• 대한한의학회지
• /
• 제38권2호
• /
• pp.61-72
• /
• 2017

Objectives: The effects of Gamiondam-tang (GMODT) co-administration within 5min on the pharmacokinetics (PK) of tamoxifen were observed as a process of the comprehensive and integrative medicine, combination therapy of tamoxifen with GMODT to achieve synergic pharmacodynamics and reduce toxicity on the breast cancer. Methods: After 50mg/kg of tamoxifen treatment, GMODT 100mg/kg was administered within 5min. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of GMODT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (Tmax, Cmax, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with tamoxifen single administered rats using noncompartmental pharmacokinetics data analyzer programs. Results: Co-administration with GMODT induced increased trends of plasma tamoxifen concentrations to 1hr after end of administration, and then showed decreased trends of plasma tamoxifen concentrations, and especially significant (p<0.05) increases of plasma tamoxifen concentrations were demonstrated at 0.5hr after end of co-administration with GMODT and also related significant (p<0.05) decreases of $AUC_{0-inf}$ and $MRT_{inf}$ as compared with tamoxifen single formula treated rats, at dosage levels of tamoxifen 10 mg/kg and GMODT 100 mg/kg within 5 min, in this experiment. Conclusion: Based on the results of the present study, it is considered that single co-administration GMODT within 5min significantly inhibited the oral bioavailability of tamoxifen through variable influences on the absorption and excretion of tamoxifen, can be influenced on the toxicity or pharmacodynamic of tamoxifen.

• Journal of Korean Neurosurgical Society
• /
• 제48권5호
• /
• pp.391-398
• /
• 2010

Objective : This study was designed to validate the cell trafficking efficiency of the in vivo bioluminescence image (BLI) study in the setting of transplantation of the luciferase expressing bone marrow-derived mesenchymal stem cells (BMSC), which were delivered at each different time after transient middle cerebral artery occlusion (MCAO) in a mouse model. Methods : Transplanting donor BMSC were prepared by primary cell culture from transgenic mouse expressing luciferase (LUC). Transient focal infarcts were induced in 4-6-week-old male nude mice. The experiment mice were divided into five groups by the time of MSC transplantation : 1) sham-operation group, 2) 2-h group, 3) 1-day group, 4) 3-day group, and 5) 1-week group. BLI for detection of spatial distribution of transplanted MSC was performed by detecting emitted photons. Migration of the transplanted cells to the infarcted area was confirmed by histological examinations. Differences between groups were evaluated by paired t-test. Results : A focal spot of bioluminescence was observed at the injection site on the next day after transplantation by Signal intensity of bioluminescence. After 4 weeks, the mean signal intensities of 2-h, 1-day, 3-day, and 1-week group were $2.6{\times}10^7{\pm}7.4{\times}10^6$. $6.1{\times}10^6{\pm}1.2{\times}10^6$, $1.7{\times}10^6{\pm}4.4{\times}10^5$, and $8.9{\times}10^6{\pm}9.5{\times}10^5$, respectively. The 2-h group showed significantly higher signal intensity (p<0.01). The engrafted BMSC showed around the infarct border zones on immunohistochemical examination. The counts of LUC-positive cells revealed the highest number in the 2-h group, in agreement with the results of BLI experiments (p<0.01). Conclusion : In this study, the results suggested that the transplanted BMSC migrated to the infarct border zone in BLI study and the higher signal intensity of LUC-positive cells seen in 2 hrs after MSC transplantation in MCAO mouse model. In addition, noninvasive imaging in real time is an ideal method for tracking stem cell transplantation. This method can be widely applied to various research fields of cell transplantation therapy.

