• Journal of Korean Elementary Science Education
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• v.32 no.4
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• pp.473-484
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• 2013

The purpose of this study was to develop science and art integrated program to improve the creativity of scientifically gifted elementary school students. This study was to develop science and art integrated program to enhance the creativity of these subjects. This program was consisted of 30 lessons covering 10 topics. It was developed of five stages including the observation stage reflecting the characteristics of the right hemisphere relevant to creativity, the interest and curiosity stage, the experiment design and performing stage, the internalization stage, and the stage of expressing arts. This program was applied to 20 senior gifted students in Y Elementary School in Gyeonggi province. Torrance Tests of Creative Thinking(TTCT) was used in order to investigate and measure the effectiveness of the program before and after its use in class. The results of this study are as follows: First, this program showed results of significant improvement of creativity of scientifically gifted elementary school students after its use in class(p<.05). Second, it was significantly effective in increasing their creativity, especially in the subdomains such as originality, abstractness of title, and territory of resistance on hasty conclusions after its use in class(p<.05). Third, it was significantly effective to increase the Creativity Index that represents creative potential(p<.01). In particular, emotional expression, internalized visualization, unique visualization, and richness of the imagery emerged. This study implies that the science and art integrated program was closely related to the right hemisphere of the features enabling the subjects to create new ideas, new things, and new reactions. In addition, this program is expected to contribute to activate the brain areas of creativity for gifted students in the science field.

• Journal of The Korean Association For Science Education
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• v.35 no.4
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• pp.549-555
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• 2015

In this study, we investigated the influences of Integrated Science on the views of 10th graders with regards to the nature of science (NOS), STS, interest in science, and science aspiration, in order to explore the effects of Integrated Science developed under the 2009 Revised National Curriculum. Participants in this study were 214 10th graders in Seoul. The survey was administered at the beginning and at the end of the Integrated Science course. The analyses of the results revealed that there was no statistically significant difference in the scores of the pre-test and post-test on the NOS survey. However, the post-test scores of the tentativeness of scientific knowledge and the use of imagination, which are the sub-constructs of the NOS, were found to be significantly lower than the pre-test scores. There were no statistically significant differences in the frequencies of the responses to each item of the STS survey. The pre-test and post-test scores of the interest in science and the science aspiration were also not significantly different. The results indicated that Integrated Science did not have any impact on students' views on NOS, STS, interest in science, and science aspiration. Educational implications of these findings are discussed.

• Bulletin of the Korean Chemical Society
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• v.25 no.9
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• pp.1366-1370
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• 2004

Controlled pore glass bead was modified with bovine serum albumin (BSA), and glutathione (GSH) was immobilized through three kinds of linkers on top of BSA. Bis(3-sulfo-N-hydroxysuccinimide suberate) sodium salt $(BS^3)$, N-hydroxysuccinimide 3-(2-pyridyldithio)propionate (SPDP), or N-hydroxysuccinimide 4-maleimidobutyrate (GMBS) was introduced into the BSA-bound matrix. Subsequently, GSH was immobilized by addition of thiol side chain into the maleimido moiety, replacing a disulfide group, or formation of an amide group upon releasing 3-sulfo-N-hydroxysuccimide group. It was observed that conjugation methodology played a critical role for activity of the immobilized GSH. SDS-PAGE chromatogram showed that the matrix of glutathione immobilized on BSA through GMBS manifested high selectivity towards glutathione-S-transferase (GST) in cell lysate.

• Genomics & Informatics
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• v.14 no.2
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• pp.46-52
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• 2016

Diverse somatic mutations have been reported to serve as cancer drivers. Recently, it has also been reported that epigenetic regulation is closely related to cancer development. However, the effect of epigenetic changes on cancer is still elusive. In this study, we analyzed DNA methylation data on colon cancer taken from The Caner Genome Atlas. We found that several promoters were significantly hypermethylated in colon cancer patients. Through clustering analysis of differentially methylated DNA regions, we were able to define subgroups of patients and observed clinical features associated with each subgroup. In addition, we analyzed the functional ontology of aberrantly methylated genes and identified the G-protein-coupled receptor signaling pathway as one of the major pathways affected epigenetically. In conclusion, our analysis shows the possibility of characterizing the clinical features of colon cancer subgroups based on DNA methylation patterns and provides lists of important genes and pathways possibly involved in colon cancer development.

• Journal of Science Education
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• v.45 no.3
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• pp.364-378
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• 2021

This study explores the perception of Engineering Design of teachers who have long experience in the Integrated STEAM education. The teachers participating in this study were 12 elementary and secondary teachers with more than five years of experience in the Integrated STEAM Education. The study conducted semi-structured interviews. Interview questions focused on experiences of Integrated STEAM Education and recognition of Engineering Design, whether or not to reflect the curriculum of Engineering Design, and actual cases of Integrated STEAM Education with Engineering Design. As a result of this study, the teachers who participated in this study recognized that 'identification and coexistence of concepts for science, technology, and engineering' about Engineering Design, 'Creative design is possible when creativity is added to Engineering Design', 'Engineering Design is to analyze the economic feasibility and utility of the output created through the creative design process', 'Engineering Design is only for students who choose a career in science and engineering'. Based on this research, We need to establish and present correct concepts for science, technology, and engineering, and make an effort to include Engineering Design for solving scientific problems in the curriculum. In addition, we will have to develop and spread the Integrated STEAM Education program including Engineering Design and apply it in the field. Through this, we will have to find concrete action plans to improve the perception of science and engineering Integrated STEAM programs and Engineering Design among novice teachers and preservice teachers.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.11a
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• pp.301-304
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• 2003

This paper presents a case study on an integration between ERP and GIS solutions. Some expected advantages of each solution of the integrated system are discussed. We select an integrated system composed of SAP R/3 ERP and ESRI GIS solutions. The data and software integration (interface) framework are discussed, and finally some further studies are added.

• Proceedings of the Safety Management and Science Conference
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• 2000.05a
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• pp.27-32
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• 2000

This study presents the design of integrated safety, quality, and environmental information system based on the internet environment. Quality management system, environmental management system, and safety management system are adapted in many manufacturing and service organization respectively but those system does not work effectively. Especially safety management system and environmental management system are very similar with format and contents. Therefore, Those system must be integrated to increase effiency.

• Proceedings of the Safety Management and Science Conference
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• 2003.11a
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• pp.291-296
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• 2003

In this paper, we purpose the integrated TMS to solve the problem of current systems. Current system resulted in the inconvenience because customer and user must contact to each systems when they want to know the information about the order. In this time, we make the system customer and user can confirm all of order information from one system to solve this problem by integrating the information brought from two systems on constructing integrated DataBase.

• Structural Engineering and Mechanics
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• v.4 no.6
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• pp.717-729
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• 1996

This paper presents the concepts of Process Innovation and Concurrent Engineering in view of their use within Integrated CAD Systems. It follows by proposing process models that support an effective implementation. The work is practically founded on the authors' experience in performing the initial steps of implementation of some of such integrated systems for the construction industry.

• Proceedings of the Safety Management and Science Conference
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• 2008.11a
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• pp.153-160
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• 2008

This paper presents the log likelihood function for integrated models for ALT such as exponential-general Eyring, Weibull-temperature and specific heat, lognormal-temperature and specific heat. Additionally this paper estimates the system reliability and mean time to failure(MTTF) for series, parallel, k of n, and standby system using ALT linkage parameter. Lastly this study designs three variable reliability acceptance sampling(RAS) plans such as type I, II censored test, sequential test by the use of integrated models for ALT.