• Journal of the Korean Society of Safety
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• v.21 no.3 s.75
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• pp.87-93
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• 2006

When a structure is constructed at the site composed of soil, the behavior of a structure is much affected by the characteristics of soil. Therefore, the effect of soil-structure interaction is an important consideration in the design of a structure at the site composed of soil. Precise analysis of soil-structure interaction requires a proper description of soil profile. However, most of approaches are nearly unpractical for soil exhibiting material discontinuity and complex geometry since those cannot consider precisely complicated soil profiles. To overcome these difficulties, an improved integration method is adopted and enables to integrate easily over an element with material discontinuity. As a result the mesh can be generated rapidly and highly structured, leading to regular and precise stiffness matrix. The influence of soil profile on the response is examined by the presented method. It is seen that the presented method can be easily used on soil-structure interaction problems with complicated soil profile and produce reliable results regardless of material discontinuities.

• Geomechanics and Engineering
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• v.2 no.4
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• pp.229-252
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• 2010

In this paper, Soil-Structure Interaction (SSI) effect is investigated using a new and integrated approach. Faster solution of time dependant differential equation of motion is achieved using numerical representation of wavelet theory while dynamic Infinite Elements (IFE) concept is utilized to effectively model the unbounded soil domain. Combination of the wavelet theory with IFE concept lead to a robust, efficient and integrated technique for the solution of complex problems. A direct method for soil-structure interaction analysis in a two dimensional medium is also presented in time domain using the frequency dependent transformation matrix. This matrix which represents the far field region is constructed by assembling stiffness matrices of the frequency dependant infinite elements. It maps the problem into the time domain where the equations of motion are to be solved. Accuracy of results obtained in this study is compared to those obtained by other SSI analysis techniques. It is shown that the solution procedure discussed in this paper is reliable, efficient and less time consuming as compared to other existing concepts and procedures.

• Genomics & Informatics
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• v.21 no.1
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• pp.6.1-6.8
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• 2023

Glaucoma is the second leading cause of irreversible blindness, and primary open-angle glaucoma (POAG) is the most common type. Due to inadequate diagnosis, treatment is often not administered until symptoms occur. Hence, approaches enabling earlier prediction or diagnosis of POAG are necessary. We aimed to identify novel drugs for glaucoma through bioinformatics and network analysis. Data from 36 samples, obtained from the trabecular meshwork of healthy individuals and patients with POAG, were acquired from a dataset. Next, differentially expressed genes (DEGs) were identified to construct a protein-protein interaction (PPI) network. In both stages, the genes were enriched by studying the critical biological processes and pathways related to POAG. Finally, a drug-gene network was constructed, and novel drugs for POAG treatment were proposed. Genes with p < 0.01 and |log fold change| > 0.3 (1,350 genes) were considered DEGs and utilized to construct a PPI network. Enrichment analysis yielded several key pathways that were upregulated or downregulated. For example, extracellular matrix organization, the immune system, neutrophil degranulation, and cytokine signaling were upregulated among immune pathways, while signal transduction, the immune system, extracellular matrix organization, and receptor tyrosine kinase signaling were downregulated. Finally, novel drugs including metformin hydrochloride, ixazomib citrate, and cisplatin warrant further analysis of their potential roles in POAG treatment. The candidate drugs identified in this computational analysis require in vitro and in vivo validation to confirm their effectiveness in POAG treatment. This may pave the way for understanding life-threatening disorders such as cancer.

• Nuclear Engineering and Technology
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• v.46 no.2
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• pp.147-158
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• 2014

In order to investigate how the microstructure of fuel/matrix-interaction (FMI) layers change during irradiation, different U-7Mo dispersion fuel plates have been irradiated to high fission density and then characterized using scanning electron microscopy (SEM). Specifially, samples from irradiated U-7Mo dispersion fuel elements with pure Al, Al-2Si and AA4043 (~4.5 wt.%Si) matrices were SEM characterized using polished samples and samples that were prepared with a focused ion beam (FIB). Features not observable for the polished samples could be captured in SEM images taken of the FIB samples. For the Al matrix sample, a relatively large FMI layer develops, with enrichment of Xe at the FMI layer/Al matrix interface and evidence of debonding. Overall, a significant penetration of Si from the FMI layer into the U-7Mo fuel was observed for samples with Si in the Al matrix, which resulted in a change of the size (larger) and shape (round) of the fission gas bubbles. Additionally, solid fission product phases were observed to nucleate and grow within these bubbles. These changes in the localized regions of the microstructure of the U-7Mo may contribute to changes observed in the macroscopic swelling of fuel plates with Al-Si matrices.

