• Korean Journal of Biological Psychiatry
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• v.8 no.2
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• pp.220-225
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• 2001

As numbers of serotonin's function are so many, studies of serotonin are numerous nowadays. In the beginning, concentration of metabolites such as 5-HIAA was a key issue, but recent studies have been challenged for serotonin receptor genes and their relation to mood disoder. Serotonin transporter(5-HTT) gene is a strong candidate gene of mood disoder for following reason. Serotonin transporter is a key protein in the serotonin pathway as it regulate the concentration of serotonin in the synaptic clept and essential pathophysiology of depression is dysregulation of 5-HTT so that all antidepressants have effect of 5-HTT antagonist. The decrease of 5-HTT in the platelet and in brain of the depressive patients is much consistent results in the studies of the pathophysiology of mood disorder till now. By this, we will be able to develop simple and easy marker for diagnosis, type, and treatment monitoring of depression. Many psychiatrists have sought the independent genes in relation to depression or schizophrenia. Obviously, the hereditary vulnerability contributes to etiology of mood disorders, but it is difficult to discriminate the independent genes because of many environmental factors. Moreover, in the hereditarily complex diseases such as mood disorder, the only vulnerability of gene can not sufficiently explain the etiology. In the future, to exclude the role of the gene-environmental interaction, the methods such as gene transfer can be considered. In the opposite direction, by using the gene destruction method, the role of target genes can be examined. As yet the concept of the gene expression, neural plasticity, neurogenesis and etc, is the elementary stage. The development of this field will help to establish the treatment strategy of chronic and refractory mood disorders.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.11
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• pp.5371-5376
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• 2013

The role of a main starting air valve is to supply compressed air to the diesel engine for starting the stopped diesel engine of a ship and cut off the air during normal operation. In this study, the main starting air valve with 80mm size was designed based on the developed valve with 50mm size. The concept design of the 80A main starting air valve was completed by using CATIA. Then, fluid analysis was performed to investigate the flow characteristics such as pressure and velocity distribution. Sequentially, structural analysis using FSI was performed. In this study, ANSYS CFX and ANSYS Workbench are utilized. The heavy weight of the body can deteriorate the strength performance of neighbor elements, leading to undesirable effect on flow characteristics. Thus, in this research, a lightweight design of the body was suggested satisfying strength requirement. The weight of the suggested design was reduced by 7kg, and the strength satisfied its requirement.

• Journal of the Korean Society of Food Science and Nutrition
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• v.13 no.4
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• pp.459-468
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• 1984

The currently accepted model of membrane structure proposes a dynamic, asymmetric lipid matrix of phospholipids and cholesterol with globular proteins embedded across the membrane to various degrees. Most phospholipids are in the bilayer arrangement and also closely associated with integral membrane proteins or loosely associated with peripheral proteins. Biological functions of membrane, such as membrane-bound enzyme functions and transport systems, are influenced by the membrane physical properties, which are determined by fatty acid composition of phospholipids, polar head group composition and membrane cholesterol content. Polar and non-polar region of the phospholipid molecule can interact, with changes in the conformation of a membrane-associated protein altering either its catalytic activity or the protein's interaction with other membrane proteins. Mammalian dietary studies attempted to change the lipid composition of a few cell membranes have shown comparisons, using essential fatty acid-deficient diets. In recent years, Clandinin and a few other workers have pioneered the study proving the influence of dietary fat fed in a nutritionally complete diet on composition of phospholipid classes of cell membrane. Modulation caused by diet fat was rapid and reversible in phospholipid fatty acyl composition of membranes of cardiac mitochondria, liver cell, brain synaptosome and lymphocytes. These changes were at the same time, accompanied by variety of membrane associated functions controlled by membrane-bound enzymes, tranporter and receptor proteins. The findings suggest the basic concept of the necessity of dietary fatty acid balance if consistency of optimal membrane structural lipid composition is to be maintained, as well as the overall inadequacy of describing the nutritional-biochemical quality of a dietary fat solely by its content of linoleic acid. Furthermore, they give light on the possible application to clinical and preventive medicine.

