• Title/Summary/Keyword: Interaction affect

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Conformational Analysis of Sulfonylureas : Acetohexamide and Tolazamide (Sulfonylurea 유도체들의 구조분석 : Acetohexamide와 Tolazamide)

  • 정우태;강기롱;이성희
    • YAKHAK HOEJI
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    • v.39 no.3
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    • pp.329-336
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    • 1995
  • Conformational free energy calculations using an empirical potential function and a hydration shell model(program CONBIO) were carried out on hypoglycemic agent acetohexamide and tolazamide in the unhydrated and hydrated states. The initial geometry of sulfonylureas was obtained from X-ray crystallographieal data and homologous molecular fragments. In both states, the feasible conformations were obtained from the calculations of conformational energy, conformational entropy, and hydration free energy by varying all the torsion angles of the molecules. From the calculation results, it is known that the conformations] entropy is the major contribution to stabflize the low-free-energy conformations of two sulfonylureas in both states. But, in hydrated state, the hydration does not directly affect each conformations. The intramolecular hydrogen bonding of sulfonylurea hydrogen and 7-membered nitrogen appeared to the conformations of tolazamide in both states. It is thought that the hydrogen bonding decrease steric hindrance on the receptor binding direction. The substitution of alicyclic or N-heterocyclic ring than that of carbons chain of urea moiety may be properly interaction between sulfonylureas and the putative pancreatic receptor.

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Stability of CWR track on the High-Speed Railway Bridges considering Braking and Accelerating Forces (고속철도 차량의 시$\cdot$제동 하중에 대한 교량상 장대레일의 주행안전성 평가)

  • Chin Won-Jong;Kim Byung-Suk;Kwark Jong-Won;Kang Jae-Yoon;Choi Eun-Suk
    • Proceedings of the KSR Conference
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    • 2004.10a
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    • pp.769-774
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    • 2004
  • In this paper, the main factors affect on the longitudinal rail force are discussed. Considering rail-bridge interaction, analytical and experimental evaluation of track behavior has been achieved. It is concluded that the horizontal ballast strength, the expansion length of the bridge span, and the stiffness of the bridge sub-structure are the significant parameters affecting the stability of the continuous welded rail (CWR) track. And, it is suggested that the ballast resistance forces should be maintained to ensure the track stability during the service.

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An Experimental Study on the Impact Collapse Characteristics of CFRP Composite Circular Structures (탄소섬유강화 복합재료 원통부재의 충격압궤특성에 관한 실험적 연구)

  • 김영남;양현수
    • Journal of the Korea Safety Management & Science
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    • v.3 no.1
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    • pp.127-137
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    • 2001
  • Because of the inherent flexibility in their design for improved material properties, composites have wide applications in aerospace vehicles and automobiles. The purpose of this study is to investigate the energy absorption characteristics of CFRf (Carbon Fiber Reinforced Plastics) tubes on static and impact tests. Static compression tests have been carried out using the static testing machine(Shin-gang buckling testing machine) and impact compression tests have been carried out using the vertical crushing testing machine. When such tubes were subjected to crushing loads, the response is complex and depends on the interaction between the different mechanisms that control the crushing process. The collapse characteristics and energy absorption were examined. Trigger and interlaminar number affect the energy absorption capability of CFRP tubes.

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Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study

  • Jeong, Hyun-hwan;Sohn, Kyung-Ah
    • Genomics & Informatics
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    • v.12 no.4
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    • pp.216-224
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    • 2014
  • Gastritis is a common but a serious disease with a potential risk of developing carcinoma. Helicobacter pylori infection is reported as the most common cause of gastritis, but other genetic and genomic factors exist, especially single-nucleotide polymorphisms (SNPs). Association studies between SNPs and gastritis disease are important, but results on epistatic interactions from multiple SNPs are rarely found in previous genome-wide association (GWA) studies. In this study, we performed computational GWA case-control studies for gastritis in Korea Associated Resource (KARE) data. By transforming the resulting SNP epistasis network into a gene-gene epistasis network, we also identified potential gene-gene interaction factors that affect the susceptibility to gastritis.

Chemical Modification of Transducin with Dansyl Chloride Hinders Its Binding to Light-activated Rhodopsin

  • Kosoy, Ana;Moller, Carolina;Perdomo, Deisy;Bubis, Jose
    • BMB Reports
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    • v.37 no.2
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    • pp.260-267
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    • 2004
  • Transducin (T), the heterotrimeric guanine nucleotide binding protein in rod outer segments, serves as an intermediary between the receptor protein, rhodopsin, and the effector protein, cGMP phosphodiesterase. Labeling of T with dansyl chloride (DnsCl) inhibited its light-dependent guanine nucleotide binding activity. Conversely, DnsCl had no effect on the functionality of rhodopsin. Approximately 2-3 mol of DnsCl were incorporated per mole of T. Since fluoroaluminate was capable of activating DnsCl-modified T, this lysine-specific labeling compound did not affect the guanine nucleotide-binding pocket of T. However, the labeling of T with DnsCl hindered its binding to photoexcited rhodopsin, as shown by sedimentation experiments. Additionally, rhodopsin completely protected against the DnsCl inactivation of T. These results demonstrated the existence of functional lysines on T that are located in the proximity of the interaction site with the photoreceptor protein.

