• Journal of the military operations research society of Korea
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• v.22 no.2
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• pp.49-72
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• 1996

This study examined the antecedents and outcomes of leader-member exchange (LMX) quality in the Korean Army platoons. Although a number of studies have devoted substantial attention to the application of the LMX theory in various organizational settings, there has been no effort to verify or to apply the model to a military situation. In this paper, we tried to build an integrative LMX model to apply to the Korean army. We developed, on the basis of literature review, an integrative framework describing the factors affecting the LMX quality, LMX quality outcomes and the moderators of LMX quality-outcomes. Then we collected data from the 404 lieutenant-soldier dyads. The analysis of the data showed that 1) interpersonal variables (perceived similarity and liking of soldier) and LMX quality were significantly related, 2) LMX quality and outcome variables(soldier's performance, job satisfaction, and morale) were significantly related, and 3) the relationship between LMX quality and soldier's performance were strongly significant when task challenge is high but nonsignificant when task challenge is low, while there were nonsignificant or weekly significant relationships between LMX quality and soldier's performance when task challenge is moderate. The results are basically coinciding with the previous research, except that, with the low challenge tasks, the LMX quality did not affect soldier's performance, which seems to be due to the directive leadership style of the lieutenants. The theoretical and practical implications and future research directions are discussed.

• Biomolecules & Therapeutics
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• v.30 no.5
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• pp.409-417
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• 2022

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, and accumulating evidence indicates that mitochondrial dysfunction is associated with progressive deterioration in PD patients. Previous studies have shown that sinapic acid has a neuroprotective effect, but its mechanisms of action remain unclear. The neuroprotective effect of sinapic acid was assayed in a PD mouse model generated by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as well as in SH-SY5Y cells. Target protein expression was detected by western blotting. Sinapic acid treatment attenuated the behavioral defects and loss of dopaminergic neurons in the PD models. Sinapic acid also improved mitochondrial function in the PD models. MPTP treatment increased the abundance of mitochondrial fission proteins such as dynamin-related protein 1 (Drp1) and phospho-Drp1 Ser616. In addition, MPTP decreased the expression of the REV-ERB α protein. These changes were attenuated by sinapic acid treatment. We used the pharmacological REV-ERB α inhibitor SR8278 to confirmation of protective effect of sinapic acid. Treatment of SR8278 with sinapic acid reversed the protein expression of phospho-Drp1 Ser616 and REV-ERB α on MPTP-treated mice. Our findings demonstrated that sinapic acid protects against MPTP-induced PD and these effects might be related to the inhibiting abnormal mitochondrial fission through REV-ERB α.

• The Journal of Korean Medicine
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• v.29 no.1
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• pp.25-38
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• 2008

Objectives : Integrative medicine in Korea is the 21st century-style medical practice of two orthodox medical doctrines, traditional Korean medicine and western conventional medicine, as well as complementary and alternative medicine (CAM). CAM with scientific evidence should be incorporated in undergraduate curricula for the purpose of Korean integrative medicine. Methods : Items of detailed objectives, syllabi, textbooks, instructor's experiences, and effectiveness and reason for difficulty of the CAM curriculum for undergraduate students were analyzed and the preference of CAM therapies and others were also evaluated. Results and Discussion : The effectiveness of this CAM class curriculum was high (8.0$\pm$1.4) enough to be used in other Oriental medical colleges. Development of ability for self-study was rated as 7.0$\pm$1.7 and the helpfulness for clinical use was marked as 6.8$\pm$1.9. Students preferred placebo, Ayurveda, aromatherapy, yoga, functional food, bio-feedback and homeopathy. The difficulty degree was 7.2$\pm$1.6, and the amount of content was suggested as the major reason for it. We also found that this curriculum can be a model for self-oriented study and problem-based learning. Discussions were made for the improvement of the implemented CAM curriculum, which was shown to be very effective for the achievement of Korean integrative medicine. Conclusion : We have successfully installed a CAM curriculum for undergraduate students at the College of Oriental Medicine, and it can be used in others.

• Journal of Korean Medicine Rehabilitation
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• v.27 no.4
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• pp.111-119
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• 2017

Objectives Clinical pathway (CP), is management plans that display goals for patients and have led to improve outcomes for many diseases. In Korea, Interest in Korean medicine's stabilization (Clinical pathway, Clinical Practice Guideline) is increasing, But the number of studies is scare. Method and Analysis This trials composes nonequivalent control group pretest-posttest design to conduct clincal pathway trial for the acute pain after back surgery. The subjects were 10 control patients with back surgery, and 10 experimental patients with application of integrative CP. Each group patient will observed 6 weeks. We check validation of CP. Also we compared the patient's status using the pain, function, Quality of life index between the two groups. Discussion This trial is the first CP for the acute pain after back surgery using integrative medicine concepts. Aim of this trial is to find the effectiveness and validity of clincal pathway for acute pain after back surgery.

