• Applied Microscopy
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• v.37 no.4
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• pp.271-280
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• 2007

Tonicity-responsive enhancer binding protein(TonEBP) is a transcriptional factor essential in the function and development of the renal medulla. TonEBP plays a critical role in protecting renal medullary cells from the deleterious effect of hypertonicity. TonEBP is a key regulator of urinary concentration via stimulation of transcription of urea transporter(UT) in a manner independent of vasopressin. UT in the renal inner medulla is important for the conservation of body water due to its role in the urine concentrating mechanism. Mongolian gerbil(Meriones unguiculatus) has been as an model animal for studying the neurological disease such as stroke and epilepsy because of the congenital incomplete in Willis circle, as well as the investigation of water metabolism because of the long time-survival in the condition of water-deprived desert condition, compared with other species animal. In this study, we divide 3 groups of which each group include the 5 animals. In the study of 7 or 14 days water restricted condition, we investigated the TonEBP and UT-A by using a immunohistochemistry in the kidney. In the normal kidney, the distribution of TonEBP is generally localized on nuclei of inner medullary cells. Nuclear distribution of TonEBP is generally increased throughout the medulla in 7 and 14 days dehydrated group compared with control group. Increased nuclear localization was particularly dramatic in thin limbs. In control groups, UT-A was expressed in inner stripe of outer medulla(ISOM) and inner medulla(IM). UT-A was present in the terminal part of the short-loop of descending thin limbs (DTL) in ISOM and also present in the inner medullary collecting duct(IMCD), where the intensity of it gradually increased toward the papillary tip. In the dehydrated kidney, UT-A immunoreactivity was increased in the short-loop of DTL in ISOM and in the long-loop of DTL in the initial part of IM, where was expressed moderate positive reaction in the normal kidney. Also it was up regulated in the IMCD in initial & middle part of IM. However UT-A down regulated in the IMCD, where the intensity of it gradually decreased toward the papillary tip. These findings suggest that increased levels of TonEBP in medulla and UT-A in shot-loop of DTL and IMCD play a important role for maintain fluid balance in the water-deprived mongolian gerbil kidney.

• The Journal of Korean Society for Radiation Therapy
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• v.18 no.1
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• pp.35-41
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• 2006

Purpose: A various find of radiotherapy treatment plans have been made to determine appropriate doses for breasts, chest walls and loco-regional lymphatics in the radiotherapy of breast cancers. The aim of this study was to evaluate the optimum radiotherapy plan technique method by analyzing dose distributions qualitatively and quantitatively. Materials and Methods: To evaluate the optimum breast cancer radiotherapy plan technique, the traditional method(two dimensional method) and computed tomography image are adopted to get breast volume, and they are compared with the three-dimensional conformal radiography (3DCRT) and the intensity modulated radiotherapy (IMRT). For this, the regions of interest (ROI) such as breasts, chest walls, loco-regional lymphatics and lungs were marked on the humanoid phantom, and the computed tomography(Volume, Siemens, USA) was conducted. Using the computed tomography image obtained, radiotherapy treatment plans (XiO 5.2.1, FOCUS, USA) were made and compared with the traditional methods by applying 3DCRT and IMRT. The comparison and analysis were made by analyzing and conducting radiation dose distribution and dose-volume histogram (DVH) based upon radiotherapy techniques (2D, 3DCRT, IMRT) and point doses for the regions of interest. Again, treatment efficiency was evaluated based upon time-labor. Results: It was found that the case of using 3DCRT plan techniques by getting breast volume is more useful than the traditional methods in terms of tumor delineation, beam direction and confirmation of field boundary. Conclusion: It was possible to present the optimum radiotherapy plan techniques through qualitative and quantitative analyses based upon radiotherapy plan techniques in case of breast cancer radiotherapy. However, further studies are required for the problems with patient setup reproducibility arising from the difficulties of planning target volume (PVT) and breast immobilization in case of three-dimensional radiotherapy planning.

