• Korean Journal of Pharmacognosy
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• v.40 no.4
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• pp.394-399
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• 2009

Aldose reductase (AR) is a critical enzyme in the development of the diabetic complications. AR, the first enzyme in the polyol pathway, catalyzes the reduction of the aldehyde form of glucose to sorbitol with concomitant conversion of NADPH to $NADP^+$. None of aldose reductase inhibitor (ARI) has achieved worldwide use because of limited efficacy or undesirable side effects. Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. Forty eight Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, seven herbal medicines, Buddleja officinalis (whole plant), Lonicera japonica (leaf and flower), Polygonum aviculare (aerial part), Polygonum aviculare (whole plant), Salvia miltiorrhiza (root), Schisandra chinensis (stem), and Zanthoxylum armatum (leaf and stem) exhibited a significant inhibitory activity against AR. Particularly, L. japonica and P. aviculare showed two times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).

• Journal of Korean Medicine Rehabilitation
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• v.31 no.3
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• pp.57-72
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• 2021

Objectives This study was conducted to investigate clinical studies about Integrated Traditional Chinese and Western Medicine therapy for Legg-Calve-Perthes disease. Methods We searched clinical studies about Integrated Traditional Chinese and Western Medicine therapy for Legg-Calve-Perthes disease through China National Knowledge Infrastructure. 17 articles published from 2000-2021 were finally chosen and analyzed by published year, study design, number of samples, diagnosis criteria, evaluation criteria, treatment period, follow up period, treatment method. Results Herbal medicine, external treatment, Chuna massage therapy were performed for traditional Chinese medical treatment. For Western medicine treatment, conservative treatment and surgical treatment were performed. Above them, herbal medicine and conservative treatment were mostly used for treating Legg-Calve-Perthes disease. Conclusions By analyzing clinical studies, We found that Integrated Traditional Chinese and Western Medicine therapy can be helpful for treating Legg-Calve-Perthes disease. In Korea, more clinical research about Legg-Calve-Perthes disease is still needed. This study will be helpful for future research on Korean medicine for Legg-Calve-Perthes disease.

• Journal of Acupuncture Research
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• v.41
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• pp.160-167
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• 2024

The present study employs the Delphi method to devise a consensus-based protocol for utilizing integrated acupuncture in treating medial tibial stress syndrome (MTSS). Twenty acupuncture experts contributed opinions across six key themes, including diagnosis, acupuncture points, additional Traditional Oriental Medicine modalities, treatment rationale, treatment duration/frequency, and integration of yoga/naturopathic therapies. Consensus, defined as a 70% agreement or higher, was reached on all themes, reflecting a collective acknowledgment of the necessity for a holistic approach to MTSS management. The final protocol includes six diagnostic criteria, six acupuncture points, one additional modality, two Traditional Oriental Medicine therapies, four treatment rationales, and six yoga/naturopathic therapies. The present comprehensive protocol offers valuable guidance for healthcare professionals seeking an integrated approach to MTSS management.

• Journal of Sasang Constitutional Medicine
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• v.24 no.3
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• pp.34-41
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• 2012

Objectives In this study, we developed a mock-up of the system for Sasang Constitutional (SC) diagnosis. This system consists of 5 devices which are the face analyzer, the voice analyzer, the skin analyzer, the pulse analyzer, and the computer-based questionnaire. Our goal is to evaluate the repeatability of the system. Methods Each device is capable of classifying SC types. The classification probability of the integrated system for the SC types was obtained by summing the probability from each device. For evaluating the repeatability of the system, we collected data for 5 subjects, and repeated the measurement three times for each individual. The average and standard deviation were used for calculating the Coefficient of Variation. Results The results showed that the repeatability of the classification probability of the integrated system is about 8%, which implies the system is repeatable. Conclusions To increase usability of this system, it is desirable for the system to offer information on health condition of the user. The integrated constitutional diagnosis system will be upgraded to complement the convenience and to develop the diagnostic algorithm for the user's health condition.

• Korean Journal of Radiology
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• v.23 no.10
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• pp.986-997
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• 2022

Objective: Whether metabolic redistribution occurs in patients with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is unknown. This study aimed 1) to propose a measure of the brain metabolic network for an individual patient and preliminarily apply it to identify impaired metabolic networks in patients with WMHs, and 2) to explore the clinical and imaging features of metabolic redistribution in patients with WMHs. Materials and Methods: This study included 50 patients with WMHs and 70 healthy controls (HCs) who underwent ¹⁸F-fluorodeoxyglucose-positron emission tomography/MRI. Various global property parameters according to graph theory and an individual parameter of brain metabolic network called "individual contribution index" were obtained. Parameter values were compared between the WMH and HC groups. The performance of the parameters in discriminating between the two groups was assessed using the area under the receiver operating characteristic curve (AUC). The correlation between the individual contribution index and Fazekas score was assessed, and the interaction between age and individual contribution index was determined. A generalized linear model was fitted with the individual contribution index as the dependent variable and the mean standardized uptake value (SUV_mean) of nodes in the whole-brain network or seven classic functional networks as independent variables to determine their association. Results: The means ± standard deviations of the individual contribution index were (0.697 ± 10.9) × 10^-3 and (0.0967 ± 0.0545) × 10^-3 in the WMH and HC groups, respectively (p < 0.001). The AUC of the individual contribution index was 0.864 (95% confidence interval, 0.785-0.943). A positive correlation was identified between the individual contribution index and the Fazekas scores in patients with WMHs (r = 0.57, p < 0.001). Age and individual contribution index demonstrated a significant interaction effect on the Fazekas score. A significant direct association was observed between the individual contribution index and the SUV_mean of the limbic network (p < 0.001). Conclusion: The individual contribution index may demonstrate the redistribution of the brain metabolic network in patients with WMHs.