• Radiation Oncology Journal
• /
• 제23권4호
• /
• pp.201-210
• /
• 2005

목적: 본 연구의 목적은 자궁경부암 환자의 삶의 질에 영향을 미치는 치료관련요인과 심리사회적 요인을 파악하기 위함이다. 대상 및 방법: 경기도 A 대학병원에서 자궁경부암 진단을 받고 치료 중이거나 추후관리 중인 환자 147명을 대상으로 삶의 질과 심리사회적 변수(기분장애, 삶의 성향, 사회적 지지)에 대해 설문조사하였다. 그리고 치료관련 변수로 암의 병기, 치료방법, 추후관리기간은 의무기록을 통해 조사하였고 증상 경험은 설문조사하였다. 결과: 치료관련 변수들과 심리사회적 변수들은 자궁경부암 환자의 전체 삶의 질의 63.3%를 설명하였다($R^2=0.533$, F=16.969, p=.000). 암의 병기, 증상 경험, 기분장애정도, 사회적지지 중 가족지지, 그리고 삶의 성향은 자궁경부암 환자의 삶의 질에 영향을 주는 유의한 요인이었으며 이 중 가족지지가 가장 영향력이 큰 변수였다. 결론: 자궁경부암 환자의 삶의 질을 증진시키기 위해서는 환자의 증상관리 뿐만 아니라 심리사회적 중재가 치료와 함께 병행되어야 하며 그 내용으로 기분조절, 사회적 지지, 삶에 대한 긍정적인 태도를 취하는 것이 포함되어야 한다.

• 대한예방한의학회지
• /
• 제21권2호
• /
• pp.127-137
• /
• 2017

Objectives : In our previous study, single co-administration GMODT within 5 min significantly inhibited the oral bioavailability of tamoxifen through variable influences on the absorption and excretion of tamoxifen. Therefore, the object of this study was to elucidate the possible effects on the pharmacokinetics of tamoxifen after single oral co-administration of GMODT with 2.5 hr-intervals. Methods : After 50 mg/kg of tamoxifen treatment, GMODT 100 mg/kg was administered with 2.5 hr-intervals. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of GMODT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (Tmax, Cmax, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with tamoxifen single administered rats. Results : Two-half hr-interval co-administration with GMODT induced variable changes on the plasma tamoxifen concentrations as compared with tamoxifen single treated rats, and especially significant (p<0.05) increases of plasma tamoxifen concentrations were demonstrated at 0.5 (199.61%) and 1 hr (101.06%) after end of co-administration with GMODT, and also related significant (p<0.05) decreases of $t_{1/2}$ (-39.54%) and $MRT_{inf}$ (-43.94%) as compared with tamoxifen single formula treated rats, at dosage levels of tamoxifen 50 mg/kg and GMODT 100 mg/kg with 2.5 hr-intervals, in this experiment. Conclusions : According to the results, GMODT critically decreased on the oral bioavailability of tamoxifen through variable influences on the absorption and excretion of tamoxifen. Hence, the co-administration of GMODT and tamoxifen should be avoided in the comprehensive and integrative medicine, combination therapy of tamoxifen with GMODT on the breast cancer.

• Child Health Nursing Research
• /
• 제20권2호
• /
• pp.75-86
• /
• 2014

목적 본 연구는 기존 문헌의 체계적인 고찰을 통해 국내에서 영유아를 대상으로 수행된 모아상호작용에 관해 보고된 중재 연구의 특성과 중 재내용을 분석, 평가하여 최적의 중재를 적용하기 위한 근거자료를 제공하고자 시도되었다. 방법 본 연구는 영유아를 대상으로 한 모아상호작용 중재 효과를 객관적으로 규명하기 위한 통합적 문헌고찰 연구이다. 결과 19편의 논문 중 18편(94.7%)이 비 무작위 대조연구(NRCCT)였고 1편은 단일군 사전사후설계연구이었다. 신생아 대상 논문이 9편, 미숙아 대상 논문이 5편, 장애 영아 대상 논문이 1편, 중환자실에 입원한 영아 대상 논문이 1편, 영유아를 대상으로 한 연구가 3편이었다. 모아상호작용에 적용한 중재연구를 내용 분석한 결과, 전신 마사지를 포함하여 총 6종류의 중재가 적용되었으며, 감각자극을 적용한 논문이 8편으로 가장 많았고, 교육 및 증진프로그램을 적용한 중재연구는 4편, 전신 마사지를 적용한 중재연구 3편, 캥거루식 돌보기를 적용한 논문 2편, 방문지원 1편, 음악요법 1편이었다. 결론 추후 연구에서는 대상자 수를 확대하여 통합적 문헌고찰에 적합한 연구설계를 적용할 필요가 있으며, 모아상호작용 중재효과의 지속시기에 대한 연구가 수행됨으로 모아상호작용 증진에 보다 적합한 간호 중재임을 증명할 수 있는 과학적인 근거가 축적될 수 있어야겠다.

