• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제34권1호
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• pp.37-44
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• 2023

Objectives: Tic disorders are highly heritable; however, growing evidence suggests that environmental factors play a significant role in their pathogenesis. Studies on these factors have been inconsistent, with conflicting results. Therefore, this study aimed to examine the associations of pre- and perinatal exposure to Tourette syndrome (TS) or chronic tic disorders (CTD) in Korean school-aged children. Methods: This case-control study used data from a large prospective cohort study. The primary outcome was TS/CTD diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria and Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version. Demographic, pre-, and perinatal information was obtained from the maternal questionnaires. Data between the TS/CTD and control groups were compared using the chi-squared or Student's t-test, as appropriate. Two-step logistic regression analyses were used to test the association between TS/CTD and pre- and perinatal risk factors. Results: We included of 223 children (78 with TS/CTD and 145 controls). Significant differences in the demographic data between the two groups were observed. The male sex ratio, mean parental age, parental final education level, and family history of tics were included as confounders. In the final adjusted multivariable model, TS/CTD was significantly associated with antiemetic exposure during pregnancy (odds ratio [OR]=16.61, 95% confidence interval [CI] 1.49-185.22, p=0.02) and medically assisted reproduction (OR=7.89, 95% CI 2.28-27.28, p=0.01). Conclusion: Antiemetic exposure and medically assisted reproduction are significantly associated with the risk of TS/CTD. These results should be replicated in future prospective and gene-by-environment studies.

• 한국엔터테인먼트산업학회논문지
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• 제13권1호
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• pp.81-88
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• 2019

본 연구는 무용공연의상에 대해 체계적으로 수집하고 분류하여 저장할 수 있는 디지털 뮤지엄 형식의 아카이빙을 구축함으로써 무용공연의상에 대한 인물이나 작품주제를 파악하고, 또 교육적으로 활용할 수 있도록 하고자 한 것이다. 먼저 이론적 배경으로 디지털 뮤지엄 아카이빙이 무엇인지를 서술하고, 연구내용으로 디지털 뮤지엄을 어떻게 만들 수 있는 지에 대해 구체적인 예를 들어 설계해 보았다. 그리고 이러한 아카이빙의 역할이나 효용성에 대해 가치를 논한 뒤 다음과 같은 결론을 내렸다. 아카이브란 텍스트 문서로 국한되어 있던 자료의 전반, 또는 자료의 저장 공간을 포괄적으로 의미하는 용어로 컴퓨터라는 가상공간에서 이루어지는 전시통합모델을 말한다. 따라서 무용공연작품의상을 디지털 뮤지엄으로 만든다면 무용공연작품의상이라는 웹상의 가상공간에 하우스를 만들고, 그 뮤지엄으로 들어가면 다시 대분류, 중분류, 소분류로 카테고리 창을 구분하였다. 대분류에서는 무용공연작품의 장르를 한국무용, 현대무용, 발레로 구분하고, 중분류에서는 안무가, 의상디자이너를 구분하여 들어갈 수 있게 하였으며, 소분류에서는 안무가나 의상디자이너의 기타자료인 신문, 방송 인터뷰, 공연사진, 프로그램 등을 보는 것으로 아카이빙 해 보았다. 이러한 디지털 뮤지엄의 가치로는 공간활용의 가치, 창작의 가치, 역사 문화적 가치, 다양한 교육프로그램으로 활용 가치, 디지털 뮤지엄 콘텐츠의 제공 및 이해의 가치, 쌍방 소통의 가치, 그리고 새로운 전시형태 프로그램 개발의 가치를 지닌다.