• Food Science and Preservation
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• v.21 no.5
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• pp.618-626
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• 2014

The physicochemical characteristics and consumer perceptions of two Fuji cultivars (Fuji and Royal Fuji) with six different size groups (3D: 30~39, 4D: 40~49, 5D: 50~59, 6D: 60~69, 7D: 70~79, and 8D: 80~89 apples/15 kg) were investigated to identify the ideal size and the drivers of consumer acceptability of apples. For the physicochemical characteristics, the weight, volume, specific volume, L, a, and b colors, hardness, pH, acidity, and brix of apples were measured. A total of 100 consumers were asked to mark the intensity of the characteristics (size, redness, glossiness, surface roughness, apple odor, apple flavor, sweetness, sourness, hardness, crunchiness, and toughness) to determine the ideal characteristics of apples before they were asked to taste the apple products. The consumers evaluated the apple samples in terms of their appearance, odor, flavor, texture, and overall acceptability; the consumers' intent to purchase such apples and willingness to pay for them; and the intensity of the aforementioned characteristics. Compared to the ideal characteristics of apples, the actual apple samples were rated low in their apple odor, apple flavor, acidity, sweetness, hardness, and crispness. The ideal size of the apples was between 4D and 5D. Their overall acceptability was highly affected by their flavor, followed by their texture, odor, and appearance. The acceptability of the appearance was highly correlated with the glossiness (r = 0.80), volume, weight, redness (r = 0.73), and size (r = 0.72). The consumer acceptability of the apples increased with the decreased pH and the increased Brix, hardness, and color b values of the peeled apples. The apple flavor, sweetness, hardness, crispiness, juiciness, and toughness during mastication were noted as sensory drivers of consumer acceptability.

• Geophysics and Geophysical Exploration
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• v.23 no.1
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• pp.22-37
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• 2020

We analyze the comprehensive three-dimensional (3D) magnetic structure characteristics from the seafloor to the deep layer of the Tofua Arc (TA) 12 seamount in the Tonga Arc, Southwestern Pacific, using bathymetric and geomagnetic data, and magnetization vector inversion (MVI) results. The seafloor features surrounding TA 12 highlight a NW-SE-oriented elliptical caldera at the summit of the seamount, two small cones in the depressed area. A large-scale sea valley is present on the western flank of the seamount, extending from these caldera cones to the southwestern base of the seamount. TA 12 seamount exhibits a low magnetic anomaly in the caldera depression, whereas a high magnetic anomaly is observed surrounding the low magnetic anomaly across the caldera summit. It is therefore presumed that there may be a strong magnetic material distribution or magma intrusion in the caldera. The 3D MVI results show that the high anomaly zones are mainly present in the surrounding slopes of the seamount from the seafloor to the -3,000 m (below the seafloor) level, with the magnetic susceptibility intensity increasing as the seafloor level increases at the caldera depression. However, small high anomaly zones are present across the study area near the seafloor level. Therefore, we expect that the magma ascent in TA 12 seamount migrated from the flanks to the depression area. Furthermore, we assume that the complex magnetic distribution near the seafloor is due to the remnant magnetization.

• Progress in Medical Physics
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• v.19 no.2
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• pp.89-94
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• 2008

TomoTherapy has a merit to treat cancer with Intensity modulated radiation and combines precise 3-D imaging from computerized tomography (CT scanning) with highly targeted radiation beams and rotating beamlets. In this paper, we comparing the dose distribution between TomoTherapy and linear accelerator based intensity modulated radiotherapy (IMRT) for 10 Head & Neck patients using TomoTherapy which is newly installed and operated at National Cancer Center since Sept. 2006. Furthermore, we estimate how the homogeneity and Normal Tissue Complication Probability (NTCP) are changed by motion of target. Inverse planning was carried out using CadPlan planning system (CadPlan R.6.4.7, Varian Medical System Inc. 3100 Hansen Way, Palo Alto, CA 94304-1129, USA). For each patient, an inverse IMRT plan was also made using TomoTherapy Hi-Art System (Hi-Art2_2_4 2.2.4.15, TomoTherapy Incorporated, 1240 Deming Way, Madson, WI 53717-1954, USA) and using the same targets and optimization goals. All TomoTherapy plans compared favorably with the IMRT plans regarding sparing of the organs at risk and keeping an equivalent target dose homogeneity. Our results suggest that TomoTherapy is able to reduce the normal tissue complication probability (NTCP) further, keeping a similar target dose homogeneity.