• 대한한방내과학회지
• /
• 제42권5호
• /
• pp.833-845
• /
• 2021

Parkinson's syndrome is a degenerative brain disease that presents characteristic motor symptoms of tremor, rigidity, and gait disturbance. In addition to these motor symptoms, Parkinson's syndrome also presents non-motor symptoms (NMSs) such as sleep disturbance and cognitive decline. NMSs reduce patient's quality of life and psychosocial functioning and cause economic burden on the patient, so appropriate evaluation and treatment are required. Lewy body dementia is one of the several diseases belonging to Parkinson's syndrome. Its symptoms such as cognitive function, memory impairment, and hallucinations occur with Parkinsonism. Although drug therapy is being used with drug treatment to treat non-motor symptoms, it has limitations such as side effects, which stimulated interest in other complementary treatment methods such as oriental medicine treatment, dance, and yoga. The patient in this case complained of tremor in the right upper extremity, muscle hypertension and pain, and persistent vision, memory, and cognitive decline. The patient was diagnosed with probable Lewy body dementia. The patient was hospitalized for 4 months and received acupuncture and herbal medicines. After treatment, the patient's NMS scale scores decreased from 90 to 63, and the Unified Parkinson's Disease Rating Scale scores (summed I, II, and III) decreased from 17 points to 8 points. The Beck Depression Inventory score decreased from 22 points to 13 points. In addition, the patient's subjective evaluation revealed improvement. In this case, a patient diagnosed with probable Lewy body dementia who did not respond to the standard treatment and did not want to take medications showed improvement in not only motor symptoms but also NMSs after integrative Korean medicine treatment.

• 수면정신생리
• /
• 제25권2호
• /
• pp.58-67
• /
• 2018

목 적 : 본 연구는 과도한 감정노동에 노출되어 있는 여성 감정노동자들을 대상으로 해양자원을 활용한 심신치유 기법이 효과가 있는지 여부를 알아보는 예비 연구이다. 방 법 : 정상 참고치 이상의 감정노동에 노출되어 있는 신체건강한 여성 감정노동자 12명을 대상으로, 경남 고성 당항포 일대에서 해양자원을 이용한 심신치유 프로그램을 4박 5일간 시행하였다. 피험자들에게 프로그램에 참여하도록 한 뒤 사전, 사후, 추후의 평가를 바탕으로 수면, 기분, 인지기능 영역의 변화를 확인하기 위해 통계분석을 실시하였다. 결 과 : 프로그램에 참가한 뒤 피험자들의 수면의 질이 호전되고 수면 잠복기가 유의하게 감소하였고 우울, 긴장, 분노, 피로 등 기분상태의 호전을 보였으며, 인지기능 또한 향상되었다. 수면의 질, 우울기분을 비롯한 상기 효과는 한 달 반 뒤 실시한 추후 평가에서도 동일하게 확인되었다(PSQI t = 2.63, p = 0.02, HAM-D t = 5.92, p < 0.001). 결 론 : 해양자원을 활용한 심신치유 기법이 긴장을 이완하고 스트레스를 낮추는데 효과적일 수 있음을 시사하며, 이와 관련해 대조군을 포함한 추후연구 및 체계적인 프로그램 개발이 필요하다.

