• Journal of The Korean Association For Science Education
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• 제33권4호
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• pp.763-777
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• 2013

This is a case study on two schools practising integrated science education (hereafter ISE). The purposes of this study are to investigate the types and features of ISE in the schools actively practising ISE, to identify the contextual factors of the schools, and to give implications for implementing ISE in schools. This study investigated the contextual factors in practicing ISE with a focus on the two schools, a middle school in Gyeonggi-do and a high school in Busan. They were breaking down the boundaries among teaching subjects and providing student-oriented instruction with problems in the real world. The data were collected by observing classes, by interviewing teachers, and by reviewing school documents and students' reports. The research findings are as follows: first, the two schools took part in ISE actively. They teach science to students providing integrated experiences mainly by using interdisciplinary knowledge and/or by solving the problems pertaining to the real world. While the former integrated subjects centering on topics, the latter focused on a project-based learning driven by students. They have differences in regard to the role of teachers and students, the level of integration and the type of integration. Second, the contextual factors that enabled ISE to be implemented there were found. The previous studies revealed six contextual factors in practising ISE: small and stable learning environment, leadership, team activities, in-school planning time, flexible timetable and community links. This study also found similar factors. However, the cases of this study provided ISE on a large scale and in a short period of time, instead of a small and stable learning environment. Teachers viewed the process of ISE not only as a tool to overcome the conservative culture of teachers but also as a pursuit of innovation.

• BMB Reports
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• 제47권1호
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• pp.15-20
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• 2014

Intracellular lipid-binding proteins (LBPs) impact fatty acid homeostasis in various ways, including fatty acid transport into mitochondria. However, the physiological consequences caused by mutations in genes encoding LBPs remain largely uncharacterized. Here, we explore the metabolic consequences of lbp-5 gene deficiency in terms of energy homeostasis in Caenorhabditis elegans. In addition to increased fat storage, which has previously been reported, deletion of lbp-5 attenuated mitochondrial membrane potential and increased reactive oxygen species levels. Biochemical measurement coupled to proteomic analysis of the lbp-5(tm1618) mutant revealed highly increased rates of glycolysis in this mutant. These differential expression profile data support a novel metabolic adaptation of C. elegans, in which glycolysis is activated to compensate for the energy shortage due to the insufficient mitochondrial ${\beta}$-oxidation of fatty acids in lbp-5 mutant worms. This report marks the first demonstration of a unique metabolic adaptation that is a consequence of LBP-5 deficiency in C. elegans.

• The Korean Journal of Community Living Science
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• 제26권4호
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• pp.675-681
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• 2015

This study investigates traditional knowledge of plants used for river fishing in local communities of North Jeolla Province, Korea. Data were collected using the participatory rural appraisal method based on interviews, informal meetings, open and group discussions, and overt observations with semi-structured questionnaires. Field investigations were conducted at 19 sites from July 2008 to April 2010. Interviews included 37 key informants (16 men and 21 women) who lived more than 50 years in the area. The average age of the informants was 83 (range = 60 to 96). The analysis recorded seven species, namely Albizia julibrissin Durazz., Juglans mandshurica Maxim., Perilla frutescens var. japonica (Hassk.) H. Hara, Nelumbo nucifera Gaertn., Persicaria hydropiper (L.) Spach, Zanthoxylum piperitum (L.) DC., and Styrax japonicus Siebold and Zucc..

• Bulletin of the Korean Chemical Society
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• 제31권10호
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• pp.2889-2892
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• 2010

The objective of this study was to validate performance characteristics of the Access 2 (Beckman coulter) system for hCG assays for use as a confirmation test for doping control. The Access 2 assay was linear up to 500 IU/L. The correlation coefficient was higher than 0.999, and the sensitivity of the linearity was 0.82. There were no false positive or false negative cases. LOD was 0.59 IU/L. The method was robust when performed by different people. Repeatability and reproducibility were below 7%. We compared reproducibility and recoveries of Access 2 and Elecsys 2010. Access 2 demonstrated higher reproducibility than Elecsys 2010. Recoveries (accuracy) of Access 2 were between 85 and 105%. Recoveries for Elecsys 2010 were between 91 and 104%.

• Polymer Science and Technology
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• 제23권3호
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• pp.296-306
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• 2012

• Proceedings of the Korean Information Science Society Conference
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• 한국정보과학회 2006년도 가을 학술발표논문집 Vol.33 No.2 (D)
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• pp.306-311
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• 2006

본 논문에서는 최초 제품의 생산에서부터 최종 소비자에 이르기까지의 전 과정에서 RFID 시스템을 이용하여 조달, 설계, 제조, 보수, 폐기의 각각의 단계별 u-Logistics 설계 및 DB통합을 통한 Integrated u-logistics 설계 방안을 제안한다. 제안한 시스템은 단계별 수집된 정보를 기초로 하여 제품 생산과정부터 소비자에게 전달되기까지의 전체 제품의 life cycle을 한곳에서 관리할 수 있기 때문에 능동적이며, 효과적인 재고 관리, 인력 관리, 수요 예측, 판매 성향 분석 등이 이루어 질수 있다. 이는 단순한 유통과정만을 관리하던 기존의 물류시스템과는 확연한 차이를 보여준다.

