• BMB Reports
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• v.50 no.11
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• pp.539-545
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• 2017

The Integrated Stress Response (ISR) refers to a signaling pathway initiated by stress-activated $eIF2{\alpha}$ kinases. Once activated, the pathway causes attenuation of global mRNA translation while also paradoxically inducing stress response gene expression. A detailed analysis of this pathway has helped us better understand how stressed cells coordinate gene expression at translational and transcriptional levels. The translational attenuation associated with this pathway has been largely attributed to the phosphorylation of the translational initiation factor $eIF2{\alpha}$. However, independent studies are now pointing to a second translational regulation step involving a downstream ISR target, 4E-BP, in the inhibition of eIF4E and specifically cap-dependent translation. The activation of 4E-BP is consistent with previous reports implicating the roles of 4E-BP resistant, Internal Ribosome Entry Site (IRES) dependent translation in ISR active cells. In this review, we provide an overview of the translation inhibition mechanisms engaged by the ISR and how they impact the translation of stress response genes.

• Journal of Science Education
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• v.37 no.2
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• pp.278-293
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• 2013

The purpose of this study was to analyze the characteristics of multiple-choice test items used in assessment of high school integrated science according to 2009 revised curriculum. For the analysis of the tendency of item setting, we devised an analytic framework specific to integrated science, and analyzed the characteristics of items by applying the devised framework and item response theory. The results of the tendency of item setting revealed that most of items run counter to the intent of integrated science in terms of item resource, integration extent, and cognitive level, which means teachers are stick to separative method in teaching-learning and assessment of integrated science. The results of the analysis applying item response theory showed that item difficulty was appropriate and item discrimination was considerably high. However, there was no relevance between the tendency of item setting and qualitative characteristics of the items. We also discussed some agendas to improve the teaching-learning and assessment of integrated science based on the results of this study.

• Proceedings of the Korean Nuclear Society Conference
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• 2005.05a
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• pp.731-732
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• 2005

• Structural Engineering and Mechanics
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• v.52 no.1
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• pp.205-220
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• 2014

This paper is concerned with the modification of multidisciplinary feasible formulation for MDO problems using the integrated coupled approximate models. A drawback of conventional MDFs is the numerical difficulty in decomposing the design variables and deriving the coupled equations of state. To overcome such a drawback of conventional methods, the coupling in analysis and design is resolved by approximating the state variables in each discipline by the response surface method and by modifying the optimization formulation using the corresponding integrated coupled approximate models. The validity, reliability and effectiveness of the proposed method are illustrated and verified through two optimization problems, a mathematical MDF problem and the multidisciplinary optimum design of suspension unit of wheeled armored vehicle.

• Journal of the Society of Naval Architects of Korea
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• v.44 no.2 s.152
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• pp.148-153
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• 2007

Two typical impact loadings, shock wave and gas bubble pulse, due to UNDEX(UNDerwater EXplosion), should be considered together for the closest response analysis of structure subjected to UNDEX to a reality. Since these two impact loadings have different response time bands, however, their response characteristics of structure are different from each other. It is impossible to consider these effectively under the current computational environment and the mathematical model has not yet been developed. Whereas Hicks model approximates the fluid-structure interaction due to gas bubble pulse as virtual mass effect, treating the flow by the response of gas bubble after shock wave as incompressible ideal fluid contrary to the compressible flow due to shock wave, Geers-Hunter model could make the closest response analysis of structure under UNDEX to a real one as a mathematical model considering the fluid-structure interaction due to shock wave and gas bubble pulse together using acoustic wave theory and DAA(Doubly Asymptotic Approximation). In this study, the application and effectiveness of integrated dynamic response analysis of submerged structure was examined with the analysis of the shock wave and gas bubble pulse together.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.7
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• pp.1169-1175
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• 2016

As an Increased penetration level of renewable resources has caused concerns about primary frequency response, an increase in BESS(Battery Energy Storage System) capacity has been expected because of its fast response to the disturbances in the power system. This paper proposes the Integrated Control Strategy of multiple BESS for effectively providing the primary frequency control in the bulk power systems by coordinating the response, SOC and its recovery of BESS. The proposed strategy prevents multiple BESS from providing exceeding response and keeps the balance between SOC of multiple BESS. In addition, It would recover the SOC of BESS efficiently. The effectiveness of the proposed strategy is verified through various case studies employing Korean power system.

• Journal of the Korean Association of Geographic Information Studies
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• v.17 no.4
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• pp.179-188
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• 2014

Social overhead capital (SOC) facilities are being threatened continuously by abnormal climate events that are increasing globally. For disaster response, rapid decision making on evacuation routes and other matters is critical. For this purpose, spatiotemporal information that combine data on disasters and SOC facilities needs to be utilized. This information is separately collected by government agencies and public organizations, and is not managed in an integrated manner. For rapid disaster response, an integrated management of separately collected disaster data and the creation of such information as the safety and damages on SOC facilities are required. To achieve this goal, it is essential to build inventories that integrate all the related information to support decision making indispensable for disaster response. In this study, a development plan for an integrated inventory management system based on the management and connection of inventories to support rapid decision making for disaster response is proposed. This system can collect and standardize data related to disasters and SOC facilities that are being managed separately and provide integrated information in line with the needs of users. The proposed system can be used as a decision making tool for proactive disaster response.

• Journal of Navigation and Port Research
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• v.35 no.9
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• pp.735-740
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• 2011

It is necessary to develop the one stop system in order to protect our marine environment rapidly from oil spill accident. The purpose of this study is to develop real time database for oil spill prediction modeling and implement real time prediction modelling with ESI and server-client GIS based user interface. The existing oil spill prediction model cannot provide one stop information system for public and government who should protect sea from oil spill accident. The development of multi user based information system permits integrated handling of real time meteorological data from external ftp. A server-client GIS based model is integrated on the basis of real time database and ESI map to provide the result of the oil spill prediction model. End users can access through the client interface and request analysis such as oil spill prediction and GIS functions on the network as their own purpose.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.05a
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• pp.1016-1020
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• 2000

In this study, a structural characteristics analysis system for motor-integrated high-speed spindle systems, “SpindleX”, is developed based on the Timoshenko theory and the multi-layered finite element method. Since “SpindleX” has the various analysis modules related to static deflection analysis, modal analysis, frequency response analysis, unbalance response analysis and so on, it is useful in performing systematically and quantitatively the design and evaluation processes of spindle system under the windows GUI environment. Also, to enhance the user-friendliness, “SpindleX” possesses the various additional functions such as the DXF file interface for auto-importing the shape and geometric data of spindle system from the DXF file, the bearing database for auto-importing the mechanical properties and geometric data of bearing by the bearing number, and the graphical visualization for certificating the imported and analysed data of spindle system.

• 한국정보디스플레이학회:학술대회논문집
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• 2007.08a
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• pp.825-828
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• 2007

This paper presents a thermally adaptive driving (TAD) technology for response time compensation of LCD with integrated sensor. The TAD is comprised of analog sensor signal conditioning and a digital feedback algorithm. Utilizing with a digital feedback system, TAD reduces response time of nearly 50% over the temperature range $0^{\circ}C-60^{\circ}C$.