• Journal of the Korean Geographical Society
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• v.29 no.3
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• pp.266-280
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• 1994

Upper-air synoptic data and surface weather elements such as temperature, relative humidity, wind speed, cloud and precipitation were analyzed in some detail to determine the characteristics of Nopsae, a foehn-like surface wind over the Youngsuh region of Central Korea. NOAA AVHRR and GMS images are also referenced to identify the distribution of clouds and precipitation to classify the tpyes of foehn over the study area. The data period examined is from 1982 until 1993 of spring and summer months from March through August. Results of the anaylsis are as follows. Warm and dry air penetration over the Younesuh region has experienced on foehn days occured between March 21 and August 10 during study perion. The mean annual number of foehn the days were 28. Foehn phenomena were prominent during March 21-25, April 5-15, May 25-June 10, and June 26-30 pentads. The intensity of the phenomena can be evaluated as the difference of daily maximum temperature and relative humidity between windward sites and leeward sites. The intensity of daily maximum temperature reached 14.5$^{\circ}C$, but most values were in the range of 5.0-7.5$^{\circ}C$ (61%). Although strong intensity of foehns usually develop in June, it is common that farmers in the region experince more aridity during the foehnday of April and May due to the transplantation of rice seedlings. Long-run foehn are not common phenomena and 55% of foehn terminate in one day, but there is a record that Nopsae persisted up to 9 days continuously. The author identified using the cloud and precipitation data out of NOAA-11, AVHRR and GMS images is that one of them has no precipitation over windward side. The available data and the results of the analysis are somewhat inadequate. Since the results imply that wave phenomenon is potentially important in terms of local surface weather and vertical momentum transport, more detailed theoretical and observational studies are necessary to clarify the mechanism and the impacts of Nopsae.

• Economic and Environmental Geology
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• v.12 no.2
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• pp.95-104
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• 1979

The position of any point on the earth's surface can be. represented in the spherical coordinates by surface spherical harmonics. Since geomagnetic field is a function of position on the earth, it can be also expressed by spherical harmonic analysis as spherical harmonics of trigonometric series of $a_m({\theta})$ cos $m{\phi}$ and $b_m({\theta})$ sin $m{\phi}$. Coefficients of surface spherical harmonics, $a_m({\theta})$ and $b_m({\theta})$, can be drawn from the components of the geomagnetic field, declination and inclination, and vice versa. In this paper, components of geomagnetic field, declination and inclination in the Korean peninsula are obtained by spherical harmonic analysis using the Gauss coefficients calculated from the world-wide magnetic charts of 1960. These components correspond to the values of normal geomagnetic field having no disturbances of subsurface mass, structure, and so on. The vertical and total components offer the zero level for the interpretation of geomagnetic data obtained by magnetic measurement in the Korean peninsula. Using this zero level, magnetic anomaly map is obtained from the data of airborne magnetic. prospecting carried out during 1958 to 1960. The conclusions of this study are as follows; (1) The intensity of horizontal component of normal geomagnetic field in Korean peninsula ranges from $2{\times}10^4$ gammas to $2.45{\times}10^4$ gammas. It decreases about 500 with the increment of $1^{\circ}$ in latitude. Along the same. latitude, it increases 250 gammas with the increment of $1^{\circ}$ in longitude. (2) Intensity of vertical component ranges from $3.85{\times}10^4$ gammas to $5.15{\times}10^4$ gammas. It increases. about 1000 gammas with the increment of $1^{\circ}$ in latitude. Along the same latitude, it decreases. 150~240 gammas with the increment of $1^{\circ}$ in longitude. Decreasing rate is considerably larger in higher latitude than in lower latitude. (3) Total intensity ranges from $4.55{\times}10^4$ gammas to $5.15{\times}10^4$ gammas. It increases 600~700 gammas with the increament of $1^{\circ}$ in latitude. Along the same latitude, it decreases 10~90 gammas. with the increment of $1^{\circ}$ in longitude. Decreasing rate is considerably larger in higher latitude as the case of vertical component. (4) The declination ranges from $-3.8^{\circ}$ to $-11.5^{\circ}$. It increases $0.6^{\circ}$ with the increment of $1^{\circ}$ in latitude. Along the same latutude, it increases $0.6^{\circ}$ with the increment of l O in longitude. Unlike the cases of vertical and total component, the rate of change is considerably larger in lower latitude than in higher latitude. (5) The inclination ranges from $57.8^{\circ}$ to $66.8^{\circ}$. It increases about $1^{\circ}$ with 'the increment of $1^{\circ}$ in latitude Along the same latitude, it dereases $0.4^{\circ}$ with the increment of $1^{\circ}$ in longitude. (6) The Boundaries of 5 anomaly zones classified on the basis of the trend and shape of anomaly curves correspond to the geologic boundaries. (7) The trend of anomaly curves in each anomaly zone is closely related to the geologic structure developed in the corresponding zone. That is, it relates to the fault in the 3rd zone, the intrusion. of granite in the 1st and 5th zones, and mountains in the 2nd and 4th zones.

