• Maxillofacial Plastic and Reconstructive Surgery
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• 제18권4호
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• pp.679-700
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• 1996

Inferior alveolar nerve dysfunction may be the result of trauma, disease, or iatrogenic injury. Inferior alveolar nerve injury is inherent risk in endodontic therapy, orthognathic surgery of the mandible, and extraction of mandibular teeth, particularly the third molars. The sensory disturbances of inferior alveolar nerve associated with such injury have been well documented clinical problem that is commonly evaluated by several clinical sensory test including Tinels sign, Von Frey test(static light touch detection), directional discrimination, two-point discrimination, pin pressure nociceptive discrimination, and thermal test. These methods used to detect and assess inferior alveolar nerve injury have been subjective in nature, relying on the cooperation of the patients. In addition, many of these techniques are sensitive to differences in the examiners experience and skill with the particular technique. Data obtained at different times or by different examiners are therefore difficult to compare. Prior experimental studies have used electro diagnostic methods(sensory evoked potential) to objectively evaluate inferior alveolar nerve after nerve injury. This study was designed with inferior alveolar nerve of rabbit. Several types of injury including mind, moderate, severe compression and perforation with 19 gauze, 21 gauze needle and 6mm, 10mm traction were applied for taking the sesory evoked ppterntial. Latency and amplitude of injury rabbit inferior alveolar nerve were investigated with sensory evoked potential using unpaired t-test. The results were as follows : 1. Intensity of threshold (T1) was $128{\pm}16{\mu}A$ : latency, $0.87{\pm}0.07$ microsecond : amplitude, $0.4{\pm}0.1{\mu}V$ : conduction velocity, 23.3 m/s in sensory evoked potential of uninjured rabbit inferior alveolar nerve. 2. Rabbit inferior alveolar nerve consists of type II and III sensory nerve fiber. 3. Latency was increased and amplitude was decreased in compression injury. The more injured, the more changed in latency and amplitude. 4. Findings in perforation injury was similar to compression injury. Waveform for sensory evoked potential improved by increasing postinjured time. 5. Increasing latency was prominent in traction injury rabbit inferior alveolar nerve. 6. In microscopic histopathological findings, significant degeneration and disorganization of the internal architecture were seen in nerve facicle of severe compression and 10mm traction group. From the above findings, electrophysiological assessment(sensory evoked potential) of rabbit injured inferior alveolar nerve is reliable technique in diagnosis and prognosis of nerve injury.

• 대한지리학회지
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• 제47권2호
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• pp.208-225
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• 2012

이 연구에서는 한국의 미래 기온극값의 변화를 전망하고자 하였다. 이를 위해 12.5km 고해상도의 지역기후모델(HadGEM3-RA)에서 생산된 일 최고 및 최저 기온 자료와 관측 자료를 이용하여 RCP4.5/8.5 시나리오에 따른 6개 극한기온 지수를 산출하고, 현재(1971-2000) 대비 21세기 말(2070-2099)의 공간 변화를 분석하였다. 현재 기간에 대해 모델에서 생산된 일 최고 및 최저 기온은 관측 자료의 확률분포 형태와 범위를 비교적 잘 모의한다. 현재 대비 21세기 말에 결빙일(ID)과 서리일(FD)은 전 지역에서 감소하고 여름일(SD)과 열대야(TR)는 증가할 것이며, 95퍼센타일을 초과하는 일 최고기온(TX95)과 5퍼센타일 미만 일 최저기온(TN5)의 평균값은 전 지역에서 상승할 것으로 전망된다. 이는 RCP4.5보다 RCP8.5 시나리오의 경우에 더 강하다. 고도는 ID, SD, TR, TX95, TN5와 위도는 ID, TR, TN5의 변화와 유의한 상관관계를 보인다. 21세기 말에 산지에서는 기온의 하위 극값 상승, 남해안에서는 열대야 증가로 인한 영향이 강하게 나타날 것으로 전망된다.

• 전자공학회논문지SC
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• 제49권3호
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• pp.53-61
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• 2012