• 한국지형학회지
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• 제17권1호
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• pp.49-57
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• 2010

한반도 중부에서의 강우사상 동안의 강우입자의 물리적 특성을 규명하고 강우강도와 강우에너지와의 관계를 도출하기 위해 2008년부터 2009년 사이에 3회에 걸쳐 경기도 안성시 고삼저수지 인근에서 laser-optical disdrometer를 이용하여 강우입자의 크기와 종말속도를 측정하였다. 측정된 강우입자의 크기분포와 강우입자의 종말속도를 이용하여 강우강도와 강우운동에너지 함유량(KE, Jm^-2mm^-1)과의 관계와 강우강도와 운동에너지 소비율(KER, Jm^-2h^-1)의 관계를 각각 제안하였다. 그리고 tipping-bucket 강우계로 측정한 강우강도를 disdrometer 의 강우강도로 보정해주는 관계도 제안하였다. 그리하여 본 연구에서 제안된 강우강도와 강우의 운동에너지와의 관계는 한반도 중부지방에서 5분 강우강도가 최대 40mmh^-1 아래인 경우에 강우강도를 이용하여 강우의 운동에너지로 변환하고자 할 때 유용한 모델이 될 수 있을 것으로 판단된다.

• 대한한방부인과학회지
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• 제22권1호
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• pp.263-278
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• 2009

Purpose: The purpose of this study is to research trends in the study of breast cancer in Traditional Chinese Medicine (TCM) and to establish the further direction for its study. Methods: We reviewed TCM papers published in the last 29 years (1979-2008). Results: 1. We researched 49 papers and the patterns of study were as follows: in vitro studies were 27 papers (55.1%), in vivo studies were 9 papers (18.4%) and clinical studies were 19 papers (38.8%). 2. In vitro studies on breast cancer research in TCM were focused on cytotoxicity (17 papers) and apoptosis (8 papers). Most of in vivo studies (6 papers) were done for the purpose of inducing growth suppression of tumor cell after administration of the test drug. Each drug acted on this effect through various types of mechanism. 3. Unlike in vitro and in vivo studies, clinical studies on growth suppression of tumor cell were rare (4 papers). Most of the studies were focused on reduction of side effect of chemotherapy or synergistic effect with chemotherapy (7 papers), immune regulation (7 papers), and improvement of quality of life (6 papers). 4. Among the treatment method we reviewed, 'Runing Ⅱ(Ⅱ號方)' was the only medication that further studied as clinical trial after experimental study. 5. Since almost all studies have defects like poorly designed model or insufficient data description, it was difficult to make any definite conclusion about these studies. Conclusion: More subsequent clinical studies based on experimental study will be needed afterwards. Strict and high-level study design with detailed description will be needed in further study.

• 생명과학회지
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• 제34권5호
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• pp.287-295
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• 2024

간세포암종은 전 세계적으로 암 관련 사망의 두 번째 주요 원인으로 새로운 치료 전략을 필요로 한다. 간세포암종 환자를 치료에 사용되는 화학요법제는 독성이 있고 심각한 부작용이 있는 것으로 알려졌다. 본 연구는 건강한 간세포에서 세포독성을 일으키지 않으면서 종양세포를 표적으로 하는 부작용을 감소시키는 항암제의 효능을 조사하였다. Berberine은 이소퀴놀린 알칼로이드의 식물 유래 화합물로 다양한 약리학적 특성으로 인해 암 치료의 잠재적 후보군으로 보고되고 있다. 간암 세포 생존율에 대한 berberine의 효과는 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide 분석을 사용하여 측정하였다. HCC 증식은 콜로니 형성 분석을 통해 실시하였다. 세포이동에 대한 berberine의 효과는 상처 치유 분석으로 실시하였다. Berberine은 HepG2 세포와 같은 간암 세포의 증식과 콜로니 형성 및 세포이동을 억제하였다. Berberine 처리는 Beclin-1 및 LC3-II 등의 자가포식 관련 유전자 발현과 단백질 발현을 증가시켰으며, Caspase-3 및 Caspase-9등의 세포자멸사의 mRNA 발현 및 활성을 증가시켰다. 또한, 세포유래 이종이식 동물실험에서 berberine 처리에 따른 종양의 크기와 무게가 감소함을 확인하였다. 본 연구 결과는 간세포암에 대한 베르베린의 효능을 조명하여 표적 및 맞춤형 치료의 기회를 제시할 수 있음을 시사한다.