• 대한한방내과학회지
• /
• 제41권6호
• /
• pp.1231-1244
• /
• 2020

Objective: This study was conducted to report the glucose-lowering effect and safety of herbal extracts in patients with type 2 diabetes mellitus. Methods: We investigated 21 patients with type 2 diabetes mellitus who were administered Daeshiho-tang, Bojungikgi-tang, Jowiseunggi-tang, and Hoechunyanggyeok-san at Kyung-Hee University Korean Medical Hospital from 2014 to 2019. The hypoglycemic effect of the herbal extracts was assessed by comparing blood glucose levels, including fasting blood sugar (FBS) and 2-hour postprandial glucose (PP2) levels. For safety assessment, the effects of herbal extracts on liver and kidney function were analyzed by liver function tests, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT), and kidney function tests, including blood urea nitrogen (BUN) and creatinine (Cr). Patients were stratified according to their glycated hemoglobin (<6.5 or >6.5) levels and the kind of herbal extract used for treatment. Results: After administration of herbal extracts, FBS and PP2 significantly decreased to 20.24 mg/dL and 35.0 mg/dL respectively. Subgroup analysis revealed that, regardless of the glycated hemoglobin level, FBS and PP2 were significantly reduced in both groups. The safety profile showed no significant difference before and after taking herbal extracts. Conclusions: Daeshigo-tang, Bojungikgi-tang, Jowiseunggi-tang, and Hoechunyanggyeok-san may show the further glucose-lowering effects on patients with type 2 diabetes mellitus who have already treated with anti-hyperglycemic agents.

• 대한한의학방제학회지
• /
• 제31권4호
• /
• pp.361-371
• /
• 2023

Objectives : Gastric cancer is a malignant tumor of the digestive tract that not only has a high mortality rate, but also affects quality of life. In Traditional Korean Medicine, acupuncture and herbal medicines can increase the survival rate for Gastric cancer and improve the quality of life. Traditional Korean Medicine treatment played an important role when used alone or in combination with chemotherapy. However, there is still insufficient evidence to support the efficacy and safety of Traditional Korean Medicine in patients undergoing chemotherapy after surgery. Therefore, the purpose of this study is to systematically evaluate the effect of oriental medicine treatment on patients as a complementary therapy for Gastric cancer. Methods : 2 researchers will search using EMBASE, Pubmed, CNKI, Cochrane Library, CiNii, KMBASE, KISS, OASIS, RISS, ScienceON. The search period of the database is from inception until June 2022. This study will include a randomized controlled trial of GC for acupuncture and herbal treatment. Primary outcomes include anti-cancer effects. Secondary outcomes evaluate survival rates and improvements in quality of life. The data uses Review Manager Software 5.4. Results : This study will provide a systematic evaluation by synthesizing the anti-cancer effect, survival rate and quality of life of Gastric cancer when Traditional Korean Medicine is combined with chemotherapy. Conclusion : The conclusion of this study will provide a basis for determining whether Traditional Korean Medicine treatment for Gastric cancer treatment is an effective and safe treatment method in clinical practice.

• 한방재활의학과학회지
• /
• 제31권4호
• /
• pp.105-116
• /
• 2021

Objectives Lumbar herniated intervertebral disc (L-HIVD) is common disease in which Western-Korean collaborative treatment is performed in Korea. This study aimed to analyze Western-Korean collaborative treatment utilization of Korean patients with L-HIVD using Health Insurance Review & Assessment Service's Patients Sample Data. Methods This study used the Health Insurance Review & Assessment Service-National Patient Sample (HIRA-NPS) in 2018. Claim data of L-HIVD patients were extracted. The claim data were rebuilt with the operational concept of 'episode of care' and divided into Korean medicine episode group (KM), Western medicine episode group (WM) and collaborative treatment episode group (CT). General characteristics, medical expenses and healthcare utilization were analyzed. In addition, the difference of average visit day and average medical expenses between non-collaborative group (KM plus WM) and CT were analyzed by the propensity score matching method. Results A Total of 64,333 patients and 365,745 claims were extracted. The number of episodes of WM, KM and CT was 69,383 (92.97%), 3,903 (5.23%), and 1,341 (1.80%) respectively. The frequency of collaborative treatment episode was higher in women and the age of 50s. The most frequently described treatment in CT was acupuncture therapy. As a result of the propensity score matching, the number of visit days and medical expenses in the collaborative treatment group was higher than in the non-collaborative group. Conclusions The analysis of healthcare utilization of Korean-Western collaborative treatment may be used as basic data for establishing medical policies and systematic collaborative treatment model in the future.