• Journal of Acupuncture Research
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• v.32 no.3
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• pp.221-227
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• 2015

Objectives : The purpose of this study is to report the clinical effects of Integrated Medicine Therapy on Tuberculous Spondylitis. Methods : The patient was diagnosed with Tuberculous Spondylitis by MRI. Despite taking antituberculous drugs for one month the back pain remained. As a result the patient was hospitalized shortly thereafter in our hospital, and was treated with acupuncture, pharmacopuncture, and herbal medication during the admission period. The clinical effects of these treatments are measured by the verbal rating scale(VRS), the range of motion(ROM) and the Korean oswestry disability index(KODI). Results : VRS is changed from 10 to 3.5, limited lumbar ROM recovered, KODI changed from 85.71 to 28.57. Conclusions : These results suggest that integrated medicine therapy may be effective for tuberculous spondylitis.

• Journal of Acupuncture Research
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• v.40 no.4
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• pp.389-394
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• 2023

In infrapatellar bursitis, an acute or chronic inflammation of the infrapatellar bursa causes pain and swelling at the front of the knee. To date, only a few studies have reported cases of infrapatellar bursitis that are treated using Korean medicine. The aim of the present study is to report a case of a 27-year-old male with front knee pain caused by infrapatellar bursitis that was treated with integrated Korean medicine treatments (e.g., acupuncture, pharmacopuncture, herbal medicine). The patient-reported numeric rating scale confirmed that the patient's pain was relieved, while the physical function tests also indicated a significant improvement. Based on the findings of this study, it can be suggested that integrated Korean medicine treatments could be an effective therapeutic option for patients diagnosed with infrapatellar bursitis.

• The Journal of Internal Korean Medicine
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• v.21 no.4
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• pp.661-665
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• 2000

Amyotrophic Lateral Sclerosis(ALS) is a fatal neuromuscular disease characterized by progressive muscle weakness resulting in paralysis. ALS is characterized by both upper and lower motor neuron damage. Diagnostic tests include magnetic resonance imaging(MRI) electromyogram(EMG), muscle biopsy, and blood tests. In order for a definitive diagnosis of ALS to be made, damage must be evident in both upper and lower motor neurons. When three limbs are sufficiently affected, the diagnosis is ALS. There is no cure for ALS. We recently experienced one case of ALS, The patients was diagnosed as ALS by EMG and Symptoms. We diagnosed her as Wea jeung and treated by Herbal-medication based on the differentiation of symtoms. we report change of his symptoms through both western medical treatment and oriental medical treatment.

• The Journal of Internal Korean Medicine
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• v.24 no.2
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• pp.387-394
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• 2003

Amiodarone is an effective antiarrhythmic agent because of its vasodilator actions. Nowadays it is mostly used to treat patients with severe cardiomyopathy or coronary artery disease complicated by disturbances in the supraventricular or ventricular rhythm. But, some doctors are reluctant to prescribe it because of its many side effects. These include impairment of liver and thyroid fuction and, rarely, damage to the lungs. Most of all, its most serious side effect is amiodarone-induced pulmonary toxicity, which can occur in up to 10% of patients, with mortality rates as high as 50%. We recently experienced one case of the patient with the Amiodarone-induced pulmonary toxicity. The clinical manifestations of the patient was cough, painful breathing, fever, presence of rales, decreased breath sounds, and sputum. We report the change of the patient's symptoms through both western medical treatment and oriental medical treatment.

• The Journal of Internal Korean Medicine
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• v.44 no.3
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• pp.366-386
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• 2023

Objective: In this study, a questionnaire survey was conducted for doctors and patients to obtain basic data necessary for the development of an integrated medical system for idiopathic pulmonary fibrosis (IPF). Methods: Questionnaires were developed separately for doctors and patients through an expert group meeting. The survey subjects were recruited online and offline, and finally, responses from 231 doctors and 59 patients were used for statistical analysis. Results: The most important parts in the treatment of IPF for both doctors and patients were the "improvement of respiratory symptoms," "improvement of quality of life," and "prevention of disease progression." Antifibrotic agents were prescribed at a high rate, and 100% of the specialists in Western medicine (WM) and 45.8% of patients reported experiencing side effects. As for the additional payment costs that patients considered as affordable for an integrated medical system, "under 50,000 won (about 38$)" was reported the most in both doctor and patient groups. With regard to the reasons for their reluctance to recommend an integrated medical system for IPF, specialists in WM responded highly to "uncertain evidence for treatment effectiveness." Regarding complementary and alternative medicine therapies that can be beneficial in patients with IPF, "lifestyle management," "diet management," "herb," "relaxation therapy," and "psychotherapy" were ranked high in both doctor and patient groups. Conclusions: In this study, a questionnaire survey on IPF was conducted to review actual treatment status, analyze shortcomings, and identify considerations for the development of an integrated medical system for IPF in the future.