• Archives of design research
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• v.14 no.2
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• pp.267-278
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• 2001

Beyond the simple stage of technical development, the growth of information networks have changed areas such as the economy, communities, and education. Existing knowledge and new knowledge about these things have developed and either coexist or conflict with each other. It is difficult to predict the result of this interaction since old and new information is changing so quickly. The transition from a simple communication to an interactive communication is related to a changed communication environment which involves a more complex level of understanding. Establishing the new design concept which is aimed at the future and developing new educational programs which respond to these new information networks are important in order to educate designers who can adjust to the new information network era and construct design education. This paper reports research about the process of developing new education systems that explore the new design paradigms, the changing information network, and the proper approaches to developing design education programs which fulfill these requirements.

• Journal of Korean Society for Quality Management
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• v.44 no.4
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• pp.799-811
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• 2016

Purpose: The conjoint analyst in marketing are interested in detecting whether there exist synergy or antagonistic effects between two attributes. In the cases where attributes have two or three levels, we research on the design of survey questionnaire to estimate all the main effect and as many two factor interaction effects as possible. Methods: We consider the balanced incomplete block (BIB) mixed level factorial design $2^f{\times}3^g$ or fractional factorial design. To reduce the number of questions in a questionnaire, we propose the balanced incomplete block mixed level design with minimum aberration which is generated by implementing proc factex in SAS. Also, we propose using two or three level BIB factorial design instead of mixed level designs by transforming three level attributes into two attributes of two levels and two level attribute into three level attribute by using dummy level technique. Results: We propose three methods for designing survey questionnaire where the block and design generators are found with practical number of questions in a questionnaire. By analyzing all the respondents survey data generated by the simulation study, we find the proper model and do the concepts optimization. Conclusion: The proposed methods of designing survey questionnaires seem to perform well in the sense that the proper model, and then the optimal concept is found in a case study where all the respondents survey data are generated by the simulation study.

• Journal of Technology Innovation
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• v.8 no.2
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• pp.19-65
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• 2000

This study analyzes the development of technological infrastructure(TI) and technological infrastructure policy(TIP) to enhance the technological capabilities of small and mid-sized manufacturing enterprises(SMEs) in the U.S. and Korea in terms of the technological system(TS) concept, which is composed of technological infrastructure, industrial organization, and institutional infrastructure. In order to analyze the internal dynamics of the system, such as incentive mechanisms, the interaction among economic actors, and the policy implementation process, we compare the MEP(Manufacturing Extension Partnership) system of the U.S. and the Joong-Jin-Gong system of Korea. Among many similarities, contrasts, and insights from each country's effort to construct TI and TS, the main findings are as follows. (1) Both the MEP system and the Joong-Jin-Cong system are TI-led or government-led type TS. However, the nation-wide picture is different: in the U.S., most TSs including the MEP system., are classified as TI-led type; in Korea, many TI-assisted or private sector-led TSs have been developed since the early 1960s. (2) the MEP system, as a representative case of the U.S., is less stable than the Joong-Jin-Gong system of Korea in terms of financing and political cycle. (3) The MEP system is a more complex and cooperative network than the Joong-Jin-Gong system. NIST, as a critical mass, generates the system, bridges various institutions, and influences the development of the system by providing funding. (4) Regarding TI components, TSs in both countries focus on utilizing off-the-shelf technologies rather than advanced technologies. However, the direction of movement is different: in the U.S., TSs have come to emphasize existing technologies to counterbalance an innovation system that has been highly focused toward new technologies; in Korea, TSs have been moving from focusing on a higher diffusion rate of imported process technologies to stressing new technology development. (5) Personnel and staffing, embodying technological capability, is an important concern in both countries. But the human capital infrastructure of the U.S. system is more efficient and industry-oriented than that of the Korean system due to a more flexible labor market. (6) While the U.S. has a strong tradition of state and local autonomy in constructing TI and TS to fit SMEs's specific need, Korea has a centralized and bureaucratically-led policy implementation process.

