism. As a result, the frequency of Taeumin constitution was significantly higher in CI patients with both apo E ε3/ε4 and ACE ID/DD genotypes than in the remaining Sasang constitutions. In summary, it was concluded that the apo E polymorphism is a major risk factor for CI in Koreans and the ACE ID/DD genotype enhanced the relative risk for CI in the subjects with apo E ε3/ε4 genotype and Taeumin constitution.

• Journal of Broadcast Engineering
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• v.16 no.4
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• pp.657-668
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• 2011

Along with the development of communication technology, DTV is gradually evolving into media that provide diverse services and information. This study is related with remote controls that control DTV interfaces and assessed the usability of remote pointing device. To this end, pointing devices using three different interaction methods that have been attempted recently by the industry were selected to conduct empirical experiments. The usability assessment was conducted centering on the existing directional task on straight tracks presented in ISO 9241-Part 9 and the steering tunnel task on curved tracks proposed in this study. The measurement variables included movement time, accuracy, throughput, subjective satisfaction and user behaviors. Based on the results of the assessment, in the case of movements on straight tracks, the GyroPoint method showed better implementing time but lower accuracy compared to the Hall Mouse and OFN methods while in the case of assessment on curved tracks, all of the GyroPoint method, Hall Mouse and OFN methods showed excellent results on both implementing time and accuracy. Besides, differences in efficiency and subjective satisfaction were shown among individual pointing devices. Based on these results, it is considered that individual pointing methods have different advantageous and disadvantageous characteristics. In this study, the usability of remote control pointing methods was assessed and diagnosed reflecting environments where DTVs are used through assessments considering the aspect of straight tracks along with curved tracks. Among others, this study is considered to be meaningful in that it provides assessment criteria and basic data for the development of remote controls suitable for the evolving DTV environments.

• Journal of KIISE:Databases
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• v.34 no.1
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• pp.1-17
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• 2007

As XML is becoming a de facto standard for distribution and sharing of information, the need for an efficient yet secure access of XML data has become very important. To enforce the fine-level granularity requirement, authorization models for regulating access to XML documents use XPath which is a standard for specifying parts of XML data and a suitable language for both query processing. An access control environment for XML documents and some techniques to deal with authorization priorities and conflict resolution issues are proposed. Despite this, relatively little work has been done to enforce access controls particularly for XML databases in the case of query access. Developing an efficient mechanism for XML databases to control query-based access is therefore the central theme of this paper. This work is a proposal for an efficient yet secure XML access control system. The basic idea utilized is that a user query interaction with only necessary access control rules is modified to an alternative form which is guaranteed to have no access violations using tree-aware metadata of XML schemes and set operators supported by XPath 2.0. The scheme can be applied to any XML database management system and has several advantages over other suggested schemes. These include implementation easiness, small execution time overhead, fine-grained controls, and safe and correct query modification. The experimental results clearly demonstrate the efficiency of the approach.

• Journal of the Korean Institute of Telematics and Electronics T
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• v.36T no.4
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• pp.123-132
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• 1999

A video conferencing system provides sharing the conference environment for geographically dispersed computer users who use the audio and video information. But the conventional video conferencing systems have some problems which are dependent on specific software and/or hardware and bound the certain platform and network environment. Furthermore the participants must know the information about other participants before joining the conference session and they have to use the same video conferencing system. This paper describes design and implementation of the video conferencing system on the WWW to solve the mentioned problems. The conference applications are transmitted from a WWW server and executed in the participants Web browsers. The participant can carry out conference services by using only the web browser. The WWW server takes charge of conferencing management including the information related to the participants and provides supported conference tools such as whiteboard, chatting and multimedia controls. Therefore the participants can easily join the conference sessions and perform conference working regardless of network connection situations. We used the Java to implement the seamless session connections and interaction between the conference participants which are the most important when implementing the video conferencing system on the WWW and used the ActiveX technology about the audio and video controls to make it easy the hardware control.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6249-6256
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• 2013

One-carbon metabolism plays an important role in colorectal carcinogenesis. Meta-analyses have suggested protective associations of folate and vitamin $B_6$ intakes with colorectal cancer primarily based on studies in Caucasians, and genetic polymorphisms pertaining to the folate metabolism have been a matter of interest. Less investigated are the roles of methionine synthase (MTR) and thymidylate synthetase (TS) polymorphisms in colorectal carcinogenesis. In a study of 816 cases and 815 community controls in Japan, we investigated associations of dietary intakes of folate, methionine, vitamin $B_2$, vitamin $B_6$, and vitamin $B_{12}$ with colorectal cancer risk. The associations with MTR 2756A>G, MTRR 66A>G, and TSER repeat polymorphism were examined in 685 cases and 778 controls. Methionine and vitamin $B_{12}$ intakes were inversely associated with colorectal cancer risk, but the associations were totally confounded by dietary calcium and n-3 fatty acids. The other nutrients showed no association with the risk even without adjustment for calcium and n-3 fatty acids. The TSER 2R allele was dose-dependently associated with an increased risk. The MTR and MTRR polymorphisms were unrelated to colorectal cancer risk. There was no measurable gene-gene or gene-nutrient interaction, but increased risk associated with the TSER 2R allele seemed to be confined to individuals with high folate status. This study does not support protective associations for folate and vitamin $B_6$. The TSER 2R allele may confer an increased risk of colorectal cancer. The role of the TSER polymorphism in colorectal carcinogenesis may differ by ethnicity.

• Journal of agriculture & life science
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• v.46 no.3
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• pp.11-17
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• 2012

This study was conducted to clarify the effect of horticultural therapy on activities of daily living and interpersonal relation of institutionalized intellectual disabilities. The experiment was performed with 8 controls and 8 experiments of J institution in Yongdam, Jeju. Horticultural therapy program was performed once a week for 2 hours total 20 times from Mar. 2009 through mid July 2009. Evaluation in activities of daily living indicated that all functions except eating showed no change or worsened in controls, however, all functions except moving were improved in experimental subjects. Interpersonal relation evaluation showed no difference from 42.25 to 42.25 in control, but increased 8.62 points from 41.75 to 50.37 showing very significant change at the level of 99% in experimental subjects. Group activity evaluation increased very significantly at the level of 99% in physical/perceptual abilities, social interaction, cognitive ability, emotion status, and vocational interests. From the above results, horticultural therapy proved effectively in activities of daily living and interpersonal relation of institutionalized intellectual disabilities.