• BMB Reports
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• 제57권6호
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• pp.281-286
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• 2024

Adult hippocampal neurogenesis plays a pivotal role in maintaining cognitive brain function. However, this process diminishes with age, particularly in patients with neurodegenerative disorders. While small, non-coding microRNAs (miRNAs) are crucial for hippocampal neural stem (HCN) cell maintenance, their involvement in neurodegenerative disorders remains unclear. This study aimed to elucidate the mechanisms through which miRNAs regulate HCN cell death and their potential involvement in neurodegenerative disorders. We performed a comprehensive microarray-based analysis to investigate changes in miRNA expression in insulin-deprived HCN cells as an in vitro model for cognitive impairment. miR-150-3p, miR-323-5p, and miR-370-3p, which increased significantly over time following insulin withdrawal, induced pronounced mitochondrial fission and dysfunction, ultimately leading to HCN cell death. These miRNAs collectively targeted the mitochondrial fusion protein OPA1, with miR-150-3p also targeting MFN2. Data-driven analyses of the hippocampi and brains of human subjects revealed significant reductions in OPA1 and MFN2 in patients with Alzheimer's disease (AD). Our results indicate that miR-150-3p, miR-323-5p, and miR-370-3p contribute to deficits in hippocampal neurogenesis by modulating mitochondrial dynamics. Our findings provide novel insight into the intricate connections between miRNA and mitochondrial dynamics, shedding light on their potential involvement in conditions characterized by deficits in hippocampal neurogenesis, such as AD.

• Journal of Ginseng Research
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• 제47권5호
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• pp.627-637
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• 2023

Background: Damage to the healthy intestinal epithelial layer and regulation of the intestinal immune system, closely interrelated, are considered pivotal parts of the curative treatment for inflammatory bowel disease (IBD). Plant-based diets and phytochemicals can support the immune microenvironment in the intestinal epithelial barrier for a balanced immune system by improving the intestinal microecological balance and may have therapeutic potential in colitis. However, there have been only a few reports on the therapeutic potential of plant-derived exosome-like nanoparticles (PENs) and the underlying mechanism in colitis. This study aimed to assess the therapeutic effect of PENs from Panax ginseng, ginseng-derived exosome-like nanoparticles (GENs), in a mouse model of IBD, with a focus on the intestinal immune microenvironment. Method: To evaluate the anti-inflammatory effect of GENs on acute colitis, we treated GENs in Caco2 and lipopolysaccharide (LPS) -induced RAW 264.7 macrophages and analyzed the gene expression of proinflammatory cytokines and anti-inflammatory cytokines such as TNF-α, IL-6, and IL-10 by real-time PCR (RT-PCR). Furthermore, we further examined bacterial DNA from feces and determined the alteration of gut microbiota composition in DSS-induced colitis mice after administration of GENs through 16S rRNA gene sequencing analysis. Result: GENs with low toxicity showed a long-lasting intestinal retention effect for 48 h, which could lead to effective suppression of pro-inflammatory cytokines such as TNF-α and IL-6 production through inhibition of NF-κB in DSS-induced colitis. As a result, it showed longer colon length and suppressed thickening of the colon wall in the mice treated with GENs. Due to the amelioration of the progression of DSS-induced colitis with GENs treatment, the prolonged survival rate was observed for 17 days compared to 9 days in the PBS-treated group. In the gut microbiota analysis, the ratio of Firmicutes/Bacteroidota was decreased, which means GENs have therapeutic effectiveness against IBD. Ingesting GENs would be expected to slow colitis progression, strengthen the gut microbiota, and maintain gut homeostasis by preventing bacterial dysbiosis. Conclusion: GENs have a therapeutic effect on colitis through modulation of the intestinal microbiota and immune microenvironment. GENs not only ameliorate the inflammation in the damaged intestine by downregulating pro-inflammatory cytokines but also help balance the microbiota on the intestinal barrier and thereby improve the digestive system.