본 논문에서는 스테레오 적외선 카메라를 이용하여 소형 및 고온으로 날아가는 이동체의 거리를 실시간으로 측정하는 시스템을 제안한다. 이동체와 주변 환경의 온도 차이를 측정하고 고속으로 이동하는 소형 이동체의 거리를 자동으로 측정하기 위하여 적외선 스테레오 카메라 시스템을 구축하였다. 우선 적외선 카메라를 이용하여 취득한 고온의 이동체 영상으로부터 주변의 온도분포와 이동체간의 온도차를 이용하여 이동체영역을 검출하고, 이동체의 움직임 정보와 적외선 카메라 영상의 밝기정보를 결합하여 이동체를 추적한다. 좌우 적외선 카메라 영상에 대하여 각각 추출된 이동체 영역을 중심으로 스테레오 정합을 수행하여 시차정보를 추정하고, 카메라 파라미터와 시차정보를 이용하여 실시간으로 이동하는 이동체의 거리를 추정한다. 본 논문에서 제안하는 적외선 스테레오 카메라 시스템을 검증하기 위하여 고온의 이동체를 촬영할 때, 3차원 궤적(x,y,z) 측정기를 함께 가동하여 이동체가 이동하는 거리를 측정하여 이를 기준 거리(ground truth)로 설정하였다. 3차례의 비디오 데이터로부터 실험한 결과, 적외선 스테레오 카메라를 이용한 고온/소형 이동체의 거리오차 측정 결과는 평균적으로 9.68%로 추정되었다. 스테레오 적외선 카메라의 타이밍 문제(jitter)를 고려하면, 실제로 추정 오차는 줄어들 것으로 판단되기 때문에, 향후 적외선 카메라를 이용하는 다양한 이동체의 거리 및 위치를 측정하는데 응용할 수 있을 것으로 기대된다.

• 한국지구과학회지
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• 제32권4호
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• pp.373-387
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• 2011

본 연구에서는 CORDEX 동아시아 영역에서 경계조건(ERA-Interim, NCEP/DOE2) 및 적운모수화방안(Grell, Emanuel)이 2010년 7월에 공개된 지역기후모델(RegCM4)의 모의성능에 미치는 영향을 평가하기 위해 1989년에 대해 총 4개의 민감도 실험(EG, EE, NG, NE)을 수행하였다. 남한에서의 기온, 강수에 대한 RegCM4의 모의성능을 분석하기 위해 기상청의 기온, 강수자료를 이용하였다. RegCM4는 경계조건 및 적운모수화방안에 관계없이 기온의 공간분포, 계절변동을 잘 모의한 반면, 모든 실험에서 강수의 시 공간 분포를 적절히 모의하지 못하였다. 특히, EG, NG, NE 실험은 여름 강수를 관측보다 현저히 적게 모의하는 등 강수의 계절변동을 전혀 모의하지 못하고 있다. 하지만 EE 실험에서는 여름 강수를 포함하여 계절변동을 상대적으로 잘 모의하였다. 동아시아 여름 몬순 및 강수강도별 강수량, 강수빈도 모의에서도 EE 실험이 우수한 모의성능을 보였다. RegCM4는 경계조건에 관계없이 기온, 강수 모두 여름보다는 겨울에, Grell 보다는 Emanuel 방안을 적용할 때 높은 모의성능을 보였다. 또한 전체적으로 모의성능은 경계조건보다는 적운모수화방안에 더 큰 영향을 받는다.

• Journal of Gastric Cancer
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• 제3권3호
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• pp.151-157
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• 2003

Purpose: In this study, we attempted to ascertain the proton magnetic resonance spectroscopy (${1}^H$ MRS) peak characteristics of human gastric tissue layers and finally to use the metabolic peaks of MRS to distinguish between normal and abnormal gastric specimens. Materials and Methods: Ex-vivo ${1}^H$ MRS examinations of thirty-five gastric specimens were performed to distinguish abnormal gastric tissues invaded by carcinoma cells from normal stomach-wall tissues. High-resolution 400-MHz (9.4-T) ${1}^H$ nuclear magnetic resonance (NMR) spectra of two gastric layers, a proper muscle layer, and a composite mucosasubmucosa layer were compared with those of clinical 64- MHz (1.5-T) MR spectra. Three-dimensional spoiled gradient recalled (SPGR) images were used to determine the size and the position of a voxel for MRS data collection. Results: For normal gastric tissue layers, the metabolite peaks of 400-MHz ${1}^H$ MRS were primarily found to be as follows: lipids at 0.9 ppm and 1.3 ppm; alanine at 1.58 ppm; N-acetyl neuraminic acid (sialic acid) at 2.03 ppm; and glutathione at 2.25 ppm in common. The broad and featureless featureless spectral peaks of the 64-MHz MRS were bunched near 0.9, 1.3, and 2.0, and 2.2 ppm in human specimens without respect to layers. In a specimen (Borrmmann type III) with a tubular adenocarcinoma, the resonance peaks were measured at 1.26, 1.36 and 3.22 ppm. All the peak intensities of the spectrum of the normal gastric tissue were reduced, but for gastric tumor tissue layers, the lactate peak split into 1.26 and 1.39 ppm, and the peak intensity of choline at 3.21 ppm was increased. Conclusion: We found that decreasing lipids, an increasing lactate peak that split into two peaks, 1.26 ppm and 1.36 ppm, and an increasing choline peak at 3.22 ppm were markers of tumor invasion into the gastric tissue layers. This study implies that MR spectroscopy can be a useful diagnostic tool for gastric cancer.