• Journal of Life Science
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• 제30권4호
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• pp.379-385
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• 2020

Phlojodicarpus sibiricus and Artemisia kruhsiana Besser are medicinal plants traditionally used in Russia. Phlojodicarpus sibiricus extracts (PSE) have been shown to have anti-obesity properties, and Artemisia kruhsiana Besser extracts (AKBE) contain terpenoid compounds that exert various medicinal effects. Here, we investigated the potential pro-apoptotic effects of PSE and AKBE in diffuse large B-cell lymphoma (DLBCL) and elucidated the underlying mechanism. PSE and AKBE treatment of six DLBCL cell lines with various genetic abnormalities effectively reduced cell viability in a dose-dependent manner, while having a minimal impact on the survival of normal murine bone marrow cells and splenocytes. This suggests that the cytotoxic effects of PSE and AKBE are specific to DLBCL cells. Therefore, we expect limited side effects when these plant extracts are administered to DLBCL patients. Our JC-1 assays demonstrate that the pro-apoptotic effects of these plant extracts are produced by a reduction of anti-apoptotic Bcl-2 family members and, thereby, disruption of the mitochondrial membrane potential. Moreover, PSE and AKBE induce cell death independently of Myc, whose abnormalities are frequently observed in patients with DLBCL and are associated with poor prognosis. Our findings reveal hitherto uncharacterized pro-apoptotic effects of PSE and AKBE in DLBCL. Isolation of single compounds with anti-lymphoma activities should be pursued further.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• 제36권5호
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• pp.428-437
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• 2008

e-AIRS, an abbreviation of ‘e-Aerospace Integrated Research System’, is a virtual organization designed to support the aerospace engineering processes in the e-Science environment. As the first step toward a virtual aerospace engineering organization, the e-AIRS intends to give a full support to aerodynamic research processes. Currently, the e-AIRS can handle both the computational and experimental aerodynamic researches on the e-Science infrastructure. In detail, users can conduct the full CFD(Computational Fluid Dynamics) research processes, request wind tunnel experiments, perform the comparative analysis between computational and experimental resultants and finally collaborate with other researchers using the web portal. The current paper will describe those functions and the internal architecture of the e-AIRS system.

• BMB Reports
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• 제53권9호
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• pp.484-489
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• 2020

Epilepsy is a neurological disorder characterized by unpredictable seizures, which are bursts of electrical activity that temporarily affect the brain. Cereblon (CRBN), a DCAFs (DDB1 and CUL4-associated factors), is a well-established protein associated with human mental retardation. Being a substrate receptor of the cullin-RING E3 ubiquitin ligase (CRL) 4 complex, CRBN mediates ubiquitination of several substrates and conducts multiple biological processes. In the central nervous system, the large-conductance Ca²⁺-activated K⁺ (BK_Ca) channel, which is the substrate of CRBN, is an important regulator of epilepsy. Despite the functional role and importance of CRBN in the brain, direct injection of pentylenetetrazole (PTZ) to induce seizures in CRBN knock-out mice has not been challenged. In this study, we investigated the effect of PTZ in CRBN knock-out mice. Here, we demonstrate that, compared with WT mice, CRBN knock-out mice do not show the intensification of seizures by PTZ induction. Moreover, electroencephalography recordings were also performed in the brains of both WT and CRBN knockout mice to identify the absence of significant differences in the pattern of seizure activities. Consistently, immunoblot analysis for validating the protein level of the CRL4 complex containing CRBN (CRL4^Crbn) in the mouse brain was carried out. Taken together, we found that the deficiency of CRBN does not affect PTZ-induced seizure.

• New Physics: Sae Mulli
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• 제68권12호
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• pp.1356-1363
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• 2018

The purpose of this study was to investigate science high-school students' creativity and scientific attitude when an integrated science, technology, engineering and mathematics (STEM) project themed 'lighting of quantum dot solution' was applied to them. The subjects were a one team composed of 3 students in the 11th grade desiring to participate in the Korea Science Exhibition. They began with a scientific inquiry related to the physical properties of the QD solution and then gradually showed the process of expansion of their ideas into the integration of engineering, technology, and mathematics. Also, during the process, they showed problem solving ability and scientific attitudes, such as cooperation, endurance, and satisfaction of accomplishment.