• The Plant Pathology Journal
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• v.28 no.1
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• pp.81-86
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• 2012

We developed a reassortant RNA virus vector derived from $Cucumber$ $mosaic$ $virus$ (CMV), which has advantages of very wide host range and can efficiently induce gene silencing in a few model plants. Certain CMV isolates, however, show limited host ranges presumably because they naturally co-evolved with their own hosts. We used a reassortant comprised of two strains of CMV, Y-CMV and Gn-CMV, to broaden the host range and to develop a virus vector for virus-induced gene silencing (VIGS). Gn-CMV could infect chili pepper and tomato more efficiently than Y-CMV. Gn-CMV RNA1, 3 and Y-CMV RNA2-A1 vector were newly reconstructed, and the transcript mixture of RNA1 and 3 genomes of Gn-CMV and RNA2 genome of Y-CMV RNA2 containing portions of the endogenous phytoene desaturase (PDS) gene (CMV2A1::PDSs) was inoculated onto chili pepper (cv. Chung-yang), tomato (cvs. Bloody butcher, Tigerella, Silvery fir tree, and Czech bush) and $Nicotiana$ $benthamiana$. All the tested plants infected by the reassortant CMV vector showed typical photo-bleaching phenotypes and reduced expression levels of $PDS$ mRNA. These results suggest that the reassortant CMV vector would be a useful tool for the rapid induction of the RNA silencing of endogenous genes in chili pepper and tomato plants.

• Genomics & Informatics
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• v.2 no.1
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• pp.7-18
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• 2004

Integrated genomics refers to the use of large-scale, systematically collected data from various sources to address biological and biomedical problems. A critical ingredient to a successful research program in integrated genomics is the establishment of an effective computational infrastructure. In this review, we suggest that the computational infrastructure challenges include developing tools for heterogeneous data organization and access, innovating techniques for combining the results of different analyses, and establishing a theoretical framework for integrating biological and quantitative models. For each of the three areas - data integration, analyses integration, and model integration - we review some of the current progress and suggest new topics of research. We argue that the primary computational challenges lie in developing sound theoretical foundations for understanding the genome rather than simply the development of algorithms and programs.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2947-2950
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• 2007

A 3D human ventricular model is proposed to simulate an integrative analysis of heart physiology and blood hemodynamics. This consists of the models of electrophysiology of human cells, electric wave propagation of tissue, heart solid mechanics, and 3D blood hemodynamics. The 3D geometry of human heart is discretized to a finite element mesh for the simulation of electric wave propagation and mechanics of heart. In cellular level, excitations by action potential are simulated using the existing human model. Then the contraction mechanics of a whole cell is incorporated to the excitation model. The excitation propagation to ventricular cells are transiently computed in the 3D cardiac tissue using a mono-domain method of electric wave propagation in cardiac tissue. Blood hemodynamics in heart is also considered and incorporated with muscle contraction. We use a PISO type finite element method to simulate the blood hemodynmaics in the human ventricular model.

• Journal of Broadcast Engineering
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• v.21 no.1
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• pp.24-35
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• 2016

By estimating environment light distribution, we can generate realistic shadow images in AR(augmented reality). When we estimate light distribution without sensing equipment, environment light model, geometry of virtual object, and surface reflection property are needed. Previous study using 3D marker builds surrounding light environment with a geodesic dome model and analyzes shadow images. Because this method employs candidate shadow maps in initial scene setup, however, it is difficult to estimate precise light information. This paper presents a novel light estimation method based on hierarchical light distribution model subdivision. By using an overlapping area ratio of the segmented shadow and candidate shadow map, we can make hierarchical subdivision of light geodesic dome.

• Korean Journal of Ecology and Environment
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• v.43 no.3
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• pp.356-368
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• 2010

In this study, we applied approach of integrative star-plot area (SPA), chemical water quality and habitat conditions (QHEI) to diagnoze ecological conditions at the eight sampling sites of Sapkyo Stream. These outcomes were compared with biological health based on the Index of Biological Integrity (IBI) using fish assemblage. And then, we evaluated the integrative ecological health condition using the star-plot method. This approach based on the sum of all the star-plot areas over these water and habitat characteristics. It was developed to reflect an integrative assessment of the ecological health in the stream. The biological health, based on the model values of IBI indicating "fair-poor" condition according to the criteria. Physical habitat health, based on the QHEI, averaged 123 indicating a "good-fair" condition. Also, chemical health, based on simply BOD values indicating "poor grade" according to the criteria of the Ministry of Environment Korea (MEK). The SPA indicating that 50% of the all was impaired condition and the most sampling sites were downstream sites influenced by the point and non-point sources. Overall our results suggest that the ecological health impact was a combined effect of eutrophication and habitat degradations in the stream. The approach of SPA can be used as a tool to evaluate the integrative health of stream environment and to identify possible causes of observed effects.

• IE interfaces
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• v.21 no.2
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• pp.209-220
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• 2008

Recently, innovative medical services are fast emerging, which include customized medical services based on bio-informatics, composition of cure and well-being exploiting ubiquitous technology, hospital supply chain management using RFID, and so forth. However, conventional approaches for new service development hardly give us systematic model to analyze and produce creative medical services. Because most of them are static and concentrate on microscopic tools or techniques. Thus, it is highly desirable to suggest an integrative framework to organize the whole transformation process from technology to medical service. The objective of this study is to propose a medical service engineering model based on the dynamic innovation theory. The proposed model contains objectives of service system, strategies of hospital, stages, activities required to deal with medical service life cycle, which incorporates the acquisition of new technology, transformation to the product, penetration into market, and adoption of consumers. In addition, the usefulness and applicability of the newly proposed model are provided using catholic medical center example.