• 한국콘텐츠학회논문지
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• 제15권1호
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• pp.242-251
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• 2015

본 연구는 직장여성의 여가제약과 여가제약을 극복하기 위한 여가제약협상전략을 파악하고, 결혼여부에 따른 여가제약과 여가제약협상의 차이를 검증하는데 목적이 있다. 이를 위해 서울소재 직장에 근무하는 직장여성을 모집단으로 집락할당표집을 이용하여 440부의 설문지를 배포하였다. 응답내용이 부실하거나 신뢰성이 없다고 판단되는 7부를 제외한 433부를 최종분석에 사용하였으며, SPSS 18.0을 활용하여 빈도분석, 탐색적 요인분석, 신뢰도분석, 독립 t-검정을 실시하였다. 이를 통해 도출된 결과는 다음과 같다. 첫째, 직장 여성의 여가제약은 대인적 제약, 개인적 제약, 시간적 제약, 비용 및 정보 제약, 환경적 제약, 신체적 제약의 6개 요인으로 도출되었으며, 기혼여성과 미혼여성 모두 환경적 제약과 시간적 제약을 가장 크게 느끼고 있다. 둘째, 직장여성의 여가제약협상전략은 기술습득, 대체활동, 강도조절, 동반자탐색, 활동비 및 시간관리의 5개 요인으로 도출되었으며, 기혼여성과 미혼여성 모두 기술습득 전략을 가장 적극적으로 활용하고 있다. 셋째, 기혼여성의 제약 수준이 미혼여성에 비해 전반적으로 높으며, 시간적 제약과 신체적 제약에서 통계적으로 유의한 차이가 나타났다. 넷째, 기혼여성의 여가제약협상 수준이 미혼여성에 비해 전반적으로 높게 나타났으며, 기술습득 전략에서 통계적으로 유의한 차이가 나타났다.

• BMB Reports
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• 제40권3호
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• pp.315-324
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• 2007

The novel $\alpha$-amylase purified from locally isolated strain, Bacillus sp. KR-8104, (KRA) (Enzyme Microb Technol; 2005; 36: 666-671) is active in a wide range of pH. The enzyme maximum activity is at pH 4.0 and it retains 90% of activity at pH 3.5. The irreversible thermoinactivation patterns of KRA and the enzyme activity are not changed in the presence and absence of $Ca^{2+}$ and EDTA. Therefore, KRA acts as a $Ca^{2+}$-independent enzyme. Based on circular dichroism (CD) data from thermal unfolding of the enzyme recorded at 222 nm, addition of $Ca^{2+}$ and EDTA similar to its irreversible thermoinactivation, does not influence the thermal denaturation of the enzyme and its Tm. The amino acid sequence of KRA was obtained from the nucleotide sequencing of PCR products of encoding gene. The deduced amino acid sequence of the enzyme revealed a very high sequence homology to Bacillus amyloliquefaciens (BAA) (85% identity, 90% similarity) and Bacillus licheniformis $\alpha$-amylases (BLA) (81% identity, 88% similarity). To elucidate and understand these characteristics of the $\alpha$-amylase, a model of 3D structure of KRA was constructed using the crystal structure of the mutant of BLA as the platform and refined with a molecular dynamics (MD) simulation program. Interestingly enough, there is only one amino acid substitution for KRA in comparison with BLA and BAA in the region involved in the calcium-binding sites. On the other hand, there are many amino acid differences between BLA and KRA at the interface of A and B domains and around the metal triad and active site area. These alterations could have a role in stabilizing the native structure of the loop in the active site cleft and maintenance and stabilization of the putative metal triad-binding site. The amino acid differences at the active site cleft and around the catalytic residues might affect their pKa values and consequently shift its pH profile. In addition, the intrinsic fluorescence intensity of the enzyme at 350 nm does not show considerable change at pH 3.5-7.0.

• Korean Journal of Acupuncture
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• 제21권1호
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• pp.113-127
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• 2004

Objectives : The usage of acupuncture has gained popularity as an alternative method of treatment for certain chronic pain conditions. However, the efficacy of acupuncture in various diseases has not been fully established and the underlying mechanism is not clearly understood. In the present study, the effect of electroacupuncture (EA) applied to foot samli$(ST_{36})$ on the carrageenan-induced knee arthritic pain was examined. Methods : A common source of persistent pain in humans is the knee arthritis. Knee arthritis was induced by injection of 2 % carrageenan $50\;{\mu}l$ into the knee joint cavity. When rats developed pain behaviors, EA was applied for 30 min. under enflurane anesthesia with repeated train stimuli at the intensity of 10X of muscle twitch threshold. The weight bearing force of the hind limb was measured for an indicator of pain level after each manipulation. Results : The average weight borne by the hind limb during normal gait was 55% of total body weight, which was reduced to less than 10% after knee arthritis. EA improved the weight bearing of the arthritic hind limb significantly for the duration of 4 hr. EA applied to $ST_{36}$ point produced a significant improvement of stepping force of the arthritic foot lasting for at least 4 h. However, $GB_{31}$ point did not produce any significant increase of weight bearing force. The analgesic effect was specific to the acupuncture point since the analgesic effect on the knee arthritis model could not be mimicked by EA applied to a nearby point, $GB_{31}$. The relations between EA-induced analgesia and endogenous nitric oxide(NO) and inducible NO synthase(iNOS)/neuronal NOS was also examined. Results were turned out that both NO production and nNOS/iNOS protein expression which is increased by arthritis were suppressed by EA stimulation applied to $ST_{36}$ point. Conclusions : The data suggest 1) that EA produces a potent analgesic effect on the rat model of chronic knee arthritis pain in a point specific manner and 2) that EA-induced analgesia modulate endogenous NO through the suppression of nNOS/iNOS protein expression.