• Progress in Medical Physics
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• v.9 no.2
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• pp.77-88
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• 1998

Wedge shaped isodoses are desired in a number of clinical situations. Hard wedge filters have provided nominal angled isodoses with dosimetric consequences of beam hardening, increased peripheral dosing, nonidealized gradients at deep depths along with the practical consequendes of filter handling and placement problems. Dynamic wedging uses a combination of a moving collimator and changing monitor dose to achieve angled isodoses. The segmented treatment tables(STT) that monitor unit setting by every distance of moving collimator, was induced by numerical formular. The characteristics of dynamic wedge by STT compared with real dosimetry. Methods and Materials : The accelerator CLINAC 2100C/D at Yonsei Cancer Center has two photon energies (6MV and 10MV), currently with dynamic wedge angles of 15$^{\circ}$, 30$^{\circ}$, 45$^{\circ}$ and 60$^{\circ}$. The segmented treatment tables(STT) that drive the collimator in concert with a changing monitor unit are unique for field sizes ranging from 4.0cm to 20.0cm in 0.5cm steps. Transmission wedge factors were measured for each STT with an standard ion chamber. Isodose profiles, isodose curves, percentage depth dose for dynamic wedge filters were measured with film dosimetry. Dynamic wedge angle by STT was well coincident with film dosimetry. Percent depth doses were found to be closer to open field but more shallow than hard wedge filter. The wedge transmission factor were decreased by increased the wedge angle and more higher than hard wedge filters. Dynamic wedging probided more consistent gradients across the field compared with hard wedge filters. Dynamic wedging has practical and dosimetric advantages over hard filters for rapid setup and keeping from table collisions. Dynamic wedge filters are positive replacement for hard filters and introduction of dynamic conformal radiotherapy and intensity modulation radiotherapy in a future.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.9 no.1
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• pp.9-16
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• 2023