• Asia pacific journal of information systems
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• 제17권4호
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• pp.61-95
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• 2007

Small-and-medium sized enterprises(SMEs) represent quite a large proportion of the industry as a whole in terms of the number of enterprises or employees. However researches on information system so far have focused on large companies, probably because SMEs were not so active in introducing information systems as larger enterprises. SMEs are now increasingly bringing in information systems such as ERP(Enterprise Resource Planning Systems) and some of the companies already entered the stage of ongoing use. Accordingly, researches should deal with the use of information systems by SME s operating under different conditions from large companies. This study examined factors and mechanism inducing faithful appropriation of information systems, in particular integrative systems such as ERP, in view of individuals` active feedback-seeking behavior. There are three factors expected to affect end users` feedback-seeking behavior for faithful appropriation of information systems. They are management support, peer IT champ support, and IT staff support. The main focus of the study is on how these factors affect feedback-seeking behavior and whether the feedback-seeking behavior plays the role of mediator for realizing faithful appropriation of information systems by end users. To examine the research model and the hypotheses, this study employed an empirical method based on a field survey. The survey used measurements mostly employed and verified by previous researches, while some of the measurements had gone through minor modifications for the purpose of the study. The survey respondents are individual employees of SMEs that have been using ERP for one year or longer. To prevent common method bias, Task-Technology Fit items used as the control variable were made to be answered by different respondents. In total, 127 pairs of valid questionnaires were collected and used for the analysis. The PLS(Partial Least Squares) approach to structural equation modeling(PLS-Graph v.3.0) was used as our data analysis strategy because of its ability to model both formative and reflective latent constructs under small-and medium-size samples. The analysis shows Reliability, Construct Validity and Discriminant Validity are appropriate. The path analysis results are as follows; first, the more there is peer IT champ support, the more the end user is likely to show feedback-seeking behavior(path-coefficient=0.230, t=2.28, p<0.05). In other words, if colleagues proficient in information system use recognize the importance of their help, pass on what they have found to be an effective way of using the system or correct others' misuse, ordinary end users will be able to seek feedback on the faithfulness of their appropriation of information system without hesitation, because they know the convenience of getting help. Second, management support encourages ordinary end users to seek more feedback(path-coefficient=0.271, t=3.06, p<0.01) by affecting the end users' perceived value of feedback(path-coefficient=0.401, t=6.01, p<0.01). Management support is far more influential than other factors that when the management of an SME well understands the benefit of ERP, promotes its faithful appropriation and pays attention to employees' satisfaction with the system, employees will make deliberate efforts for faithful appropriation of the system. However, the third factor, IT staff support was found not to be conducive to feedback-seeking behavior from end users(path-coefficient=0.174, t=1.83). This is partly attributable to the fundamental reason that there is little support for end users from IT staff in SMEs. Even when IT staff provides support, end users may find it less important than that from coworkers more familiar with the end users' job. Meanwhile, the more end users seek feedback and attempt to find ways of faithful appropriation of information systems, the more likely the users will be able to deploy the system according to the purpose the system was originally meant for(path-coefficient=0.35, t=2.88, p<0.01). Finally, the mediation effect analysis confirmed the mediation effect of feedback-seeking behavior. By confirming the mediation effect of feedback-seeking behavior, this study draws attention to the importance of feedback-seeking behavior that has long been overlooked in research about information system use. This study also explores the factors that promote feedback-seeking behavior which in result could affect end user`s faithful appropriation of information systems. In addition, this study provides insight about which inducements or resources SMEs should offer to promote individual users' feedback-seeking behavior when formal and sufficient support from IT staff or an outside information system provider is hardly expected. As the study results show, under the business environment of SMEs, help from skilled colleagues and the management plays a critical role. Therefore, SMEs should seriously consider how to utilize skilled peer information system users, while the management should pay keen attention to end users and support them to make the most of information systems.