The influence of different support movements and heights of piers on the dynamic behavior of bridges -Part II: earthquake acting along the bridge axis

  • Raftoyiannis, I.G.;Konstantakopoulos, T.G.;Michaltsos, G.T.
    • Interaction and multiscale mechanics
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    • v.3 no.1
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    • pp.39-54
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    • 2010
  • In this paper, a simple approach is presented for studying the dynamic response of multi-span steel bridges supported by pylons of different heights, subjected to earthquake motions acting along the axis of the bridge with spatial variations. The analysis is carried out using the modal analysis technique, while the solution of the integral-differential equations derived is obtained using the successive approximations technique. It was found that the height of piers and the quality of the foundation soil can affect significantly the dynamical behavior of the bridges studied. Illustrative examples are presented to highlight the points of concern and useful conclusions are gathered.

Constructing the mode shapes of a bridge from a passing vehicle: a theoretical study

  • Yang, Y.B.;Li, Y.C.;Chang, K.C.
    • Smart Structures and Systems
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    • v.13 no.5
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    • pp.797-819
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    • 2014
  • This paper presents a theoretical algorithm for constructing the mode shapes of a bridge from the dynamic responses of a test vehicle moving over the bridge. In comparison with those approaches that utilize a limited number of sensors deployed on the bridge, the present approach can offer much more spatial information, as well as higher resolution in mode shapes, since the test vehicle can receive the vibration characteristics of each point during its passage on the bridge. Basically only one or few sensors are required to be installed on the test vehicle. Factors that affect the accuracy of the present approach for constructing the bridge mode shapes are studied, including the vehicle speed, random traffic, and road surface roughness. Through numerical simulations, the present approach is verified to be feasible under the condition of constant and low vehicle speeds.

입계기공의 확산성장 모델을 이용한 고온 기기의 크립균열전파해석(3)

  • Jeon, Jae-Young
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.20 no.4
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    • pp.1194-1201
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    • 1996
  • For the case of creep-fatigue interaction, the damage zone developed in front of the growing crack-tip during creep regime is important because it can affect the damage mechanism to be occured by the following fatigue load. These are studied in theis paper through proper consideration of the cavitiy-size dependent sintering stress which is approximated by polynomials. It is shown that the inclination of reversed damage zone size with respect to the applied load parameter can be explained by considering realistic sintering stress distribution. However, the resultant stress field has $r^{1/2+\theta}$ singularity, regardliss of the profile of variable sintering stress, which is the same to that case solved for constant sintering stress.

Study on Fluid Flow and Thermal Characteristics in a Nanoscale Channel Using MD Simulation (분자 동역학 시뮬레이션을 이용한 나노 스케일 채널 내에서의 유체 유동 및 열적 특성에 관한 연구)

  • Choi, Yong-Seok;Kim, Sung-Jin
    • Proceedings of the KSME Conference
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    • 2004.04a
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    • pp.1880-1884
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    • 2004
  • To analyze the fluid flow and thermal characteristics in a nanoscale system, the planar Poiseuille flow of a Lennar-Jones liquid through parallel plates formed by fixed atoms is studied using nonequilibrium molecular dynamics simulations. The role of important simulation parameters such as the channel width, the magnitude of external field, the temperatures of the top and bottom plates, and the interaction potential parameter between fluid and wall atoms, which affect flow patterns and heat transfer rate inside the channel, are investigated. Under the various simulation conditions, interesting phenomena deviated from the continuum predictions have found.

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Analysis of the Human Performance and Communication Effects on the Operator Tasks of Military Robot Vehicles by Using Extended Petri Nets (확장된 페트리네트를 이용한 차량형 군사로봇의 운용자 성능 및 통신장애 영향분석)

  • Choi, Sang Yeong;Yang, Ji Hyeon
    • Korean Journal of Computational Design and Engineering
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    • v.22 no.2
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    • pp.162-171
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    • 2017
  • Unmanned military vehicles (UMVs) are most commonly characterized as dealing with dull, dirty, and dangerous tasks with automation. Although most of the UMVs are designed to a high degree of autonomy, the human operator will still intervene in the robot's operation, and teleoperate them to achieve his or her mission. Thus, operator capacity, together with robot autonomy and user interface, is one of the most important design factors in the research and development of the UMVs. Further, communication may affect the operator task performance. In this paper, we analyze the operator performance and the communication effects on the operator performance by using the extended Petri nets, called OTSim nets. The OTSim nets was designed by the authors, being extended using pure Petri nets.