• Journal of Korean Society for Quality Management
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• v.46 no.1
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• pp.113-134
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• 2018

Purpose: The purpose of this study was to clarify the causal relationship and correlation between audit quality and audit performance and to analyze theoretical discussions and actual facts in order to improve audit performance on public enterprise audit and to identify what factors contribute to management and to seek ways to secure business performance. Methods: In this study, theoretical consideration was conducted that concerned the definition of audit, the concept of internal audit, the audit quality and the audit performance after having considered advanced researches, related regulations, and literatures. Through the foundation of such theoretical consideration, the components of the audit quality were deducted and each component's impact on the audit performance was empirically proven. The collected data through the survey were analyzed using multi-regression analysis. The measurement tools used for this study were divided into three dimensions such as internal quality, interaction quality and environmental quality. Result: First remark, out of the various components of the audit quality, independence, professionalism, and empathy appear to positively impact the audit degree of satisfaction. However, the measure of sufficiency is shown to bear no correlation to the audit degree of satisfaction. Second, out of the various components of the audit quality, professionalism, sufficiency, and empathy appear to positively impact the audit degree of applicability. However, the measure of independence is shown to bear no correlation to the audit degree of applicability. Third, audit quality appears to positively impact the audit degree of satisfaction and applicability, and also the performance of management. Concusion: It appears that the audit quality positively impacts the audit degree of satisfaction, applicability and management performance indicated by the audit performance.

• The Journal of the Korea Contents Association
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• v.12 no.2
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• pp.86-93
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• 2012

The emergence of cable TV, satellite broadcasting and IPTV provides viewers with a variety of TV programs. However, viewers' desire for watching their favorite TV program at convenient time has increased because of insufficient spare time. As an increase in smart phone market has accelerated an entry into "the age of smart network media" since 2009, mobile media suggests services connected to other digital devices. Recently, there has been growing interest in TV controling system of smart phone. Therefore, the present study aims to provide an concept of the smart phone application which recommends contents of TV program by analyzing personal watching pattern. To suggest detailed direction of the interaction and UI design, we analyzed previous research and examples of TV controlling applications and products. In addition, public opinion survey was carried out to rationalize this study and suggest suitable UI structure.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2011.04a
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• pp.531-538
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• 2011

To ensure the structural integrity of membrane type LNG tank, the rational assessment of impact pressure and structural responses due to sloshing should be preceded. The sloshing impact pressures acting on the insulation system of LNG tank are typical irregular loads and the structural responses caused by them also very complex behaviors including fluid structure interaction. So it is not easy to estimate them accurately and huge time consuming process would be necessary. In this research, a simplified method to analyze the dynamic structural responses of LNG tank insulation system under pressure time histories obtained by sloshing model test or numerical analysis was proposed. This technique basically based on the concept of linear combination of the triangular response functions which are obtained by the transient response analysis under the unit triangular impact pressure acting on structures in time domain. The validity of suggested method was verified through the example calculations and applied to the structural analysis of real Mark III type insulation system using the sloshing impact pressure time histories obtained by model test.

• The Journal of the Korea Contents Association
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• v.14 no.9
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• pp.110-119
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• 2014

Product design should reflect environment and experience of use in consideration of product's role as well as roles in life. In doing so, it is expected to realize interaction between product's role and users. Therefore, design of a recycling bin should also consider not only colors, shape, or materials but also process and experience of use. This study was conducted targeting public recycling bins in Beijing. As for the study method, first concept of a recycling bin was defined while specifying significance of recycling in Beijing City. Also, advanced research on recycling related policies that are currently being promoted was carried out. Second, current status of recycling in Beijing and problems of recycling bins were analyzed through on-campus survey. Lastly, users' psychological demand on a recycling bin was assessed and analyzed to suggest developmental direction of recycling bin design in the future.