Liposomes as drug delivery system have proved useful carrier for various disease, including cancer. In addition, perfluorocarbon cored microbubbles are utilized in conjunction with high-intensity focused-ultrasound (HIFU) to enable simultaneous diagnosis and treatment. However, microbubbles generally exhibit lower drug loading efficiency, so the need for the development of a novel liposome-based drug delivery material that can efficiently load and deliver drugs to targeted areas via HIFU. This study aims to develop a liposome-based drug delivery material by introducing a substance that can burst liposomes using ultrasound energy and confirm the ability to target tumors using PET imaging. Liposomes (Lipo-DOX, Lipo-DOX-Au, Lipo-DOX-Au-RGD) were synthesized with gold nanoparticles using an avidin-biotin bond, and doxorubicin was mounted inside by pH gradient method. The size distribution was measured by DLS, and encapsulation efficiency of doxorubicin was analyzed by UV-vis spectrometer. The target specificity and cytotoxicity of liposomes were assessed in vitro by glioblastoma U87mg cells to HIFU treatment and analyzed using CCK-8 assay, and fluorescence microscopy at 6-hour intervals for up to 24 hours. For the in vivo study, U87mg model mouse were injected intravenously with 1.48 MBq of ⁶⁴Cu-labeled Lipo-DOX-Au and Lipo-DOX-Au-RGD, and PET images were taken at 0, 2, 4, 8, and 24 hours. As a result, the size of liposomes was 108.3 ± 5.0 nm at Lipo-DOX-Au and 94.1 ± 12.2 nm at Lipo-DOX-Au-RGD, and it was observed that doxorubicin was mounted inside the liposome up to 52%. After 6 hours of HIFU treatment, the viability of U87mg cells treated with Lipo-DOX-Au decreased by around 20% compared to Lipo-DOX, and Lipo-DOX-Au-RGD had a higher uptake rate than Lipo-DOX. In vivo study using PET images, it was confirmed that ⁶⁴Cu-Lipo-DOX-Au-RGD was taken up into the tumor immediately after injection and maintained for up to 4 hours. In this study, drugs released from liposomes-gold nanoparticles via ultrasound and RGD targeting were confirmed by non-invasive imaging. In cell-level experiments, HIFU treatment of gold nanoparticle-coupled liposomes significantly decreased tumor survival, while RGD-liposomes exhibited high tumor targeting and rapid release in vivo imaging. It is expected that the combination of these models with ultrasound is served as an effective drug delivery material with therapeutic outcomes.

• Journal of Yeungnam Medical Science
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• v.1 no.1
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• pp.67-87
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• 1984

The earliest memories and dreams have been investigated in many aspects; biological, psychological, statistical, and psychotherapeutic, in psychiatric field. The approach methods to these psychic contents are innumerable according to the schools, the collector's attitudes to these materials, the collecting methods and the variable factors of the reporter. In this study the author attempted to compare the distribution of the aggression and dependency themes in these psychic contents among groups of different sexes and clinical diagnoses. In this purpose the author devised new scales, the Aggression and the Dependency Scales for the earliest memories and dreams which are composed of 12-theme classes, according to 3 aspects of the ego attitudes and 4 degrees of the intensity of drives. The scales were tested on a series of the earliest memories and dreams from 100 male medical students by two raters. The interrater reliabilities, measured by kappa method, were all significant at better than the .001 level. The author collected the reports of the earliest memories and dreams from 293 schizophrenics (161 males and 132 females) and 301 neurotics (164 males and 137 females) who were either outpatients or inpatients of 5 general hospitals and 2 private neurospychiatric clinics and from 310 controls (169 males and 141 females) who were either students, housewives or employees in Taegu area during the periods from March to August, 1980 and from April to August, 1983. The author compared the contents of the earliest memories and dreams from these 3 clinical groups on the newly devised scales and the results could be summarized as follows: In general, the contents of the earliest memories showed more differences among diagnostically different groups, while the contents of dreams showed more differences among sexually different groups. The dependency themes were more frequent than the aggression thems in all groups. The aggression themes were more frequent in dreams than in the earliest memories. Of the earliest memory themes, the distribution of the aggression themes was different among clinical groups, i.e., most frequent in schizophrenics, next in neurotics, and least in controls. The distribution of the dependency themes was in reverse order. Attitudes of being attacked were more frequent in schizophrenics. Observing attitudes of dependency need were more frequent in neurotics while gratifying attitudes were more frequent in controls. Highest degrees of aggression and delpendency were more frequent in neurotics. In the distribution of the dream themes, there were some differences among male and female schizophrenics. Aggression themes, especially active and the highest degree of aggression, were more frequent in male sclizophrenics, while dependency themes, especially frustrated themes, were more frequent in female schizophrenics. Among 3 clinical groups, observing attitudes of dependency need were more frequent in female groups, while gratifying attitudes were more frequent in male groups.