• Proceedings of the Korean Nuclear Society Conference
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• 2001.05a
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• pp.360.2-360
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• 2001

• Proceedings of the Korean Society of Potoscience Conference
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• 2006.06a
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• pp.32-32
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• 2006

• Journal of Korean Society of Steel Construction
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• v.10 no.3 s.36
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• pp.437-449
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• 1998

In order that the steel girder and the concrete slab act as a composite structure, the connectors must have adequate strength and stiffness. If there are no horizontal or vertical separations at the interface, the connectors are described as rigid, and complete interaction can be said to exist under these idealized circumstances. However, all connectors are flexible to some extent, and therefore incomplete interaction always exists. This paper presents a practical structural analysis of composite girders with incomplete interaction by three methods. One is the stiffness matrix method derived from the general solutions of differential equation, another is the finite element analysis that alternate method of solution treats the structure as a frame and defines the spring as an additional member, and the other is the finite element analysis using principle of virtual work. The deflection characteristic of composite girder is investigated using these three methods. Also, this paper propose a simplified procedure of estimating a degree of imperfection for a composite girder with incomplete interaction using the sectional properties of girder and spring constants of shear connectors.

• Steel and Composite Structures
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• v.21 no.1
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• pp.195-216
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• 2016

The dynamic characteristics of continuous steel-concrete composite beams considering the effect of interlayer slip were investigated based on Euler Bernoulli's beam theory. A simplified calculation model was presented, in which the Mode Stiffness Matrix (MSM) was developed. The natural frequencies and modes of partial-interaction composite continuous beams can be calculated accurately and easily by the use of MSM. Proceeding from the present method, the natural frequencies of two-span steel-concrete composite continuous beams with different span-ratios (0.53, 0.73, 0.85, 1) and different shear connection stiffnesses on the interface are calculated. The influence pattern of interfacial stiffness on bending vibration frequency was found. With the decrease of shear connection stiffness on the interface, the flexural vibration frequencies decrease obviously. And the influence on low order modes is more obvious while the reduction degree of high order is more sizeable. The real natural frequencies of partial-interaction continuous beams commonly used could have a 20% to 40% reduction compared with the fully-interaction ones. Furthermore, the reduction-ratios of natural frequencies for different span-ratios two-span composite beams with uniform shear connection stiffnesses are totally the same. The span-ratio mainly impacts on the mode shape. Four kinds of shear connection stiffnesses of steel-concrete composite continuous beams are calculated and compared with the experimental data and the FEM results. The calculated results using the proposed method agree well with the experimental and FEM ones on the low order modes which mainly determine the vibration properties.

• The Journal of the Korea Contents Association
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• v.11 no.3
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• pp.241-253
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• 2011

The present thesis is to concretize process stages and methods for effective use of online CGTS(creative group thinking system), or the web-storming program, in space design and to propose a support system for idea generation specific to space design. For the purpose of this study, activity factors in space design process and functional factors of the web-storming program were written into an interaction matrix, which was used for a questionnaire survey on correlations. Then, the results of the interaction matrix were visualized and analyzed following the procedure of observation-interpretation-application. The analysis found that the schematic design stage is most correlated where close collaboration is performed in the process of space design and that differences in correlation arise upon division of work. As such, the present study proposed 'provision of media for ideas in accordance with specific process and UI optimization' as a means of improving usability in schematic design that is closely correlated and suggested an idea to enhance the applicability of web-storming system in division of work.

• Journal of Microbiology and Biotechnology
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• v.9 no.1
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• pp.119-121
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• 1999

Tumor cell interaction with the extracellular matrix is defined as the critical event of tumor invasion that signals the initiation of a metastatic cascade. Sesquicillin has been identified as an inhibitor of melanoma cell adhesion to the components of the extracellular matrix (ECM) in cultured broth of fungal strain F60063. Sesquicillin strongly inhibited the adhesion of B16 melanoma cells to laminin, fibronectin, and typeIV collagen. It also inhibited B16 melanoma cell invasion of reconstituted basement membrane Matrigel in vitro in a dose-dependent manner. These results suggest that sesquicillin is a new class of nonpeptidic ECM adhesion inhibitor having anti-invasive activity.