• 한국산학기술학회논문지
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• 제18권2호
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• pp.514-523
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• 2017

본 연구는 여성 관리자가 경험하는 일과 가족 간 이중부담과 조직문화와의 관계가 조직애착 형성에 작용하는 기제를 파악하는데 목적을 두고 있다. 이를 위해 여성 관리자 패널자료 중 4차, 5차 자료를 취합하고, 5차 자료 중 근속 여성 1,627명을 대상으로 분석을 시행하였다. 분석 결과 첫째, 조직애착에 있어 일-가족 간 긍정관계 형성은 주요한 요인으로 밝혀졌다. 일하는 여성으로서 경험하는 조직과 가족의 지원은 여성 관리자가 경력을 유지함에 있어 가장 큰 동력이 됨을 확인하였다. 둘째, 여성 관리자의 조직애착은 일에서의 부정전이보다 가족에서의 부정전이에 더 영향을 받는 것으로 나타났다. 즉, 근로자임에도 가족 내 여성으로서의 지위에서 자유롭지 못하고, 이에 가족에서 발생하는 갈등관계는 여성의 조직애착에 더 큰 영향을 주는 것이다. 셋째, 3단계 모델에서 일-가족전이와 조직문화 간 상호작용 변수를 추가 투입한 결과, 조직애착에 대한 일-가족전이 및 조직문화의 독립적 영향력은 거의 나타나지 않고, 상호작용에 의한 영향력만 감지되었다. 구체적으로, 합리적 조직문화일 경우에 가족-일 긍정전이는 조직애착에 정적(+) 영향을 미치며, 일-가족 부정전이는 부적(-) 영향을 미치는 것으로 나타났다. 또한 가족-일 부정전이와 합리적 조직문화의 결합은 조직애착을 높이는 반면, 전통적 조직문화의 경우 가족-일 부정전이는 부적 영향을 가짐을 보여 주었다. 연구결과가 시사하는 바는 여성이 경험하는 가족에서 일로의 부정전이가 조직애착을 약화시킬 수 있는데, 합리적 조직문화와 결합할 경우 오히려 여성의 조직애착에 긍정적으로 기여할 수 있으리라는 점이다. 한편, 일에서 가족으로의 부정전이가 일어나는 상황에서는 이와 같은 조절효과가 나타나지 않았는데, 이처럼 전이의 방향성에 따른 상이한 효과에 대해서는 추후 연구에서 밝혀져야 할 것으로 보인다. 향후 조직문화와 일-가족전이의 통합모델을 더욱 확대하여 관련 변수들을 보다 포괄적으로 고려하고, 여성 관리자 하위그룹 분석을 통해 여성 관리자 내부의 차이를 밝혀낼 필요가 있다.

• 대한한의학회지
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• 제44권1호
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• pp.65-75
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• 2023

Objectives: Objectives: In this study, we define a medical service type that combines Western medicine, Korean medicine, and complementary and alternative medicine (CAM) as an integrated medical service. This study, as part of tertiary hospital-based integrated medical service model and clinical field application, aims to collect status and opinions on integrated medical service for medical staff in the field. Methods: This is a survey study, and was conducted on doctors from Kyung Hee University Hospital and Korean medicine doctors from Kyung Hee University Korean Medicine Hospital. Respondents were recruited on a first-come, first-served basis until the number of respondents reached 120. The investigation was conducted for a total of 16 days from October 4, 2021 to October 19, 2021 by e-mail. Results: Recognition of integrated medical services was confirmed to be 45.8%, and 49.2% responded positively to the necessity of it. As a group of diseases that require the establishment of integrated medical services in the future, 'disorders of musculoskeletal systems and connective tissues' was the highest. The most expected advantages of providing integrated medical services were 'increased satisfaction of patients and guardians' and 'increased treatment effects.' Conclusions: In this study, we investigated the perception of doctors and Korean medicine doctors on integrated medical services that combine Western medicine, Korean medicine, and CAM. It has been confirmed that medical staff generally have a positive perception of integrated medical services, and if the scientific basis for the effect of integrated medical services is supported, the rate of positive perception is expected to increase.