• Korean Journal of Acupuncture
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• 제30권4호
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• pp.220-229
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• 2013

Objectives : Electroacupuncture(EA) has been used effectively in producing analgesia on ankle sprain pain of humans and animals. Currently to examine the underlying mechanisms of the EA-induced analgesia, the effects of EA on weight-bearing forces(WBR) were examined at ankle sprain classified as grade 3 in rats. Methods : The severe ankle sprain classified as grade 3 was induced surgically by ankle ligament injury in the Sprague-Dawley rats. WBR of the affected foot were examined to evaluate effects and mechanism of EA(2 Hz, 1 ms pulse width, 2 mA intensity, for 15 min) which was applied to either SI6, GB34, or GB39 acupoints. The rats were pretreated with naltrexone(10 mg/kg, i.p.) as an opioid receptor antagonist or phentolamine(5 mg/kg, i.p) as an ${\alpha}$-adrenoceptor antagonist at 30 min before EA. Results : The daily repeat EA at either SI6, GB34, or GB39 showed significant analgesic effects on the severe ankle sprain. Particularly, daily EA at GB34 showed more potent analgesic effect than the others. In addition, the naltrexone pretreatment completely blocked the analgesic effect of EA at GB34, indicating the involvement of the endogenous opioid system in mediating the effect of EA at GB34. However, the phentolamine pretreament blocked analgesic effects of EA at either SI6 or GB39, indicating the involvement of ${\alpha}$-adrenoceptors in mediating the effect of EA at either SI6 or GB39. Conclusions : These data suggest that EA-induced analgesia on ankle sprain pain is mediated through either endogenous opioids or ${\alpha}$-adrenoceptors dependant on acupoint specific pattern.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6267-6272
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• 2015

Background: Extra nodal lymphoma (ENL) constitutes about 33 % of all non-Hodgkin's lymphoma. 18-28% develops in the head and neck region. A multimodality treatment with multi-agent chemotherapy (CT) and radiotherapy (RT) is considered optimum. Materials and Methods: We retrieved the treatment charts of patients of HNENL treated in our institute from 2001-2012. The charts were reviewed and the demographic, treatment details and outcome of HNENL patients were retrieved using predesigned pro-forma. Results: We retrieved data of 75consecutive patients HNENL. Median age was 47years (Range: 8-76 years). Of the 75 patients 51 were male and 24 were female. 55patients were evaluable. The patient and tumor characteristics are summarized in Table 1. All patients were staged comprehensively with contrast enhanced computed tomography of head, neck, thorax, abdomen, pelvis and bone marrow aspiration and biopsy 66 patients received a combination multi-agent CT with CHOP being the commonest regimen. 42 patients received 4 or lesser number of cycles of chemotherapy whereas 24received more than 4 cycles chemotherapy. Post radiotherapy, 41 out of 42 patients had a complete response at 3 months. Only 21patients had a complete response after chemotherapy. All patients received radiation (mostly involved field radiation) as a part of the treatment. The median radiation dose was 45 Gray (Range: 36 Gray-50 Gray). The radiation was planned by 2D fluoro simulation based technique in 37cases and by 3 Dimensional conformal radiation therapy (3DCRT) in 36 cases. Two patients were planned by the intensity modulated radiation therapy (IMRT) technique. IMRT was planned for one thyroid and one nasal cavity primary. 5 patients experienced relapse after a median follow up of 19 months. The median survival was not reached. The estimated two and three year survival were 92.9% (95%CI- 68.6- 95.35) and 88% (95%CI- 60.82 - 92.66) respectively. Univariate analysis revealed higher stage and poorer baseline performance status to be significantly associated with worse progression free survival. 5 patients progressed (relapse or primary disease progression) after treatment. Of the 5 patients, two patients were primary orbital NHL, two patients had NHL nasal cavity and one was NHL thyroid. Conclusions: Combined modality treatment in HNENL confers excellent disease control with acceptable side effects.